Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Glycidol (CAS No. 556-52-5) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Gavage Study)

Download Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Glycidol (CAS No. 556-52-5) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Gavage Study) PDF Online Free

Author :
Publisher : DIANE Publishing
ISBN 13 : 1437902243
Total Pages : 81 pages
Book Rating : 4.4/5 (379 download)

DOWNLOAD NOW!


Book Synopsis Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Glycidol (CAS No. 556-52-5) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Gavage Study) by : J. K. Dunnick

Download or read book Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Glycidol (CAS No. 556-52-5) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Gavage Study) written by J. K. Dunnick and published by DIANE Publishing. This book was released on 2008-06 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycidol is used as a chemical intermediate in the pharmaceutical industry, as a stabilizer in the manufacture of vinyl polymers, and as an intermediate in the synthesis of glycerol, Glycidol ethers, and amines. Glycidol was nominated for carcinogenecity study by the Environmental Protection Agency (EPA). Glycidol was selected for study in the haploinsufficient p16Ink4a/p19Arf mouse because it was found to be carcinogenic in rats and mice in conventional 2-year rodent studies (NTP, 1990), but was negative in a study in p53+/- mice (Tennant et al., 1999). In this study, male and female mice received Glycidol (greater than 95% pure) by gavage for 40 weeks. Genetic toxicology studies were conducted in mouse peripheral blood erythrocytes. Illustrations.

NTP GMM.

Download NTP GMM. PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 90 pages
Book Rating : 4.:/5 (9 download)

DOWNLOAD NOW!


Book Synopsis NTP GMM. by :

Download or read book NTP GMM. written by and published by . This book was released on 2005 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:

NTP Report on the Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (feed Study)

Download NTP Report on the Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (feed Study) PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 86 pages
Book Rating : 4.:/5 (241 download)

DOWNLOAD NOW!


Book Synopsis NTP Report on the Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (feed Study) by : National Toxicology Program (U.S.)

Download or read book NTP Report on the Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (feed Study) written by National Toxicology Program (U.S.) and published by . This book was released on 2007 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Feed Study)

Download Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Feed Study) PDF Online Free

Author :
Publisher : DIANE Publishing
ISBN 13 : 1428988815
Total Pages : 364 pages
Book Rating : 4.4/5 (289 download)

DOWNLOAD NOW!


Book Synopsis Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Feed Study) by : J. K. Dunnick

Download or read book Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Feed Study) written by J. K. Dunnick and published by DIANE Publishing. This book was released on 2008-04 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phenolphthalein (PH) was commonly used as a laxative for most of the 20th cent. The use of PH in laxatives has decreased since 1997 when the FDA proposed to withdraw its classification as an OTC drug. PH has been previously evaluated in carcinogenecity studies in 1996. The major route of human exposure to PH is via ingestion, dermal contact, & inhalation of contaminated air originating from process units manufacturing the compound. In this study, the carcinogenic effects of PH were studied in the haploinsufficient p16Ink4a/p19Arf mouse model as an ongoing goal to seek model systems for toxicology & carcinogenesis studies, especially those that can provide mechanistic info. relative to understanding an agent¿s model of action. Illustrations.

NTP GMM.

Download NTP GMM. PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 146 pages
Book Rating : 4.:/5 (9 download)

DOWNLOAD NOW!


Book Synopsis NTP GMM. by :

Download or read book NTP GMM. written by and published by . This book was released on 2005 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mutagenic Impurities

Download Mutagenic Impurities PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 1119551218
Total Pages : 548 pages
Book Rating : 4.1/5 (195 download)

DOWNLOAD NOW!


Book Synopsis Mutagenic Impurities by : Andrew Teasdale

Download or read book Mutagenic Impurities written by Andrew Teasdale and published by John Wiley & Sons. This book was released on 2022-02-15 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment. The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination. Readers will also benefit from the inclusion of: A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.

Genotoxic Impurities

Download Genotoxic Impurities PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 0470934751
Total Pages : 455 pages
Book Rating : 4.4/5 (79 download)

DOWNLOAD NOW!


Book Synopsis Genotoxic Impurities by : Andrew Teasdale

Download or read book Genotoxic Impurities written by Andrew Teasdale and published by John Wiley & Sons. This book was released on 2011-03-29 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately control genotoxic impurities, thus aiding the reader to develop effective control measures. An opening section covers the development of guidelines and the threshold of toxicological concern (TTC) and is followed by a section on safety aspects, including safety tests in vivo and vitro, and data interpretation. The second section addresses the risk posed by genotoxic impurities from outside sources and from mutagens within DNA. In the final section, the book deals with the quality perspective of genotoxic impurities focused on two critical aspects, the first being the analysis and the second how to practically evaluate the impurities.

Handbook of Carcinogenic Potency and Genotoxicity Databases

Download Handbook of Carcinogenic Potency and Genotoxicity Databases PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 9781439810644
Total Pages : 840 pages
Book Rating : 4.8/5 (16 download)

DOWNLOAD NOW!


Book Synopsis Handbook of Carcinogenic Potency and Genotoxicity Databases by : Lois Swirsky Gold

Download or read book Handbook of Carcinogenic Potency and Genotoxicity Databases written by Lois Swirsky Gold and published by CRC Press. This book was released on 1996-11-26 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique new reference contains the Carcinogenic Potency Database (CPDB), which analyzes results of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) and the general published literature. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and never-before published analyses. For each of 5,000 long-term experiments on 1,300 chemicals, the user-friendly format includes data on the species, strain, and sex of the test animal; features of experimental protocol such as the route of administration, duration of dosing, dose levels, and duration of the experiment; histopathology and tumor incidence; the shape of the dose-response curve; published author's opinion about the carcinogenicity at each site; and reference to the original publication of the test results. In addition, a measure of carcinogenic potency, the TD50, its statistical significance and confidence limits, are given for each tumor site. An overview is provided of earlier publication updates, such as positivity rates, reproducibility, interspecies extrapolation, and ranking possible carcinogenic hazards. The book also includes a summary of the NTP genetic toxicity test results on 1,500 chemicals, which are referenced to the original publications, including the Salmonella (Ames) test, L5178Y mouse lymphoma cell mutation test, chromosome aberration and sister chromatid exchange tests in cultured Chinese hamster ovary cells, and the sex-linked recessive lethal mutation test in Drosophila melanogaster. An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find.

NTP GMM.

Download NTP GMM. PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 94 pages
Book Rating : 4.:/5 (9 download)

DOWNLOAD NOW!


Book Synopsis NTP GMM. by :

Download or read book NTP GMM. written by and published by . This book was released on 2005 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Some industrial chemicals and dyestuffs : this publication represents the views and expert opinions of an IARC working group on the evaluation of the carcinogenic risk of chemicals to humans which met in Lyon, 13-20 October 1981

Download Some industrial chemicals and dyestuffs : this publication represents the views and expert opinions of an IARC working group on the evaluation of the carcinogenic risk of chemicals to humans which met in Lyon, 13-20 October 1981 PDF Online Free

Author :
Publisher :
ISBN 13 : 9789283212294
Total Pages : 0 pages
Book Rating : 4.2/5 (122 download)

DOWNLOAD NOW!


Book Synopsis Some industrial chemicals and dyestuffs : this publication represents the views and expert opinions of an IARC working group on the evaluation of the carcinogenic risk of chemicals to humans which met in Lyon, 13-20 October 1981 by :

Download or read book Some industrial chemicals and dyestuffs : this publication represents the views and expert opinions of an IARC working group on the evaluation of the carcinogenic risk of chemicals to humans which met in Lyon, 13-20 October 1981 written by and published by . This book was released on 1982 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Carcinogen Testing

Download Handbook of Carcinogen Testing PDF Online Free

Author :
Publisher : William Andrew Inc.
ISBN 13 : 9780815513568
Total Pages : 856 pages
Book Rating : 4.5/5 (135 download)

DOWNLOAD NOW!


Book Synopsis Handbook of Carcinogen Testing by : Harry A. Milman

Download or read book Handbook of Carcinogen Testing written by Harry A. Milman and published by William Andrew Inc.. This book was released on 1994-01-01 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1961 the National Cancer Institute initiated a program to conduct bioassays of selected compounds to determine whether they might be carcinogens. Although some similarities continue with the program as it was in 1961, there are many more differences. Since 1985 when the first edition of this book appeared, these differences have been substantial enough to merit an updated version. This updated edition will provide the reader with an overview of how to proceed with the various tests and how the data are eventually used for regulatory decisions.

Chemical Carcinogenesis

Download Chemical Carcinogenesis PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1617379956
Total Pages : 447 pages
Book Rating : 4.6/5 (173 download)

DOWNLOAD NOW!


Book Synopsis Chemical Carcinogenesis by : Trevor M. Penning

Download or read book Chemical Carcinogenesis written by Trevor M. Penning and published by Springer Science & Business Media. This book was released on 2011-03-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.

Chemical Carcinogenesis

Download Chemical Carcinogenesis PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1468443348
Total Pages : 496 pages
Book Rating : 4.4/5 (684 download)

DOWNLOAD NOW!


Book Synopsis Chemical Carcinogenesis by : Claudio Nicolini

Download or read book Chemical Carcinogenesis written by Claudio Nicolini and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: During October 18-30, 1981, the second course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held at the Ettore Majorana Center for Scientific Culture in Erice, Italy, co-sponsored by the International Union Against Cancer, the Italian League Against Cancer, the Italian Ministry of Public Education, the Italian Ministry of Scientific and Technological Research, the North Atlantic Treaty Organization, the Italian National Research Council, the Sicilian Regional Government and two pharmaceutical Companies (Zambeletti and Farmitalia). The subject of the course was "Chemical Carcino genesis" with participants selected world-wide from 18 different countries. It is now eminently clear that.the bulk of human cancers are related to one of several types of environmental exposure. Of the environmental hazards, chemicals are among the best characterized carcinogens. However, how chemicals induce cancer is still poorly understood. Because of the magnitude of the problem and the ob vious need for a much more critical scientific analysis of the process by which cancer is induced (carcinogenesis), it was highly desirable to expose a greater number of scientists with varying background to some of the latest thinking in chemical carcino genesis. The course had this as its major objective and the re sulting book does reflect it.

OECD Guidelines for Testing of Chemicals

Download OECD Guidelines for Testing of Chemicals PDF Online Free

Author :
Publisher : Organisation for Economic Co-operation and Development ; [Montréal : Renouf]
ISBN 13 : 9789264122215
Total Pages : pages
Book Rating : 4.1/5 (222 download)

DOWNLOAD NOW!


Book Synopsis OECD Guidelines for Testing of Chemicals by : Organisation for Economic Co-operation and Development

Download or read book OECD Guidelines for Testing of Chemicals written by Organisation for Economic Co-operation and Development and published by Organisation for Economic Co-operation and Development ; [Montréal : Renouf]. This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

DNA-Pharmaceuticals

Download DNA-Pharmaceuticals PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 3527607005
Total Pages : 275 pages
Book Rating : 4.5/5 (276 download)

DOWNLOAD NOW!


Book Synopsis DNA-Pharmaceuticals by : Martin Schleef

Download or read book DNA-Pharmaceuticals written by Martin Schleef and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its focus on a completely novel class of pharmaceuticals, this book collates the hitherto scarce literature about DNA drug formulation keenly desired by biotechnologists, molecular biologists and pharmacists, as well as those working in the biotechnological and pharmaceutical industries. As such, this volume presents a wide range of gene delivery systems needed for different therapeutic applications. It fills the gap between research and clinical trials and describes pharmaceutical fundamentals for the development of efficient DNA pharmaceuticals.

Ntp Technical Report on the Toxicology and Carcinogenesis Studies of Nitrofurantoin (Cas No. 67-20-9) in F344/N Rats and B6c3f Mice (Feed Studies)

Download Ntp Technical Report on the Toxicology and Carcinogenesis Studies of Nitrofurantoin (Cas No. 67-20-9) in F344/N Rats and B6c3f Mice (Feed Studies) PDF Online Free

Author :
Publisher : Palala Press
ISBN 13 : 9781379167723
Total Pages : 228 pages
Book Rating : 4.1/5 (677 download)

DOWNLOAD NOW!


Book Synopsis Ntp Technical Report on the Toxicology and Carcinogenesis Studies of Nitrofurantoin (Cas No. 67-20-9) in F344/N Rats and B6c3f Mice (Feed Studies) by : National Toxicology Program (U S )

Download or read book Ntp Technical Report on the Toxicology and Carcinogenesis Studies of Nitrofurantoin (Cas No. 67-20-9) in F344/N Rats and B6c3f Mice (Feed Studies) written by National Toxicology Program (U S ) and published by Palala Press. This book was released on 2018-03-03 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,2-bis(bromomethyl)-1,3-propanediol (FR-1138) (CAS No. 3296-90-0) in F344/N Rats and B6C3F1 Mice (feed Studies)

Download NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,2-bis(bromomethyl)-1,3-propanediol (FR-1138) (CAS No. 3296-90-0) in F344/N Rats and B6C3F1 Mice (feed Studies) PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.3/5 ( download)

DOWNLOAD NOW!


Book Synopsis NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,2-bis(bromomethyl)-1,3-propanediol (FR-1138) (CAS No. 3296-90-0) in F344/N Rats and B6C3F1 Mice (feed Studies) by :

Download or read book NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,2-bis(bromomethyl)-1,3-propanediol (FR-1138) (CAS No. 3296-90-0) in F344/N Rats and B6C3F1 Mice (feed Studies) written by and published by . This book was released on 1996 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: