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Author : Quinn Acelia Spadola
Publisher :
ISBN 13 :
Total Pages : 276 pages
Book Rating : 4.:/5 (276 download)
Download or read book Novel Approaches to DNA Sequencing written by Quinn Acelia Spadola and published by . This book was released on 2008 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lisha Lin
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (88 download)
Download or read book The Proof of Concept for a Novel Approach to DNA Sequencing written by Lisha Lin and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sarah Marie Lee
Publisher :
ISBN 13 :
Total Pages : 88 pages
Book Rating : 4.F/5 ( download)
Download or read book Novel Approaches to DNA Sequencing written by Sarah Marie Lee and published by . This book was released on 1996 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : George M Church
Publisher : Basic Books
ISBN 13 : 0465038654
Total Pages : 305 pages
Book Rating : 4.4/5 (65 download)
Download or read book Regenesis written by George M Church and published by Basic Books. This book was released on 2014-04-08 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Harvard biologist and master inventor explores how new biotechnologies will enable us to bring species back from the dead, unlock vast supplies of renewable energy, and extend human life. In Regenesis, George Church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies-far from the out-of-control nightmare depicted in science fiction-have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.
Download or read book The Proof of Concept for a Novel Approach to DNA Sequencing written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The proof of concept for a novel approach to DNA sequencing.
Author : Annette M. Griffin
Publisher : Springer Science & Business Media
ISBN 13 : 1592595103
Total Pages : 386 pages
Book Rating : 4.5/5 (925 download)
Download or read book DNA Sequencing Protocols written by Annette M. Griffin and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of DNA Sequencing Protocols is to provide detailed practical procedures for the widest range of DNA sequencing meth ods, and we believe that all the vanguard techniques now being applied in this fast-evolving field are comprehensively covered. Sequencing technology has advanced at a phenomenal rate since the original methods were first described in the late 1970s and there is now a huge variety of strategies and methods that can be employed to determine the sequence of any DNA of interest. More recently, a large number of new and innovative sequencing techniques have been developed, including the use of such novel polymerases as Tag poly merase and Sequenase, the harnessing of PCR technology for linear amplification (cycle) sequencing, and the advent of automated DNA sequencers. DNA sequencing is surely one of the most important techniques in the molecular biology laboratory. Sequence analysis is providing an increasingly useful approach to the characterization of biological systems, and major multinational projects are already underway to map and sequence the entire genome of organisms, such as Escherichia coli, Saccharomyces cerevisiae, Caenorhabditis elegans, and Homo sapiens. Most scientists recognize the importance of DNA sequence data and perceive DNA sequencing as a valuable and indispensable aspect of their work. Recent technological advances, especially in the area of automated sequencing, have removed much of the drudg ery that was formerly associated with the technique, whereas innova tive computer software has greatly simplified the analysis and manipulation of sequence data.
Author : Hameer Ruparel
Publisher :
ISBN 13 :
Total Pages : 298 pages
Book Rating : 4.:/5 (62 download)
Download or read book Novel DNA Sequencing and Genotyping Approaches Using Modified Nucleotide Analogues written by Hameer Ruparel and published by . This book was released on 2005 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anjana Munshi
Publisher : BoD – Books on Demand
ISBN 13 : 9535105647
Total Pages : 188 pages
Book Rating : 4.5/5 (351 download)
Download or read book DNA Sequencing written by Anjana Munshi and published by BoD – Books on Demand. This book was released on 2012-04-20 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates methods of DNA sequencing and its application in plant, animal and medical sciences. It has two distinct sections. The one includes 2 chapters devoted to the DNA sequencing methods and the second includes 6 chapters focusing on various applications of this technology. The content of the articles presented in the book is guided by the knowledge and experience of the contributing authors. This book is intended to serve as an important resource and review to the researchers in the field of DNA sequencing.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309038405
Total Pages : 128 pages
Book Rating : 4.3/5 (9 download)
Download or read book Mapping and Sequencing the Human Genome written by National Research Council and published by National Academies Press. This book was released on 1988-01-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Author : Mirko Palla
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (873 download)
Download or read book Novel Engineering Approaches for DNA Sequencing and Analysis written by Mirko Palla and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The following is a summary of the resulting work presented herein: first, a new DNA sequencing technology development is presented that utilizes surface-enhanced Raman spectroscopy (SERS); second, a novel approach of SERS-based biosensing for quantitative detection of biomolecules is demonstrated; third, a rigorous mathematical development of an analytical model is described to predict experimental SERS signal intensity distributions for biomolecular quantification; fourth, a versatile SERS-based quantitative method is developed to monitor the catalyst-free click reaction efficiency for small molecule conjugation; fifth, theoretical work using molecular dynamics simulations for analyzing the mechanical behavior of a molecular motor involved in DNA processing are described; and finally, the thesis presents a proposed nanodevice to combine the SERS-SBS technology with our bioquantification method into one functional unit. Consequently, these research efforts provide a foundation for the novel use and integration of SERS-SBS into microfluidic systems for a wide range of applications, such as high-throughput DNA sequencing and genetic diagnostics, as well as the theoretical framework to investigate DNA polymerase function at the atomic level.
Author : Daryl Clifford Williams
Publisher :
ISBN 13 :
Total Pages : 264 pages
Book Rating : 4.:/5 (421 download)
Download or read book A Novel Approach to DNA Sequencing Employing Near-IR Flourescence Detection Coupled with Micro-scale Reaction Vessels with Capillary Gel Separations written by Daryl Clifford Williams and published by . This book was released on 1999 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Eugene V. Koonin
Publisher : Springer Science & Business Media
ISBN 13 : 1475737831
Total Pages : 482 pages
Book Rating : 4.4/5 (757 download)
Download or read book Sequence — Evolution — Function written by Eugene V. Koonin and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.
Author :
Publisher : World Scientific
ISBN 13 : 9812790381
Total Pages : 324 pages
Book Rating : 4.8/5 (127 download)
Download or read book Biodata Mining and Visualization: Novel Approaches written by and published by World Scientific. This book was released on 2009 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: "There is a lack of an exposition on interdisciplinary and innovative methods of data mining and visualization for biodata. This book fills the gap by introducing an interdisciplinary set of the most recent methods and references on novel techniques from artificial intelligence, data mining, engineering, pattern recognition, and ontological data mining fields that are applicable to bioinformatics. The latest novel approaches are explained in detail, their advantages and disadvantages are summarized, and pointers to the future development of new applications are given. By widening the pool from which biologists and bioinformaticians can adopt methods for biodata mining and visualization, computational data mining experts in nonbiological fields are also encouraged to utilize their expertise in order to contribute to the progress of computational biology, thus enhancing the collaboration between these two disciplines."--Publisher's website
Author : Ion Mandoiu
Publisher : John Wiley & Sons
ISBN 13 : 1119272165
Total Pages : 464 pages
Book Rating : 4.1/5 (192 download)
Download or read book Computational Methods for Next Generation Sequencing Data Analysis written by Ion Mandoiu and published by John Wiley & Sons. This book was released on 2016-09-12 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces readers to core algorithmic techniques for next-generation sequencing (NGS) data analysis and discusses a wide range of computational techniques and applications This book provides an in-depth survey of some of the recent developments in NGS and discusses mathematical and computational challenges in various application areas of NGS technologies. The 18 chapters featured in this book have been authored by bioinformatics experts and represent the latest work in leading labs actively contributing to the fast-growing field of NGS. The book is divided into four parts: Part I focuses on computing and experimental infrastructure for NGS analysis, including chapters on cloud computing, modular pipelines for metabolic pathway reconstruction, pooling strategies for massive viral sequencing, and high-fidelity sequencing protocols. Part II concentrates on analysis of DNA sequencing data, covering the classic scaffolding problem, detection of genomic variants, including insertions and deletions, and analysis of DNA methylation sequencing data. Part III is devoted to analysis of RNA-seq data. This part discusses algorithms and compares software tools for transcriptome assembly along with methods for detection of alternative splicing and tools for transcriptome quantification and differential expression analysis. Part IV explores computational tools for NGS applications in microbiomics, including a discussion on error correction of NGS reads from viral populations, methods for viral quasispecies reconstruction, and a survey of state-of-the-art methods and future trends in microbiome analysis. Computational Methods for Next Generation Sequencing Data Analysis: Reviews computational techniques such as new combinatorial optimization methods, data structures, high performance computing, machine learning, and inference algorithms Discusses the mathematical and computational challenges in NGS technologies Covers NGS error correction, de novo genome transcriptome assembly, variant detection from NGS reads, and more This text is a reference for biomedical professionals interested in expanding their knowledge of computational techniques for NGS data analysis. The book is also useful for graduate and post-graduate students in bioinformatics.
Author : Chunmei Qiu
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (867 download)
Download or read book Novel Molecular Engineering Approaches for Genotyping and DNA Sequencing written by Chunmei Qiu and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: We reported the design, synthesis, and characterization of a binary probe (BP) that consists of carboxylic quantum dot (CdSe/ZnS core shell)-DNA (QD-DNA) conjugated donor and a cyanine-5 (Cy5)-DNA acceptor for the detection of a sensorin mRNA-based synthetic DNA molecule. We have demonstrated that in the absence of target DNA, the QD fluorescence is the main signal observed (605 nm); in the presence of the complementary target DNA sequence, a decrease of QD emission and an increase of Cy5 emission at 667 nm was observed. We have demonstrated the distance dependence of FRET, with the finding that the target with 16 base separation between the QD and Cy5 after probe hybridization gave the most efficient FRET. Further studies are in progress to evaluate the effectiveness of this QD-based probe inside a cell extract and in living cells.
Author : Jerzy Kulski
Publisher : BoD – Books on Demand
ISBN 13 : 9535122401
Total Pages : 466 pages
Book Rating : 4.5/5 (351 download)
Download or read book Next Generation Sequencing written by Jerzy Kulski and published by BoD – Books on Demand. This book was released on 2016-01-14 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and the bioinformatics challenges in processing and analysing huge amounts of sequencing data. Following an overview of the evolution of NGS in the brave new world of omics, the book examines the advances and challenges of NGS applications in basic and applied research on microorganisms, agricultural plants and humans. This book is of value to all who are interested in DNA sequencing and bioinformatics across all fields of the life sciences.
Author : Ali Masoudi-Nejad
Publisher : Springer Science & Business Media
ISBN 13 : 1461477263
Total Pages : 92 pages
Book Rating : 4.4/5 (614 download)
Download or read book Next Generation Sequencing and Sequence Assembly written by Ali Masoudi-Nejad and published by Springer Science & Business Media. This book was released on 2013-07-09 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this book is to introduce the biological and technical aspects of next generation sequencing methods, as well as algorithms to assemble these sequences into whole genomes. The book is organized into two parts; part 1 introduces NGS methods and part 2 reviews assembly algorithms and gives a good insight to these methods for readers new to the field. Gathering information, about sequencing and assembly methods together, helps both biologists and computer scientists to get a clear idea about the field. Chapters will include information about new sequencing technologies such as ChIp-seq, ChIp-chip, and De Novo sequence assembly.
