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Parameter Estimation Techniques Applied To A Model Of Human Respiratory Gas Exchange Processes
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Book Synopsis Parameter Estimation Techniques Applied to a Model of Human Respiratory Gas Exchange Processes by : Kenneth George Pearson
Download or read book Parameter Estimation Techniques Applied to a Model of Human Respiratory Gas Exchange Processes written by Kenneth George Pearson and published by . This book was released on 1975 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modeling and Parameter Estimation in Respiratory Control by : M.C.K. Khoo
Download or read book Modeling and Parameter Estimation in Respiratory Control written by M.C.K. Khoo and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimentalists tend to revel in the complexity and multidimensionality of biological processes. Modelers, on the other hand, generally look towards parsimony as a guiding prin ciple in their approach to understanding physiological systems. It is therefore not surprising that a substantial degree of miscommunication and misunderstanding still exists between the two groups of truth-seekers. However, there have been numerous instances in physiology where the marriage of mathematical modeling and experimentation has led to powerful in sights into the mechanisms being studied. Respiratory control represents one area in which this kind of cross-pollination has proven particularly fruitful. While earlier modeling ef forts were directed primarily at the chemical control of ventilation, more recent studies have extended the scope of modeling to include the neural and mechanical aspects pertinent to respiratory control. As well, there has been a greater awareness of the need to incorpo rate interactions with other organ systems. Nevertheless, it is necessary from time to time to remind experimentalists of the existence of modelers, and vice versa. The 4th Annual Biomedical Simulations Resource (BMSR) Short Course was held in Marina Del Rey on May 21-22,1989, to acquaint respiratory physiologists and clinical researchers with state-of-the art methodologies in mathematical modeling, experiment design and data analysis, as well as to provide an opportunity for experimentalists to challenge modelers with their more recent findings.
Book Synopsis Mathematical and Computational Methods in Physiology by : L. Fedina
Download or read book Mathematical and Computational Methods in Physiology written by L. Fedina and published by Elsevier. This book was released on 2013-10-22 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical and Computational Methods in Physiology discusses the importance of quantitative description of physiological phenomena and for quantitative comparison of experimental data. An article explains the homeostasis of the body with a focus on the controlling aspects. This section evaluates the concepts of modern physiology and biocybernetics. The canal-ocular reflex and the otolith-ocular reflex in man stimulates eye rotations compensatory for head angular and linear displacements. The book enumerates some modelling and simulation to observe the visual-vestibular interaction during angular and linear body acceleration. A section on the determination of cardiovascular control is given. The text reviews the mathematical models of the biological age of the rat. A numerical simulation of water transport in epithelial junctions is explained comprehensively. A chapter analyzing the computer simulation of drug-receptor interaction is presented. The book will provide useful information to zoologists, doctors, ophthalmologists, students and researchers in the field of medicine.
Book Synopsis Computational Models for Respiratory Gas Exchange and Their Applications by : Wendy Wenying Kang
Download or read book Computational Models for Respiratory Gas Exchange and Their Applications written by Wendy Wenying Kang and published by . This book was released on 2017 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary function of the lungs is the transport and exchange of oxygen and removal of carbon dioxide that is critical in supporting normal function of vital body organs. Various modelling studies have attempted to investigate and capture aspects of the gas exchange process and its regulation with different levels of complexity and detail. The aim of this thesis is to assess the trade-off between gas exchange model complexity and feasibility and within a respiratory system modelling framework, and its applications to facilitate understanding of lung physiology during normal function and pathology. An integrated comprehensive modelling framework that allows gas exchange prediction within anatomically based lung geometry is presented. Structural and functional simplifications are assessed to result in a class of models with increasing complexity in their description of gas exchange in the human lungs, which span from simple steady state prediction, to fitting empirical equations that capture characteristic behaviour, to complex equations derived from underlying physiological principles; and the model can be scaled from a few compartments to distributions of approximately 32,000 compartments in the whole lung. The classes of gas exchange models are assessed for their applicability in modelling key pulmonary functions and appropriate models are used to investigate three questions relating to physiology, experimentation/imaging, and gas exchange during clinical therapy. First, the simplest steady state model is used to study structure-function relationships in the normal lung and reconcile differing experimental observations on the relative importance of passive ventilation-perfusion matching mechanisms. Simulation results show that during quiet supine breathing, the effects of gravity introduce significant heterogeneity in ventilation and perfusion but also provide spatial correlation, while the effects of ‘matched’ airway and arterial structure play a relatively minor role. Second, the model at its highest resolution is validated through simulations of two well-established experimental protocols: the gold standard multiple inert gas elimination technique, and high resolution specific ventilation imaging (SVI). The model is able to mimic the two experimental protocols and can give accurate O2 predictions of global and regional function in normal and abnormal lung states. Furthermore, an in-silico examination of the assumptions of the specific ventilation imaging technique are performed, which pointed to the confounding influence of venous blood flow and image misalignment on experimental obtained SVI maps. Third, the feasibility of model application to a clinical setting is examined by applying the simplified model to systematically investigate several mechanisms of efficacy for nasal high flow therapy in a cohort of 20 post-cardiac surgery patients. Results showed that this generic model can be parameterised to represent individualised patient respiratory response. Moreover, model predictions show that flow induced nasopharyngeal washout largely reduce respiratory efforts without improving oxygenation, when arterial carbon dioxide is within the normal range. The highly debated mechanism of pressure induced alveolar recruitment is required to produce model predictions that are consistent with clinical measurements for some individuals in this patient cohort. The models and studies presented here provide a basis for extension and application to future research in studying interaction of underlying physiology mechanisms, biomedical imaging of pulmonary function, and clinical problems of gas exchange.
Book Synopsis Identification and System Parameter Estimation 1982 by : G. A. Bekey
Download or read book Identification and System Parameter Estimation 1982 written by G. A. Bekey and published by Elsevier. This book was released on 2016-06-06 with total page 869 pages. Available in PDF, EPUB and Kindle. Book excerpt: Identification and System Parameter Estimation 1982 covers the proceedings of the Sixth International Federation of Automatic Control (IFAC) Symposium. The book also serves as a tribute to Dr. Naum S. Rajbman. The text covers issues concerning identification and estimation, such as increasing interrelationships between identification/estimation and other aspects of system theory, including control theory, signal processing, experimental design, numerical mathematics, pattern recognition, and information theory. The book also provides coverage regarding the application and problems faced by several engineering and scientific fields that use identification and estimation, such as biological systems, traffic control, geophysics, aeronautics, robotics, economics, and power systems. Researchers from all scientific fields will find this book a great reference material, since it presents topics that concern various disciplines.
Book Synopsis Advanced Simulation in Biomedicine by : Dietmar P.F. Möller
Download or read book Advanced Simulation in Biomedicine written by Dietmar P.F. Möller and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a collection of invited contributions, each reflecting an area of biomedicine in which simulation techniques have been successfully applied. Thus, it provides a state-of-the-art survey of simulation techniques in a variety of biomedical applications. Chapter one presents the conceptual framework for advanced simulations such as parallel processing in biological systems. Chapter two focuses on structured biological modeling based on the bond graph method. This is followed by an up-to-date account of advanced simulation of a variety of sophisticated biomedical processes. The authors provide many insights into how computer simulation techniques and tools can be applied to research problems in biomedicine. The idea for this book arose out of the daily work by experts in their field and reflects developing areas. Therefore, I think the material is timely and hope that the work described will be an encouragement for others. It is the objective of this book to present advanced simulation techniques in biomedicine and outline current research, as well as to point out open problems, in this dynamic field. Finally, I wish to express my thanks to those colleagues who have made this book possible with their contributions.
Author :Sponsored by The Health Effects Institute Publisher :National Academies Press ISBN 13 :0309037263 Total Pages :703 pages Book Rating :4.3/5 (9 download)
Book Synopsis Air Pollution, the Automobile, and Public Health by : Sponsored by The Health Effects Institute
Download or read book Air Pollution, the Automobile, and Public Health written by Sponsored by The Health Effects Institute and published by National Academies Press. This book was released on 1988-01-01 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The combination of scientific and institutional integrity represented by this book is unusual. It should be a model for future endeavors to help quantify environmental risk as a basis for good decisionmaking." â€"William D. Ruckelshaus, from the foreword. This volume, prepared under the auspices of the Health Effects Institute, an independent research organization created and funded jointly by the Environmental Protection Agency and the automobile industry, brings together experts on atmospheric exposure and on the biological effects of toxic substances to examine what is knownâ€"and not knownâ€"about the human health risks of automotive emissions.
Book Synopsis Non-invasive Clinical Measurement by : David Ernest Meguyer Taylor
Download or read book Non-invasive Clinical Measurement written by David Ernest Meguyer Taylor and published by . This book was released on 1977 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Index to Theses Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards by :
Download or read book Index to Theses Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards written by and published by . This book was released on 1980 with total page 862 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pulmonary Gas Exchange by : G. Kim Prisk
Download or read book Pulmonary Gas Exchange written by G. Kim Prisk and published by Biota Publishing. This book was released on 2013-08-01 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lung receives the entire cardiac output from the right heart and must load oxygen onto and unload carbon dioxide from perfusing blood in the correct amounts to meet the metabolic needs of the body. It does so through the process of passive diffusion. Effective diffusion is accomplished by intricate parallel structures of airways and blood vessels designed to bring ventilation and perfusion together in an appropriate ratio in the same place and at the same time. Gas exchange is determined by the ventilation-perfusion ratio in each of the gas exchange units of the lung. In the normal lung ventilation and perfusion are well matched, and the ventilation-perfusion ratio is remarkably uniform among lung units, such that the partial pressure of oxygen in the blood leaving the pulmonary capillaries is less than 10 Torr lower than that in the alveolar space. In disease, the disruption to ventilation-perfusion matching and to diffusional transport may result in inefficient gas exchange and arterial hypoxemia. This volume covers the basics of pulmonary gas exchange, providing a central understanding of the processes involved, the interactions between the components upon which gas exchange depends, and basic equations of the process.
Book Synopsis Proceedings of the 2nd European Simulation Congress, Sept. 9-12, 1986, The Park Hotel, Antwerp, Belgium by : Philippe Geril
Download or read book Proceedings of the 2nd European Simulation Congress, Sept. 9-12, 1986, The Park Hotel, Antwerp, Belgium written by Philippe Geril and published by VSP. This book was released on 1986 with total page 832 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Scientific and Technical Aerospace Reports by :
Download or read book Scientific and Technical Aerospace Reports written by and published by . This book was released on 1988 with total page 968 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :United States. Public Health Service. Office of the Surgeon General Publisher : ISBN 13 : Total Pages :728 pages Book Rating :4.:/5 (318 download)
Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Book Synopsis Modelling Methodology for Physiology and Medicine by : Ewart Carson
Download or read book Modelling Methodology for Physiology and Medicine written by Ewart Carson and published by Newnes. This book was released on 2013-12-05 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practice Editors are internationally renowned leaders in their respective fields Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems
Book Synopsis Testing and Validation of Computer Simulation Models by : David J. Murray-Smith
Download or read book Testing and Validation of Computer Simulation Models written by David J. Murray-Smith and published by Springer. This book was released on 2015-10-08 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This must-read text/reference provides a practical guide to processes involved in the development and application of dynamic simulation models, covering a wide range of issues relating to testing, verification and validation. Illustrative example problems in continuous system simulation are presented throughout the book, supported by extended case studies from a number of interdisciplinary applications. Topics and features: provides an emphasis on practical issues of model quality and validation, along with questions concerning the management of simulation models, the use of model libraries, and generic models; contains numerous step-by-step examples; presents detailed case studies, often with accompanying datasets; includes discussion of hybrid models, which involve a combination of continuous system and discrete-event descriptions; examines experimental modeling approaches that involve system identification and parameter estimation; offers supplementary material at an associated website.
Book Synopsis Comparative Biology of the Normal Lung by : Richard A. Parent
Download or read book Comparative Biology of the Normal Lung written by Richard A. Parent and published by Academic Press. This book was released on 2015-03-13 with total page 835 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comparative Biology of the Normal Lung, Second Edition, offers a rigorous and comprehensive reference for all those involved in pulmonary research. This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. This edition includes several new chapters and expanded content, including aging and development of the normal lung, mechanical properties of the lung, genetic polymorphisms, the comparative effect of stress of pulmonary immune function, oxygen signaling in the mammalian lung and much more. By addressing scientific advances and critical issues in lung research, this 2nd edition is a timely and valuable work on comparative data for the interpretation of studies of animal models as compared to the human lung. Edited and authored by experts in the field to provide an excellent and timely review of cross-species comparisons that will help you interpret and compare data from animal studies to human findings Incorporates lung anatomy and physiology, cell specific interactions and immunological responses to provide you with a single and unique multidisciplinary source on the comparative biology of the normal lung Includes new and expanded content on neonatal and aged lungs, developmental processes, cell signaling, antioxidants, airway cells, safety pharmacology and much more Section IV on Physical and Immunological Defenses has been significantly updated with 9 new chapters and an increased focus on the pulmonary immunological system
Download or read book Research Awards Index written by and published by . This book was released on 1982 with total page 1170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
