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Optimization And Characterization Of Multifunctional Polymer Based Nanoparticles Containing Dtpa Gd Contrast Agent For Mri Enhancement
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Book Synopsis Optimization and Characterization of Multifunctional Polymer-based Nanoparticles Containing DTPA-Gd Contrast Agent for MRI Enhancement by : Xinyu Wu
Download or read book Optimization and Characterization of Multifunctional Polymer-based Nanoparticles Containing DTPA-Gd Contrast Agent for MRI Enhancement written by Xinyu Wu and published by . This book was released on 2015 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Polymeric Nanoparticle and Bioconjugate MRI Contrast Agents for In Vivo Imaging by : Clare Lee Matilda Le Guyader
Download or read book Polymeric Nanoparticle and Bioconjugate MRI Contrast Agents for In Vivo Imaging written by Clare Lee Matilda Le Guyader and published by . This book was released on 2017 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoparticles are the hallmark of nanomedicine, proving clinically relevant for the delivery of therapeutic and diagnostic drugs. Nanomaterials are highly versatile, with the ability for scientists to tailor composition and function to suit the desired application. Herein, two types of nanocarriers are investigated in the context of magnetic resonance imaging contrast agents: polymeric nanoparticles and protein carriers. A key research focus in applying nanoparticles for drug delivery is in understanding physicochemical properties affecting in vivo fate. Shape or morphology of a particle is a vastly underutilized property in the design of nanoparticles, and is difficult to predictably control in the context of polymeric nanoparticles. Investigations of block copolymer nanoassemblies evaluate effects of the polymer structure and the self-assembly process to form interesting and diverse structures. In this work, ring-opening metathesis polymerization is employed to prepare and study block copolymer amphiphile self-assembly. First, a small library of amphiphiles are prepared in which the hydrophobic block functionality is varied. In varying the polymer structure and the solvent for assembly, different morphologies are produced, including small and large spheres, cylinders, y-junctions, and rods. In several cases, one polymer can take on different morphologies depending on the organic cosolvent used during micellization, highlighting the importance of assembly conditions and dynamics in forming kinetically trapped structures versus thermodynamically stable structures. These are important considerations when designing, synthesizing, and formulating polymeric nanoparticles for in vivo applications. Next, direct incorporation of a gadolinium based contrast agent for magnetic resonance imaging is studied. A novel monomer and chain transfer agent of a gadolinium-chelate are used to directly incorporate the contrast agent in to a polynorbornene polymer backbone. The resulting spherical and fibrillar nanoparticles exhibited enhanced relaxivity and are studied as MRI contrast agents using live imaging in murine models. Finally, a fatty acid ligand is conjugated to a gadolinium-based contrast agent is prepared and formulated with human serum albumin. In formulation with HSA, the agent exhibits high relaxivity and prolonged blood circulation. In addition, therapeutic conjugates formulated with HSA are evaluated for in vitro cytotoxicity and found to be effective in tumor growth suppression in vivo.
Book Synopsis Multifunctional Polymeric Materials Programming Interfaces and Designed Artificial Melanosomes by : Yuran Huang
Download or read book Multifunctional Polymeric Materials Programming Interfaces and Designed Artificial Melanosomes written by Yuran Huang and published by . This book was released on 2017 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interfaces with micro/nanostructures in nature play important roles to bring in specific functions, which inspired and drove the development of novel nanostructures, including inorganic nanoparticles and organic nanoparticles. Among them, polymeric nanoparticles have been widely explored to programming interfaces because of the precise controlling in synthesis of polymers. Ring opening metathesis polymerization (ROMP) is a unique polymerization technique, which can incorporate versatile functional groups, tunable composition (hydrophobicity, molecular weight), and stimuli-responsiveness to endow various functionalities for the polymers, which have been explored for different application areas. In our research, we focused on designing and synthesizing multifunctional ROMP-based polymeric materials programming interfaces for different applications. For Chapter 2, we describe amphiphilic tri-block copolymers containing FeIII-catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles (SMN and CMN respectively) as new T1-weighted agents with high relaxivity, low cytotoxicity, and long-term stability in biological fluids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide range of magnetic field strengths. Interestingly, shape-dependent behavior was observed in terms of the particles' interactions with HeLa cells, with CMN exhibiting enhanced uptake and contrast via magnetic resonance imaging (MRI) compared with SMN. These results suggest that control over soft nanoparticle shape will provide an avenue for optimization of particle based contrast agents as biodiagnostics. We propose those polycatechol nanoparticles as suitable for pre-clinical investigations into their viability as gadolinium-free, safe and effective imaging agents for MRI contrast enhancement. For Chapter 3, we describe a method for the stabilization of low-boiling point (low-bp) perfluorocarbons (PFCs) at physiological temperatures by an amphiphilic triblock copolymer which can emulsify PFCs and be crosslinked. After UV-induced thiol-ene crosslinking, the core of the PFC emulsion remains in liquid form even at temperatures exceeding their boiling points. Critically, the formulation permits vaporization at rarefactional pressures relevant for clinical ultrasound. For Chapter 4, liquid crystals confined within micrometer-scale domains have been explored as the basis of a wide range of field- and stimuli-responsive materials for use in technologies spanning from biological sensors to electro-optical devices. We aim to build up a versatile stimuli-responsive polymeric surfactant to modulate the orientation of liquid crystal microdroplets. By incorporated different types of cleavable linkers into this system, we are able to endow versatile stimuli-responsiveness (UV, Redox, pH, ROS) in order to adapt to different certain circumstances. We proved that those cleavable linker-contained homopolymers were able to emulsify with liquid crystal droplets and generate radial configuration. Then, by introducing specific stimuli, the linker will be cleaved and the homopolymer will be disassembled from the surface, then the configurations of liquid crystal droplets will change into bipolar. This work will provide fundamental information for designing a stimuli-responsive ROMP-based polymeric system, and it is promising to utilize this system as biosensor to detect some specific behaviors. For Chapter 5, we prepared melanin-like nanoparticles (MelNPs) via spontaneous oxidation of dopamine, as biocompatible, synthetic analogues of naturally occurring melanosomes, and investigated their uptake, transport, distribution, and UV-protective capabilities in human keratinocytes. Critically, we demonstrate that MelNPs are endocytosed, undergo perinuclear aggregation, and form a supranuclear cap, or so-called microparasol in human epidermal keratinocytes (HEKa), mimicking the behavior of natural melananosomes in terms of cellular distribution and the fact that they serve to protect the cells from UV damage.
Book Synopsis Multifunctional Polymer Platform as Ligand and MRI Contrast Agent for Inorganic Nanocrystals by : Liang Du
Download or read book Multifunctional Polymer Platform as Ligand and MRI Contrast Agent for Inorganic Nanocrystals written by Liang Du and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The unique physical and optical properties of inorganic nanocrystals have generated tremendous interest over the past two decades. They have been extensively studied to prepare photovoltaic devices and diagnostic tools. Luminescent quantum dots, gold nanomaterials and iron oxide nanoparticles have found promising success in a broad range of areas including light-emitting diodes, therapeutic tomography, photodynamic therapy drug delivery and magnetic resonance imaging. However, most of the as-prepared nanoparticles are stabilized by hydrophobic coordinating ligands which impede their biological applications. In this dissertation, we summarize the application of poly(isobutylene-alt-maleic anhydride) (PIMA) polymer platform to prepare biocompatible nanomaterials as well as MRI contrast agents. In chapter 2, we designed a new set of multi-coordinating polymer ligands based on the phosphonate anchoring motif and applied them for the surface coating of luminescent quantum dots, gold nanoparticles and iron oxide nanoparticles alike. The ligand is synthesized via nucleophilic addition reaction between poly(isobutylene-alt-maleic anhydride) and amine-modified phosphonate derivatives and short polyethylene glycol hydrophilic blocks, which allows the flexibility to tune the architecture and stoichiometry of the final compound. We find that these phosphonate-based polymers exhibit strong coordinating affinity to ZnS-overcoated quantum dots (QDs), Au nanoparticles (AuNPs) as well as iron oxide nanoparticles (IONPs), yielding nanocrystal dispersions that exhibit good colloidal stability for all three systems. The affinity of these ligands is also preserved when additional coordinating groups are introduced, such as imidazoles. Furthermore, the resulting polymer-coated nanocrystals are easily functionalized with reactive groups, introduced along the polymer chain during synthesis. They are compact enough to allow implementation of resonance energy transfer coupling of luminescent QDs to proximal dyes. Affinity between the ligands and gold nanoparticle surfaces was compared to that of thiol groups using NaCN digestion tests. In Chapter 3, we designed a novel set of polymeric multicoordinating ligands based on the N-heterocyclic carbene (NHC) anchoring molecules and applied them for stabilizing luminescent quantum dots in aqueous media. The ligand is synthesized via nucleophilic addition reaction between amine-appended imidazole/poly(ethylene glycol) compounds and poly(isobutylene-alt-maleic anhydride) (PIMA), which yields coordinating ligands with tunable number of lateral motifs. We find that these NHC-based polymers exhibit fast and robust coordinating affinity to CdSe QDs overcoated with ZnS shells. The removal of pristine coating and the generation of carbene are demonstrated by NMR techniques. 13C and HMBC NMR spectroscopy also confirm the existence of the carbene-carbon which is crucial for binding the transition-metals on QD surfaces. These QDs exhibit essentially identical absorption and emission features before and after the cap exchange, and their compact architecture is demonstrated by diffusion ordered NMR spectroscopy. Agarose gel electrophoresis measurements indicate that the polymer coating imparts the QDs good compatibility in different pH, and it prevents protein adsorption. Excellent colloidal stability of these QD samples is observed in a wide range of competitive conditions over extended period of time. In Chapter 4, we detail the design of a set of polymeric contrast agents used for 19F magnetic resonance imaging (19F MRI). The agent is synthesized via a nucleophilic addition reaction between poly(isobutylene-alt-maleic anhydride) and amine-appended fluorinated precursors and short polyethylene glycol (PEG) coils, which permits the tunability of the stoichiometric architecture. We find that introducing PEG moieties to ~70% of the repeating units on the polymers is essential for balancing the hydrophobic feature of fluorine groups. We show that the signal to noise ratio (SNR) of the contrast agents is highly dependent on the arm-length between the polymer scaffold and the magnetic responding CF3 groups. A series of lateral fluorinated chains with different lengths are installed onto the polymers, and extended transverse relaxation time (T2) is observed from the agents with long arm-lengths. Data from Diffusion-ordered NMR spectroscopy (DOSY) indicate that using a pegylated arm between the macromolecule and CF3 groups does not greatly increase the hydrodynamic size of the resulting contrast agents. The effectiveness of inserting the arm is also confirmed by phantom images collected from agent dispersions with different concentrations. In Chapter 5, we provide a summary of the versatility of PIMA platform and discuss the outlook of these multifunctional polymeric molecules.
Book Synopsis Single-Chain Polymer Nanoparticles by : José A. Pomposo
Download or read book Single-Chain Polymer Nanoparticles written by José A. Pomposo and published by John Wiley & Sons. This book was released on 2017-08-18 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first book on this important and emerging topic presents an overview of the very latest results obtained in single-chain polymer nanoparticles obtained by folding synthetic single polymer chains, painting a complete picture from synthesis via characterization to everyday applications. The initial chapters describe the synthetics methods as well as the molecular simulation of these nanoparticles, while subsequent chapters discuss the analytical techniques that are applied to characterize them, including size and structural characterization as well as scattering techniques. The final chapters are then devoted to the practical applications in nanomedicine, sensing, catalysis and several other uses, concluding with a look at the future for such nanoparticles. Essential reading for polymer and materials scientists, materials engineers, biochemists as well as environmental chemists.
Book Synopsis Nanoscale Magnetic Materials and Applications by : J. Ping Liu
Download or read book Nanoscale Magnetic Materials and Applications written by J. Ping Liu and published by Springer Science & Business Media. This book was released on 2010-04-05 with total page 731 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoscale Magnetic Materials and Applications covers exciting new developments in the field of advanced magnetic materials. Readers will find valuable reviews of the current experimental and theoretical work on novel magnetic structures, nanocomposite magnets, spintronic materials, domain structure and domain-wall motion, in addition to nanoparticles and patterned magnetic recording media. Cutting-edge applications in the field are described by leading experts from academic and industrial communities. These include new devices based on domain wall motion, magnetic sensors derived from both giant and tunneling magnetoresistance, thin film devices in micro-electromechanical systems, and nanoparticle applications in biomedicine. In addition to providing an introduction to the advances in magnetic materials and applications at the nanoscale, this volume also presents emerging materials and phenomena, such as magnetocaloric and ferromagnetic shape memory materials, which motivate future development in this exciting field. Nanoscale Magnetic Materials and Applications also features a foreword written by Peter Grünberg, recipient of the 2007 Nobel Prize in Physics.
Book Synopsis Fluorine Magnetic Resonance Imaging by : Ulrich Flogel
Download or read book Fluorine Magnetic Resonance Imaging written by Ulrich Flogel and published by CRC Press. This book was released on 2016-10-26 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.
Book Synopsis Functionally Labeled Polymers And Nanoparticles by : Lyndsay M. Randolph
Download or read book Functionally Labeled Polymers And Nanoparticles written by Lyndsay M. Randolph and published by . This book was released on 2014 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the development of labeled polymers and polymeric nanoparticles for biomedical applications, one desires synthetic approaches that allow the most direct route to incorporate functional moieties. We contend the most desirable route is via the direct incorporation of functional groups during the polymerization process itself as monomers and/or chain transfer agents. In this work, we utilize ring-opening metathesis polymerization (ROMP) due to the high functional group tolerance of initiators and the ability to synthesize well-defined polymers of low dispersity and high molecular weight. Our research group has had great success in developing peptide-polymeric nanomaterials with ROMP via a graft-to strategy for the incorporation of peptide substrates of matrix matalloproteinases (MMPs). However, this technique does not allow for complete conjugation of peptide substrates to the polymer backbone. For this reason we sought to develop peptidyl monomers that contain a MMP peptide substrate for graft-through polymerization. Amphiphilic block-copolymers were synthesized with the peptidyl-monomer as the hydrophilic block and slowly transitioned into water to form nanoparticles (NPs). A pilot study determined that if the peptide substrate is displayed on the shell of a polymeric nanoparticle, it no longer maintains bioactivity. To further demonstrate the utility of labeling polymeric nanomaterials, a series of amphiphilic block copolymers end-labeled with dyes were synthesized and formulated into micellar nanoparticles. Dye monomer and chain transfer agent combinations were chosen that are known to operate either as a FRET acceptor (rhodamine) or as a quencher (DABCYL) of the donors, fluorescein and/or EDANS. Dye-labeled block copolymers were formulated into micellar nanoparticles, such that, the NP contained both a donor and acceptor. The FRET properties of mixed micellar nanoparticles were characterized by fluorescence spectroscopy and fluorescence lifetime. Lastly, we endeavored to move toward more clinically relevant systems that utilize MRI as an imaging modality. For this reason, polymers were synthesized containing the FDA approved MRI-contrast agent gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Gd-DOTA). Gd-containing hydrophilic and amphiphilic block copolymers were synthesized that were capable of self-assembly into spherical and fibril-shaped morphologies. Utilizing a 7T MRI scanner, polymeric nanomaterials were injected into the peritoneal cavity (IP injection) of healthy C57Bl/6 mice to analyze the retention and biodistribution of these polymer materials.
Book Synopsis Magnetic Resonance Imaging by : Vadim Kuperman
Download or read book Magnetic Resonance Imaging written by Vadim Kuperman and published by Elsevier. This book was released on 2000-03-15 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended as a text/reference for students, researchers, and professors interested in physical and biomedical applications of Magnetic Resonance Imaging (MRI). Both the theoretical and practical aspects of MRI are emphasized. The book begins with a comprehensive discussion of the Nuclear Magnetic Resonance (NMR) phenomenon based on quantum mechanics and the classical theory of electromagnetism. The first three chapters of this book provide the foundation needed to understand the basic characteristics of MR images, e.g.,image contrast, spatial resolution, signal-to-noise ratio, common image artifacts. Then MRI applications are considered in the following five chapters. Both the theoretical and practical aspects of MRI are emphasized. The book ends with a discussion of instrumentation and the principles of signal detection in MRI. Clear progression from fundamental physical principles of NMR to MRI and its applications Extensive discussion of image acquisition and reconstruction of MRI Discussion of different mechanisms of MR image contrast Mathematical derivation of the signal-to-noise dependence on basic MR imaging parameters as well as field strength In-depth consideration of artifacts in MR images Comprehensive discussion of several techniques used for rapid MR imaging including rapid gradient-echo imaging, echo-planar imaging, fast spin-echo imaging and spiral imaging Qualitative discussion combined with mathematical description of MR techniques for imaging flow
Download or read book Cancer Nanotechnology written by and published by Academic Press. This book was released on 2018-06-23 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 139, provides invaluable information on the exciting and fast-moving field of cancer research. Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, Nanotechnology and cancer immunotherapy, Ultrasound imaging agents and delivery systems, Dendronized systems for the delivery of chemotherapeutics, Thermosensitive liposomes for image-guided drug delivery, Supramolecular Chemistry in Tumor Analysis and Drug Delivery, Gold nanoparticles for delivery of cancer therapeutics, and Single cell barcode microchip for cancer research and therapy. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Book Synopsis Polymers for Biomedical Applications by : Anil Mahapatro
Download or read book Polymers for Biomedical Applications written by Anil Mahapatro and published by American Chemical Society. This book was released on 2008-04-17 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on applications of polymers for biomedical applications has increased dramatically to find improved medical plastics for this rapidly evolving field. This book brings together various aspects of recent research and developments within academia and industry related to polymers for biomedical applications.
Book Synopsis Magnetic Nanoparticles in Biosensing and Medicine by : Nicholas J. Darton
Download or read book Magnetic Nanoparticles in Biosensing and Medicine written by Nicholas J. Darton and published by Cambridge University Press. This book was released on 2019-02-14 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing together topics from a wide range of disciplines, and featuring up-to-date examples of clinical usage and research applications, this text provides a comprehensive insight into the fundamentals of magnetic biosensors and the applications of magnetic nanoparticles in medicine.
Book Synopsis Duke Review of MRI Principles:Case Review Series E-Book by : Wells Mangrum
Download or read book Duke Review of MRI Principles:Case Review Series E-Book written by Wells Mangrum and published by Elsevier Health Sciences. This book was released on 2012-03-09 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The newest title in the popular Case Review Series, Duke Review of MRI Principles, by Wells Mangrum, MD; Kimball Christianson, MD; Scott Duncan, MD; Phil Hoang, MD; Allen W. Song, PhD; and Elmar Merkle, MD, uses a case-based approach to provide you with a concise overview of the physics behind magnetic resonance imaging (MRI). Written by radiology residents, practicing radiologists, and radiology physicists, this multidisciplinary text introduces you to the basic physics of MRI and how they apply to successful and accurate imaging, interpretation, and diagnosis. Clinically relevant cases with associated questions and images reinforce your understanding of essential principles needed to confidently interpret a wide range of MRI images for all organ systems. Review the basic physics of MRI in a concise, high-yield manner and learn how to apply them for successful and accurate imaging, interpretation, and diagnosis. Master 17 essential MRI principles you need to know through clinically relevant cases accompanied by associated questions and 600 images that reinforce your understanding and help you confidently interpret a wide range of MRI images. Effectively diagnose disease in all organ systems. Authors are fellowship-trained in each body system – neuro, breast, body, vascular and MSK, providing you with practical guidance in every area Focus on the information that’s most relevant to your needs from a multidisciplinary author team comprised of radiology residents, practicing radiologists and radiology physicists. See the underlying simplicity behind MRI physics. Despite employing the same MRI principles, similar imaging systems use slightly different names. A simplified explanation of these principles and how they are applied to each body system deepens your understanding and helps avoid any confusion.
Book Synopsis Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy by : Challa S.S.R. Kumar
Download or read book Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy written by Challa S.S.R. Kumar and published by Springer Nature. This book was released on 2019-11-22 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ninth volume of a 40 volume series on nanoscience and nanotechnology, edited by the renowned scientist Challa S.S.R. Kumar. This handbook gives a comprehensive overview about Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy. Modern applications and state-of-the-art techniques are covered and make this volume an essential reading for research scientists in academia and industry.
Download or read book MRI written by Brian M. Dale and published by John Wiley & Sons. This book was released on 2015-08-06 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fifth edition of the most accessible introduction to MRI principles and applications from renowned teachers in the field provides an understandable yet comprehensive update. Accessible introductory guide from renowned teachers in the field Provides a concise yet thorough introduction for MRI focusing on fundamental physics, pulse sequences, and clinical applications without presenting advanced math Takes a practical approach, including up-to-date protocols, and supports technical concepts with thorough explanations and illustrations Highlights sections that are directly relevant to radiology board exams Presents new information on the latest scan techniques and applications including 3 Tesla whole body scanners, safety issues, and the nephrotoxic effects of gadolinium-based contrast media
Book Synopsis Contrast Agents I by : Werner Krause
Download or read book Contrast Agents I written by Werner Krause and published by Springer. This book was released on 2003-07-01 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1–2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1].
Book Synopsis Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications by : Abdel Salam Hamdy Makhlouf
Download or read book Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications written by Abdel Salam Hamdy Makhlouf and published by Woodhead Publishing. This book was released on 2018-10-24 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications: Volume Two: Advanced Nanocarriers for Therapeutics discusses, in detail, the recent trends in designing dual and multi-responsive polymers and nanoparticles for safe drug delivery. Chapters cover dual-responsive polymeric nanocarriers for drug delivery and their different stimuli, multi-responsive polymeric nanocarriers, and the therapeutic applications of stimuli-responsive polymers. With an emphasis on advanced medical applications and synergistic operational and technological methodologies for the improvement of polymers systems for the production of stimuli-responsive polymers, this book is essential reading for materials scientists and researchers working in the drug delivery and pharmaceutical industries. As innovation and development in the area of stimuli responsive polymer-based nanomaterials for drug delivery is moving fast and there is an increased global demand for biodegradable and biocompatible responsive polymers and nanoparticles for safe drug delivery, users will find this to be a timely resource. Focusses on the most advanced technologies, recent evaluation methods, technical aspects, and advanced synthesis techniques stimuli-responsive polymers Examines advanced medical applications of stimuli responsive polymers Analyzes synergistic operational and technological methodologies for the improvement of polymer systems for the production of stimuli-responsive polymers in drug delivery
