Nuclear Receptors As Molecular Targets For Cardiometabolic And Central Nervous System Diseases

Download Nuclear Receptors As Molecular Targets For Cardiometabolic And Central Nervous System Diseases full books in PDF, epub, and Kindle. Read online Nuclear Receptors As Molecular Targets For Cardiometabolic And Central Nervous System Diseases ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Nuclear Receptors as Molecular Targets for Cardiometabolic and Central Nervous System Diseases

Author : J.L. Junien
Publisher : IOS Press
ISBN 13 : 1607503271
Total Pages : 128 pages
Book Rating : 4.6/5 (75 download)

DOWNLOAD NOW!

Book Synopsis Nuclear Receptors as Molecular Targets for Cardiometabolic and Central Nervous System Diseases by : J.L. Junien

Download or read book Nuclear Receptors as Molecular Targets for Cardiometabolic and Central Nervous System Diseases written by J.L. Junien and published by IOS Press. This book was released on 2008-07-16 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear receptors are a family of transcription factors consisting of 49 members identified in the human genome. Nuclear receptors regulate transcription by binding to response elements in the regulatory regions of target genes and thereby affect expression of genes involved in differentiation, growth, lipid homeostasis, inflammation and immunity. Over the past two decades significant advances have been made in the understanding of the regulation of gene expression by nuclear receptors. The knowledge on nuclear receptors has delivered novel therapies for lipid control and hormone replacement, and for management of cancer and diabetes. Therefore, nuclear receptors are attractive molecular targets for design of therapy for diabetes, obesity, atherosclerosis, cancer, inflammation and neurodegeneration. The focus of this volume is centered on the mechanistic involvement of nuclear receptors in cardiological, metabolic and neurological disorders, on possible explanation of pathways involved in pathogenesis, on susceptibility to and prevention of metabolic and neurological disorders and on the aspects of drug finding including chemistry and rational drug design. This volume reviews recent progress on nuclear receptors critically and will intrigue those pursuing interest in physiology, pathology and medicine.

Nuclear Receptors as Molecular Targets for Cardiometabolic and Central Nervous System Diseases

Author : Jean-Louis Junien
Publisher : IOS Press
ISBN 13 : 1586038575
Total Pages : 128 pages
Book Rating : 4.5/5 (86 download)

DOWNLOAD NOW!

Book Synopsis Nuclear Receptors as Molecular Targets for Cardiometabolic and Central Nervous System Diseases by : Jean-Louis Junien

Download or read book Nuclear Receptors as Molecular Targets for Cardiometabolic and Central Nervous System Diseases written by Jean-Louis Junien and published by IOS Press. This book was released on 2008 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Nuclear receptors are a family of transcription factors consisting of 49 members identified in the human genome. Nuclear receptors regulate transcription by binding to response elements in the regulatory regions of target genes and thereby affect expression of genes involved in differentiation, growth, lipid homeostasis, inflammation and immunity. This volume reviews recent progress on nuclear receptors critically and will intrigue those pursuing interest in physiology, pathology and medicine."--BOOK JACKET.

Towards Drugs of the Future

Author : Chris G. Kruse
Publisher : IOS Press
ISBN 13 : 1586039490
Total Pages : 140 pages
Book Rating : 4.5/5 (86 download)

DOWNLOAD NOW!

Book Synopsis Towards Drugs of the Future by : Chris G. Kruse

Download or read book Towards Drugs of the Future written by Chris G. Kruse and published by IOS Press. This book was released on 2008 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The ninth Solvay Pharmaceutical Conference on Medicinal Chemistry held in Garmisch-Partenkirchen (Germany) September 26-28, 2007"--P. vi.

Pulmonary Arterial Hypertension

Author : Jochen Antel
Publisher : IOS Press
ISBN 13 : 1607506017
Total Pages : 116 pages
Book Rating : 4.6/5 (75 download)

DOWNLOAD NOW!

Book Synopsis Pulmonary Arterial Hypertension by : Jochen Antel

Download or read book Pulmonary Arterial Hypertension written by Jochen Antel and published by IOS Press. This book was released on 2010 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pulmonary hypertension is a fatal lung and heart disease. It is characterized by shortness of breath, fatigue and fainting. It is exacerbated by an increase of the pressure in the lung vasculature through exercise, leading to progressive worsening of hemodynamics, right ventricular hypertrophy, right heart insufficiency and finally right heart failure. This book focuses on pulmonary arterial hypertension, a rare and progressive subgroup of pulmonary hypertension, which is today incurable and terminally faal. Classification of pulmonary arterial hypertension, its pathology, and strategies for future therapy will be of interest both to those suffering from the disease and those who take care of patients. This volume will also engage physicians and other scientists contributing to an understanding of the pathophysiology of pulmonary arterial hypertension and attempting to extend life of humans with pulmonary arterial hypertension by developing causal and curative therapies.

Immunometabolism, Atherosclerosis and Metabolic Diseases

Author : Xuewei Zhu
Publisher : Frontiers Media SA
ISBN 13 : 2889747972
Total Pages : 166 pages
Book Rating : 4.8/5 (897 download)

DOWNLOAD NOW!

Book Synopsis Immunometabolism, Atherosclerosis and Metabolic Diseases by : Xuewei Zhu

Download or read book Immunometabolism, Atherosclerosis and Metabolic Diseases written by Xuewei Zhu and published by Frontiers Media SA. This book was released on 2022-03-29 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Autonomic Failure

Author : C. J. Mathias
Publisher : Oxford University Press, USA
ISBN 13 : 9780192628510
Total Pages : 562 pages
Book Rating : 4.6/5 (285 download)

DOWNLOAD NOW!

Book Synopsis Autonomic Failure by : C. J. Mathias

Download or read book Autonomic Failure written by C. J. Mathias and published by Oxford University Press, USA. This book was released on 1999 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth edition of Autonomic Failure (now available in paperback) covers the many recent advances made in our understanding of the autonomic nervous system. There are 20 new chapters and extensive revisions of all other contributions. Autonomic failure, fourth edition makes diagnosis increasingly precise by fully evaluating the underlying anatomical and functional deficits, thereby allowing more effective treatment. This new edition continues to provide practitioners from a variety of fields, including neurology, cardiology, geriatric medicine, diabetology, and internal medicine, with a rational guide to aid in the recognition and management of autonomic disorders. The book starts with an updated classification of autonomic disorders and a history of the autonomic nervous system. The first two sections of the book deal with the fundamental aspects of autonomic structure, function, and integration. There are new chapters dealing with neurobiology, nerve growth factors, genetic mutations, neural and hormonal control of the cerebral circulation, innervation of the lung, and pathophysiological mechanisms causing nausea and vomiting. Advances in the clinical management of autonomic disorders are critically dependent on the bridge made between the basic and applied sciences.

Quo Vadis Lipid Mediators – Lipid Mediators Implication in Inflammation and Chronic Inflammatory Diseases

Author : Juan Bautista De Sanctis
Publisher : Frontiers Media SA
ISBN 13 : 2889669890
Total Pages : 122 pages
Book Rating : 4.8/5 (896 download)

DOWNLOAD NOW!

Book Synopsis Quo Vadis Lipid Mediators – Lipid Mediators Implication in Inflammation and Chronic Inflammatory Diseases by : Juan Bautista De Sanctis

Download or read book Quo Vadis Lipid Mediators – Lipid Mediators Implication in Inflammation and Chronic Inflammatory Diseases written by Juan Bautista De Sanctis and published by Frontiers Media SA. This book was released on 2021-07-08 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pharmacotherapy of Obesity

Author : John P. H. Wilding
Publisher : Springer Science & Business Media
ISBN 13 : 376437425X
Total Pages : 120 pages
Book Rating : 4.7/5 (643 download)

DOWNLOAD NOW!

Book Synopsis Pharmacotherapy of Obesity by : John P. H. Wilding

Download or read book Pharmacotherapy of Obesity written by John P. H. Wilding and published by Springer Science & Business Media. This book was released on 2008-01-08 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: After three introductory chapters that deal with the general theme of obesity – now regarded as a chronic disease – this volume discusses the drugs sibutramine and orlistat, which are approved for long-term use in the US and in much of the rest of the world. The three final chapters discuss future drug targets, like the central nervous system and gut hormones, and how to influence energy expenditure and substrate utilization.

The ESC Textbook of Cardiovascular Medicine

Author : A. John Camm
Publisher :
ISBN 13 : 9780198824879
Total Pages : 3198 pages
Book Rating : 4.8/5 (248 download)

DOWNLOAD NOW!

Book Synopsis The ESC Textbook of Cardiovascular Medicine by : A. John Camm

Download or read book The ESC Textbook of Cardiovascular Medicine written by A. John Camm and published by . This book was released on 2019 with total page 3198 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Encyclopedia of Endocrine Diseases

Author : Luciano Martini
Publisher : Academic Press
ISBN 13 : 9780124755727
Total Pages : 818 pages
Book Rating : 4.7/5 (557 download)

DOWNLOAD NOW!

Book Synopsis Encyclopedia of Endocrine Diseases by : Luciano Martini

Download or read book Encyclopedia of Endocrine Diseases written by Luciano Martini and published by Academic Press. This book was released on 2004 with total page 818 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Endocrine Diseases is an authoritative reference developed by 16 international experts who recruited the world's top scientists for contributions. This stellar reference work focuses on nearly 500 endocrine diseases addressing everything from acromeglay, diabetes, hypertension, osteoporosis, thyroid disease, Von Hippel-Lindau Disease, unexplained weight loss, to androgen related disorders. This encyclopedia is an essential addition to any library collection written to be accessible for both the clinical and non-clinical reader. Associate Editors include: Eli Y. Adashi, John P. Bilezikian, George P. Chrousos, Junichi Fukata, Julianne Imperato-McGinley, Hiroo Imura, Antonio Liuzzi, Frank L. Moore, Daniel Porte, Jens F. Rehfeld, Ellis Samols, Gustav Schonfeld, Pierre C. Sizonenko, Wilmar M. Wiersinga. Also available online via ScienceDirect featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com. * Includes nearly 500 entries addressing all aspects of endocrine diseases * More than 800 eminent researchers contributed from 25 different countries around the world * More than 900 figures and 450 tables displayed * Comprehensive glossary comprising 1500 definitions * The Editor-in-Chief is former editor of the journal Frontiers in Neuroendocrinology and has contributed to over 40 books in the field of endocrinology.

Inflammation in Heart Failure

Author : Matthijs Blankesteijn
Publisher : Academic Press
ISBN 13 : 0128004851
Total Pages : 220 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!

Book Synopsis Inflammation in Heart Failure by : Matthijs Blankesteijn

Download or read book Inflammation in Heart Failure written by Matthijs Blankesteijn and published by Academic Press. This book was released on 2014-12-05 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details clinical applications of the pathophysiological mechanisms of heart failure, diagnosis and therapeutic strategies. Inflammation in Heart Failure’s breadth of subject matter, easy-to-follow structure, portability, and high-quality illustrations create an accessible benefit for researchers, clinicians and students. Presents updated information and research on the relevant inflammatory mediators of heart failure to aid in targeting future translational research as well as the improvement of early diagnosis and treatment Provides research into better understanding the different inflammatory mediators that signal the underlying diseases that potentially lead to heart failure Contains 20 years of research, offering a brief overview of the topic leading to current opinions on, and treatment of, heart failure Provides a structured, systematic and balanced overview of the role of inflammation in heart failure making it a useful resource for researchers and clinicians, as well as those studying cardiovascular diseases

CCN Proteins

Author : Bernard Perbal
Publisher : World Scientific
ISBN 13 : 1783260335
Total Pages : 324 pages
Book Rating : 4.7/5 (832 download)

DOWNLOAD NOW!

Book Synopsis CCN Proteins by : Bernard Perbal

Download or read book CCN Proteins written by Bernard Perbal and published by World Scientific. This book was released on 2005-06-17 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: The CCN Proteins are thought to play key roles in the biology of normal cell, tissue, organ, and body, and altered expression of CCN proteins is associated with several pathologies, including fibrosis and cancer. Because of its importance, the CCN field is expanding at a fast pace. Research articles in this field have recently increased logarithmically, and a book that is up-to-date, comprehensive, authoritative and affords insights into the biological roles of CCN proteins, is timely. CCN Protein: A New Family of Cell Growth and Differentiation Regulators presents the most recent progress in the field of CCN proteins, a new family of secretory signaling molecules that are involved in several fundamental biological progress. These proteins share a unique multimodular organization and present a partial identity with four families of regulatory proteins controling growth and development. The book covers the roles of CCN proteins in the control of cell proliferation and differentiation during normal development, wound repair, chondrogenesis and bone development, angiogenesis, tissue regeneration, fibrosis, renal diseases and cancer development. Contents: The CCN Family of Proteins: An Overview (B Perbal & M Takigawa)Roles of CCN2/CTGF in the Control of Growth and Regeneration (M Takigawa et al.)Integrin-Mediated CCN Functions (L F Lau & S C-T Lam)Expression and Roles of CCN2 During Odontogenesis (M Kanyama et al.)CCN Genes and the Kidney (B L Riser et al.)CCN Proteins in Liver Injury and Disease (A W Rachfal & D R Brigstock)Genetic Analysis of CCN Gene Function in Mammalian Development (L M Dornbach & K M Lyons)CCN Family in Embryonic Development (Non-Mammalian Models) (B Latinkic)CCN3 Expression and its Role During Development (K-I Katsube)Regulation of CCN Proteins by Alternations of the Cytoskeleton (B Chaqour & M Goppelt-Struebe)Pathogenesis of Systemic Sclerosis and CCN2 (Connective Tissue Growth Factor) (K Takehara)Function and Regulation of CCN5 (M R Gray & J J Castellot Jr)CCN3: A Multifunctional Signaling Regulator (N Planque et al.)CCN Proteins and Connexins: Interactions and Growth Control (C Fu et al.)The Role of CCN1 in Tumorigenesis and Cancer Progression (J O'Kelly & H P Koeffler)CCN4 and CCN6 Variants in Wnt-Inducible Signaling Pathway (S Tanaka) Readership: Biochemists, biologists, molecular biologists, physiologists, pathologists, and medical and dental doctors interested in the study of CCN proteins, growth factors, extracellular matrix proteins, signaling molecules, and mechanisms of gene expression. Key Features:First such book in the CCN fieldChapters are written by the most prominent specialists in the fieldKeywords:Cyr 61;CTGF;NOV;WISP;Elm-1;rCop-1;Growth Factor;Extracellular Matrix;Signaling;Gene Expression;Cancer Fibrogenesis

Uremic Toxins

Author : Severin Ringoir
Publisher : Springer Science & Business Media
ISBN 13 : 1468454455
Total Pages : 292 pages
Book Rating : 4.4/5 (684 download)

DOWNLOAD NOW!

Book Synopsis Uremic Toxins by : Severin Ringoir

Download or read book Uremic Toxins written by Severin Ringoir and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book contains the Proceedings of a two day Symposium on Uremic Toxins organized at the University of Ghent in Belgium. A series of guest lectures, free communications and posters have been presented. An international audience of 163 scientists from 16 nationalities listened to and discussed extensively a spectrum of topics brought forward by colleagues and researchers who worked for many years in the field of Uremic Toxins. There is a striking contrast between all the new dialysis strategies available in the work to "clean" the uremic patients and the almost non-progression of our knowledge on uremic toxins in the past decade. In this sense the symposium was felt by all participants as a new start for the research in the biochemical field of the definition of uremia. If the present volume would stimulate new work in this field in order to define uremia, or identify the uremic toxins, the purpose of the organizers would be maximally fulfilled.

Hormones, Metabolism and the Benefits of Exercise

Author : Bruce Spiegelman
Publisher : Springer
ISBN 13 : 3319727907
Total Pages : 108 pages
Book Rating : 4.3/5 (197 download)

DOWNLOAD NOW!

Book Synopsis Hormones, Metabolism and the Benefits of Exercise by : Bruce Spiegelman

Download or read book Hormones, Metabolism and the Benefits of Exercise written by Bruce Spiegelman and published by Springer. This book was released on 2018-03-07 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.

Prevention and Treatment of Atherosclerosis

Author : Arnold von Eckardstein
Publisher : Springer Nature
ISBN 13 : 3030860760
Total Pages : 537 pages
Book Rating : 4.0/5 (38 download)

DOWNLOAD NOW!

Book Synopsis Prevention and Treatment of Atherosclerosis by : Arnold von Eckardstein

Download or read book Prevention and Treatment of Atherosclerosis written by Arnold von Eckardstein and published by Springer Nature. This book was released on 2022 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book is supported by the European Atherosclerosis Society Association (EAS). This follow-up edition of the well-received Handbook volume 'Atherosclerosis: Diet and Drugs' reflects the state-of-the-art and most recent developments in atherosclerosis research. Outstanding international experts give a comprehensive overview of the field covering topics, such as improving the treatment focusing on established targets, novel drug developments addressing pre-defined targets, hypothesis-based and hypothesis-free approaches to unravel novel targets.

Free Fatty Acid Receptors

Author : Graeme Milligan
Publisher : Springer
ISBN 13 : 9783319844640
Total Pages : 0 pages
Book Rating : 4.8/5 (446 download)

DOWNLOAD NOW!

Book Synopsis Free Fatty Acid Receptors by : Graeme Milligan

Download or read book Free Fatty Acid Receptors written by Graeme Milligan and published by Springer. This book was released on 2018-07-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.

Oxidative Stress and Vascular Disease

Author : John F. Keaney Jr.
Publisher : Springer Science & Business Media
ISBN 13 : 1461546494
Total Pages : 373 pages
Book Rating : 4.4/5 (615 download)

DOWNLOAD NOW!

Book Synopsis Oxidative Stress and Vascular Disease by : John F. Keaney Jr.

Download or read book Oxidative Stress and Vascular Disease written by John F. Keaney Jr. and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.