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Ontology Led Molecular Classification Of Colorectal Cancer Uncovers Distinct Tumour Subtypes With Therapeutic And Clinical Relevance
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Book Synopsis Ontology-led Molecular Classification of Colorectal Cancer Uncovers Distinct Tumour Subtypes with Therapeutic and Clinical Relevance by : Sudhir Malla
Download or read book Ontology-led Molecular Classification of Colorectal Cancer Uncovers Distinct Tumour Subtypes with Therapeutic and Clinical Relevance written by Sudhir Malla and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Targeted Therapy of Colorectal Cancer Subtypes by : Peter Jordan
Download or read book Targeted Therapy of Colorectal Cancer Subtypes written by Peter Jordan and published by Springer. This book was released on 2019-01-08 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. Recent years have increased significantly our understanding of the genetic alterations that can underlie CRC, but also unraveled the molecular heterogeneity of the disease. Although a simple correlation between genetic pathways, histopathological features and clinical outcome cannot be established, the heterogeneity of CRC is also an opportunity for the development of targeted therapeutic approaches, able to treat an individual tumor with higher efficiency and less toxic side effects. One CRC subtype is characterized by high mutation rates (MSI-H), DNA methylation changes (CIMP-H), mutation in the BRAF oncogene and occurrence of serrated adenomas in the proximal colon. Other groups prevail in the distal colon and consist of either adenomatous polyps with chromosomal aberrations (CIN) and WNT pathway activation, or carry frequent KRAS mutation and metabolic deregulation, or have strong mesenchymal and infiltrative characteristics. Characterization of driver-mutation events in these CRC subgroups has led to the development of specific drugs targeting, for example, the MAPK pathway, but initial clinical trials have revealed unexpected response rates. The collection of chapters in this volume address the biology of specific CRC subtypes and how these may be targeted to improve precision therapy and clinical benefit for the patients.
Author :Kevin M. Haigis, Ph.D. Publisher :Springer Science & Business Media ISBN 13 :146148412X Total Pages :319 pages Book Rating :4.4/5 (614 download)
Book Synopsis Molecular Pathogenesis of Colorectal Cancer by : Kevin M. Haigis, Ph.D.
Download or read book Molecular Pathogenesis of Colorectal Cancer written by Kevin M. Haigis, Ph.D. and published by Springer Science & Business Media. This book was released on 2013-10-02 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.
Book Synopsis Advances in the Molecular Understanding of Colorectal Cancer by : Eva Segelov
Download or read book Advances in the Molecular Understanding of Colorectal Cancer written by Eva Segelov and published by BoD – Books on Demand. This book was released on 2019-02-06 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of the molecular pathogenesis of colorectal cancer by researchers and clinicians is essential to facilitate progress in improving patient outcomes in this common cancer that still carries a poor prognosis if not identified early. This book covers the major areas of importance in the field, incorporating new knowledge that has arisen due to the advancement of molecular techniques and the ability to correlate molecular changes with clinical behaviour of tumours. Each chapter is a summary written by experts, concisely summarising current data as well as highlighting potential areas for advancement. Appreciating the differences between tumours on a molecular level is the key to developing and delivering precision medicine, and nowhere is this more critically required than in the field of colorectal cancer.
Book Synopsis Computational Systems Biology of Cancer by : Emmanuel Barillot
Download or read book Computational Systems Biology of Cancer written by Emmanuel Barillot and published by CRC Press. This book was released on 2012-08-25 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models—integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools. Novel Approaches to Fighting Cancer Drawn from the authors’ decade-long work in the cancer computational systems biology laboratory at Institut Curie (Paris, France), Computational Systems Biology of Cancer explains how to apply computational systems biology approaches to cancer research. The authors provide proven techniques and tools for cancer bioinformatics and systems biology research. Effectively Use Algorithmic Methods and Bioinformatics Tools in Real Biological Applications Suitable for readers in both the computational and life sciences, this self-contained guide assumes very limited background in biology, mathematics, and computer science. It explores how computational systems biology can help fight cancer in three essential aspects: Categorising tumours Finding new targets Designing improved and tailored therapeutic strategies Each chapter introduces a problem, presents applicable concepts and state-of-the-art methods, describes existing tools, illustrates applications using real cases, lists publically available data and software, and includes references to further reading. Some chapters also contain exercises. Figures from the text and scripts/data for reproducing a breast cancer data analysis are available at www.cancer-systems-biology.net.
Book Synopsis Molecular Epidemiology by : Paul A. Schulte
Download or read book Molecular Epidemiology written by Paul A. Schulte and published by Academic Press. This book was released on 2012-12-02 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.
Author :Fabrizio d'Adda di Fagagna Publisher :Springer Science & Business Media ISBN 13 :0387691162 Total Pages :274 pages Book Rating :4.3/5 (876 download)
Book Synopsis Advances in Molecular Oncology by : Fabrizio d'Adda di Fagagna
Download or read book Advances in Molecular Oncology written by Fabrizio d'Adda di Fagagna and published by Springer Science & Business Media. This book was released on 2007-07-18 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the 2nd Annual IFOM-IEO Meeting on Cancer. This is a new meeting, it has about 200 attendees from Australia, Austria, Belgium, Brazil, Canada, England, France, Germany, Greece, Ireland, Italy, Japan, Netherlands, Spain, Sweden, Switzerland, and the USA. The 2nd IFOM-IEO international meeting on cancer will provide a forum in which the world’s leading cancer researchers and young scientists will discuss the latest advances in molecular oncology. The impact of recent breakthroughs in basic research and of emerging technologies on molecular medicine in cancer will be highlighted.
Book Synopsis Gigantism and Acromegaly by : Constantine A. Stratakis
Download or read book Gigantism and Acromegaly written by Constantine A. Stratakis and published by Academic Press. This book was released on 2021-06-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim's appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. - Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism - Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics - Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism
Book Synopsis Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies by : Chi Hin Cho
Download or read book Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies written by Chi Hin Cho and published by Academic Press. This book was released on 2020-06-10 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer. Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding Updates current trends in the field with pioneering information on drug resistance Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view
Book Synopsis Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs by : International Agency for Research on Cancer
Download or read book Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs written by International Agency for Research on Cancer and published by IARC. This book was released on 2004 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume in the WHO series on histological and genetic typing of human tumors covers tumors of the kidney, the urinary system, the prostate, the testis and paratesticular tissue and the penis. Each entity is extensively discussed with information on clinicopathological, epidemiological, immunophenotypic and genetic aspects of these diseases. This book is an authoritative, concise reference, prepared by 131 authors from 22 countries. It contains more than 800 color photographs, numerous MRIs, ultrasound images, CT scans, charts and 3000 references.This book is in the series commonly referred to as the "Blue Book" series."Pathology and Genetics of Tumors of the Urinary System and Male Genital Organs"Contributors:: Dr Lauri A. Aaltonen, Dr Ferran Algaba, Dr William C. Allsbrook Jr., Dr Isabel Alvarado-Cabrero, Dr Mahul B. Amin, Dr Pedram Argani, Dr Hans Arnholdt, Dr Alberto G. Ayala, Dr Sheldon Bastacky, Dr Louis R. Begin, Dr Athanase Billis, Dr Liliane Boccon-Gibod, Dr Stephen M. Bonsib, Dr Christer Busch, Dr Paul Cairns, Dr Liang Cheng, Dr John Cheville, Dr Carlos Cordon-Cardo, Dr Antonio L. Cubilla, Dr Ivan Damjanov, Dr Charles J. Davis, Dr Angelo M. De Marzo, Dr Louis P. Dehner, Dr Brett Delahunt, Dr Gonzague De Pinieux, Dr P. Anthony Di Sant agnese, Dr Joakim Dillner, Dr John N. Eble, Dr Diana M. Eccles, Dr Lars Egevad, Dr M.N. El-Bolkainy, Dr Jonathan I. Epstein, Dr John F. Fetsch, Dr Masakuni Furusato, Dr Thomas Gasser, Dr William L. Gerald, Dr A. Geurts Van Kessel, Dr David J. Grignon, Dr Kenneth Grigor, Dr Jay L. Grosfeld, Dr Louis Guillou Dr Seife Hailemariam, Professor Ulrike Maria Hamper, Dr Arndt Hartmann, Dr Tadashi Hasegawa, Dr Axel Heidenreich, Dr Philipp U. Heitz, Dr Burkhard Helpap, Dr Riitta Herva, Professor Ferdinand Hofstadter, Professor Simon Horenblas, Dr Peter A. Humphrey, Dr Kenneth A. Iczkowski, Dr Grete Krag Jacobsen, Dr Sonny L. Johansson, Dr Michael A. Jones, Dr Peter A. Jones, Dr George W. Kaplan, Dr Charles E. Keen, Dr Kyu Rae Kim, Dr Maija Kiuru, Dr Paul Kleihues, Dr Margaret A. Knowles, Dr Gyula Kovacs, Dr Marc Ladanyi, Dr Virpi Launonen, Dr Ivo Leuschner, Dr Howard S. Levin, Dr W. Marston Linehan, Dr Leendert H.J. Looijenga, Dr Antonio Lopez-Beltran, Dr J. Carlos Manivel, Dr Guido Martignoni, Dr Alexander Marx, Dr David G. Mcleod, Dr L. Jeffrey Medeiros, Dr Maria J. Merino, Dr Helen Michael, Dr Markku Miettinen, Dr Holger Moch, Dr Henrik Moller, Dr Rodolfo Montironi, Dr F. Kash Mostofi, Dr Hartmut P.H. Neumann, Dr Manuel Nistal, Dr Lucien Nochomovitz, Dr Esther Oliva, Dr Tim D. Oliver, Dr J. Wolter Oosterhuis, Dr Attilio Orazi, Dr Chin-Chen Pan, Dr Ricardo Paniagua, Dr David M. Parham, Dr D. Max Parkin, Dr M. Constance Parkinson, Dr Christian P. Pavlovich, Dr Elizabeth J. Perlman, Dr Paola Pisani, Dr Andrew A. Renshaw, Dr Victor E. Reuter, Dr Jae Y. Ro, Professor Mark A. Rubin, Dr H. Gil Rushton, Dr Wael A. Sakr, Dr Hemamali Samaratunga, Dr Guido Sauter, Dr Paul F. Schellhammer, Dr Bernd J. Schmitz-Drager, Dr Mark Philip Schoenberg, Dr Isabell A. Sesterhenn, Dr David Sidransky, Dr Ronald Simon, Dr Leslie H. Sobin, Dr Poul H. B. Sorensen, Dr John R. Srigley, Dr Stephan Storkel, Dr Aleksander Talerman, Dr Pheroze Tamboli, Dr Puay H. Tan, Dr Bernard Tetu, Dr Kaori Togashi, Dr Lawrence True, Dr Jerzy E. Tyczynski, Dr Thomas M. Ulbright, Dr Eva Van Den Berg, Dr Theo H. Van Der Kwast, Dr Annick Vieillefond, Dr Geo Von Krogh, Dr Thomas Wheeler, Dr Paula J. Woodward, Dr Ximing J. Yang, Dr Berton Zbar"
Book Synopsis Microarray Bioinformatics by : Dov Stekel
Download or read book Microarray Bioinformatics written by Dov Stekel and published by Cambridge University Press. This book was released on 2003-09-08 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to all of the mathematics, statistics and computing you will need to successfully operate DNA microarray experiments. It is written for researchers, clinicians, laboratory heads and managers, from both biology and bioinformatics backgrounds, who work with, or who intend to work with microarrays. The book covers all aspects of microarray bioinformatics, giving you the tools to design arrays and experiments, to analyze your data, and to share your results with your organisation or with the international community. There are chapters covering sequence databases, oligonucleotide design, experimental design, image processing, normalisation, identifying differentially expressed genes, clustering, classification and data standards. The book is based on the highly successful Microarray Bioinformatics course at Oxford University, and therefore is ideally suited for teaching the subject at postgraduate or professional level.
Book Synopsis Applied Bioinformatics by : Paul Maria Selzer
Download or read book Applied Bioinformatics written by Paul Maria Selzer and published by Springer Science & Business Media. This book was released on 2008-01-18 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: At last, here is a baseline book for anyone who is confused by cryptic computer programs, algorithms and formulae, but wants to learn about applied bioinformatics. Now, anyone who can operate a PC, standard software and the internet can also learn to understand the biological basis of bioinformatics, of the existence as well as the source and availability of bioinformatics software, and how to apply these tools and interpret results with confidence. This process is aided by chapters that introduce important aspects of bioinformatics, detailed bioinformatics exercises (including solutions), and to cap it all, a glossary of definitions and terminology relating to bioinformatics.
Book Synopsis Gaseous Molecular Ions by : Eugen Illenberger
Download or read book Gaseous Molecular Ions written by Eugen Illenberger and published by Springer Science & Business Media. This book was released on 1992-05-26 with total page 944 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the matter in our solar system, and, probably, within the whole universe, exists in the form of ionized particles. On the other hand, in our natural environ ment, gaseous matter generally consists of neutral atoms and molecules. Only under certain conditions, such as within the path oflightning or in several technical devices (e. g. gas discharges, rocket engines, etc. ) will some of the atoms and molecules be ionized. It is also believed that the chemistry of the earth's troposphere predomi nantly proceeds via reactions between neutral particles. (The complex system of atmospheric chemistry will be treated in one of the forthcoming volumes to this series. ) Why, then, are ions considered so important that hundreds oflaboratories all over the world (including some of the most prestigious) are involved in research pro grams on ions, covering many different facets, from biochemistry to physics? One may obtain as many different answers as there are research groups busy in this field. There is, however, one simple, common feature which makes it attractive to work with ions: since they carry one or more net elementary charges, they can easily be gui ded, focused or separated by appropriate electric and magnetic fields, and, last but not least, they can easily be detected. Apart from these advantages, which are welcome and appreciated by the researcher, the study of molecular ions can provide insight into very fundamental aspects of the general behavior of molecules.
Book Synopsis Pediatric Neuro-oncology by : Katrin Scheinemann
Download or read book Pediatric Neuro-oncology written by Katrin Scheinemann and published by Springer. This book was released on 2024-09-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the first edition of this book provided a succinct introduction to pediatric neuro-oncology, biological knowledge of childhood CNS tumors has “exploded” over the past few years and a new edition of this textbook is needed to keep it up-to-date. This updated edition will include chapters on cancer predisposition in children with brain tumors, gliomas, embryonal brain tumors, ependymoma, CNS-GCT, targeted therapies in pediatric brain tumors, and long-term sequelae. New developments covered include the following: - Techniques like DNA methylation have improved the diagnostic process, and have led to an integrated diagnosis of histology, ICH and methylation. - Tumor pathways have been detected, which defines more subgroups within a tumor entity, and results in more individualized treatment for the patient. - Therapeutic options outside the standard combination of surgery, chemotherapy, and radiation have either been implemented within the last years, or are currently under consideration. This book will be aimed at pediatric oncologists and neurooncologists, neurosurgeons, radiation oncologists. Chapters detailing quality of life and supportive care will make this 2nd edition a useful resource for nurses, social workers, physiotherapists, and occupational therapists alike.
Book Synopsis Histological Typing of Urinary Bladder Tumours by : F.K. Mostofi
Download or read book Histological Typing of Urinary Bladder Tumours written by F.K. Mostofi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text reflects the revised WHO classification and terminology. One major change is in the introduction of a new category: papillary urothelial neoplasm of low malignant potential. Many of the tumours previously designated as papillary transitional cell carcinoma, grade I now fall into that category. Another major change is in the designation of flat lesions, and this includes a definition of carcinoma in situ. Furthermore, a number of variant forms of urothelials carcinomas are included as well as new entities not recognized when the 1st edition was issued.
Book Synopsis Cancer Patient Survival by : National Cancer Institute (U.S.)
Download or read book Cancer Patient Survival written by National Cancer Institute (U.S.) and published by . This book was released on 1976 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book ggplot2 written by Hadley Wickham and published by Springer Science & Business Media. This book was released on 2009-10-03 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides both rich theory and powerful applications Figures are accompanied by code required to produce them Full color figures
