Omic Association Studies With R And Bioconductor

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Omic Association Studies with R and Bioconductor

Author : Juan R. González
Publisher : CRC Press
ISBN 13 : 0429803370
Total Pages : 376 pages
Book Rating : 4.4/5 (298 download)

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Book Synopsis Omic Association Studies with R and Bioconductor by : Juan R. González

Download or read book Omic Association Studies with R and Bioconductor written by Juan R. González and published by CRC Press. This book was released on 2019-06-14 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: After the great expansion of genome-wide association studies, their scientific methodology and, notably, their data analysis has matured in recent years, and they are a keystone in large epidemiological studies. Newcomers to the field are confronted with a wealth of data, resources and methods. This book presents current methods to perform informative analyses using real and illustrative data with established bioinformatics tools and guides the reader through the use of publicly available data. Includes clear, readable programming codes for readers to reproduce and adapt to their own data. Emphasises extracting biologically meaningful associations between traits of interest and genomic, transcriptomic and epigenomic data Uses up-to-date methods to exploit omic data Presents methods through specific examples and computing sessions Supplemented by a website, including code, datasets, and solutions

Omic Association Studies with R and Bioconductor

Author : Juan R. González
Publisher : CRC Press
ISBN 13 : 0429803362
Total Pages : 348 pages
Book Rating : 4.4/5 (298 download)

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Book Synopsis Omic Association Studies with R and Bioconductor by : Juan R. González

Download or read book Omic Association Studies with R and Bioconductor written by Juan R. González and published by CRC Press. This book was released on 2019-06-14 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: After the great expansion of genome-wide association studies, their scientific methodology and, notably, their data analysis has matured in recent years, and they are a keystone in large epidemiological studies. Newcomers to the field are confronted with a wealth of data, resources and methods. This book presents current methods to perform informative analyses using real and illustrative data with established bioinformatics tools and guides the reader through the use of publicly available data. Includes clear, readable programming codes for readers to reproduce and adapt to their own data. Emphasises extracting biologically meaningful associations between traits of interest and genomic, transcriptomic and epigenomic data Uses up-to-date methods to exploit omic data Presents methods through specific examples and computing sessions Supplemented by a website, including code, datasets, and solutions

ISSUES RELATED TO WOMEN: ESSAYS IN ECONOMETRICS AND STATISTICS

Author : Ebru Çağlayan Akay - Merve Ertok Onurlu
Publisher : HOLISTENCE PUBLICATIONS
ISBN 13 : 6256942140
Total Pages : 419 pages
Book Rating : 4.2/5 (569 download)

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Book Synopsis ISSUES RELATED TO WOMEN: ESSAYS IN ECONOMETRICS AND STATISTICS by : Ebru Çağlayan Akay - Merve Ertok Onurlu

Download or read book ISSUES RELATED TO WOMEN: ESSAYS IN ECONOMETRICS AND STATISTICS written by Ebru Çağlayan Akay - Merve Ertok Onurlu and published by HOLISTENCE PUBLICATIONS. This book was released on 2023-03-21 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the world, many women are at risk of being exposed to economic, physical, sexual, psychological, and emotional violence, or even intentional homicide. They might also be exposed to discrimination based on their socio-demographic characteristics, such as their ethnic background, religion, and educational level. The purpose of this book is to bring together academics and researchers working in the fields of applied econometrics and applied statistics as they pertain to women’s issues. The twelve-chapter book includes insights on present econometric and statistical methodologies on women’s issues, as well as a better understanding and evaluation of contemporary policy implications, initiatives, and procedures pertaining to women.

Integrative Omics

Author : Manish Kumar Gupta
Publisher : Elsevier
ISBN 13 : 0443160937
Total Pages : 434 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Integrative Omics by : Manish Kumar Gupta

Download or read book Integrative Omics written by Manish Kumar Gupta and published by Elsevier. This book was released on 2024-05-10 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrative Omics: Concepts, Methodology and Applications provides a holistic and integrated view of defining and applying network approaches, integrative tools, and methods to solve problems for the rationalization of genotype to phenotype relationships. The reference includes a range of chapters in a systemic ‘step by step’ manner, which begins with the basic concepts from Omic to Multi Integrative Omics approaches, followed by their full range of approaches, applications, emerging trends, and future trends. All key areas of Omics are covered including biological databases, sequence alignment, pharmacogenomics, nutrigenomics and microbial omics, integrated omics for Food Science and Identification of genes associated with disease, clinical data integration and data warehousing, translational omics as well as omics technology policy and society research. Integrative Omics: Concepts, Methodology and Applications highlights the recent concepts, methodologies, advancements in technologies and is also well-suited for researchers from both academic and industry background, undergraduate and graduate students who are mainly working in the area of computational systems biology, integrative omics and translational science. The book bridges the gap between biological sciences, physical sciences, computer science, statistics, data science, information technology and mathematics by presenting content specifically dedicated to mathematical models of biological systems. Provides a holistic, integrated view of a defining and applying network approach, integrative tools, and methods to solve problems for rationalization of genotype to phenotype relationships Offers an interdisciplinary approach to Databases, data analytics techniques, biological tools, network construction, analysis, modeling, prediction and simulation of biological systems leading to ‘translational research’, i.e., drug discovery, drug target prediction, and precision medicine Covers worldwide methods, concepts, databases, and tools used in the construction of integrated pathways

Omics Science for Rhizosphere Biology

Author : Ramesh Namdeo Pudake
Publisher : Springer Nature
ISBN 13 : 981160889X
Total Pages : 279 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Omics Science for Rhizosphere Biology by : Ramesh Namdeo Pudake

Download or read book Omics Science for Rhizosphere Biology written by Ramesh Namdeo Pudake and published by Springer Nature. This book was released on 2021-05-08 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a timely review of the latest advances in rhizosphere biology, which have been facilitated by the application of omics tools. It includes chapters on the use of various omics tools in rhizosphere biology, focusing on understanding plant and soil microbe interactions. The role of proteomics and metagenomics in research on symbiotic association is also discussed in detail. The book also includes chapters on the use of omics tools for the isolation of functional biomolecules from rhizospheric microorganisms. The book’s respective sections describe and provide detailed information on important omics tools, such as genomics, transcriptomics, proteomics, metabolomics and meta-epigenomics. In turn, the book promotes and describes the combined use of plant biology, microbial ecology, and soil sciences to design new research strategies and innovative methods in soil biology. Lastly, it highlights the considerable potential of the rhizosphere in terms of crop productivity, bioremediation, ecological engineering, plant nutrition and health, as well as plant adaptation to stress conditions. This book offers both a practical guide and reference source for all scientists working in soil biology, plant pathology, etc. It will also benefit students studying soil microbiology, and researchers studying rhizosphere structure.

Applied Statistical Genetics with R

Author : Andrea S. Foulkes
Publisher : Springer Science & Business Media
ISBN 13 : 038789554X
Total Pages : 264 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Applied Statistical Genetics with R by : Andrea S. Foulkes

Download or read book Applied Statistical Genetics with R written by Andrea S. Foulkes and published by Springer Science & Business Media. This book was released on 2009-04-28 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical genetics has become a core course in many graduate programs in public health and medicine. This book presents fundamental concepts and principles in this emerging field at a level that is accessible to students and researchers with a first course in biostatistics. Extensive examples are provided using publicly available data and the open source, statistical computing environment, R.

Statistical Approaches in Omics Data Association Studies

Author : Qi Yan
Publisher : Frontiers Media SA
ISBN 13 : 2889763625
Total Pages : 169 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Statistical Approaches in Omics Data Association Studies by : Qi Yan

Download or read book Statistical Approaches in Omics Data Association Studies written by Qi Yan and published by Frontiers Media SA. This book was released on 2022-06-07 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Artificial Intelligence and Bioinformatics Applications for Omics and Multi-Omics Studies

Author : Angelo Facchiano
Publisher : Frontiers Media SA
ISBN 13 : 2832544452
Total Pages : 160 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Artificial Intelligence and Bioinformatics Applications for Omics and Multi-Omics Studies by : Angelo Facchiano

Download or read book Artificial Intelligence and Bioinformatics Applications for Omics and Multi-Omics Studies written by Angelo Facchiano and published by Frontiers Media SA. This book was released on 2024-02-07 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Data Analysis for the Life Sciences with R

Author : Rafael A. Irizarry
Publisher : CRC Press
ISBN 13 : 1498775861
Total Pages : 461 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Data Analysis for the Life Sciences with R by : Rafael A. Irizarry

Download or read book Data Analysis for the Life Sciences with R written by Rafael A. Irizarry and published by CRC Press. This book was released on 2016-10-04 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers several of the statistical concepts and data analytic skills needed to succeed in data-driven life science research. The authors proceed from relatively basic concepts related to computed p-values to advanced topics related to analyzing highthroughput data. They include the R code that performs this analysis and connect the lines of code to the statistical and mathematical concepts explained.

Big Data, Big Challenges: A Healthcare Perspective

Author : Mowafa Househ
Publisher : Springer
ISBN 13 : 3030061094
Total Pages : 144 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Big Data, Big Challenges: A Healthcare Perspective by : Mowafa Househ

Download or read book Big Data, Big Challenges: A Healthcare Perspective written by Mowafa Househ and published by Springer. This book was released on 2019-02-26 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to offer a comprehensive yet concise overview of the challenges and opportunities presented by the use of big data in healthcare. The respective chapters address a range of aspects: from health management to patient safety; from the human factor perspective to ethical and economic considerations, and many more. By providing a historical background on the use of big data, and critically analyzing current approaches together with issues and challenges related to their applications, the book not only sheds light on the problems entailed by big data, but also paves the way for possible solutions and future research directions. Accordingly, it offers an insightful reference guide for health information technology professionals, healthcare managers, healthcare practitioners, and patients alike, aiding them in their decision-making processes; and for students and researchers whose work involves data science-related research issues in healthcare.

Advancement in Gene Set Analysis: Gaining Insight From High-throughput Data

Author : Farhad Maleki
Publisher : Frontiers Media SA
ISBN 13 : 2889764230
Total Pages : 195 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Advancement in Gene Set Analysis: Gaining Insight From High-throughput Data by : Farhad Maleki

Download or read book Advancement in Gene Set Analysis: Gaining Insight From High-throughput Data written by Farhad Maleki and published by Frontiers Media SA. This book was released on 2022-08-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Multi-omic Data Integration

Author : Paolo Tieri
Publisher : Frontiers Media SA
ISBN 13 : 2889196488
Total Pages : 137 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Multi-omic Data Integration by : Paolo Tieri

Download or read book Multi-omic Data Integration written by Paolo Tieri and published by Frontiers Media SA. This book was released on 2015-09-17 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stable, predictive biomarkers and interpretable disease signatures are seen as a significant step towards personalized medicine. In this perspective, integration of multi-omic data coming from genomics, transcriptomics, glycomics, proteomics, metabolomics is a powerful strategy to reconstruct and analyse complex multi-dimensional interactions, enabling deeper mechanistic and medical insight. At the same time, there is a rising concern that much of such different omic data –although often publicly and freely available- lie in databases and repositories underutilised or not used at all. Issues coming from lack of standardisation and shared biological identities are also well-known. From these considerations, a novel, pressing request arises from the life sciences to design methodologies and approaches that allow for these data to be interpreted as a whole, i.e. as intertwined molecular signatures containing genes, proteins, mRNAs and miRNAs, able to capture inter-layers connections and complexity. Papers discuss data integration approaches and methods of several types and extents, their application in understanding the pathogenesis of specific diseases or in identifying candidate biomarkers to exploit the full benefit of multi-omic datasets and their intrinsic information content. Topics of interest include, but are not limited to: • Methods for the integration of layered data, including, but not limited to, genomics, transcriptomics, glycomics, proteomics, metabolomics; • Application of multi-omic data integration approaches for diagnostic biomarker discovery in any field of the life sciences; • Innovative approaches for the analysis and the visualization of multi-omic datasets; • Methods and applications for systematic measurements from single/undivided samples (comprising genomic, transcriptomic, proteomic, metabolomic measurements, among others); • Multi-scale approaches for integrated dynamic modelling and simulation; • Implementation of applications, computational resources and repositories devoted to data integration including, but not limited to, data warehousing, database federation, semantic integration, service-oriented and/or wiki integration; • Issues related to the definition and implementation of standards, shared identities and semantics, with particular focus on the integration problem. Research papers, reviews and short communications on all topics related to the above issues were welcomed.

Encyclopedia of Bioinformatics and Computational Biology

Author :
Publisher : Elsevier
ISBN 13 : 0128114320
Total Pages : 3421 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Encyclopedia of Bioinformatics and Computational Biology by :

Download or read book Encyclopedia of Bioinformatics and Computational Biology written by and published by Elsevier. This book was released on 2018-08-21 with total page 3421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases

Multi-omic Data Integration in Oncology

Author : Chiara Romualdi
Publisher : Frontiers Media SA
ISBN 13 : 2889661512
Total Pages : 187 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Multi-omic Data Integration in Oncology by : Chiara Romualdi

Download or read book Multi-omic Data Integration in Oncology written by Chiara Romualdi and published by Frontiers Media SA. This book was released on 2020-12-03 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Gene Network Inference

Author : Alberto Fuente
Publisher : Springer Science & Business Media
ISBN 13 : 3642451616
Total Pages : 130 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Gene Network Inference by : Alberto Fuente

Download or read book Gene Network Inference written by Alberto Fuente and published by Springer Science & Business Media. This book was released on 2014-01-03 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents recent methods for Systems Genetics (SG) data analysis, applying them to a suite of simulated SG benchmark datasets. Each of the chapter authors received the same datasets to evaluate the performance of their method to better understand which algorithms are most useful for obtaining reliable models from SG datasets. The knowledge gained from this benchmarking study will ultimately allow these algorithms to be used with confidence for SG studies e.g. of complex human diseases or food crop improvement. The book is primarily intended for researchers with a background in the life sciences, not for computer scientists or statisticians.

Gene Quantification

Author : Francois Ferre
Publisher : Springer Science & Business Media
ISBN 13 : 1461241642
Total Pages : 379 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Gene Quantification by : Francois Ferre

Download or read book Gene Quantification written by Francois Ferre and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Geneticists and molecular biologists have been interested in quantifying genes and their products for many years and for various reasons (Bishop, 1974). Early molecular methods were based on molecular hybridization, and were devised shortly after Marmur and Doty (1961) first showed that denaturation of the double helix could be reversed - that the process of molecular reassociation was exquisitely sequence dependent. Gillespie and Spiegelman (1965) developed a way of using the method to titrate the number of copies of a probe within a target sequence in which the target sequence was fixed to a membrane support prior to hybridization with the probe - typically a RNA. Thus, this was a precursor to many of the methods still in use, and indeed under development, today. Early examples of the application of these methods included the measurement of the copy numbers in gene families such as the ribosomal genes and the immunoglo bulin family. Amplification of genes in tumors and in response to drug treatment was discovered by this method. In the same period, methods were invented for estimating gene num bers based on the kinetics of the reassociation process - the so-called Cot analysis. This method, which exploits the dependence of the rate of reassociation on the concentration of the two strands, revealed the presence of repeated sequences in the DNA of higher eukaryotes (Britten and Kohne, 1968). An adaptation to RNA, Rot analysis (Melli and Bishop, 1969), was used to measure the abundance of RNAs in a mixed population.

Systems Analysis of Human Multigene Disorders

Author : Natalia Maltsev
Publisher : Springer Science & Business Media
ISBN 13 : 1461487781
Total Pages : 122 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Systems Analysis of Human Multigene Disorders by : Natalia Maltsev

Download or read book Systems Analysis of Human Multigene Disorders written by Natalia Maltsev and published by Springer Science & Business Media. This book was released on 2013-11-29 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.