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Novel Targets In Breast Disease
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Book Synopsis Targeted Therapies in Breast Cancer by : Gw Sledge
Download or read book Targeted Therapies in Breast Cancer written by Gw Sledge and published by Clinical Pub. This book was released on 2012-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.
Book Synopsis Breast Cancer Metastasis and Drug Resistance by : Aamir Ahmad
Download or read book Breast Cancer Metastasis and Drug Resistance written by Aamir Ahmad and published by Springer Nature. This book was released on 2019-08-27 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.
Book Synopsis Developing Technologies for Early Detection of Breast Cancer by : National Research Council
Download or read book Developing Technologies for Early Detection of Breast Cancer written by National Research Council and published by National Academies Press. This book was released on 2000-07-06 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: In November 1999, the Institute of Medicine, in consultation with the Commission on Life Sciences, the Commission on Physical Sciences, Mathematics, and Applications, and the Board on Science, Technology and Economic Policy launched a one year study on technologies for early detection of breast cancer. The committee was asked to examine technologies under development for early breast cancer detection, and to scrutinize the process of medical technology development, adoption, and dissemination. The committee is gathering information on these topics for its report in a number of ways, including two public workshops that bring in outside expertise. The first workshop on "Developing Technologies for Early Breast Cancer Detection" was held in Washington DC in February 2000. The content of the presentations at the workshop is summarized here. A second workshop, which will focus on the process of technology development and adoption, will be held in Washington, DC on June 19-20. A formal report on these topics, including conclusions and recommendations, will be prepared by the committee upon completion of the one-year study.
Download or read book Her-2 written by Robert Bazell and published by Random House. This book was released on 2011-04-27 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free. Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers. Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.
Book Synopsis Precision Medicine in Oncology by : Angela Re
Download or read book Precision Medicine in Oncology written by Angela Re and published by Frontiers Media SA. This book was released on 2019-01-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: The emerging precision medicine approach aims to tailor disease prevention and treatment to each patient on the basis of individual variability, environmental factors and lifestyle. Fundamental achievements in the last few decades have converged to offer nowadays the compelling opportunity to move towards this innovative approach: i) unprecedented improvements in disease modeling in silico, in vitro and in vivo; ii) acquisition of a wide range of biomedical information combined with the development of computational toolsets for flexible and integrative analyses of multi-assay datasets. Our deeper understanding of oncogenic mechanisms has finally begun to have a crucial impact on clinical decisions at several steps, from cancer prevention and diagnosis to therapeutic intervention. However, precision oncology still encounters several unresolved hurdles including tumour heterogeneity and recurrence as well as unexplained drug resistance and lack of effective ways to monitor response to therapeutic treatments. Notably, limitations in biomedical research regulation and governance represent additional debatable issues that need careful consideration.
Book Synopsis Targeted Radionuclide Therapy by : Tod W. Speer
Download or read book Targeted Radionuclide Therapy written by Tod W. Speer and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.
Book Synopsis Central Nervous System Metastases by : Manmeet Ahluwalia
Download or read book Central Nervous System Metastases written by Manmeet Ahluwalia and published by Springer Nature. This book was released on 2019-11-05 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.
Book Synopsis Novel Targets in Breast Disease by : Stan Lipkowitz
Download or read book Novel Targets in Breast Disease written by Stan Lipkowitz and published by IOS Press. This book was released on 2003 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is devoted to therapies that take advantage of molecular targets relevant to breast cancer - so called novel molecular therapies. It presents a sampling of both old and new molecularly targeted therapies that are being developed.
Book Synopsis HER2-Positive Breast Cancer by : Sara Hurvitz
Download or read book HER2-Positive Breast Cancer written by Sara Hurvitz and published by Elsevier Health Sciences. This book was released on 2018-07-26 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of clinically-focused topics and guidelines that are relevant to testing for HER2, which contributes to approximately 25% of breast cancers today. This concise resource by Drs. Sara Hurvitz, and Kelly McCann consolidates today's available information on this growing topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee oncologists. - Covers the diagnosis, treatments and targeted therapies, and management of breast cancers that are HER2-positive. - Contains sections on background and testing, advanced disease, therapeutics, and toxicity considerations. - Includes a timely section on innovative future therapies.
Book Synopsis Triple-Negative Breast Cancer by : Antoinette R. Tan
Download or read book Triple-Negative Breast Cancer written by Antoinette R. Tan and published by Springer. This book was released on 2018-01-11 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide provides practical information that will assist clinicians involved in the diagnosis, assessment, treatment, and follow-up care of patients with triple-negative breast cancer. After opening chapters on the pathologic evaluation, clinical presentation, genetics, and imaging features, the full range of current treatment approaches is thoroughly reviewed from a multidisciplinary perspective. Readers will find up-to-date information and guidance on surgical management, radiation therapy, tailored adjuvant therapy, neoadjuvant treatment, systemic treatment for metastatic disease, molecular profiling, and targeted therapy. The coverage is completed by discussion of special issues in young women with triple-negative breast cancer and individualization of the management approach in older patients affected with the disease. All healthcare professionals who care for patients with triple-negative breast cancer will find the book to be an invaluable source of expert advice on the issues faced in real-world practice.
Book Synopsis Patient-Derived Xenograft Models of Human Cancer by : Yuzhuo Wang
Download or read book Patient-Derived Xenograft Models of Human Cancer written by Yuzhuo Wang and published by Springer. This book was released on 2017-06-27 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.
Book Synopsis Radiotherapy in Cancer Care by : International Atomic Energy Agency
Download or read book Radiotherapy in Cancer Care written by International Atomic Energy Agency and published by . This book was released on 2017-11-28 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer treatment is complex and calls for a diverse set of services. Radiation therapy is recognized as an essential tool in the cure and palliation of cancer. Currently, access to radiation treatment is limited in many countries and non-existent in some. This lack of radiation therapy resources exacerbates the burden of disease and underscores the continuing health care disparity among States. Closing this gap represents an essential measure in addressing this global health equity problem. This publication presents a comprehensive overview of the major topics and issues to be taken into consideration when planning a strategy to address this problem, in particular in low and middle income countries. With contributions from leaders in the field, it provides an introduction to the achievements and issues of radiation therapy as a cancer treatment modality around the world. Dedicated chapters focus on the new radiotherapy technologies, proton beams, carbon ion, intraoperative radiotherapy, radiotherapy for children, treatment of HIV-AIDS malignancies, and costing and quality management issues.
Book Synopsis Metronomic Chemotherapy by : Guido Bocci
Download or read book Metronomic Chemotherapy written by Guido Bocci and published by Springer. This book was released on 2014-09-04 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.
Book Synopsis Cell and Molecular Biology of Breast Cancer by : Heide Schatten
Download or read book Cell and Molecular Biology of Breast Cancer written by Heide Schatten and published by Springer Science & Business Media. This book was released on 2013-09-27 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book. Included are reviews of genetics, epigenetics, various aspects of cell and molecular biology, and several other areas of breast cancer that are aimed at determining new intervention sites for treatments and cures of the disease. The chapters are written by internationally recognized experts and include reviews of key topics in breast cancer research. Each chapter highlights the new aspects of specific research topics and the various impacts of designing new strategies as well as identifies new targets for therapeutic intervention. The topics addressed are selected to be of interest to patients, scientists, students, teachers, and anyone else interested in expanding their knowledge of breast cancer imaging, diagnostics, therapeutics, or basic biomedical research on breast cancer.
Download or read book The Bright Hour written by Nina Riggs and published by Simon and Schuster. This book was released on 2017-06-06 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Built on her ... Modern Love column, 'When a Couch is More Than a Couch' (9/23/2016), a ... memoir of living meaningfully with 'death in the room' by the 38-year-old great-great-great granddaughter of Ralph Waldo Emerson--mother to two young boys, wife of 16 years--after her terminal cancer diagnosis"--
Book Synopsis Cancer as a Metabolic Disease by : Thomas Seyfried
Download or read book Cancer as a Metabolic Disease written by Thomas Seyfried and published by John Wiley & Sons. This book was released on 2012-05-18 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.
Download or read book 1Q84 written by Haruki Murakami and published by Bond Street Books. This book was released on 2011-10-25 with total page 1342 pages. Available in PDF, EPUB and Kindle. Book excerpt: The long-awaited magnum opus from Haruki Murakami, in which this revered and bestselling author gives us his hypnotically addictive, mind-bending ode to George Orwell's 1984. The year is 1984. Aomame is riding in a taxi on the expressway, in a hurry to carry out an assignment. Her work is not the kind that can be discussed in public. When they get tied up in traffic, the taxi driver suggests a bizarre 'proposal' to her. Having no other choice she agrees, but as a result of her actions she starts to feel as though she is gradually becoming detached from the real world. She has been on a top secret mission, and her next job leads her to encounter the superhuman founder of a religious cult. Meanwhile, Tengo is leading a nondescript life but wishes to become a writer. He inadvertently becomes involved in a strange disturbance that develops over a literary prize. While Aomame and Tengo impact on each other in various ways, at times by accident and at times intentionally, they come closer and closer to meeting. Eventually the two of them notice that they are indispensable to each other. Is it possible for them to ever meet in the real world?
