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Nk Cell Subsets In Health And Disease New Developments
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Book Synopsis NK Cell Subsets in Health and Disease: New Developments by : Emanuela Marcenaro
Download or read book NK Cell Subsets in Health and Disease: New Developments written by Emanuela Marcenaro and published by Frontiers Media SA. This book was released on 2017-11-29 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Killer (NK) cells were discovered ca 1975, as the first group of lymphoid cells that were neither T cells nor B cells. Since then, the dissection of the biology of NK cells has been growing exponentially with many seminal discoveries from the identification of MHC class I-specific inhibitory receptors to the discovery of receptor-ligand pairs involved in NK cell activation and to the manipulation of NK cells in cancer. In this research topic, we asked a group of thought leaders in NK cell biology to review recent advances in their origins and biology, and their roles in cancer, infection and inflammation. Together, these 25 articles provide a timely survey of NK cells as critical immunologic components of health and disease. They will hopefully prompt further dialogue and developments in basic and translational immunology.
Book Synopsis NK Cell Subsets in Health and Disease: New Developments by :
Download or read book NK Cell Subsets in Health and Disease: New Developments written by and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Killer (NK) cells were discovered ca 1975, as the first group of lymphoid cells that were neither T cells nor B cells. Since then, the dissection of the biology of NK cells has been growing exponentially with many seminal discoveries from the identification of MHC class I-specific inhibitory receptors to the discovery of receptor-ligand pairs involved in NK cell activation and to the manipulation of NK cells in cancer. In this research topic, we asked a group of thought leaders in NK cell biology to review recent advances in their origins and biology, and their roles in cancer, infection and inflammation. Together, these 25 articles provide a timely survey of NK cells as critical immunologic components of health and disease. They will hopefully prompt further dialogue and developments in basic and translational immunology.
Book Synopsis Natural Killer Cells by : Eric Vivier
Download or read book Natural Killer Cells written by Eric Vivier and published by Springer. This book was released on 2016-02-15 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: To celebrate the 40th anniversary of the discovery of Natural Killer (NK) cells, this volume focuses on the recent advances in our understanding of NK cell development and differentiation and their acquisition of functional properties, as well as the latest models for NK-cell analysis in mice and applications in clinical medicine. NK cells have travelled a circuitous path from their initial description as ‘spontaneous killers’ (for some simply an experimental artifact) to being a bona fide subset of innate lymphoid cells with a complementary mode of action in immune defense and an important mediator of immune reactivity in health and disease. Together, these reviews provide a timely and concise picture of the evolution of NK cells as essential agents in immunity and as potent weapons against disease. This book offers an appealing and insightful resource for scientists and clinicians.
Book Synopsis Molecular and Cellular Pathways in NK Cell Development by : Ewa Sitnicka
Download or read book Molecular and Cellular Pathways in NK Cell Development written by Ewa Sitnicka and published by Frontiers Media SA. This book was released on 2020-09-02 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis New Insights Into B cell Subsets in Health and Disease by : Judith Fraussen
Download or read book New Insights Into B cell Subsets in Health and Disease written by Judith Fraussen and published by Frontiers Media SA. This book was released on 2022-03-04 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Natural Killer Cells by : Jacques Zimmer
Download or read book Natural Killer Cells written by Jacques Zimmer and published by Springer Science & Business Media. This book was released on 2010-01-12 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural killer (NK) cells have been at the forefront of immunology for two decades. During that time, a great amount of information about these cells has been obtained. They are important in antiinfectious and antitumoral defense and shape the adaptive immune response. In addition, they can act as immunoregulatory cells. In recent years, the therapeutic potential of NK cells in cancer immunotherapy has become increasingly evident. This book describes in detail current knowledge about NK cells and covers a broad range of NK cell-related topics, including those that are not frequently reviewed, e.g. NK cells and allergy or NK cells and skin diseases.
Book Synopsis Natural Killer Cells in Tissue Compartments by : Massimo Vitale
Download or read book Natural Killer Cells in Tissue Compartments written by Massimo Vitale and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: N the last years, our knowledge of human NK cell biology has increased significantly. Several stimulating studies have provided the basis for understanding how NK cells can be "educated" to acquire immunological competence following maturation, or to adapt their function to the environmental changes of "self". New information has been acquired on their lifespan and on the persistence of memory-like NK cell subsets in response to certain viral infections. In addition, the identification and characterization of new markers and the development of more effective analytic approaches have led to the definition of various phenotypically and/or functionally-defined cell subsets. These advances have, in turn, enabled us to study NK cells beyond the peripheral blood, in different tissue compartments including the bone marrow, liver, lungs, skin, intestine and uterus. Recent data indicates that at least part of the tissue NK cell compartment consists of resident cells (which rarely recirculate) characterized by tissue-specific phenotypes and, in some cases, endowed with specialized functions related to the distinct organs in which they reside. These findings stimulate further questions (i) on the origins of these putative tissue-specific NK cell subsets; (ii) on their functional interplay with the local microenvironment; (iii) on their immunological competence and memory capacity and (iv) on their possible specific functional role in healthy and diseased tissues. In this context, the assessment of phenotype, function, maturation, education, differentiation and reprogramming of effector functions in tissue NK cells represents a new stimulating field of investigation that would help to get a more comprehensive picture of NK cell biology. In this Research Topic, we collect articles that highlight the recent advances in our understanding of tissue NK cells and that provide insight into opening new viewpoints on the role of NK cells in both health and disease.
Book Synopsis Natural Killer Cells: Methods and Protocols by : Srinivas S. Somanchi
Download or read book Natural Killer Cells: Methods and Protocols written by Srinivas S. Somanchi and published by Methods in Molecular Biology. This book was released on 2018-05-27 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New insights into innate immune cell-based immunotherapies in cancer by : Mary Poupot-Marsan
Download or read book New insights into innate immune cell-based immunotherapies in cancer written by Mary Poupot-Marsan and published by Frontiers Media SA. This book was released on 2024-04-17 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Primary and Secondary Immunodeficiency by : Jonathan A. Bernstein
Download or read book Primary and Secondary Immunodeficiency written by Jonathan A. Bernstein and published by Springer Nature. This book was released on 2021-01-28 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a broad clinical overview of primary and secondary immunodeficiencies nested in clinical cases that will help the reader understand the approach to evaluation, diagnosis, and management of these challenging cases. Chapters begin with a comprehensive overview of immunodeficiencies to ground the reader in practical knowledge of the field and these complex conditions. Chapters cover B lymphocyte immunodeficiency, T cell immunodeficiency, immune dysregulation syndromes, and innate immune defects. They discuss a range of treatment options including gene therapy or bone marrow transplant. The book continues with a discussion on secondary immunodeficiencies and their treatment. Each chapter was written by authors with expertise related to different immunodeficiency disorders and provide a succinct overview of pathomechanisms, diagnosis, and treatment of a specific condition. Primary and Secondary Immunodeficiency will be an excellent resource for practicing allergists, hematologists, clinical immunologists, fellows, residents, and other clinicians who work with immunodeficiency patients.
Book Synopsis Natural Killer Cells in Tissue Compartments by : Massimo Vitale
Download or read book Natural Killer Cells in Tissue Compartments written by Massimo Vitale and published by Frontiers Media SA. This book was released on 2020-03-24 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation by : Dominik Schneidawind
Download or read book Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation written by Dominik Schneidawind and published by Frontiers Media SA. This book was released on 2020-05-22 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Signaling Mechanisms Regulating T Cell Diversity and Function by : Jonathan Soboloff
Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Book Synopsis The RNA Revolution in Embryonic Development and Cell Differentiation in Health and Disease by : Francesco Fazi
Download or read book The RNA Revolution in Embryonic Development and Cell Differentiation in Health and Disease written by Francesco Fazi and published by Frontiers Media SA. This book was released on 2021-11-02 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis NK Cell-Based Cancer Immunotherapy by : Francisco Borrego
Download or read book NK Cell-Based Cancer Immunotherapy written by Francisco Borrego and published by Frontiers Media SA. This book was released on 2016-09-08 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expressed on target cells, such as the natural cytotoxicity receptors or NCRs (NKp30, NKp44 and NKp46), NKG2D, CD244 and DNAM-1. In addition, NK cells express Fc?RIIIA or CD16, the receptor that exerts antibody-dependent cell mediated cytotoxicity (ADCC). NK cells also express the death ligands FasL and TRAIL. The killing or sparing of target cells depends on the integration of distinct signals that originate from NK cell receptors. NK cells spare healthy cells that express normal levels of MHC class I molecules and low amounts of stress-induced self-molecules, whereas they kill target cells that down-regulate MHC class I molecules and/or up-regulate stress-induced self-molecules. The latter are common signatures of virus-infected cells and tumors. All the accumulated knowledge on NK cell biology, along with many clinical observations, is driving multiple efforts to improve the arsenal of NK cell-based therapeutic tools in the fight against malignant diseases. Indeed, NK cell-based immunotherapy is becoming a promising approach for the treatment of many cancers. It is well known that NK cells have a significant role in the anti-tumor effect of therapeutic antibodies that use ADCC as a mechanism of action. In addition to this, administration of autologous and allogeneic NK cells after activation and expansion ex vivo is used in the treatment of cancer. Moreover, adoptive transfer of NK cell lines has been tested in humans, and genetically modified NK cells expressing chimeric antigen receptors are being studied in preclinical models for potential use in the clinic.
Book Synopsis The Role of Immune Cells in Hepatic Ischemia Reperfusion by : Tao Qiu
Download or read book The Role of Immune Cells in Hepatic Ischemia Reperfusion written by Tao Qiu and published by Frontiers Media SA. This book was released on 2022-12-01 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Janeway's Immunobiology by : Kenneth Murphy
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
