Optimization in the Analysis of Nutritionally Important Stable Isotope Tracers Using Inductively Coupled Plasma-mass Spectrometry

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ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.:/5 (379 download)

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Book Synopsis Optimization in the Analysis of Nutritionally Important Stable Isotope Tracers Using Inductively Coupled Plasma-mass Spectrometry by : Kristine Yerkie Patterson

Download or read book Optimization in the Analysis of Nutritionally Important Stable Isotope Tracers Using Inductively Coupled Plasma-mass Spectrometry written by Kristine Yerkie Patterson and published by . This book was released on 1997 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Inductively Coupled Plasma-Mass Spectrometry

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Publisher : Academic Press
ISBN 13 : 9780126838657
Total Pages : 320 pages
Book Rating : 4.8/5 (386 download)

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Book Synopsis Inductively Coupled Plasma-Mass Spectrometry by : Howard E. Taylor

Download or read book Inductively Coupled Plasma-Mass Spectrometry written by Howard E. Taylor and published by Academic Press. This book was released on 2001 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: It also includes information on processing and interpreting results to obtain high-quality data.".

Isotope Tracers in Metabolic Research

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Publisher : John Wiley & Sons
ISBN 13 : 9780471462095
Total Pages : 494 pages
Book Rating : 4.4/5 (62 download)

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Book Synopsis Isotope Tracers in Metabolic Research by : Robert R. Wolfe

Download or read book Isotope Tracers in Metabolic Research written by Robert R. Wolfe and published by John Wiley & Sons. This book was released on 2004-10-18 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few years, the number of applications of tracers for in vivo biomedical studies has greatly increased. New analytical tools at the genetic and protein levels have spurred this growth, opening the door for a deeper understanding of metabolic events. This in turn promises to yield significant advances in the understanding and treatment of human disease. Now fully revised and expanded, Isotope Tracers in Metabolic Research, Second Edition is the established definitive text on stable and radioactive isotope tracers. In unique, multidisciplinary fashion, it presents comprehensive coverage of new methodological, mathematical, and theoretical approaches. This new Second Edition includes: All-new chapters on nuclear magnetic resonance, mass isotopomer analysis, and methods of protein metabolism analysis A completely updated categorized list of over 750 references Major advances in the development of mass isotopomer and positional isotopomer techniques, noninvasive isotope techniques for studying metabolic pathways, hyphenated techniques, and new tracer techniques The latest developments in quantification of DNA synthesis and mass spectrometry spurred by genome sequencing and proteomics New coverage of mathematical modeling Expanded coverage of microdialysis probes, laboratory procedures, and regulatory issues related to human studies In this complete guide to performing tracer studies, the authors systematically cover tracer selection, modeling considerations, sample derivitization, mass spectrometry analysis, and data interpretation. Problems and discussion questions highlight key points in each chapter. Isotope Tracers in Metabolic Research, Second Edition offers students and researchers a comprehensive, practical resource for utilizing the latest tracer methodologies.

Inductively Coupled Plasma Mass Spectrometry for Stable Isotope Metabolic Tracer Studies of Living Systems

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ISBN 13 :
Total Pages : 174 pages
Book Rating : 4.:/5 (893 download)

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Book Synopsis Inductively Coupled Plasma Mass Spectrometry for Stable Isotope Metabolic Tracer Studies of Living Systems by :

Download or read book Inductively Coupled Plasma Mass Spectrometry for Stable Isotope Metabolic Tracer Studies of Living Systems written by and published by . This book was released on 1999 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation focuses on the development of methods for stable isotope metabolic tracer studies in living systems using inductively coupled plasma single and dual quadrupole mass spectrometers. Sub-nanogram per gram levels of molybdenum (Mo) from human blood plasma are isolated by the use of anion exchange alumina microcolumns. Million-fold more concentrated spectral and matrix interferences such as sodium, chloride, sulfate, phosphate, etc. in the blood constituents are removed from the analyte. The recovery of Mo from the alumina column is 82 ± 5% (n = 5). Isotope dilution inductively coupled plasma mass spectrometry (ID-ICP-MS) is utilized for the quantitative ultra-trace concentration determination of Mo in bovine and human blood samples. The average Mo concentration in reference bovine serum determined by this method is 10.2 ± 0.4 ng/g, while the certified value is 11.5 ± 1.1 ng/g (95% confidence interval). The Mo concentration of one pool of human blood plasma from two healthy male donors is 0.5 ± 0.1 ng/g. The inductively coupled plasma twin quadrupole mass spectrometer (ICP-TQMS) is used to measure the carbon isotope ratio from non-volatile organic compounds and bio-organic molecules to assess the ability as an alternative analytical method to gas chromatography combustion isotope ratio mass spectrometry (GC-combustion-IRMS). Trytophan, myoglobin, and [beta]-cyclodextrin are chosen for the study, initial observation of spectral interference of 13C with 12C1H comes from the incomplete dissociation of myoglobin and/or [beta]-cyclodextrin.

Mass Spectrometry and Stable Isotopes in Nutritional and Pediatric Research

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Publisher : John Wiley & Sons
ISBN 13 : 1118858778
Total Pages : 407 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Mass Spectrometry and Stable Isotopes in Nutritional and Pediatric Research by : Henk Schierbeek

Download or read book Mass Spectrometry and Stable Isotopes in Nutritional and Pediatric Research written by Henk Schierbeek and published by John Wiley & Sons. This book was released on 2017-02-06 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide for scientists, pediatricians and students involved in metabolic studies in pediatric research Addresses the availability of modern analytical techniques and how to apply these techniques in metabolic studies Covers the whole range of available mass spectrometric techniques used for metabolic studies including Stable Isotope Methodology Presents the relevance of mass spectrometry and stable isotope methodology in pediatric research covering applications in Nutrition, Obesity, Metabolic Disorders, and Kidney Disorders Focuses on the interactions between nutrients and the endogenous metabolism within the body and how these factors affect the health of a growing infant

American Doctoral Dissertations

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Publisher :
ISBN 13 :
Total Pages : 872 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis American Doctoral Dissertations by :

Download or read book American Doctoral Dissertations written by and published by . This book was released on 1996 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Tracers in Metabolic Research

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ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Tracers in Metabolic Research by : Robert R. Wolfe

Download or read book Tracers in Metabolic Research written by Robert R. Wolfe and published by . This book was released on 1984 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods for studying metabolism. Determination of substrate kinetics. Constant isotope infusion technique. Determination of substrate kinetics. Bolus-injection technique. Determination of substrate oxidation. Bicarbonate kinetics and natural enrichment. Priming the pool. Nonsteady state kinetics. Selection of sites for infusing isotope andj drawing samples. Specific application. Glucose metabolism. Specific application. Urea. Specific application. Fat meltabolism. Amino acids. Whole-body protein turnover. Total body water. Clinical application of stable isotopes. Analytical methods. Instrumentation. Mass spectrometry. Selected ion monitoring. Preparation of samples. Chromatography. Determination of specific radioactivity. Collection of CO2. Isotope ratio mass spectrometry techniques. Gas chromatography-mass spectrometry methods. In vivo approaches. Isotopic tracers. Advantages of stable isotopes. Biological effects. Enzymatic effects. Definition of terms. Influence of uptake on calculation of rate of appearance. Influence of pool size and complexity. Net movement of tracer and tracee. Clearance. Stable versus radioisotopes. Single-pool analysis. Bicarbonate recovery. Natural abundance of 13C. Practical consideration of performing recovery studies. Determining NaH13 CO3 infusion rate. Determining VCO2. Theory of priming dose. Priming secondary pools. Steele equation. In vivo assessment of steele equation. Glucose. Effective volume of distribution. Urea. Arterial versus central venous infusion.

Isotope Dilution Mass Spectrometry

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Publisher : Royal Society of Chemistry
ISBN 13 : 1788018168
Total Pages : 473 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Isotope Dilution Mass Spectrometry by : Jose Alonso

Download or read book Isotope Dilution Mass Spectrometry written by Jose Alonso and published by Royal Society of Chemistry. This book was released on 2019-03-22 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Isotope Dilution Mass Spectrometry (IDMS) has become an essential tool in research laboratories and is increasingly used in routine analysis labs (including environmental, food safety and clinical applications). This is the first textbook to present a comprehensive and instructive view of the theory and applications of this growing technique. The main objective of this book is to cover the theory and applications of Isotope Dilution in Analytical Chemistry. The scope is comprehensive to include elemental analysis, speciation analysis, organic analysis and biochemical and clinical analysis together with applications in metabolism studies and traceability of goods. Until now there have been no books published with the same general scope (only book chapters on particular applications). This is a textbook focused at post-graduate level covering the basic knowledge required for doctoral studies in this field. Isotope Dilution Mass Spectrometry will also outline practical applications of interest for routine testing laboratories where isotope dilution procedures are implemented or can be implemented in the future. This unique book covers all the theoretical and practical aspects of Isotope Dilution Mass Spectrometry (IDMS). Due to the increasing application of IDMS in many research laboratories and the increasing implementation of IDMS methodologies in routine testing laboratories, scientists in industry and working in or affiliated to this area will this an invaluable source of information. Concerning the theoretical aspects, the authors present a uniform theoretical background which grows from previous developments in Organic, Speciation and Elemental analysis both in their own laboratory and in other laboratories around the world. This general approach will be simpler and will also include new emerging fields such as quantitative proteomics and metabolism studies.

Dissertation Abstracts International

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ISBN 13 :
Total Pages : 876 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Dissertation Abstracts International by :

Download or read book Dissertation Abstracts International written by and published by . This book was released on 1997 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Metabolic Analysis Using Stable Isotopes

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Publisher : Academic Press
ISBN 13 : 0128025344
Total Pages : 424 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Metabolic Analysis Using Stable Isotopes by :

Download or read book Metabolic Analysis Using Stable Isotopes written by and published by Academic Press. This book was released on 2015-09-21 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Analysis Using Stable Isotopes, the newest volume in Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in metabolic analysis using stable isotopes. Continues the legacy of this premier serial with quality chapters on metabolic analysis using stable isotopes Represents the newest volume in Methods in Enzymology, providing a premier serial with quality chapters authored by leaders in the field Ideal reference for those interested in the study of metabolism, metabolic tracing, isotopic labeling, and lipogenesis

Stable Isotopes in Human Nutrition

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Publisher : CABI
ISBN 13 : 9780851997964
Total Pages : 200 pages
Book Rating : 4.9/5 (979 download)

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Book Synopsis Stable Isotopes in Human Nutrition by : S. A. Abrams

Download or read book Stable Isotopes in Human Nutrition written by S. A. Abrams and published by CABI. This book was released on 2003-04-25 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of stable isotopes in nutritional studies is now widespread, and the technique is becoming increasingly popular. Practical applications are numerous and include:calcium and iron absorption studiesstudies looking at the impacts of diet, physical activity, aging, and medical therapy and supplementation on nutrient metabolismthe measurement of energy cost of pregnancystudies on the causes of growth faltering in infantsinvestigations into childhood and adult obesity.This book is designed as a laboratory handbook of methods used to perform stable isotope studies in humans. It covers basic principles, dosage information, sample preparation procedures, analytical instrumentation, and necessary mathematical methods and provides the fundamentals to enable researchers to evaluate and establish stable isotope methods in their own laboratories.

Guidelines for Achieving High Accuracy in Isotope Dilution Mass Spectrometry (IDMS)

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Publisher : Royal Society of Chemistry
ISBN 13 : 1847559301
Total Pages : 59 pages
Book Rating : 4.8/5 (475 download)

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Book Synopsis Guidelines for Achieving High Accuracy in Isotope Dilution Mass Spectrometry (IDMS) by : Peter Bedson

Download or read book Guidelines for Achieving High Accuracy in Isotope Dilution Mass Spectrometry (IDMS) written by Peter Bedson and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 59 pages. Available in PDF, EPUB and Kindle. Book excerpt: The isotope dilution mass spectrometry (IDMS) technique is well known and widely reported in the literature. However, its application can present considerable difficulties with regard to obtaining reliable results. Produced jointly by the Royal Society of Chemistry's Analytical Methods Committee and the Valid Analytical Measurement (VAM) programme, the aim of this book is to provide a simplified yet robust methodology, together with adequate guidance, to enable laboratories wishing to use the technique to obtain reliable data. The methodologies, for inorganic and organic mass spectrometry, which use exact and approximate matching, are illustrated with worked examples and clear diagrammatic representations. A comprehensive glossary of terms, references to key publications and an extensive IDMS bibliography are also provided. Clear and comprehensive in coverage, Guidelines for Achieving High Accuracy in Isotope Dilution Mass Spectrometry (IDMS) will provide valuable assistance to a wide variety of analytical chemists interested in applying the IDMS technique to their own measurement applications.

Radioactive and Stable Isotope Tracers in Biomedicine

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Publisher : Wiley-Liss
ISBN 13 : 9780471561316
Total Pages : 480 pages
Book Rating : 4.5/5 (613 download)

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Book Synopsis Radioactive and Stable Isotope Tracers in Biomedicine by : Robert R. Wolfe

Download or read book Radioactive and Stable Isotope Tracers in Biomedicine written by Robert R. Wolfe and published by Wiley-Liss. This book was released on 1992-04-09 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date, detailed, authoritative overview regarding all aspects of the theory and practice involved in utilizing isotopic tracers for the in vivo study of human metabolic function. Presents specific technical information on performing tracer studies including isotope infusion, analysis and interpretation of data.

Inductively Coupled Plasma Mass Spectrometry for Stable Isotope Metabolic Tracer Studies of Living Systems

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Publisher :
ISBN 13 :
Total Pages : 322 pages
Book Rating : 4.:/5 (425 download)

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Book Synopsis Inductively Coupled Plasma Mass Spectrometry for Stable Isotope Metabolic Tracer Studies of Living Systems by : Elise Tuy Luong

Download or read book Inductively Coupled Plasma Mass Spectrometry for Stable Isotope Metabolic Tracer Studies of Living Systems written by Elise Tuy Luong and published by . This book was released on 1999 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many improvements have been made to the current ICP-TQMS device. A new skimmer interface together with the new ion optics arrangement improves the ion collection efficiency 19-fold. A second-generation ion beam splitter has been designed to reduce the background count rate and improve the ion transmission. A modified ion beam splitter transmits 5 times more ions while maintaining the performance characteristics of the ICP-TQMS system. The precision is further improved by measuring each data point for a longer dwell time (9s instead of 1.5s) and keeping the total ion collection time low ([Less then or equal to] 50s instead of 150s).

Tracers in Metabolic Research

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Publisher :
ISBN 13 : 9780471834380
Total Pages : 300 pages
Book Rating : 4.8/5 (343 download)

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Book Synopsis Tracers in Metabolic Research by : Robert R. Wolfe

Download or read book Tracers in Metabolic Research written by Robert R. Wolfe and published by . This book was released on 1984-06 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Applications of Inductively Coupled Plasma-mass Spectrometry to Radionuclide Determinations

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Publisher : ASTM International
ISBN 13 : 0803124961
Total Pages : 153 pages
Book Rating : 4.8/5 (31 download)

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Book Synopsis Applications of Inductively Coupled Plasma-mass Spectrometry to Radionuclide Determinations by : Roy W. Morrow

Download or read book Applications of Inductively Coupled Plasma-mass Spectrometry to Radionuclide Determinations written by Roy W. Morrow and published by ASTM International. This book was released on 1995 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Stable Isotope Forensics

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Publisher : John Wiley & Sons
ISBN 13 : 1119080223
Total Pages : 509 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Stable Isotope Forensics by : Wolfram Meier-Augenstein

Download or read book Stable Isotope Forensics written by Wolfram Meier-Augenstein and published by John Wiley & Sons. This book was released on 2017-09-28 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: The number-one guide, internationally, to all aspects of forensic isotope analysis, thoroughly updated and revised and featuring many new case studies This edition of the internationally acclaimed guide to forensic stable isotope analysis uses real-world examples to bridge discussions of the basic science, instrumentation and analytical techniques underlying forensic isotope profiling and its various technical applications. Case studies describe an array of applications, many of which were developed by the author himself. They include cases in which isotope profiling was used in murder, and drugs-related crime investigations, as well as for pharmaceutical and food authenticity control studies. Updated with coverage of exciting advances occurring in the field since the publication of the 1st edition, this 2nd edition explores innovative new techniques and applications in forensic isotope profiling, as well as key findings from original research. More than a simple update, though, this edition has been significantly revised in order to address serious problems that can arise from non-comparable and unfit-for-purpose stable isotope data. To that end, Part II has been virtually rewritten with greater emphasis now being placed on important quality control issues in stable isotope analysis in general and forensic stable isotope analysis in particular. Written in a highly accessible style that will appeal to practitioners, researchers and students alike Illustrates the many strengths and potential pitfalls of forensic stable isotope analysis Uses recent case examples to bridge underlying principles with technical applications Presents hands-on applications that let experienced researchers and forensic practitioners match problems with success stories Includes new chapters devoted to aspects of quality control and quality assurance, including scale normalisation, the identical treatment principle, hydrogen exchange and accreditation Stable Isotope Forensics, 2nd Edition is an important professional resource for forensic scientists, law enforcement officials, public prosecutors, defence attorneys, forensic anthropologists and others for whom isotope profiling has become an indispensable tool of the trade. It is also an excellent introduction to the field for senior undergraduate and graduate forensic science students. "All students of forensic criminology, and all law enforcement officers responsible for the investigation of serious crime , will want to study this book. Wolfram highlights the value, and future potential, of Stable Isotope Forensics as an emerging powerful tool in the investigation of crime." —Roy McComb, Deputy Director, Specialist Investigations, National Crime Agency (NCA), UK “A single author text in these days is rare and the value of this book lies in the dedication and experience of the author which is evident in the clarity of prose, the honest illustration of evidence and the realistic practical application of the subject - it makes this a text of genuine scientific value.” — Prof Dame Sue Black, PhD, DBE, OBE, FRSE, Leverhulme Research Centre for Forensic Science, University of Dundee, UK The book provides an excellent, vivid and comprehensible introduction into the world of stable isotope science and analytics. Compared to the first edition, the aspects of quality control and assurance in the analysis of stable isotopes in general, and forensic application in particular, are now taking much more room. This allows the book to serve the target groups: students, academic professionals and practitioners, and serves as a solid resource of basic and applicable information about the strengths and potential pitfalls of the application of stable isotope signatures. The present high-quality book shows the great potential of stable isotopes and is a must for everyone interested in isotope forensics. M.E. Böttcher & U. Flenker, Isotopes in Environmental and Health Studies, January 2018. A list of errata is available at http://booksupport.wiley.com