Pain Control, an Issue of Hematology/Oncology Clinics of North America

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Author :
Publisher : Elsevier
ISBN 13 : 9780323610568
Total Pages : pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Pain Control, an Issue of Hematology/Oncology Clinics of North America by : Janet L. Abrahm

Download or read book Pain Control, an Issue of Hematology/Oncology Clinics of North America written by Janet L. Abrahm and published by Elsevier. This book was released on 2018-06-28 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics, edited by Dr. Janet Abrahm, focuses on Pain Control. Topics include, but are not limited to, Complex pain assessment; Evidence-based non-pharmacologic therapies; Non-opioid pharmacologic therapies; Opioid caveats, newer agents, and prevention/management of side effects and of aberrant use; Cancer pain syndromes; Agents for neuropathic pain RX; Mechanism of and Adjuvants for bone pain; Interventional anesthetic methods; Radiation therapy methods; Rehabilitation methods; Psychological treatment; Spiritual considerations; Pain in patients with SS diseases; and Pain in HSCT patients.

Sickle Cell Syndromes, An Issue of Hematology/Oncology Clinics of North America, E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323986641
Total Pages : 289 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Sickle Cell Syndromes, An Issue of Hematology/Oncology Clinics of North America, E-Book by : Sophie Lanzkron

Download or read book Sickle Cell Syndromes, An Issue of Hematology/Oncology Clinics of North America, E-Book written by Sophie Lanzkron and published by Elsevier Health Sciences. This book was released on 2022-11-20 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Hematology/Oncology Clinics, guest editors Drs. Sophie Lanzkron and Jane Little bring their considerable expertise to the topic of Sickle Cell Syndromes. Top experts in the field cover key topics such as structural racism and impact on sickle cell disease (SCD); pathophysiology and biomarkers of SCD; genetic modifiers of SCD; allogeneic transplant and gene therapy: reproductive health; chronic pain; and more. Contains 16 relevant, practice-oriented topics including innovative therapies, addressing challenging complications, novel science on mechanisms of disease; preventing cognitive decline in people with SCD; quality of life in SCD; and more. Provides in-depth clinical reviews on sickle cell syndromes, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Central Nervous System Malignancies, An Issue of Hematology/Oncology Clinics of North America - E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 1455747637
Total Pages : 240 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Central Nervous System Malignancies, An Issue of Hematology/Oncology Clinics of North America - E-Book by : Jill Lacy

Download or read book Central Nervous System Malignancies, An Issue of Hematology/Oncology Clinics of North America - E-Book written by Jill Lacy and published by Elsevier Health Sciences. This book was released on 2012-07-29 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics include: Neoplastic Meningitis and Epidural Metastases: Evaluation and Management; Management of Brain Metastases: Surgery, Radiation, or Both?; Meningiomas/Nerve Sheath Tumors/Pituitary Tumors: Diagnosis and Treatment; Medulloblastoma/Primitive Neuroectodermal Tumor and Germ Cell Tumors: The Uncommon but Potentially Curable Primary Brain Tumors; Primary CNS Lymphoma: Overview of Current Treatment Strategies; Anaplastic Gliomas: Radiation, Chemotherapy, or Both?; Low Grade Gliomas: When and How to Treat?; Glioblastoma Multiforme: Overview of Current Treatment and Future Perspectives.

Mantle Cell Lymphoma, An Issue of Hematology/Oncology Clinics of North America,E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323763138
Total Pages : 225 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Mantle Cell Lymphoma, An Issue of Hematology/Oncology Clinics of North America,E-Book by : John P. Leonard

Download or read book Mantle Cell Lymphoma, An Issue of Hematology/Oncology Clinics of North America,E-Book written by John P. Leonard and published by Elsevier Health Sciences. This book was released on 2020-09-11 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics, Guest Edited by Dr. John P. Leonard, is devoted to Mantle Cell Lymphoma. This issue is one of six selected each year by our series Consulting Editors, George P. Canellos and Edward J. Benz. Topics discussed in this important issue include: Molecular pathogenesis of Mantle Cell Lymphoma; MCL and cell cycle dysregulation; Heterogeneity in MCL biology and outcomes; Watch and wait in mantle cell lymphoma; Limited stage mantle cell lymphoma; Initial and consolidation therapy for younger patients with MCL; Approach to the initial treatment of older patients with MCL; Current and future approaches to the use of minimal residual disease monitoring in the treatment of patients with MCL; Bruton’s Tyrosine Kinase inhibitors for treatment of Mantle Cell Lymphoma; BTKi resistance in MCL; Blastoid MCL; Allogeneic transplant and CAR-T cell therapy in MCL; Quality of life considerations and chronic therapy in management of patients with MCL; and Key clinical and translational research questions.

Gynecologic Cancer, An Issue of Hematology/Oncology Clinics of North America - E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 1455742856
Total Pages : 1440 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Gynecologic Cancer, An Issue of Hematology/Oncology Clinics of North America - E-Book by : Ross S. Berkowitz

Download or read book Gynecologic Cancer, An Issue of Hematology/Oncology Clinics of North America - E-Book written by Ross S. Berkowitz and published by Elsevier Health Sciences. This book was released on 2012-02-28 with total page 1440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics include:Genetic Risk and Gynecologic Cancer, Current Management of Preinvasive Cervical Neoplasia, Current Surgical Management of Cervical Neoplasia, Current Surgical Management of Ovarian Cancer, Current Management of Trophoblastic Disease, and New Developments in Radiation Management and Gynecologic Cancers

Chronic Lymphocytic Leukemia, An Issue of Hematology/Oncology Clinics of North America, E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323896936
Total Pages : 217 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Chronic Lymphocytic Leukemia, An Issue of Hematology/Oncology Clinics of North America, E-Book by : Jennifer R. Brown︎

Download or read book Chronic Lymphocytic Leukemia, An Issue of Hematology/Oncology Clinics of North America, E-Book written by Jennifer R. Brown︎ and published by Elsevier Health Sciences. This book was released on 2021-07-01 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics, guest edited by Dr. Jennifer R. Brown?, will focus on Chronic Lymphocytic Leukemia. This issue is one of six selected each year by our series consulting editors, Dr. George P. Canellos and Dr. Edward J. Benz. Topics discussed in this issue will include: Chronic Lymphocytic Leukemia: Do We Know the Cell of Origin Yet?; Significance of BCR Stereotypy; Prognostic and Predictive Implications of Cytogenetics and Genomics; Role of Epigenetics in Chronic Lymphocytic Leukemia; Genomics of Resistance to Targeted Therapies; First Line Therapy for Chronic Lymphocytic Leukemia; The Ongoing Unmet Needs in Chronic Lymphocytic Leukemia Therapy; BTK Inhibitors; Minimal Residual Disease; Should Undetectable MRD Be the Goal of Chronic Lymphocytic Leukemia Therapy?; Management of Chronic Lymphocytic Leukemia after Progression on BTK Inhibitors; Role of PI3K Inhibitors in Chronic Lymphocytic Leukemia; Can We Restore the Immunodeficiency of Chronic Lymphocytic Leukemia?; and Immune Therapy for Chronic Lymphocytic Leukemia

Lung Cancer, An Issue of Hematology/Oncology Clinics of North America, E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0443183074
Total Pages : 209 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Lung Cancer, An Issue of Hematology/Oncology Clinics of North America, E-Book by : Sarah B. Goldberg

Download or read book Lung Cancer, An Issue of Hematology/Oncology Clinics of North America, E-Book written by Sarah B. Goldberg and published by Elsevier Health Sciences. This book was released on 2023-05-11 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Hematology/Oncology Clinics, guest editors Drs. Sarah B. Goldberg and Roy S. Herbst bring their considerable expertise to the topic of Lung Cancer. Top experts in the field cover key topics such as state-of-the-art pathologic and molecular testing; neoadjuvant vs. adjuvant therapy for early-stage NSCLC; new therapies on the horizon (immunotherapy, ADCs, etc.); supportive care and symptom management; smoking cessation; and more. Contains 15 relevant, practice-oriented topics including lung cancer screening; advances in surgical techniques for lung cancer; non-surgical therapy for early-stage lung cancer; locally advanced lung cancer; what’s new in small cell lung cancer; and more. Provides in-depth clinical reviews on lung cancer, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Pain Control, An Issue of Hematology/Oncology Clinics of North America, E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323610579
Total Pages : 273 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Pain Control, An Issue of Hematology/Oncology Clinics of North America, E-Book by : Janet L. Abrahm

Download or read book Pain Control, An Issue of Hematology/Oncology Clinics of North America, E-Book written by Janet L. Abrahm and published by Elsevier Health Sciences. This book was released on 2018-05-14 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics, edited by Dr. Janet Abrahm, focuses on Pain Control. Topics include, but are not limited to, Complex pain assessment; Evidence-based non-pharmacologic therapies; Non-opioid pharmacologic therapies; Opioid caveats, newer agents, and prevention/management of side effects and of aberrant use; Cancer pain syndromes; Agents for neuropathic pain RX; Mechanism of and Adjuvants for bone pain; Interventional anesthetic methods; Radiation therapy methods; Rehabilitation methods; Psychological treatment; Spiritual considerations; Pain in patients with SS diseases; and Pain in HSCT patients.

Non-Hodgkin’s Lymphoma , An Issue of Hematology/Oncology Clinics of North America

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323682731
Total Pages : pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Non-Hodgkin’s Lymphoma , An Issue of Hematology/Oncology Clinics of North America by : Caron A Jacobson

Download or read book Non-Hodgkin’s Lymphoma , An Issue of Hematology/Oncology Clinics of North America written by Caron A Jacobson and published by Elsevier Health Sciences. This book was released on 2019-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics, guest edited by Dr. Caron A. Jacobson, with consulting editors George P. Canellos and H. Franklin Bunn, will focus on Non-Hodgkin’s Lymphoma. Topics include, but are not limited to: Ontogeny, Genetics, Molecular Biology and Classification of B and T cell Non-Hodgkin’s Lymphoma; Diffuse large B cell lymphoma and high grade B cell lymphoma; Burkitt lymphoma and other highly aggressive B cell lymphomas; CNS lymphoma; Mantle cell lymphoma; Follicular lymphoma; Marginal zone lymphoma and lymphoplasmacytic lymphoma; Non-cutaneous T cell lymphoma; Cutaneous T cell lymphoma; Transplant and other adoptive immune cell therapies for non-Hodgkin lymphoma; Non-cellular immune therapies for non-Hodgkin’s lymphoma; and Targeting biology in non-Hodgkin’s lymphoma.

Inherited Bleeding Disorders, An Issue of Hematology/Oncology Clinics of North America, E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323813380
Total Pages : 209 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Inherited Bleeding Disorders, An Issue of Hematology/Oncology Clinics of North America, E-Book by : Nathan T. Connell︎

Download or read book Inherited Bleeding Disorders, An Issue of Hematology/Oncology Clinics of North America, E-Book written by Nathan T. Connell︎ and published by Elsevier Health Sciences. This book was released on 2021-11-01 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inherited Bleeding Disorders, An Issue of Hematology/Oncology Clinics of North America, E-Book

Thalassemia, An Issue of Hematology/Oncology Clinics of North America, E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 044318321X
Total Pages : 241 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Thalassemia, An Issue of Hematology/Oncology Clinics of North America, E-Book by : Edward J. BenzJr

Download or read book Thalassemia, An Issue of Hematology/Oncology Clinics of North America, E-Book written by Edward J. BenzJr and published by Elsevier Health Sciences. This book was released on 2023-03-16 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Hematology/Oncology Clinics, guest editors Drs. Edward J. Benz, Jr. and Vijay G. Sankaran bring their considerable expertise to the topic of Thalassemia. Top experts in the field provide an overview of the history, epidemiology, pathogenic mechanisms, and clinical management of the thalassemia syndromes. Contains 16 practice-oriented topics including molecular basis and genetic modifiers of thalassemia; fetal hemoglobin in thalassemia; clinical complications and their management; iron chelation in thalassemia; fertility and pregnancy in women with transfusion-dependent thalassemia; gene therapy and genome editing in thalassemia; emerging medical therapies for thalassemia; and more. Provides in-depth clinical reviews on thalassemia, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Pancreatic Cancer, An Issue of Hematology/Oncology Clinics of North America, E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323986560
Total Pages : 201 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Pancreatic Cancer, An Issue of Hematology/Oncology Clinics of North America, E-Book by : Matthew B. Yurgelun

Download or read book Pancreatic Cancer, An Issue of Hematology/Oncology Clinics of North America, E-Book written by Matthew B. Yurgelun and published by Elsevier Health Sciences. This book was released on 2022-10-22 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Hematology/Oncology Clinics, guest editors Drs. Matthew B. Yurgelun and Douglas A. Rubinson bring their considerable expertise to the topic of Pancreatic Cancer. Top experts in the field cover key topics such as pancreatic adenocarcinoma: trends in epidemiology, risk factors, and outcomes; decision making regarding perioperative therapy in individuals with localized pancreatic adenocarcinoma; the evolving role of radiotherapy in the management of individuals with pancreatic adenocarcinoma; and more. Contains 14 relevant, practice-oriented topics including diabetes, cachexia, sarcopenia, and metabolic factors in individuals with pancreatic adenocarcinoma; PARP inhibitors and other novel therapeutics in pancreatic adenocarcinoma; screening and surveillance for pancreatic adenocarcinoma in high-risk individuals; germline testing for individuals with pancreatic adenocarcinoma and novel genetic risk factors; and more. Provides in-depth clinical reviews on pancreatic cancer, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Transfusion Medicine, an Issue of Hematology/Oncology Clinics of North America

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Publisher : Elsevier
ISBN 13 : 9780323709064
Total Pages : pages
Book Rating : 4.7/5 (9 download)

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Book Synopsis Transfusion Medicine, an Issue of Hematology/Oncology Clinics of North America by : Edward L. Snyder

Download or read book Transfusion Medicine, an Issue of Hematology/Oncology Clinics of North America written by Edward L. Snyder and published by Elsevier. This book was released on 2019-08-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics, Guest Edited by Drs. Edward Snyder and Eric A. Gehrie, with Consulting Editors George P. Canellos and H. Franklin Bunn, will focus on Transfusion Medicine. Topics include, but are not limited to, Pathogen Reduction, Transfusion Reactions-Infectious Complications, Txn Rxn-Non-Infectious Complications, Iron Deficiency and Teen Blood Donors, Advances in RBC Serology, Advances in Immunotherapy, Therapeutic Monoclonal Antibody Effect on RBC Compatibility Testing, Cell Therapy-New Regulations and Standards, Alternatives to Platelet and RBC Transfusions, New Hemostatic Agents, Tx Practices for Children with Cancer, and Relevance of Cold Platelets and WB to the Bleeding Oncology Patient.

Breast Cancer, An Issue of Hematology/Oncology Clinics of North America, E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0443181861
Total Pages : 265 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Breast Cancer, An Issue of Hematology/Oncology Clinics of North America, E-Book by : Harold J. Burstein

Download or read book Breast Cancer, An Issue of Hematology/Oncology Clinics of North America, E-Book written by Harold J. Burstein and published by Elsevier Health Sciences. This book was released on 2022-11-25 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Hematology/Oncology Clinics, guest editor Dr. Harold J. Burstein brings his considerable expertise to Breast Cancer. Top experts provide a comprehensive update on multidisciplinary management of early- and late-stage breast cancer, including key topics such as global perspectives on the epidemiology and treatment of breast cancer; breast cancer pathology in the era of genomics; optimizing radiation therapy after breast conserving surgery; and more. Contains 16 relevant, practice-oriented topics including disparities in breast cancer outcomes and how to resolve them; genetic testing in breast cancer; the role of ovarian suppression in early stage premenopausal breast cancer; multidisciplinary management of brain metastases from breast cancer; evidence-based guidance for breast cancer survivorship; and more. Provides in-depth clinical reviews on breast cancer, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Non-Hodgkin's Lymphoma, an Issue of Hematology/Oncology Clinics of North America

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Author :
Publisher : Elsevier
ISBN 13 : 9780323682251
Total Pages : pages
Book Rating : 4.6/5 (822 download)

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Book Synopsis Non-Hodgkin's Lymphoma, an Issue of Hematology/Oncology Clinics of North America by : Caron A. Jacobson

Download or read book Non-Hodgkin's Lymphoma, an Issue of Hematology/Oncology Clinics of North America written by Caron A. Jacobson and published by Elsevier. This book was released on 2019-08-28 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics, guest edited by Dr. Caron A. Jacobson, with consulting editors George P. Canellos and H. Franklin Bunn, will focus on Non-Hodgkin's Lymphoma. Topics include, but are not limited to: Ontogeny, Genetics, Molecular Biology and Classification of B and T cell Non-Hodgkin's Lymphoma; Diffuse large B cell lymphoma and high grade B cell lymphoma; Burkitt lymphoma and other highly aggressive B cell lymphomas; CNS lymphoma; Mantle cell lymphoma; Follicular lymphoma; Marginal zone lymphoma and lymphoplasmacytic lymphoma; Non-cutaneous T cell lymphoma; Cutaneous T cell lymphoma; Transplant and other adoptive immune cell therapies for non-Hodgkin lymphoma; Non-cellular immune therapies for non-Hodgkin's lymphoma; and Targeting biology in non-Hodgkin's lymphoma.

Global Oncology: Disparities, Outcomes and Innovations Around the Globe, An Issue of Hematology/Oncology Clinics of North America, E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0443182590
Total Pages : 297 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Global Oncology: Disparities, Outcomes and Innovations Around the Globe, An Issue of Hematology/Oncology Clinics of North America, E-Book by : Mary D. Chamberlin

Download or read book Global Oncology: Disparities, Outcomes and Innovations Around the Globe, An Issue of Hematology/Oncology Clinics of North America, E-Book written by Mary D. Chamberlin and published by Elsevier Health Sciences. This book was released on 2023-11-21 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Hematology/Oncology Clinics, guest editors Drs. Mary D. Chamberlin and Narjust Duma bring theirconsiderable expertise to the topic of Global Oncology: Disparities, Outcomes and Innovations Around the Globe. The first section of this issue is non-disease site-specific, covering broad topics that influence global health and oncology in various world regions, such as disparities, political unrest, the role of ASCO and ICEC and other organizations for education and research collaborations, access to training and innovations, etc. The second section is disease site-specific (lung, CNS, lymphoma, etc.), addressing approaches to prevention, access to treatment, survivorship, palliative care, and more. Contains 16 relevant, practice-oriented topics including North America: disparities of care and the role of ASCO in addressing disparities of cancer care; evolving epidemiology: impact of lifestyle and prevention for breast and lung cancers; education and training models for remote learning: GlobalMedNet, GI Rising, Global Oncology for a new generation of fellows; breast cancer disparities: shared decision making and technological innovations; and more. Provides in-depth clinical reviews on global oncology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Central Nervous System Malignancies, An Issue of Hematology/Oncology Clinics of North America, E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 032381073X
Total Pages : 313 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Central Nervous System Malignancies, An Issue of Hematology/Oncology Clinics of North America, E-Book by : David A. Reardon

Download or read book Central Nervous System Malignancies, An Issue of Hematology/Oncology Clinics of North America, E-Book written by David A. Reardon and published by Elsevier Health Sciences. This book was released on 2021-11-24 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Hematology/Oncology Clinics, guest editor David A. Reardon? brings his considerable expertise to the topic of Central Nervous System Malignancies. Top experts in the field cover key topics such as CNS Metastases, Leptomeningeal Disease, Neurofibromatoses, Imaging Advances for CNS Tumors, and more. Contains 16 relevant, practice-oriented topics including CNS Tumor Classification: An Update on the Integration of Tumor Genetics; Etiology and Epidemiology of CNS Tumors; The Evolving Role of Neurosurgical Intervention for CNS Tumor ; Update on Radiation Therapy for CNS Tumors; and more. Provides in-depth clinical reviews on CNS Malignancies, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.