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Author : Peter Kugler
Publisher :
ISBN 13 : 9783642685538
Total Pages : 102 pages
Book Rating : 4.6/5 (855 download)
Download or read book ON ANGIOTENSIN-DEGRADING AMINOPEPTIDASES IN THE RAT KIDNEY written by Peter Kugler and published by . This book was released on 1982 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : P. Kugler
Publisher : Springer Science & Business Media
ISBN 13 : 3642685528
Total Pages : 95 pages
Book Rating : 4.6/5 (426 download)
Download or read book On Angiotensin-Degrading Aminopeptidases in the Rat Kidney written by P. Kugler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: The octapeptide angiotensin II (ANG II, Fig. 1) is the key effector substance of the renin-angiotensin system (RAS) (Werning 1972, Page and Bumpus 1974, Hierholzer 1977, Vecsei et al. 1978, Johnson and Anderson 1980 lit.). ANG II is formed in two enzymatic steps. Renin acts on renin substrate, a glycoprotein, to produce angiotensin I (ANG I, a decapeptide), which in turn is acted upon by converting enzyme to form ANG II (Skeggs et al. 1968, Fig. 1). Renin substrate (angiotensinogen) is produced mainly in the liver (Page et al. 1941) and is a constituent of the ~-globulin fraction in the circulating plasma (Plentl et al. 1943). The two enzymes involved in the formation of ANG II from renin substra te are formed at various sites in the body. Renin (E.C. 3. 4. 99. 19) is produced mainly in the granular epithelioid cells of the kidney (Cook 1971, Taugner et al. 1979, Davi doff and Schiebler 1981), and converting enzyme (CE, E.C. 3. 4. 15. 1) occurs chiefly in the lung (Ng and Vane 1967, Bakhle 1974 lit.) as well as in numerous other tissues, such as the juxtaglomerular apparatus of the kidney (Granger et al. 1969, 1972) and the brush border of the renal proximal tubule (Ward et al. 1975, 1976; Ward und Erdos 1977). The biological effects of ANG II are numerous.
Author :
Publisher :
ISBN 13 :
Total Pages : 1860 pages
Book Rating : 4.:/5 (319 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joseph Harding
Publisher : Elsevier
ISBN 13 : 0323159117
Total Pages : 251 pages
Book Rating : 4.3/5 (231 download)
Download or read book Angiotensin and Blood Pressure Regulation written by Joseph Harding and published by Elsevier. This book was released on 2012-12-02 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiotensin and Blood Pressure Regulation examines the role of angiotensin in blood pressure regulation, with emphasis on its ability to influence the inotropic state directly via activation of myocardial receptors and indirectly by potentiating the release of catecholamines from sympathetic nerve terminals. The book also explains how angiotensin acts directly to regulate thirst and sodium appetite, and via antidiuretic hormone to control water reabsorption in the kidney. This book is comprised of eight chapters and begins with a review of the neuronal actions of angiotensin, primarily those in the brain, as well as the location and function of brain angiotensin II receptors. The effects of angiotensin on elements of the vascular wall and myocardium are also discussed, along with its function in hypovolemia, reproduction, and neurotransmission. Subsequent chapters explore some basic and functional considerations of the renin-angiotensin system in the brain; the biochemical processing that is required for angiotensin activation and inactivation; how angiotensin affects peripheral resistance; and the potency of angiotensin III as a pressor and dipsogenic agent in normotensive and hypertensive animal models. This monograph will be a useful resource for pharmacologists and physiologists.
Author : Diether Neubert
Publisher : Springer Science & Business Media
ISBN 13 : 3642777538
Total Pages : 556 pages
Book Rating : 4.6/5 (427 download)
Download or read book Risk Assessment of Prenatally-Induced Adverse Health Effects written by Diether Neubert and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the thalidomide (Contergan) tragedy about 30 years ago the induction of prenatally-induced morphological or functional defects has been an area of extensive research. Risk assessment of prenatally-induced adverse health effects is still a difficult task from both experimental data as well asfrom observations in humans. In the contributions to this book three major aspects are dealt with: - Quantitative extrapolations of experimental data to the situation possibly relevant for man. - The significance for a risk assessment with respect to man of minor or rare structural abnormalities observed in experimental studies - The future need to assess congenital dysfunctions (e.g. of the hormone or the immune system) beside the present evaulation of structural defects. Limitations as well as gaps of the present knowledge in this area of basic and applied research are pointed out. Since the results of prenatally-induced lesions may manifest themselves not only pre- but often not before late postnatally, numerous aspects of structural and functional abnormaldevelopment must be studied in experimental and clinical investigations.
Author : G. Grün
Publisher : Springer Science & Business Media
ISBN 13 : 3642687199
Total Pages : 96 pages
Book Rating : 4.6/5 (426 download)
Download or read book The Development of the Vertebrate Retina written by G. Grün and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mature vertebrate retina is a highly complicated array of several kinds of cells, capable of receiving light impulses, transforming them into neuronal membrane currents, and transmitting these in a meaningful way to central processing. Before it starts to develop, it is a small sheet of unconspicuous cells, which do not differ from other cells of the central nervous system. The chain of events which lead to the trans formation from this stage into that of highly specialized cells ready to fulfll a specific task, is usually called "differentiation. " Originally, this word indicated firstly the proc ess of divergence from other cells which were previously alike, and secondly, the change from an earlier stage of the same cello lt has become widespread practice to imply by the word "differentiation" also the acquisition of specific properties and capacities which are characteristic of a mature, Le. , specifically active, cello Every cell is active at any stage of development, but certain activities are shared by most cells (e. g. , the activities of preparing and accomplishing proliferation, that of initiating development, that of maintaining a certain level of metabolism), while there are others which are shared by only a small number of - originally relate- cells. In most cases these latter activities are acquired by the fmal steps of cellular development, the terminal "differentiation. " In the context of the present paper, the word "function" will refer to this latter type of specific activity.
Author : Steven F. Perry
Publisher : Springer Science & Business Media
ISBN 13 : 3642689647
Total Pages : 90 pages
Book Rating : 4.6/5 (426 download)
Download or read book Reptilian Lungs written by Steven F. Perry and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph has attempted to bring together morphological and physiological studies of reptilian lungs, to analyze the nature of the resulting correlations, and to risk some speculations regarding the evolution of reptilian lung structure. Central to this work is the morphometric evaluation of the lungs in two species of lizard: "the teju (Tupinambis nigropunctatus Spix) and the savanna monitor (Varanus exanthema ticus [Bosc]) which is presented here for the first time. These two species are similar in body form, and both are diurnally active predators, but their lungs are of basic ally different structural types. The teju possesses relatively small, single-chambered (unicameral) lungs in which the homeycomb-like (faveolar) parenchyma is more or less evenly distributed along their length. In the monitor the lungs are large and many-chambered (multicameral), the individual chambers connecting to an unbranched, intrapulmonary bronchus. The parenchyma is in the form of shallow cubicles (ediculae), which are elaborated on the intercameral septa. The parenchyma is heterogeneously distributed within the lungs, tending to be most concentrated near the intrapulmonary bronchus and the middle third of the lung length. The ventral and caudal portions of these lungs are thin-walled and highly flexible. In both species those portions of the lungs which are most exposed to air convection possess dense capillary nets which almost completely cover both sides of the parenchymal partitions. In more distal regions of the parenchy ma or of the lung, the intercapillary spaces become larger, creating a pseudo-single capillary net.
Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1442 pages
Book Rating : 4.3/5 (91 download)
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1983 with total page 1442 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1456 pages
Book Rating : 4.:/5 (319 download)
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1983 with total page 1456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : F. Hajos
Publisher : Springer Science & Business Media
ISBN 13 : 3642696236
Total Pages : 89 pages
Book Rating : 4.6/5 (426 download)
Download or read book The Surface-Contact Glia written by F. Hajos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. 1 Brief History The diversity of cells constituting the central nervous system did not deceive last century neurohistologists in recognizing that this organ contained essentially two cell types: the nerve cells, or as termed according to the emerging concept of neural contiguity, the neurons, and the neuroglial cells. Neurons were clearly shown to be the means of excitability, impulse generation, impulse transmission, and connectivity in the neural tissue. The neuroglia, as indicated by its name (YAloc=cement or glue) given by Virchow (1860), was thought to be the cement ing material ensuring the coherence of the nervous tissue, filling in the spaces of the neuropil, and isolating neuronal cell bodies. While this supposedly passive role did not attract multidisciplinary research on the neuroglia, successful efforts were made to extend our knowledge of the physiology, morphology, and bio chemistry of neurons. As a result of this, the investigation of the neuroglia carried out in the first half of this century was mainly confined to morphology, often as a by-product of comprehensive analyses of neuronal systems. At any rate, the histological classification of the neuroglia was accomplished, laying a framework which has been used to the present day. Accordingly, the glia was divided into two major groups: the macro- and microglia. The former comprises two further subclasses, the astroglia and oligodendroglia.
Author : Barry M. Brenner
Publisher : W.B. Saunders Company
ISBN 13 :
Total Pages : 1240 pages
Book Rating : 4.3/5 (555 download)
Download or read book Brenner and Rector's the Kidney written by Barry M. Brenner and published by W.B. Saunders Company. This book was released on 1996 with total page 1240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fifth edition of this text provides the practitioner with comprehensive coverage in the area of nephrology. The source aims to help the reader effectively diagnose, treat and explore preventative measures associated with every aspect of renal disease.
Author : Thomas Unger
Publisher : Academic Press
ISBN 13 : 0128014857
Total Pages : 312 pages
Book Rating : 4.1/5 (28 download)
Download or read book The Protective Arm of the Renin Angiotensin System (RAS) written by Thomas Unger and published by Academic Press. This book was released on 2015-04-18 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.
Author : Jens H. Henriksen
Publisher : CRC Press
ISBN 13 : 9780849368585
Total Pages : 332 pages
Book Rating : 4.3/5 (685 download)
Download or read book Degradation of Bioactive Substances written by Jens H. Henriksen and published by CRC Press. This book was released on 1991-05-28 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended primarily for researchers working with bioactive substances such as hormones, neurotransmitters, growth factors, and connective tissue makers, this book discusses the principles of degradation in major groups of bioactive materials with respect to physiology, location, and regulation. Peptidases; receptor-mediated endocytosis; organ extraction and clearance; and the degradation of specific proteins, peptides, amines, steroids, and polysaccharoides are featured. Pathophysiology and its role in diagnostics and disease are considered throughout the book, in addition to updates of recent literature and substantial new information on physiology and pathophysiology of degradation of bioactive material. No special mathematical or kinetic background is necessary to read this book because the mathematic and kinetic concepts are facilitated through the presentation of fundamental and more advanced principles. Furthermore, illustrations and tables are provided to facilitate the understanding of the dynamic aspects of degradation processes. Degradation of Bioactive Substances: Physiology and Pathophysiology is the first comprehensive work describing the degradation of bioactive material, including information not found in biochemical textbooks on internal metabolism or pharmacokinetic textbooks on drug metabolism.
Author :
Publisher :
ISBN 13 :
Total Pages : 792 pages
Book Rating : 4.:/5 (39 download)
Download or read book Acta Physiologica Hungarica written by and published by . This book was released on 1983 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paul M. Pilowsky
Publisher : Elsevier
ISBN 13 : 0323996191
Total Pages : 834 pages
Book Rating : 4.3/5 (239 download)
Download or read book Angiotensin written by Paul M. Pilowsky and published by Elsevier. This book was released on 2023-02-20 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiotensin: From the Kidney to Coronavirus, a new volume in the Molecular Mediators in Health and Disease series, presents the communication role of the hormone in both health and disease states. Beyond the most common conditions, the book also explores the role of Angiotensin in infectious diseases, like COVID-19. Sections provide background to its discovery and role in homeostasis, focus on molecular biology aspects, including genetics and measurements of its associated proteins, describe the specific actions of angiotensin in normal physiology with different organ systems, survey different classes of drugs that act on the Renin-angiotensin-aldosterone system, cover non-angiotensin II peptides, and more. The final part of the book is dedicated to angiotensin’s role in disease states, making this the ideal reference for researchers in life sciences interested in understanding the physiological role of Angiotensin in a complete fashion. Research physicians will also benefit from the book’s complete coverage of organ systems and diseases where Angiotensin plays a key role. Covers the traditional disorders related to Angiotensin and new findings like its role in infectious diseases like COVID-19 Offers an overview of all important aspects of angiotensin, from discovery to clinical application, from physical and chemical properties to the physiological/cellular interaction Expands on the role of angiotensin beyond the individual system the researcher is focusing, providing a comprehensive coverage of the additional effects at cell, tissue, organ, and system levels
Author : Po Sing Leung
Publisher : Springer Science & Business Media
ISBN 13 : 1402063725
Total Pages : 310 pages
Book Rating : 4.4/5 (2 download)
Download or read book Frontiers in Research of the Renin-Angiotensin System on Human Disease written by Po Sing Leung and published by Springer Science & Business Media. This book was released on 2007-10-16 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary aim of this book is to provide a topical and timely forum for the critical appraisal of an area of renin-angiotensin system (RAS) research that is expanding rapidly. In this respect, a collection of thirteen chapters from distinguished and world-class experts in the field has been presented on the contemporary research of the RAS and their implications in human disease. This book is an indispensable tool tailor-made for specialists, non-specialists and the novice.
Author : Alan J. Barrett
Publisher : Elsevier
ISBN 13 : 0080984150
Total Pages : 1182 pages
Book Rating : 4.0/5 (89 download)
Download or read book Handbook of Proteolytic Enzymes, Volume 1 written by Alan J. Barrett and published by Elsevier. This book was released on 2012-12-02 with total page 1182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.
