Novel Aspects On Motor Neuron Disease

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Novel Aspects on Motor Neuron Disease

Author : Humberto Foyaca Sibat
Publisher : BoD – Books on Demand
ISBN 13 : 183880773X
Total Pages : 120 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Novel Aspects on Motor Neuron Disease by : Humberto Foyaca Sibat

Download or read book Novel Aspects on Motor Neuron Disease written by Humberto Foyaca Sibat and published by BoD – Books on Demand. This book was released on 2020-05-20 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dedicated to our readers, we include novel information (not reported in IntechOpen’s books before) about new contributions of aberrant astrocytes to MND damage and death in the SOD1G93A rat experimental model of ALS; novel genetic studies on ALS; an update of the structural and functional consequences of the spinal muscular atrophy-linked mutations of the survival motor neuron protein; stem cell therapy for MND; and the novel treatment for SMA and ALS in the introductory chapter. This book contains selected peer-reviewed chapters written by international researchers. In this publication, the readers will find a compilation of state-of-the-art reviews about etiology, therapies, investigations, the molecular basis of disease progression and clinical manifestations, and the genetic familial ALS, as well as novel therapeutic modalities. We look forward with confidence and pride to the remarkable role that this book will play for a new vision and mission.

Novel Aspects on Motor Neuron Disease

Author : Junling Wang
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Novel Aspects on Motor Neuron Disease by : Junling Wang

Download or read book Novel Aspects on Motor Neuron Disease written by Junling Wang and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: At present, with the advanced affordable genetic testing, the rate of discovering amyotrophic lateral sclerosis (ALS)-related genes rapidly increases. These genetic findings provide new insights into therapies that target genetic subset of ALS.¬†However, the research on the genetic and environmental causes of ALS is still in the early stage. In this chapter, we review the current understanding of ALS-related genes and summarize the worldwide ALS distribution feature by the frequency of occurrence in different regions. We summarize the advances in genetic testing and counseling for ALS.¬†Based on the increase in genetic testing, we believe that the ALS patients and families would be benefited from our studies in the near future.

Motor Neuron Disease in Adults

Author : M. B. Bromberg
Publisher :
ISBN 13 : 9780190202279
Total Pages : pages
Book Rating : 4.2/5 (22 download)

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Book Synopsis Motor Neuron Disease in Adults by : M. B. Bromberg

Download or read book Motor Neuron Disease in Adults written by M. B. Bromberg and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Motor Neuron Disease in Adults' reviews new information from 1998 as it applies to all aspects of motor neuron disease. Articles included use evidence-based methods to ensure that the new information is solid and advances the topic. The book can be used by anyone who provides any type of care to ALS patients.

Motor Neuron Disease in Adults

Author : Mark B. Bromberg
Publisher : Contemporary Neurology
ISBN 13 : 019978311X
Total Pages : 369 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Motor Neuron Disease in Adults by : Mark B. Bromberg

Download or read book Motor Neuron Disease in Adults written by Mark B. Bromberg and published by Contemporary Neurology. This book was released on 2014-10-28 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Motor Neuron Disease in Adults' reviews new information from 1998 as it applies to all aspects of motor neuron disease. Articles included use evidence-based methods to ensure that the new information is solid and advances the topic. The book can be used by anyone who provides any type of care to ALS patients.

Clinical and Molecular Aspects of Motor Neuron Disease

Author : Johnathan Cooper-Knock
Publisher : Morgan & Claypool
ISBN 13 : 9781615044283
Total Pages : 62 pages
Book Rating : 4.0/5 (442 download)

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Book Synopsis Clinical and Molecular Aspects of Motor Neuron Disease by : Johnathan Cooper-Knock

Download or read book Clinical and Molecular Aspects of Motor Neuron Disease written by Johnathan Cooper-Knock and published by Morgan & Claypool. This book was released on 2013-09-01 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this e-book, motor neuron disease (MND) shall refer to amyotrophic lateral sclerosis (ALS), the most common neurodegenerative disorder affecting both the upper and lower motor neurons. With the discovery of C9ORF72 expansions in approximately 10% of all MND cases, in certain populations, we stand at the brink of a new era of MND research and hopefully treatment facilitated by the ability to associate a relatively large group of patients with a similar disease mechanism. This review will summarise both current clinical management of MND and our present understanding of the molecular pathogenesis of MND. Study of C9ORF72-MND has the potential to rapidly advance both of these aspects in the coming years. In the first section, we will discuss the clinical features of MND and describe how patients with this devastating condition present, are investigated, and managed in the 21st century. Although, currently, management is limited by an incomplete understanding of disease pathophysiology, there is much which can be done to assist and support patients with MND. In the following sections, we will discuss molecular mechanisms implicated in MND, highlighting observations which unify different theories. Particular attention will be given to placing proposed mechanisms within the clinical course of MND. Furthermore, novel therapeutic targets will be discussed. Table of Contents: Clinical Aspects of MND / Molecular Aspects of MND / References / Author Biographies / Titles of Related Interest / Series of Related Interest

Motor Neuron Disease

Author : P.N. Leigh
Publisher : Springer Science & Business Media
ISBN 13 : 1447118715
Total Pages : 477 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Motor Neuron Disease by : P.N. Leigh

Download or read book Motor Neuron Disease written by P.N. Leigh and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is the first book to provide a comprehensive overview of the clinical, pathological, and research aspects of motor neuron disease (MND). The text contains all essential features of the anatomy, physiology, pharmacology and toxicology of the motor system, a full description of MND and its variants, as well as historical developments and a review of the current concepts and controversies. This book comes at a time of increasing interest in neurodegenerative disorders and MND in particular. It will prove a key reference book with an integrated overview of the field, and will be indispensable to practicing neurologists, researchers, and all those with an interest in MND.

Molecular and Cellular Therapies for Motor Neuron Diseases

Author : Nicholas M Boulis
Publisher : Academic Press
ISBN 13 : 0128025247
Total Pages : 337 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Molecular and Cellular Therapies for Motor Neuron Diseases by : Nicholas M Boulis

Download or read book Molecular and Cellular Therapies for Motor Neuron Diseases written by Nicholas M Boulis and published by Academic Press. This book was released on 2017-01-18 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy

Clinical and Molecular Aspects of Motor Neuron Disease

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (993 download)

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Book Synopsis Clinical and Molecular Aspects of Motor Neuron Disease by :

Download or read book Clinical and Molecular Aspects of Motor Neuron Disease written by and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Motor Neuron Disease

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (785 download)

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Book Synopsis Motor Neuron Disease by :

Download or read book Motor Neuron Disease written by and published by . This book was released on 1994 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Update on Amyotrophic Lateral Sclerosis

Author : Humberto Foyaca Sibat
Publisher : BoD – Books on Demand
ISBN 13 : 9535126008
Total Pages : 281 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Update on Amyotrophic Lateral Sclerosis by : Humberto Foyaca Sibat

Download or read book Update on Amyotrophic Lateral Sclerosis written by Humberto Foyaca Sibat and published by BoD – Books on Demand. This book was released on 2016-09-14 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains selected peer-reviewed chapters which cover updated information on ALS written by international researchers. Update on Amyotrophic Lateral Sclerosis is comprised of 13 chapters from some of the world's top central nervous system researchers and neurologists to provide a timely review of the most recent developments in ALS, covering historic aspects, experimental animal models, genetics, pathogenesis, clinical aspects and imagenology among others. Contributors from Belgium, France, Japan, India, Italy, Mexico, Russia, South Africa, and Switzerland have collaborated enthusiastically and efficiently, dedicating their time to create this reader-friendly yet comprehensive work which includes many explanatory figures, tables and photos to enhance legibility and make the book clinically useful. We are looking forward with confidence and pride in the remarkable role that this book will play for a new vision and mission.

Motor Neuron Disease

Author : Hendrik Kerkhoff
Publisher :
ISBN 13 : 9789039302583
Total Pages : 149 pages
Book Rating : 4.3/5 (25 download)

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Book Synopsis Motor Neuron Disease by : Hendrik Kerkhoff

Download or read book Motor Neuron Disease written by Hendrik Kerkhoff and published by . This book was released on 1993 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Spinal Muscular Atrophy

Author : Charlotte J Sumner
Publisher : Academic Press
ISBN 13 : 0128036869
Total Pages : 508 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Spinal Muscular Atrophy by : Charlotte J Sumner

Download or read book Spinal Muscular Atrophy written by Charlotte J Sumner and published by Academic Press. This book was released on 2016-10-24 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spinal Muscular Atrophy: Disease Mechanisms and Therapy provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development. This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of care, multifaceted aspects of SMN protein functions and SMA disease pathology, various animal models, and biomarkers, as well as current therapeutic development. This title is ideal for graduate students/postdocs and principal investigators who are already in the SMA field and need to keep updated on recent findings and approaches, and for those who are new to, or would like to join, the field. Likewise, users will find an excellent source of reading for biotech/pharma scientists, clinical researchers, and practitioners, regulators, and patients and their advocacy organizations. Furthermore, this book is a handy reference for researchers and clinicians who may want to apply the research strategies and therapeutic approaches in SMA to other rare diseases. Provides comprehensive, up-to-date reviews by leading investigators on diverse topics of SMA, including clinical features and patient care, SMN genetics and protein functions, animal models, disease pathology and mechanisms, biomarkers, current therapeutic development, and the role of non-profit organizations in therapeutic development Written to bridge multiple disciplines and promote better communications among basic scientists, clinical researchers, and health care providers on the latest developments in SMA Includes outstanding questions and perspectives for future investigations and key references for additional detailed study

Novel Aspects on Epilepsy

Author : Humberto Foyaca-Sibat
Publisher : BoD – Books on Demand
ISBN 13 : 953307678X
Total Pages : 353 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Novel Aspects on Epilepsy by : Humberto Foyaca-Sibat

Download or read book Novel Aspects on Epilepsy written by Humberto Foyaca-Sibat and published by BoD – Books on Demand. This book was released on 2011-10-12 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers novel aspects of epilepsy without ignoring its foundation and therefore, apart from the classic issues that cannot be missing in any book about epilepsy, we introduced novel aspects related with epilepsy and neurocysticercosis as a leading cause of epilepsy in developing countries. We are looking forward with confidence and pride in the vital role that this book has to play for a new vision and mission. Therefore, we introduce novel aspects of epilepsy related to its impact on reproductive functions, oral health and epilepsy secondary to tuberous sclerosis, mithocondrial disorders and lisosomal storage disorders.

Amyotrophic Lateral Sclerosis

Author : V. Cosi
Publisher : Springer Science & Business Media
ISBN 13 : 1468453025
Total Pages : 341 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Amyotrophic Lateral Sclerosis by : V. Cosi

Download or read book Amyotrophic Lateral Sclerosis written by V. Cosi and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: An International Conference on "Therapeutic. Psychological and Research Aspects of Amyotrophic Lateral Sclerosis" was held in Varese. Italy from the 27th to the 31st March 1985. Health care professionals. scientists. patients and their families from twenty countries around the world participated in this meeting. The objectives of the Varese conference were the following: a. To provide a forum for the proponents of the various paths of research into ALS. b. To correlate the useful therapies employed regionally. for the purpose of developing a common guide for patients, families, and supporting professionals. c. To encourage self-examination by the health care professionals into the psychological barriers imposed by a diagnosis of terminal illness for which there is no known cause or cure. Not surprisingly, there were no announcements of "breakthroughs" or "miracle cures", which are nonetheless hoped for in the confrontation of a disease such as ALS. It is fair to say, however, that Varese provided the context for a thorough review of what is known about ALS and we hope that the papers will renew some of the enthusiasm which has characterized this conference. The book contains six sections: Basic Research Aspects, Diagnostic Tools, Clinical Management, Therapeutic Trials, Psychological Aspects and the Epidemiology of ALS. Certain aspects, such as pathological studies and animal models, have not been covered; these subjects were partially treated during the informal sessions. Nevertheless, the large number of papers bears evidence to the growing interest in ALS and to the success of the Varese meeting.

Practical Guide to Neurogenetics E-Book

Author : Thomas T. Warner
Publisher : Elsevier Health Sciences
ISBN 13 : 0702038458
Total Pages : 343 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Practical Guide to Neurogenetics E-Book by : Thomas T. Warner

Download or read book Practical Guide to Neurogenetics E-Book written by Thomas T. Warner and published by Elsevier Health Sciences. This book was released on 2008-11-04 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This simple guide to neurogenetics demystifies the overwhelming amount of information on the subject so you can identify key clinical features and understand your management options. Reach relevant differential diagnoses and provide appropriate counseling to your patients using the symptom-based approach. By integrating genetic and neurological approaches to diagnoses, this book ensures that the neurological consequences of a genetic diagnosis and the genetic consequences of a neurological diagnosis are clear and explicit. Concise and portable, this book is ideal for easy reference in clinical use. Details the underlying basic science and clinical features of genetic disorders by taking a symptom-based approach to provide you with a comprehensive understanding of the field. Focuses on the clinical application of neurogenetics to be of practical use to you in the clinic. Clarifies the neurological consequences of a genetic diagnosis and the genetic consequences of a neurological diagnosis by integrating genetic and neurological approaches to diagnoses. Discusses and evaluates necessary investigations so you know when to use them and when to refer. Highlights diagnostic and therapeutic tips so you can learn new concepts or refine your skills in practice. Refers to online sources, such as Online Mendelian Inheritance in Man (OMIM) and others, to help you supplement your knowledge.

Introduction to Novel Motor Neuron Disease

Author : Humberto Foyaca Sibat
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Introduction to Novel Motor Neuron Disease by : Humberto Foyaca Sibat

Download or read book Introduction to Novel Motor Neuron Disease written by Humberto Foyaca Sibat and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motor neuron disease (MND) is a progressive and fatal neuromuscular disease; the most common and severe form of MND presentation is amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig,Äôs disease. The majority of ALS patients die within 2,Äì5¬†years of receiving a diagnosis. Familial ALS is a hereditary form of the disease and accounts for 5,Äì10% of cases, whereas the remaining cases have no clearly defined etiology. ALS affects persons of all ethnicities and races; currently, no curative treatment for ALS is available worldwide. ALS is also the major adult-onset MND and is clinically, pathologically, and genetically associated with fronto-temporal dementia in some cases, which is the second cause of dementia in elderly people. However, MND does not affect sphincter, sexual function, or eye movements. MND is the most common degenerative disorder affecting the upper and lower motor neurons at the same time. Most of the patients presenting MND in our series complained of muscle weakness, muscle wasting, fasciculation, and spasticity plus lower cranial nerve disturbances. According to our bibliographic studies, apart from nusinersen, it seems to be that riluzole and edaravone also improve motor neuron function by acting on SK channels.

Spectrums of Amyotrophic Lateral Sclerosis

Author : Christopher A. Shaw
Publisher : John Wiley & Sons
ISBN 13 : 1119745500
Total Pages : 240 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Spectrums of Amyotrophic Lateral Sclerosis by : Christopher A. Shaw

Download or read book Spectrums of Amyotrophic Lateral Sclerosis written by Christopher A. Shaw and published by John Wiley & Sons. This book was released on 2021-04-20 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: SPECTRUMS OF AMYOTROPHIC LATERAL SCLEROSIS Discover state-of-the-art research findings on ALS from leading authors and editors in the field In Spectrums of Amyotrophic Lateral Sclerosis: Heterogeneity, Pathogenesis & Therapeutic Directions, distinguished researchers and editors Dr. Christopher A. Shaw and Jessica R. Morrice deliver a practical and powerful perspective on Amyotrophic Lateral Sclerosis (ALS) as a heterogeneous spectrum of disorders. This increasingly accepted point-of-view allows researchers and medical professionals to develop better targeted interventions and more precise therapies. In the book, readers will find chapters on a wide variety of critical issues facing ALS researchers and healthcare practitioners treating ALS sufferers, including animal models of ALS, neuronal support cells known to have a pivotal role in ALS, and current challenges in ALS clinical trials, among others. The authors describe pathologic features common to all cases of ALS and why animal models, though crucial, should be interpreted with caution. Finally, multiple genetic and environmental etiologies of the disease are discussed. Readers will also benefit from the inclusion of: A thorough introduction to ALS as a spectrum disease and the implications for models, therapeutic development and clinical trial design Explorations of the genetic basis of ALS, prospective sALS etiologies, and the involvement of microbiome in ALS Discussions of ALS-PDC and environmental risk factors, protein aggregation in ALS, defects in RNA metabolism in ALS, and the non-cell autonomous nature of ALS and the involvement of glial cells Examinations of animal models of ALS and perspectives on previously failed ALS therapeutics and current therapeutic strategies Perfect for clinical neurologists, healthcare providers and caretakers, clinicians, and researchers studying motor neuron disease, Spectrums of Amyotrophic Lateral Sclerosis: Heterogeneity, Pathogenesis & Therapeutic Directions is also an indispensable resource for the neurodegenerative research community, neurology residents, and graduate-level neuroscience students.