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Author : Z. Deyl
Publisher : Elsevier
ISBN 13 : 0080860664
Total Pages : 539 pages
Book Rating : 4.0/5 (88 download)
Download or read book Separation Methods written by Z. Deyl and published by Elsevier. This book was released on 2011-09-22 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: Separation Methods
Author : Lucyna Antkiewicz-Michaluk
Publisher : Springer Science & Business Media
ISBN 13 : 146141542X
Total Pages : 181 pages
Book Rating : 4.4/5 (614 download)
Download or read book Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants written by Lucyna Antkiewicz-Michaluk and published by Springer Science & Business Media. This book was released on 2011-12-07 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: The specific topic, “Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants – New Perspectives In Parkinson`S Disease Therapy,” was chosen in light of accumulating neurobiological evidence indicating that, in addition to exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP]), endogenous compounds may play an important role in the most common neurodegenerative disorders (e.g., Parkinson`s disease). Two groups of amine related compounds, which appeared chemically like MPTP, were detected in human brain and cerebrospinal fluid (CSF): ß-carbolines (BCs) and tetrahydroisoquinolines (TIQs). These are heterocyclic compounds formed endogenously from phenylalanine/tyrosine (TIQs) and tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively and exert a wide spectrum of psychopharmacological and behavioral effects. The TIQs and BCs may bind to their own high affinity sites on neuronal membranes associated with or located close to the receptors of neurotransmitters. Research on TIQs and BCs is stimulated also by their possible role in pathological conditions, especially parkinsonism and alcoholism. Recently, clinical interest has been spurred by their role as neuroprotective, and even neurorestorative, anticonvulsant and antiaddictive, substances. In this book we are going to summarize, for the first time, the results from behavioral, neurochemical and molecular experiments, which demonstrate a wide spectrum of TIQs and BCs effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties. Additionally, the recent results of experimental studies in vivo have allowed a much better understanding and simultaneous comparison of the neurochemical and molecular mechanisms underlying the neuroprotective and neurotoxic actions of endogenous TIQs and BCs and have pointed to the possibility of their therapeutic applications in neurodegenerative diseases such as Parkinson's disease.
Author : Alan A. Boulton
Publisher : Springer Science & Business Media
ISBN 13 : 1461250102
Total Pages : 508 pages
Book Rating : 4.4/5 (612 download)
Download or read book Neuropsychopharmacology of the Trace Amines written by Alan A. Boulton and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: A probable neurobiological role for the trace amines began to emerge as soon as techniques sufficiently sophisticated to detect them were developed. Techniques for quantitative analyses included radioenzymatic procedures and, more recently, HPlC-EC and auto mated GC-MS. The methods are applied after separation of the sub stances to be analyzed and after their purification by physicochemical procedures that are becoming more and more efficient. The identification and quantitative analysis of minute amounts of trace amines in biological fluids or tissues is in itself a remarkable technological achievement. The enormous task that several teams of research workers have set themselves is to investigate the origin of the trace amines, to understand their metabolism, and to discover whether or not they possess an important biological role. The 2nd Trace Amines Symposium at Weitenburg Castle near Tubingen from the 15th to the 19th May 1985 was held to gain a somewhat clearer insight into the present state of knowledge. Since the first meeting in 1983 our knowledge has increased and interest is deepening. Hence the idea proposed at that first meeting, of organizing similar gather ings at regular intervals, has come to fruition. Covered in the Neuropsychopharmacology section of this book are studiesof the effects of certain trace amines on different forms of be havior, on neurotransmission mediated by . the classical neuro transmitters, on their biosynthesis or on catabolism, on their possible occurrence as a result of alternative metabolic pathways for the amino acids, and in some instances their neuroanatomical distributions.
Author : Alan A. Boulton
Publisher : Springer Science & Business Media
ISBN 13 : 1461253128
Total Pages : 584 pages
Book Rating : 4.4/5 (612 download)
Download or read book Neurobiology of the Trace Amines written by Alan A. Boulton and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many of the trace amines-more correctly called biogenic amines have been known for decades, but because of their tiny concentra tions (0. 01-100 ng/g) in brain, it was only after the development of sophisticated analytical techniques (such as mass spectrometry) that they could be identified and quantitated in nervous tissue. There are now more than 20 of them and most are related to the catecholamines and 5-hydroxytryptamine both structurally and metabolically. Their pharmacological and physiological properties make them prime candidates for a transmitter or neuromodulator role and many of them elicit profound behavioral syndromes after injection--one of them, phenylethylamine, has even been referred to as nature's amphetamine. In the clinical sphere several have been shown to be involved in: Parkinsonism, schizophrenia, depression, agoraphobia, aggression, hyperkinesis, migraine, hypertensive crises, hypertyrosinemia, he patic encephalopathy, epilepsy, and cystic fibrosis. Thus the research reported here on these intriguing "new" substances will be of great interest to psychiatrists, neurologists, biochemists, pharmacologists, physiologists, psychologists, behaviorists and indeed to all those working in the neurosciences and related fields today. ACKNOWLEDGMENTS This book is based on the proceedings of Trace Amines and the Neurosciences, a meeting held at the University of Alberta, Edmonton, July 19-21, 1983. This meeting was organized as a Satellite Meeting of the Ninth Meeting of the International Society for Neurochemistry, held in Vancouver, July 10-15, 1983. International organizers of the satellite meeting were Drs. A.A. Boulton (Saskatoon), W.G. Dewhurst (Edmonton), G.B. Baker (Edmonton), and M. Sandler (London)
Author : World Federation of Neurology
Publisher :
ISBN 13 :
Total Pages : 906 pages
Book Rating : 4.E/5 ( download)
Download or read book Progress in Neuro-genetics written by World Federation of Neurology and published by . This book was released on 1969 with total page 906 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : André Barbeau
Publisher :
ISBN 13 :
Total Pages : 898 pages
Book Rating : 4.0/5 ( download)
Download or read book Progress in neuro-genetics written by André Barbeau and published by . This book was released on 1969 with total page 898 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Florencio Zaragoza Dörwald
Publisher : John Wiley & Sons
ISBN 13 : 3527645659
Total Pages : 627 pages
Book Rating : 4.5/5 (276 download)
Download or read book Lead Optimization for Medicinal Chemists written by Florencio Zaragoza Dörwald and published by John Wiley & Sons. This book was released on 2013-02-04 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small structural modifications can significantly affect the pharmacokinetic properties of drug candidates. This book, written by a medicinal chemist for medicinal chemists, is a comprehensive guide to the pharmacokinetic impact of functional groups, the pharmacokinetic optimization of drug leads, and an exhaustive collection of pharmacokinetic data, arranged according to the structure of the drug, not its target or indication. The historical origins of most drug classes and general aspects of modern drug discovery and development are also discussed. The index contains all the drug names and synonyms to facilitate the location of any drug or functional group in the book. This compact working guide provides a wealth of information on the ways small structural modifications affect the pharmacokinetic properties of organic compounds, and offers plentiful, fact-based inspiration for the development of new drugs. This book is mainly aimed at medicinal chemists, but may also be of interest to graduate students in chemical or pharmaceutical sciences, preparing themselves for a job in the pharmaceutical industry, and to healthcare professionals in need of pharmacokinetic data.
Author : Paul G. Pearson
Publisher : CRC Press
ISBN 13 : 1482262045
Total Pages : 755 pages
Book Rating : 4.4/5 (822 download)
Download or read book Handbook of Drug Metabolism, Third Edition written by Paul G. Pearson and published by CRC Press. This book was released on 2019-05-20 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.
Author : Bartley G. Hoebel
Publisher :
ISBN 13 :
Total Pages : 592 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Neural Basis of Feeding and Reward written by Bartley G. Hoebel and published by . This book was released on 1982 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jr. Ruffolo
Publisher : Springer Science & Business Media
ISBN 13 : 1461245826
Total Pages : 548 pages
Book Rating : 4.4/5 (612 download)
Download or read book The alpha-1 Adrenergic Receptors written by Jr. Ruffolo and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade, great strides have been made in our un derstanding of the biochemistry and pharmacology of the alpha-l adrenergic receptor. The alpha-l adrenergic receptor plays a key role in biological function. This is evidenced by the fact that the alpha-l adrenergic receptor plays a prominent functional role in most organs of the body and in the key systems responsible for survival of the organism and maintenance of optimum biological activity. This is most apparent in the cardiovascular system, in which alpha-l adrenergic receptors are the single most important receptor involved in the maintenance of blood pressure and circu latory function. It is appropriate, therefore, that recent findings related to the pharmacology and biochemistry of the alpha-l adrenergic receptor be compiled, since this subject has not been reviewed in detail in recent years. It is the purpose of this book to present a series of reviews of key experimental findings that shed new light on the alpha-l adrenergic receptor and the manner in which it functions. Classically, most receptors have been characterized based on structure-activity relationships obtained for selective agonists and antagonists interacting with the receptor. Although there are many newer and more sophisticated approaches to receptor char acterization, structure-activity relationships still provide impor tant information regarding the chemical requirements made by the receptor for its occupation by ligands and its subsequent acti vation by those ligands possessing intrinsic efficacy and, there fore, agonist activity.
Author : R.C.W. Hall
Publisher : Springer Science & Business Media
ISBN 13 : 9401167257
Total Pages : 344 pages
Book Rating : 4.4/5 (11 download)
Download or read book Handbook of Psychiatric Diagnostic Procedures Vol. I written by R.C.W. Hall and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Science of Psychiatry We live in exciting times. Psychiatrists practicing their specialty are beset as never before with news of developments in the field. The conduits of news to the practicing clinician are usually either stories written in the popular medical press such as news circulars and advertisements from commercial concerns, or from de tailed scientific articles written for the scientific community. In both forms, the news has been coming thick and fast. The problem encountered most often by practicing psychiatrists and clini cians responsible for hospital facilities is integrating this material into a coherent whole, with sufficient technical detail to permit the appropriate development or use of the new tests and procedures in the clinical setting. The two volumes comprising the Handbook of Psychiatric Diagnostic Pro cedures represent an attempt to provide a clinically useful review of the current accepted applicability of these tests and procedures, to enable the clinician to properly implement and evaluate the procedures as well as the results obtained.
Author :
Publisher :
ISBN 13 :
Total Pages : 940 pages
Book Rating : 4.1/5 (177 download)
Download or read book Proceedings written by and published by . This book was released on 1969 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : S.H. Parvez
Publisher : Elsevier
ISBN 13 : 1483290220
Total Pages : 436 pages
Book Rating : 4.4/5 (832 download)
Download or read book Methods in Neurotransmitter and Neuropeptide Research written by S.H. Parvez and published by Elsevier. This book was released on 2013-10-22 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-part book provides the most advanced biochemical and histochemical analytical methods on neurotransmitters, neuromodulators, and neuropeptides described by international specialists. The biochemical methods include liquid chromatography/electrochemistry, liquid chromatography/fluorescence and chemiluminescence detection, gas chromatography or liquid chromatography with mass spectrometry, and immunoassays. Morphological and physiological methods are also described, including immunohistochemistry, in situ hybridization, in vivo microdialysis, electrophysiological analysis, microwave irradiation, electrophysiological analysis, micro-anatomical dissection, peptide sequence analysis, quantitative autoradiographic analysis, and isolated CNS preparations. The neurotransmitters and neuropeptides include catecholamines, indoleamines, histamine, polyamines, and various neuropeptides, and their related enzymes. The book is the most comprehensive, advanced and versatile volume on the biochemical, morphological and physiological analysis of neurotransmitters and neuropeptides.
Author : Amitava Dasgupta
Publisher : Academic Press
ISBN 13 : 0128156082
Total Pages : 544 pages
Book Rating : 4.1/5 (281 download)
Download or read book Critical Issues in Alcohol and Drugs of Abuse Testing written by Amitava Dasgupta and published by Academic Press. This book was released on 2019-01-10 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Critical Issues in Alcohol and Drugs of Abuse Testing, Second Edition, addresses the general principles and technological advances for measuring drugs and alcohol, along with the pitfalls of drugs of abuse testing. Many designer drugs, for example, are not routinely tested in drugs of abuse panels and may go undetected in a drug test. This updated edition is a must-have for clinical pathologists, toxicologists, clinicians, and medical review officers and regulators, bridging the gap between technical and clinical information. Topics of note include the monitoring of pain management drugs, bath salts, spices (synthetic marijuana), designer drugs and date rape drugs, and more. - Serves as a ready resource of information for alcohol and drug testing - Ideal resource for making decisions related to the monitoring and interpretation of results - Includes concise content for clinical laboratory scientists, toxicologists and clinicians
Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642466257
Total Pages : 585 pages
Book Rating : 4.6/5 (424 download)
Download or read book Catecholamines I written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catecholamines are important transmitter substances in the autonomic and central nervous systems. These two volumes provide a comprehensive presentation of the state-of-the-art of catecholamine research and development in the past 15 years. The volumes present in-depth reviews of topical areas of catecholamine research in which substantial progress has been made and which are of current interest to various theoretical and clinical disciplines. Each topic has been dealt with by an established expert. Clinical subjects of relevant importance are included. Catecholamines are of interest in pharmacology, physiology, biochemistry, as well as in neurology, psychiatry, internal medicine (cardiology, hypertension, asthma), ophthalmology and anesthesiology.
Author :
Publisher :
ISBN 13 :
Total Pages : 906 pages
Book Rating : 4.3/5 (555 download)
Download or read book Proceedings of the 2nd International Congress of Neuro-genetics and Neuro-Ophthalmology of the World Federation of Neurology, Montreal, 17-22 September 1967: Progress in neuro-genetics written by and published by . This book was released on 1969 with total page 906 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Israel Hanin
Publisher : Raven Press (ID)
ISBN 13 :
Total Pages : 408 pages
Book Rating : 4.3/5 (91 download)
Download or read book Dynamics of Neurotransmitter Function written by Israel Hanin and published by Raven Press (ID). This book was released on 1984 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
