On Angiotensin Degrading Aminopeptidases In The Rat Kidney

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On Angiotensin-Degrading Aminopeptidases in the Rat Kidney

Author : P. Kugler
Publisher : Springer Science & Business Media
ISBN 13 : 3642685528
Total Pages : 95 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis On Angiotensin-Degrading Aminopeptidases in the Rat Kidney by : P. Kugler

Download or read book On Angiotensin-Degrading Aminopeptidases in the Rat Kidney written by P. Kugler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: The octapeptide angiotensin II (ANG II, Fig. 1) is the key effector substance of the renin-angiotensin system (RAS) (Werning 1972, Page and Bumpus 1974, Hierholzer 1977, Vecsei et al. 1978, Johnson and Anderson 1980 lit.). ANG II is formed in two enzymatic steps. Renin acts on renin substrate, a glycoprotein, to produce angiotensin I (ANG I, a decapeptide), which in turn is acted upon by converting enzyme to form ANG II (Skeggs et al. 1968, Fig. 1). Renin substrate (angiotensinogen) is produced mainly in the liver (Page et al. 1941) and is a constituent of the ~-globulin fraction in the circulating plasma (Plentl et al. 1943). The two enzymes involved in the formation of ANG II from renin substra te are formed at various sites in the body. Renin (E.C. 3. 4. 99. 19) is produced mainly in the granular epithelioid cells of the kidney (Cook 1971, Taugner et al. 1979, Davi doff and Schiebler 1981), and converting enzyme (CE, E.C. 3. 4. 15. 1) occurs chiefly in the lung (Ng and Vane 1967, Bakhle 1974 lit.) as well as in numerous other tissues, such as the juxtaglomerular apparatus of the kidney (Granger et al. 1969, 1972) and the brush border of the renal proximal tubule (Ward et al. 1975, 1976; Ward und Erdos 1977). The biological effects of ANG II are numerous.

ON ANGIOTENSIN-DEGRADING AMINOPEPTIDASES IN THE RAT KIDNEY

Author : Peter Kugler
Publisher :
ISBN 13 : 9783642685538
Total Pages : 102 pages
Book Rating : 4.6/5 (855 download)

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Book Synopsis ON ANGIOTENSIN-DEGRADING AMINOPEPTIDASES IN THE RAT KIDNEY by : Peter Kugler

Download or read book ON ANGIOTENSIN-DEGRADING AMINOPEPTIDASES IN THE RAT KIDNEY written by Peter Kugler and published by . This book was released on 1982 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Frontiers in Research of the Renin-Angiotensin System on Human Disease

Author : Po Sing Leung
Publisher : Springer Science & Business Media
ISBN 13 : 1402063725
Total Pages : 310 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Frontiers in Research of the Renin-Angiotensin System on Human Disease by : Po Sing Leung

Download or read book Frontiers in Research of the Renin-Angiotensin System on Human Disease written by Po Sing Leung and published by Springer Science & Business Media. This book was released on 2007-10-16 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary aim of this book is to provide a topical and timely forum for the critical appraisal of an area of renin-angiotensin system (RAS) research that is expanding rapidly. In this respect, a collection of thirteen chapters from distinguished and world-class experts in the field has been presented on the contemporary research of the RAS and their implications in human disease. This book is an indispensable tool tailor-made for specialists, non-specialists and the novice.

The Protective Arm of the Renin Angiotensin System (RAS)

Author : Thomas Unger
Publisher : Academic Press
ISBN 13 : 0128014857
Total Pages : 312 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Protective Arm of the Renin Angiotensin System (RAS) by : Thomas Unger

Download or read book The Protective Arm of the Renin Angiotensin System (RAS) written by Thomas Unger and published by Academic Press. This book was released on 2015-04-18 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. - Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor - Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. - Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases - Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.

Heart Failure: A Companion to Braunwald's Heart Disease E-Book

Author : G. Michael Felker
Publisher : Elsevier Health Sciences
ISBN 13 : 0323609880
Total Pages : 937 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Heart Failure: A Companion to Braunwald's Heart Disease E-Book by : G. Michael Felker

Download or read book Heart Failure: A Companion to Braunwald's Heart Disease E-Book written by G. Michael Felker and published by Elsevier Health Sciences. This book was released on 2019-02-06 with total page 937 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald's Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. - Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. - Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. - Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). - Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. - Covers the pathophysiological basis for the development and progression of heart failure. - Serves as a definitive resource to prepare for the ABIM's Heart Failure board exam. - 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).

Aminopeptidases in Biology and Disease

Author : N. M. Hooper
Publisher : Springer Science & Business Media
ISBN 13 : 9780306484650
Total Pages : 364 pages
Book Rating : 4.4/5 (846 download)

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Book Synopsis Aminopeptidases in Biology and Disease by : N. M. Hooper

Download or read book Aminopeptidases in Biology and Disease written by N. M. Hooper and published by Springer Science & Business Media. This book was released on 2004 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aminopeptidases in Biology and Disease provides a comprehensive review of the emerging role of aminopeptidases in a range of biological processes and disease situations. Processes as diverse as angiogenesis, antigen presentation, neuropeptide and hormone processing, pregnancy and reproduction, protein turnover, memory, inflammation, tumour growth, cancer and metastasis, blood pressure and hypertension all critically involve one or more aminopeptidases. The individual chapters have been written by experts in the field who have provided detailed accounts of the central roles played by various aminopeptidases in biology and disease. Aminopeptidases in Biology and Disease will be a timely and useful source of information both for those immersed in the field of aminopeptidases and those just taking their first steps into this exciting and ever-expecting field of research. Each chapter starts with a brief abstract summarizing the content and biological reference. Aminopeptidases in Biology and Disease : -Provides an up-to-date presentation of the role of aminopeptidases in biological processes, -Highlights the critical role played by aminopeptidases in various diseases, -Provides background information on the structure and function of each aminopeptidase, -Covers the use of aminopeptidase inhibitors in therapeutic applications.

Sex Differences in Cardiovascular Physiology and Pathophysiology

Author : Babbette LaMarca
Publisher : Academic Press
ISBN 13 : 0128131977
Total Pages : 392 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Sex Differences in Cardiovascular Physiology and Pathophysiology by : Babbette LaMarca

Download or read book Sex Differences in Cardiovascular Physiology and Pathophysiology written by Babbette LaMarca and published by Academic Press. This book was released on 2019-04-11 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sex Differences in Cardiovascular Physiology and Pathophysiology is a comprehensive look into the often overlooked and underappreciated fundamental sex differences between men and women and how those differences affect the cardiovascular system. It covers cardiovascular function, anatomy, cell signaling and the development of pathology. With contributions from world-renowned research investigators, this up-to-date reference compiles critical knowledge on cardiovascular sex differences, providing researchers and clinicians with a better understanding of the diagnosis, prevention and treatment of cardiovascular diseases in both men and women.

Degradation of Bioactive Substances

Author : Jens H. Henriksen
Publisher : CRC Press
ISBN 13 : 9780849368585
Total Pages : 332 pages
Book Rating : 4.3/5 (685 download)

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Book Synopsis Degradation of Bioactive Substances by : Jens H. Henriksen

Download or read book Degradation of Bioactive Substances written by Jens H. Henriksen and published by CRC Press. This book was released on 1991-05-28 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended primarily for researchers working with bioactive substances such as hormones, neurotransmitters, growth factors, and connective tissue makers, this book discusses the principles of degradation in major groups of bioactive materials with respect to physiology, location, and regulation. Peptidases; receptor-mediated endocytosis; organ extraction and clearance; and the degradation of specific proteins, peptides, amines, steroids, and polysaccharoides are featured. Pathophysiology and its role in diagnostics and disease are considered throughout the book, in addition to updates of recent literature and substantial new information on physiology and pathophysiology of degradation of bioactive material. No special mathematical or kinetic background is necessary to read this book because the mathematic and kinetic concepts are facilitated through the presentation of fundamental and more advanced principles. Furthermore, illustrations and tables are provided to facilitate the understanding of the dynamic aspects of degradation processes. Degradation of Bioactive Substances: Physiology and Pathophysiology is the first comprehensive work describing the degradation of bioactive material, including information not found in biochemical textbooks on internal metabolism or pharmacokinetic textbooks on drug metabolism.

The Histochemical Journal

Author :
Publisher :
ISBN 13 :
Total Pages : 740 pages
Book Rating : 4.:/5 (5 download)

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Book Synopsis The Histochemical Journal by :

Download or read book The Histochemical Journal written by and published by . This book was released on 1985 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Proceedings of KININ2018CLE, Cleveland, Ohio, June 18-20, 2018: A Compendium of the Presentations

Author : Alvin H. Schmaier
Publisher : Frontiers Media SA
ISBN 13 : 2889633322
Total Pages : 147 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Proceedings of KININ2018CLE, Cleveland, Ohio, June 18-20, 2018: A Compendium of the Presentations by : Alvin H. Schmaier

Download or read book Proceedings of KININ2018CLE, Cleveland, Ohio, June 18-20, 2018: A Compendium of the Presentations written by Alvin H. Schmaier and published by Frontiers Media SA. This book was released on 2020-01-14 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Concepts in Biochemical Pharmacology

Author : Bernard B. Brodie
Publisher : Springer Science & Business Media
ISBN 13 : 3642651771
Total Pages : 797 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Concepts in Biochemical Pharmacology by : Bernard B. Brodie

Download or read book Concepts in Biochemical Pharmacology written by Bernard B. Brodie and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 797 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) will show that pharma cology has finally arrived as a true discipline in its own right, and is no longer the handmaiden of organic chemistry and physiology. Instead it is an amalgam of all the biological sciences including biochemistry, biophysical chemistry, physiology, pathology and clinical medicine. In the volumes that make up Concepts in Bio chemical Pharmacology we hope to convince Medical Schools what should now be obvious, that pharmacology is no longer that dull topic bridging the basic sciences with medicine, but is probably the most important subject in the medical curriculum. We are grateful for the advice of Dr. Byron Clark, Director of the Pharmacology-Toxicology Program at the National Institutes of Health whose support made possible much of the work described in this volume. Contents Section Four: Methods 01 Stooging the MetoholiBm 01 Drugs Subsection A. Assay 01 Drugs and Their M etoholites Chapter 22 : Basic Principles in Development of Methods for Drug Assay. B. B. BRODIE. With 2 Figures 1 1 A. Introduction . . . . . . . . . . B. Principles of Developing a Method. . . . . . 1 I. Section of Method of Assay . . . . . . 1 II. Choice of Solvent for Extraction of Drug 2 III. Adsorption of Drugs by Glass Surfaces . . . . . . . . . . . . . . 3 IV. Recoveries of Known Amounts of Compound from Biological Material. 4 V. Assessment of Sensitivity 5 VI. Assessment of Specificity 5 References. . . . . . . . . . .

Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1442 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Current Catalog by : National Library of Medicine (U.S.)

Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1983 with total page 1442 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

National Library of Medicine Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1456 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1983 with total page 1456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Olives and Olive Oil in Health and Disease Prevention

Author : Victor R Preedy
Publisher : Academic Press
ISBN 13 : 0080922201
Total Pages : 1520 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Olives and Olive Oil in Health and Disease Prevention by : Victor R Preedy

Download or read book Olives and Olive Oil in Health and Disease Prevention written by Victor R Preedy and published by Academic Press. This book was released on 2010-03-23 with total page 1520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long used in sacred ceremonies and associated with good health, the nutritional and health promoting benefits of olives and olive oils have been proven by an ever-increasing body of science. From cardiovascular benefits to anti-microbial, anti-cancer, antioxidant activity and effects on macrophages and aptoptosis to cellular and pathophysiollogical process, olives and olive oils are proving important in many healthful ways. For example, reactive components in olive oils or olive oil by-products have now been isolated and identified. These include tyrosol, hydroxytyrosol, 3,4-dihydroxyphenyl acetic acid elenolic acid and oleuropein. Oleic acid is the main monosaturated fatty acid of olive oil. These have putative protective effects and modulate the biochemistry of a variety of cell types including those of the vascular system. Some but not all components have been characterised by their putative pharmacological properties. It is possible that usage of these aforementioned products may have beneficial application in other disease. However, in order for this cross-fertilization to take place, a comprehensive understanding of olives and olive oils is required. Finding this knowledge in a single volume provides a key resource for scientists in a variety of food an nutritional roles. - Explores olives and olive oil from their general aspects to the detailed level of important micro-and micronutrients - Includes coverage of various methodologies for analysis to help scientists and chemists determine the most appropriate option for their own studies, including those of olive-related compounds in other foods - Relates, in a single volume resource, information for food and nutritional chemists, pharmaceutical scientists, nutritionists and dieticians - Presents information in three key categories: General aspects of olives an olive oils; Nutritional, pharmacological and metabolic properties of olives and olive oil; Specific components of olive oil and their effects on tissue and body systems

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1860 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Anatomy and Embryology

Author :
Publisher :
ISBN 13 :
Total Pages : 498 pages
Book Rating : 4.:/5 (48 download)

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Book Synopsis Anatomy and Embryology by :

Download or read book Anatomy and Embryology written by and published by . This book was released on 1983 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neuropeptides in the Spinal Cord

Author : F. Nyberg
Publisher : Elsevier
ISBN 13 : 0080862292
Total Pages : 439 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Neuropeptides in the Spinal Cord by : F. Nyberg

Download or read book Neuropeptides in the Spinal Cord written by F. Nyberg and published by Elsevier. This book was released on 1995-10-30 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book devoted exclusively to examining the role of neuropeptides in the spinal cord. Great progress has been made recently in our understanding of the role of neuropeptides in neurotransmission. New tools have been developed to help study the function of endogenous neuropeptides in health and disease. Because the general organization of the spinal cord is well conserved among species and neuropeptides appear to have a major role in spinal neurotransmission, this book is a timely compendium of recent research in this field. The volume will help to stimulate further research in the field of neuropeptides which will lead to better understanding of this role in health and disease.