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Author : Haixi Miao
Publisher :
ISBN 13 :
Total Pages : 400 pages
Book Rating : 4.:/5 (611 download)
Download or read book Notch Signaling is a Therapeutic Target in Breast Cancer written by Haixi Miao and published by . This book was released on 2004 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book תקון (בלתי שלם). written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jörg Reichrath
Publisher : Springer Nature
ISBN 13 : 3030550311
Total Pages : 228 pages
Book Rating : 4.0/5 (35 download)
Download or read book Notch Signaling in Embryology and Cancer written by Jörg Reichrath and published by Springer Nature. This book was released on 2020-10-08 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more. Taken as a whole, with its companion books -- Notch Signaling and Embryologic Development and Molecular Basis of Notch Signaling – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
Author : Lucio Miele
Publisher : Springer
ISBN 13 : 149398859X
Total Pages : 389 pages
Book Rating : 4.4/5 (939 download)
Download or read book Targeting Notch in Cancer written by Lucio Miele and published by Springer. This book was released on 2018-11-23 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets. Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected
Author : Yan Cheng
Publisher : Frontiers Media SA
ISBN 13 : 2832541844
Total Pages : 198 pages
Book Rating : 4.8/5 (325 download)
Download or read book Molecular Mechanisms of Drug Resistance And Strategies of Sensitization in Breast Cancer, 2nd edition written by Yan Cheng and published by Frontiers Media SA. This book was released on 2024-01-11 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic scientific background Breast cancer is one of the most common cancer and the most frequent cause of cancer death among women worldwide. Currently, subtyping breast cancers into hormone receptor (HR) positive, human epidermal growth factor receptor-2 overexpressing (HER2+), and triple negative breast cancer (TNBC) is the basis of diagnosing and treating this disease. The main treatment strategies for breast cancer include surgery, endocrine therapy, molecular targeted therapy, chemotherapy, radiotherapy, immunotherapy and gene therapy. However, resistance of breast cancer cells to chemotherapeutic agents, molecular targeted therapies and immunotherapy may occur either intrinsically or de nova, and is often ultimately responsible for treatment failure. Therefore, drug resistance poses a major challenge to breast cancer treatment. Current developments: Drug resistance in breast cancer is a complex clinical condition originating from a wide range of molecular alterations. The development of endocrine therapy resistance is believed to be associated with many cellular changes, such as ESR1 gene mutations, bypassing estrogen signaling pathway and altered tamoxifen metabolism. Meanwhile, changes in immune response, alternation of drug-binding property and downstream pathways are involved in the mechanisms of drug resistance in HER2+ breast cancer. In addition, resistance to chemotherapeutic agents predominantly arises from increased drug efflux and cross resistance. Current studies suggest that treatment strategies and therapeutics have to be designed specifically to each patient in different clinical situations. The use of modern genomic, proteomic and functional analytical techniques has contributed to identify novel genes and signaling networks involved in breast cancer drug resistance. Moreover, the use of high-throughput techniques in combination with bioinformatics and systems biology approaches has aided the interrogation of clinical samples and allowed the identification of molecular signatures and genotypes that predict responses to certain drugs. Despite much progress has been made in the field of breast cancer drug resistance, such as combination therapy and drug-loaded nanoparticles, the complexity and variability of drug resistance mechanism still inevitably lead to the continuous occurrence of drug resistance. Therefore, with the increasing amounts of anti-breast cancer agents, there are now unprecedented opportunities to understand and overcome drug resistance through further research into mechanisms and corresponding strategies, which will help achieve lasting disease control and bring survival benefits to patients with advanced cancer. Papers of interest: The current Research Topic of Frontiers in Pharmacology focuses on publishing Original Research, Review articles and Case Reports focusing on (a) elucidating mechanisms of drug resistance in breast cancer, target mutations, tumor microenvironment, undiscovered genes and signaling pathways; (b) promising drug delivery systems that can enhance the sensitivity of anti- breast cancer agents to various tumors; (c) strategies that can improve patient care during bio-chemotherapeutic treatments; (d) small molecule compounds that are effective against drug-resistant breast tumors (e) biomarkers of chemotherapy resistance in breast cancer patients and (f) in vitro and in vivo models. Guidelines for article of submission: - Authors must stick to the set guidelines for ethical practices by the Frontiers journals. - The main content of the article must have certain innovation and research significance. - The authors should describe the construction method of drug-resistant cell lines when using them for experiments in the article.
Author : Jörg Reichrath
Publisher : Springer Nature
ISBN 13 : 3030364224
Total Pages : 179 pages
Book Rating : 4.0/5 (33 download)
Download or read book Notch Signaling in Embryology and Cancer written by Jörg Reichrath and published by Springer Nature. This book was released on 2020-02-18 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
Author : Julian Adams
Publisher : Springer Science & Business Media
ISBN 13 : 1592597947
Total Pages : 319 pages
Book Rating : 4.5/5 (925 download)
Download or read book Proteasome Inhibitors in Cancer Therapy written by Julian Adams and published by Springer Science & Business Media. This book was released on 2004-05-25 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (VelcadeTM) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma.
Author : Giampietro Gasparini
Publisher : Springer Science & Business Media
ISBN 13 : 159259915X
Total Pages : 335 pages
Book Rating : 4.5/5 (925 download)
Download or read book Biomarkers in Breast Cancer written by Giampietro Gasparini and published by Springer Science & Business Media. This book was released on 2008-01-17 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.
Author : Jörg Reichrath
Publisher : Springer Science & Business Media
ISBN 13 : 1461408997
Total Pages : 346 pages
Book Rating : 4.4/5 (614 download)
Download or read book Notch Signaling in Embryology and Cancer written by Jörg Reichrath and published by Springer Science & Business Media. This book was released on 2012-03-07 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer. Experts in the field as well as scientists and health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for every clinician or scientist interested in the role of Notch signalling in embryology and cancer. We hope that this volume will be adopted as the standard text in this area of science and will stimulate new interest in the role of Notch signalling for embryology and cancer. We further hope that this compendium will serve as both a source for current researchers and a guide to stimulate and assist those in related disciplines to enter this exciting field of research.
Author : João Pessoa
Publisher : Frontiers Media SA
ISBN 13 : 283253144X
Total Pages : 224 pages
Book Rating : 4.8/5 (325 download)
Download or read book Altered Expression of Proteins in Cancer: Function and Potential Therapeutic Targets, Volume II written by João Pessoa and published by Frontiers Media SA. This book was released on 2023-08-02 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David A. Frank
Publisher : Springer Science & Business Media
ISBN 13 : 0306481588
Total Pages : 358 pages
Book Rating : 4.3/5 (64 download)
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2006-04-18 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Author : Kasirajan Ayyanathan
Publisher : CRC Press
ISBN 13 : 1482299453
Total Pages : 402 pages
Book Rating : 4.4/5 (822 download)
Download or read book Cancer Cell Signaling written by Kasirajan Ayyanathan and published by CRC Press. This book was released on 2014-06-20 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title includes a number of Open Access chapters.Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment. When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may have implications for developi
Author :
Publisher : Elsevier
ISBN 13 : 0443235473
Total Pages : 276 pages
Book Rating : 4.4/5 (432 download)
Download or read book Targeting Signaling Pathways in Solid Tumors Part A written by and published by Elsevier. This book was released on 2024-04-23 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeting Signaling Pathways in Solid Tumors, Part A, Volume 385 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Drugging the Undruggable: Advances in Targeting KRAS Signaling in Solid Tumors, Emerging Trends in Gastrointestinal Cancers: Targeting Developmental Pathways in their Carcinogenesis and Tumor Progression, Importance of targeting various cell signaling pathways in solid cancers, Targeting signaling pathways in cancer stem cells: a potential approach for developing novel anticancer therapeutics, Factors affecting heterogeneity in breast cancer microenvironment: A narrative review, and much more. Additional sections cover Exploring TLR Signaling Pathways as Promising Targets in Cervical Cancer: The Road Less Travelled Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Author : Jennifer Chien Villa
Publisher :
ISBN 13 :
Total Pages : 260 pages
Book Rating : 4.:/5 (858 download)
Download or read book Mechanism of Hypoxia-regulated Gamma-secretase in Notch-mediated Breast Cancer Metastasis written by Jennifer Chien Villa and published by . This book was released on 2012 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Notch signaling is responsible for critical developmental events from cell-fate determination to proliferation, while the aberrant activation of Notch signaling has been associated with breast cancer malignancies. Notch activation is initiated through the binding of Notch ligands (Jagged/Serrate Family) to Notch receptors (Notch1-4), followed by successive cleavages by TACE and ?-secretase to subsequently release the Notch intracellular domain (NICD) for nuclear transcription. Due to the crucial role of ?-secretase in mediating the release NICD, research in ?-secretase regulation and function in breast cancer is essential for the implementation of effective ?-secretase inhibitors (GSIs). Tumor hypoxia contributes to therapeutic resistance and the metastatic progression of breast cancer. It has been reported that hypoxia can promote Notch signaling through stabilizing the ?-secretase cleaved product NICD. However, little is known if hypoxia also modulates ?-secretase activity. In our study, we showed that ?-secretase activity of breast cancer lines were enhanced under hypoxia. Furthermore, we demonstrated that hypoxia did not elevate the level of ?-secretase subunits including Presenilin, Nicastrin, Aph-1 and Pen2, but rather directly increased the amount of active complex formed. We found that Hif-1? engaged with the active enzyme complex to regulate ?-secretase activity. More importantly, the increased invasive potential of breast cancer cells in hypoxic setting could be diminished with ?-secretase inhibition using a sulfonamide GSI (GSI-34), indicating that ?-secretase plays a critical role in the migration and invasion of breast cancer. Finally, we showed that both GSI treatment and knockout of Notch signaling significantly reduced metastasis to distant lung organ in mice using 4T1 mammary fatpad metastasis model. These studies together demonstrated that the administration of GSI-34 could be used to ameliorate the progression of metastatic lesion from highly aggressive hypoxic tumor types. In addition, breast cancer is a heterogeneous disease that can be characterized by distinct molecular signatures. To date, there are no target-based therapies to combat triple-negative Basal B breast cancer subtypes. In our study, we showed hat the highly invasive Basal B breast cancer subtypes exhibited unique properties that contribute to the aggressiveness and resistance of this cell type to therapy. First, breast cancer cells expressed Notch receptors and ligands, and most importantly, were active in Notch signaling. Secondly, we demonstrated that Basal B subtype breast cancer cells differ in ?-secretase activity for the cleavage of Notch and APP and in ?-secretase active site conformation. Basal B cells exhibited differential response to ?-secretase inhibition, leading to decreased DNA synthesis and clonogenic survival. Collectively, these above studies demonstrated that ?-secretase is a unique target for the treatment of hypoxic and aggressive breast cancer. We also provided mechanistic evidence to support ?-secretase mediated Notch signaling in cancer metastasis by showing the potential used of GSIs for the treatment of highly aggressive breast cancer types. These studies will ultimately provide prognostic and therapeutic value for the management of breast cancer malignancies.
Author : Kathleen H. Goss
Publisher : Springer Science & Business Media
ISBN 13 : 1441980237
Total Pages : 249 pages
Book Rating : 4.4/5 (419 download)
Download or read book Targeting the Wnt Pathway in Cancer written by Kathleen H. Goss and published by Springer Science & Business Media. This book was released on 2011-01-25 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.
Author : Aaron J. Ciechanover
Publisher : Wiley-Liss
ISBN 13 :
Total Pages : 256 pages
Book Rating : 4.3/5 (91 download)
Download or read book Cellular Proteolytic Systems written by Aaron J. Ciechanover and published by Wiley-Liss. This book was released on 1994-11-03 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of cellular proteolysis is advancing rapidly and has great potential impact in a variety of research and clinical areas, including AIDS and cancer research and treatment. The editors, pioneers in the field of cellular and protein research, describe our current understanding of the three major cellular proteolytic systems: the ubiquitin system, the lysosomal and vacuolar systems, and physiological and pathophysiological cellular proteolysis.
Author :
Publisher : Elsevier
ISBN 13 : 0124166768
Total Pages : 421 pages
Book Rating : 4.1/5 (241 download)
Download or read book Hormones and Breast Cancer written by and published by Elsevier. This book was released on 2013-06-25 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on hormones and breast cancer. Contributions from leading authorities Informs and updates on all the latest developments in the field
