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Oecd Guidelines For The Testing Of Chemicals Section 3 Test No 319b Determination Of In Vitro Intrinsic Clearance Using Rainbow Trout Liver S9 Sub Cellular Fraction Rt S9
Download Oecd Guidelines For The Testing Of Chemicals Section 3 Test No 319b Determination Of In Vitro Intrinsic Clearance Using Rainbow Trout Liver S9 Sub Cellular Fraction Rt S9 full books in PDF, epub, and Kindle. Read online Oecd Guidelines For The Testing Of Chemicals Section 3 Test No 319b Determination Of In Vitro Intrinsic Clearance Using Rainbow Trout Liver S9 Sub Cellular Fraction Rt S9 ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 319B: Determination of in vitro intrinsic clearance using rainbow trout liver S9 sub-cellular fraction (RT-S9) by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 319B: Determination of in vitro intrinsic clearance using rainbow trout liver S9 sub-cellular fraction (RT-S9) written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Test Guideline (TG) describes the use of liver S9 sub-cellular fraction (RT-S9) of rainbow trout (Oncorhynchus mykiss) as a metabolising system to determine the clearance (CL, IN VITRO, INT ) of a test chemical using a substrate depletion approach. Introduction of the test chemical to the ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 319A: Determination of in vitro intrinsic clearance using cryopreserved rainbow trout hepatocytes (RT-HEP) by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 319A: Determination of in vitro intrinsic clearance using cryopreserved rainbow trout hepatocytes (RT-HEP) written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Test Guideline (TG) describes the use of cryopreserved rainbow trout (Oncorhynchus mykiss) hepatocytes (RT-HEP) as a metabolising system to determine the clearance (CL, IN VITRO, INT) of a test chemical using a substrate depletion approach. Introduction of the test chemical to the RT-HEP ...
Book Synopsis Toxicology of Fishes by : Kristine L. Willett
Download or read book Toxicology of Fishes written by Kristine L. Willett and published by CRC Press. This book was released on 2024-02-06 with total page 1118 pages. Available in PDF, EPUB and Kindle. Book excerpt: This up-to-date, comprehensive toxicology handbook is devoted to the effects of environmental pollution on fish. Fish species represent nearly half of all vertebrates and have become important sentinels for environmental contamination and model organisms for understanding adverse outcomes from exposures. This new edition is written by recognized experts, and it highlights the significant research progress in fish toxicology that has resulted from rapid technological developments in analytical, biochemical, and genomic sciences. The book: Discusses fundamental topics such as toxicokinetics in fishes, processes governing biotransformation within these organisms, and reactive oxygen species and oxidative stress. Explains key target organ systems for chemical impacts in fish, such as the nervous and immune systems, and how fishes can develop resistance to chemical toxicity. Covers multi-transgenerational effects on fishes, epigenetics, proteomics and metabolomics, and adverse outcome pathways. Replacing the case studies in the first edition, this update delves into the impacts of microplastics, pharmaceuticals, and oil spills in dedicated final chapters. With nearly 200 illustrations and tables, this comprehensive reference work presents concepts in a way that is useful for both novices to and experts in the field of fish toxicology.
Book Synopsis Ecotoxicology of Nanoparticles in Aquatic Systems by : Julian Blasco
Download or read book Ecotoxicology of Nanoparticles in Aquatic Systems written by Julian Blasco and published by CRC Press. This book was released on 2019-07-19 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of nanoparticles in medicine, industrial, and other applications has triggered an interest in their potential. This book explores the use of nanoparticles related to their occurrence in the environment, their impact on biota in aquatic systems, application of new methodologies, and changes associated with new global scenarios. The book also covers the bioaccumulation and internalization of nanoparticles as key aspects to assess their uptake and discusses the methodologies for testing ENPs ecotoxicity at different trophic levels.
Book Synopsis Human and Ecological Risk Assessment by : Dennis J. Paustenbach
Download or read book Human and Ecological Risk Assessment written by Dennis J. Paustenbach and published by John Wiley & Sons. This book was released on 2024-04-15 with total page 1319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understand the fundamentals of human risk assessment with this introduction and reference Human risk assessments are a precondition for virtually all industrial action or environmental regulation, all the more essential in a world where chemical and environmental hazards are becoming more abundant. These documents catalog potential environmental, toxicological, ecological, or other harms resulting from a particular hazard, from chemical spills to construction projects to dangerous workplaces. They turn on a number of variables, of which the most significant is the degree of human exposure to the hazardous agent or process. Human and Ecological Risk Assessment combines the virtues of a textbook and reference work to introduce and analyze these vital documents. Beginning with the foundational theory of human health risk assessment, it then supplies case studies and detailed analysis illustrating the practice of producing risk assessment documents. Fully updated and authored by leading authorities in the field, the result is an indispensable work. Readers of the second edition of Human and Ecological Risk Assessment will also find: Over 40 entirely new case studies reflecting the latest in risk assessment practice Detailed discussion of hazards including air emissions, contaminated food and soil, hazardous waste sites, and many more Case studies from multiple countries to reflect diverse international standards Human and Ecological Risk Assessment is ideal for professionals and advanced graduate students in toxicology, industrial hygiene, occupational medicine, environmental science, and all related subjects.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 312: Leaching in Soil Columns by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 312: Leaching in Soil Columns written by OECD and published by OECD Publishing. This book was released on 2004-11-23 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: The method described in this Test Guideline is based on soil column chromatography in disturbed soil. Two types of experiments are performed to determine (i) the leaching potential of the test substance, and (ii) the leaching potential of ...
Book Synopsis OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP) by : OECD
Download or read book OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP) written by OECD and published by OECD Publishing. This book was released on 2018-12-10 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing, the test methods and conditions under which ...
Book Synopsis Optimization in Drug Discovery by : Gary W. Caldwell
Download or read book Optimization in Drug Discovery written by Gary W. Caldwell and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates. Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.
Book Synopsis Metabolism of Polycyclic Aromatic Hydrocarbons in the Aquatic Environment by : Usha Varanasi
Download or read book Metabolism of Polycyclic Aromatic Hydrocarbons in the Aquatic Environment written by Usha Varanasi and published by CRC Press. This book was released on 1989-03-31 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book shows how the biological transport, bioaccumulation, disposition, and toxicity of polycyclic aromatic hydrocarbons (PAH) in the aquatic environment are influenced by the ability or inability of organisms to metabolize these environmental pollutants. Written by leading scientists in the fields of PAH metabolism and toxicity in both aquatic and mammalian systems, this book discusses recent advances in the areas of PAH biogeochemistry and bioaccumulation, microbial degradation, enzymes of activation, and detoxication, metabolism of PAH, and laboratory and field studies on carcinogenic/toxic effects. Additionally, important similarities and differences in metabolism of PAH by aquatic and terrestrial organisms are featured. The discussion of bioavailability, metabolism, and subsequent toxic effects should aid in the assessment of the ecological consequences of PAH in the aquatic environment.
Download or read book Xenobiotics in Fish written by D.J. Smith and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquaculture is rapidly becoming a major source of fish protein used to meet the nutritional needs of humans. As the aquaculture industry grows, exposure of farmed fish to environmental contaminants, and the need for chemical therapeutic agents for fish, will increase. This book is designed to bring together authorities worldwide on the regulation of environmental contaminants and food chemicals and researchers investigating the metabolism and disposition of foreign chemicals (xenobiotics) in fish species.
Book Synopsis Toxicity Testing in the 21st Century by : National Research Council
Download or read book Toxicity Testing in the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2007-11-05 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.
Book Synopsis Endocrine Disrupters by : Peter Matthiessen
Download or read book Endocrine Disrupters written by Peter Matthiessen and published by John Wiley & Sons. This book was released on 2013-03-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enables researchers to assess the effects of endocrine disrupters as well as comply with new environmental regulations Endocrine disrupters are chemicals—both man-made and natural—that interfere with the body's endocrine system, potentially resulting in adverse developmental, reproductive, neurological, and immune effects. In recent years, a number of regulatory authorities around the world have drafted or enacted legislation that requires the detection and assessment of the effects of endocrine disrupters on both humans and wildlife. In response, this book provides comprehensive, up-to-date information on the latest tested and proven methods used to detect and assess the environmental hazards posed by endocrine-disrupting chemicals. Endocrine Disrupters is divided into chapters covering each major taxon as well as chapters dedicated to hazard assessment and regulation. The book covers testing methods for all the vertebrate groups and several invertebrate phyla, including: Crustaceans and mollusks Insects Fish Amphibians and reptiles Birds and mammals Moreover, the book emphasizes practical, ethical testing methods that combine sensitivity, efficiency, statistical power, and reasonable cost. Each chapter is written by one or more international experts in ecotoxicology, offering readers step-by-step guidance for implementing each method based on the latest research and the authors' firsthand laboratory experience. Furthermore, all the chapters have been subjected to a rigorous peer review and edited in light of the reviewers' comments. References at the end of each chapter guide readers to the literature in the field. Endocrine Disrupters is recommended for scientists who need to test chemicals for possible endocrine-disrupting properties. It is also recommended for regulatory authorities who need to decide whether particular chemicals can be safely marketed.
Book Synopsis The Toxicology of Fishes by : Richard T. Di Giulio
Download or read book The Toxicology of Fishes written by Richard T. Di Giulio and published by CRC Press. This book was released on 2008-02-25 with total page 1102 pages. Available in PDF, EPUB and Kindle. Book excerpt: When looking for a book on fish toxicology, you might find one that discusses the biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You can find resources that cover human and animal toxicology or ecotoxicology in general, but no up-to-date, comprehensive monograph devoted to the effects of chemical pollution on
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 305: Bioaccumulation in Fish: Aqueous and Dietary Exposure by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 305: Bioaccumulation in Fish: Aqueous and Dietary Exposure written by OECD and published by OECD Publishing. This book was released on 2012-10-02 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes a procedure for characterising the bioconcentration potential of substances in fish, using an aqueous (standard and minimised tests) or dietary exposure, under flow-through conditions (but semi-static regimes are ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 317: Bioaccumulation in Terrestrial Oligochaetes by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 317: Bioaccumulation in Terrestrial Oligochaetes written by OECD and published by OECD Publishing. This book was released on 2010-07-23 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes procedures designed to assess bioaccumulation of chemicals in soil oligochaetes. The parameters which characterise the bioaccumulation of a substance include the bioaccumulation factor (BAF), the uptake rate constant ...
Book Synopsis Anticoagulant Rodenticides and Wildlife by : Nico W. van den Brink
Download or read book Anticoagulant Rodenticides and Wildlife written by Nico W. van den Brink and published by Springer. This book was released on 2017-11-09 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Commensal rodents pose health risks and cause substantial damage to property and food supplies. Rats have also invaded islands and pose a serious threat to native wildlife, particularly raptors and seabirds. Estimates of total damage from introduced rats range into the billions of dollars in developed countries. This book aims to provide a state-of-the-art overview of the scientific advancements in the assessment of exposure, effects and risks that currently used rodenticides may pose to non-target organisms in the environment, along with practical guidance for characterization of hazards. This will be discussed in relation to their efficacy, and the societal needs for rodent control, and discussion of risk mitigation and development of alternatives. The flow in the book is planned as: a. introduction and setting the scene b. problem description (risks and effects on non-targets and secondary poisoning, development of resistance) c. ; alternatives, regulation and risk mitigation d. conclusions and recommendations
Book Synopsis Fish Physiology: The Multifunctional Gut of Fish by :
Download or read book Fish Physiology: The Multifunctional Gut of Fish written by and published by Academic Press. This book was released on 2010-10-21 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Multifunctional Gut of Fish provides a comprehensive synthesis and an integrative overview of the range of gut functions and their implications for organismal physiology. The highly diversified anatomy and functions of the gut, including nutrient uptake, immune barrier function, salt and water homeostasis and respiration, as well as neuroendocrine actions and control are covered in detail by leading authors. In addition, this volume explores the pronounced implications of gut function for whole animal integrative physiology and compensatory demands for non-gastrointestinal organs. As the first comprehensive reference to discuss the diverse morphological and functional adaptations of the gut, this volume provides an excellent resource for comparative physiologists, aquaculturists and biomedical researchers employing fish as model organisms for mammalian physiology. Includes chapters dedicated to anatomical and functional features of the gastro-intestinal tract of fish as well as integrative aspects of gut organ function Includes in depth coverage of recently recognized implications of feeding on salt homeostasis and acid-base balance Provides syntheses of implications of gut function for homeostasis Essential text for those interested in the wide diversity of functions performed by the gut
