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Ntp Report On The Toxicology And Carcinogenicity Studies Of 3 Azido 3 Deoxythymidine Cas No 30516 87 1 In Genetically Modified C3b6129f1 Trp53tm1brd N12 Haploinsufficient Mice In Utero And Postnatal Gavage Study
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Book Synopsis NTP Report on the Toxicology and Carcinogenicity Studies of 3'-Azido-3'-Deoxythymidine (CAS NO. 30516-87-1) in Genetically Modified C3B6.129F1-Trp53tm1Brd N12 Haploinsufficient Mice (In Utero and Postnatal Gavage Study) by :
Download or read book NTP Report on the Toxicology and Carcinogenicity Studies of 3'-Azido-3'-Deoxythymidine (CAS NO. 30516-87-1) in Genetically Modified C3B6.129F1-Trp53tm1Brd N12 Haploinsufficient Mice (In Utero and Postnatal Gavage Study) written by and published by . This book was released on 2013 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: BACKGROUND: 3′Azido-3′-deoxythymidine (AZT) is the most widely used chemotherapeutic agent for the treatment of people with acquired immune deficiency syndrome (AIDS) or positive for human immunodeficiency virus (HIV). AZT treatment is also given to prevent transmission of HIV from pregnant mothers to children before or during birth. We tested the effects of AZT on the offspring of female mice (genetically modified to be sensitive to cancer induction) where the mothers were given the drug during pregnancy and the pups were given the drug following birth. METHOD: We exposed groups of haploinsufficient C3B6.129F1-Trp53tm1Brd N12 mice by depositing solutions of AZT in a methylcellulose solvent directly into the animals' stomachs through a tube five times per week for 30 or 45 weeks following birth; in addition, their mothers were exposed to the drug for seven days during pregnancy. Other sets of mothers and pups received only the methylcellulose solvent and served as the control groups. Tissues from 34 organs were examined for every animal. RESULTS: Exposure to AZT caused increases in the rates of liver cancer in the male pups after 45 weeks. In addition, there were occurrences of a few malignant lymphomas in both male and female pups exposed to AZT in the 30-week studies. CONCLUSIONS: We conclude that AZT caused liver cancers in male pups exposed to AZT before and following birth. Malignant lymphomas in male and female pups may have been related to AZT exposure before and following birth.
Book Synopsis NTP Report on the Toxicology and Carcinogenicity Study of Mixtures of 3'-azido-3'-deoxythymidine (CAS Nos. 30516-87-1) in Genetically Modified C3B6.129F1-TRP53TMLBrd N12 Haploinsufficient Mice (in Utero and Postnatal Gavage Study) by : National Toxicology Program (U.S.)
Download or read book NTP Report on the Toxicology and Carcinogenicity Study of Mixtures of 3'-azido-3'-deoxythymidine (CAS Nos. 30516-87-1) in Genetically Modified C3B6.129F1-TRP53TMLBrd N12 Haploinsufficient Mice (in Utero and Postnatal Gavage Study) written by National Toxicology Program (U.S.) and published by . This book was released on 2013 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis NTP Report on the Toxicology and Carcinogenicity Study of Mixtures of 3'-azido-3'-deoxythymidine (AZT), Lamivudine (3TC), and Nevirapine (NVP) (CAS Nos. 30516-87-1, 134678-17-4, 129618-40-2) in Genetically Modified C3B6.129F1-Trp53tm1Brd N12 Haploinsufficient Mice (in Utero and Postnatal Gavage Study) by : National Toxicology Program (U.S.)
Download or read book NTP Report on the Toxicology and Carcinogenicity Study of Mixtures of 3'-azido-3'-deoxythymidine (AZT), Lamivudine (3TC), and Nevirapine (NVP) (CAS Nos. 30516-87-1, 134678-17-4, 129618-40-2) in Genetically Modified C3B6.129F1-Trp53tm1Brd N12 Haploinsufficient Mice (in Utero and Postnatal Gavage Study) written by National Toxicology Program (U.S.) and published by . This book was released on 2013 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis NTP Report on the Toxicology and Carcinogenicity Study of Mixtures of 3'-Azido-3'-Deoxythymidine (AZT), Lamivudine (3TC), and Nevirapine (NVP) (CAS NOs 30516-87-1, 134678-17-4, 129618-40-2) in Genetically Modified C3B6.129F1-Trp53tm1Brd N12 Haploinsu by :
Download or read book NTP Report on the Toxicology and Carcinogenicity Study of Mixtures of 3'-Azido-3'-Deoxythymidine (AZT), Lamivudine (3TC), and Nevirapine (NVP) (CAS NOs 30516-87-1, 134678-17-4, 129618-40-2) in Genetically Modified C3B6.129F1-Trp53tm1Brd N12 Haploinsu written by and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis NTP Technical Report on the Toxicology Study of Dicyclohexylcarbodiimide (CAS No. 538-75-0) in F344/N Rats, B6C3F[1] Mice and Genetically Modified (FVB Tg. AC Hemizygous) Mice and Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (gavage Studies) by : National Toxicology Program (U.S.)
Download or read book NTP Technical Report on the Toxicology Study of Dicyclohexylcarbodiimide (CAS No. 538-75-0) in F344/N Rats, B6C3F[1] Mice and Genetically Modified (FVB Tg. AC Hemizygous) Mice and Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (gavage Studies) written by National Toxicology Program (U.S.) and published by . This book was released on 2006 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis NIEHS Technical Report on the 13-Week Toxicity Study of 3'-Azido-3'-deoxythymidine (AZT) and Isoniazid Combinations (CAS Nos. 30516-87-1 and 54-85-3) Administered by Gavage to B6C3F1 Mice by :
Download or read book NIEHS Technical Report on the 13-Week Toxicity Study of 3'-Azido-3'-deoxythymidine (AZT) and Isoniazid Combinations (CAS Nos. 30516-87-1 and 54-85-3) Administered by Gavage to B6C3F1 Mice written by and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis NTP Report on the Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tg. AC Hemizygous) Mice (dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (drinking Water and Gavage Studies) by :
Download or read book NTP Report on the Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tg. AC Hemizygous) Mice (dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (drinking Water and Gavage Studies) written by and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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