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Nitric Oxide In Mammary Tumor Progression
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Book Synopsis Nitric Oxide in Mammary Tumor Progression by :
Download or read book Nitric Oxide in Mammary Tumor Progression written by and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric Oxide (NO) is a potent bioactive molecule produced in the presence of endothelial (e), neuronal (n) and inducible (i) types of NO synthase (NOS) enzymes. We discovered that IL-2 therapy-induced capillary leakage was due to iNOS induction followed by overproduction of NO and then peroxyhnitrite. We also found that tumor-derived NO promoted mammary tumor progression in C3H/HeJ mice. eNOS expression by tumor cells was positively correlated with metastasis in spontaneous C3H/HeJ mammary tumors and transplants of two clonal derivatives of a spontaneous tumor differing in metastatic phenotype: highly metastatic C3L5 and weakly metastatic C 10 cell lines. These cell lines also exhibited a parallel difference in invasiveness in vitro and growth rates as well as angiogenic abilities in vivo. A causal relationship between NO production by the tumor cells and invasive, migratory and angiogenic abilities was demonstrated. Invasion stimulation by NO resulted from an upregulation of MMP-2 and a downregulation of MMP inhibitors TIMP-2 and TIMP-3. Migration stimulation by NO resulted from activation of MAP- kinase pathway Thus NOS inhibitors should have a valuable therapeutic role for blocking multiple steps in mammary tumor growth and metastasis such as tumor cell migration, invasion and angiogenesis.
Book Synopsis Nitric Oxide in Mammary Tumor Progession by : Peeyush K. Lala
Download or read book Nitric Oxide in Mammary Tumor Progession written by Peeyush K. Lala and published by . This book was released on 1999 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric Oxide (NO) is a potent bioactive molecule produced in the presence of endothelial (e), neuronal (n) and inducible (i) types of NO synthases (NOS) enzymes. We have shown that NO was responsible for IL-2 therapy-induced capillary leakage because of iNOS induction in various tissues by IL-2 therapy. We also found that tumor-derived NO promoted mammary tumor progression in C3H/HeJ mice. eNOS expression by tumor cells was positively correlated with metastasis in spontaneous C3H/HeJ mammary tumors and transplants of two clonal derivatives of a spontaneous tumor differing in metastatic phenotype: highly metastatic C3L5 and weakly metastatic Cl0 cell lines. These cell lines also exhibited a parallel difference in invasiveness in vitro and growth rates as well as angiogenic abilities in vivo. A causal relationship between NO production by the tumor cells and invasive, migratory and angiogenic abilities was demonstrated. Invasion stimulation by NO was mediated by an upregulation of matrix degrading enzyme matrix metalloprotease (MMP)2 and a downregulation of MMP inhibitors TIMP-2 and TIMP-3. Thus tumor-derived NO promoted mammary tumor progression by stimulating tumor cell migration, invasiveness and angiogenesis, indicating a valuable therapeutic role of NOS inhibitors for blocking multiple steps in tumor growth and metastasis.
Book Synopsis Nitric Oxide (NO) and Cancer by : Benjamin Bonavida
Download or read book Nitric Oxide (NO) and Cancer written by Benjamin Bonavida and published by Springer Science & Business Media. This book was released on 2010-06-16 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.
Book Synopsis The Role of Nitric Oxide in Breast Cancer Tumor Growth and Angiogenesis by : Cameron Carlen
Download or read book The Role of Nitric Oxide in Breast Cancer Tumor Growth and Angiogenesis written by Cameron Carlen and published by . This book was released on 2000 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nitric Oxide in Health and Disease by : Lucia Morbidelli
Download or read book Nitric Oxide in Health and Disease written by Lucia Morbidelli and published by Elsevier. This book was released on 2023-04-13 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric Oxide in Health and Disease: Therapeutic Applications in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities. The book discusses many examples of research related to the application of novel therapeutic compounds that focus on a chemical—nitric oxide—and its applications that have been shown to exert significant therapeutic activities against various resistant cancers unresponsive to current treatments and different inflammatory diseases which continue to require novel treatments. This is a valuable resource for cancer researchers, oncologists, graduate students and researchers from medical and biomedical fields who want to know more about NO and its therapeutic applications in cancer and inflammatory diseases. Provides updated reviews on the chemistry and signaling of newly derived therapeutic nitric oxide (NO) donors/inhibitors and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities Discusses the application of NO in monotherapy or in combination with conventional therapies in a variety of cancers and inflammatory diseases Encompasses real-world examples of recent research related to NO and cancer
Book Synopsis The Stimulatory Effect of Nitric Oxide on Tumorigenesis and Metastasis in a Transgenic Breast Cancer Model by : Michele Charise Frilot
Download or read book The Stimulatory Effect of Nitric Oxide on Tumorigenesis and Metastasis in a Transgenic Breast Cancer Model written by Michele Charise Frilot and published by . This book was released on 1998 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nitric Oxide Synthase Expression and Murine Mammary Tumour Progression by :
Download or read book Nitric Oxide Synthase Expression and Murine Mammary Tumour Progression written by and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nitric Oxide and Cancer: Pathogenesis and Therapy by : Benjamin Bonavida
Download or read book Nitric Oxide and Cancer: Pathogenesis and Therapy written by Benjamin Bonavida and published by Springer. This book was released on 2015-05-12 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs. The volume explores nitric oxide and its relationship to cancer spanning from its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxics, and therapeutic applications. With chapters written by leading experts, the volume addresses the burgeoning interest in a rapidly advancing field and provides a valuable resource to scientists who have initiated research as well as clinical investigations in their laboratories on the various roles of NO and cancer.
Book Synopsis The Role of Nitric Oxide in Tumour Progression by : Lorraine C. Jadeski
Download or read book The Role of Nitric Oxide in Tumour Progression written by Lorraine C. Jadeski and published by . This book was released on 2003 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders by : Lucia Morbidelli
Download or read book Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders written by Lucia Morbidelli and published by Academic Press. This book was released on 2019-02-09 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research
Book Synopsis Nitric Oxide (Donor/Induced) in Chemosensitization by : Benjamin Bonavida
Download or read book Nitric Oxide (Donor/Induced) in Chemosensitization written by Benjamin Bonavida and published by Academic Press. This book was released on 2017-06-28 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric Oxide as a Chemosensitizing Agent, Volume One is the first book to describe several reviews by authoritative scientists and clinicians on novel findings in the reversal of drug resistant cancers by the combination treatment of Nitric Oxide and sub toxic concentrations of chemotherapeutic drugs that have been reported in both in vitro, in vivo and preclinical models. The book describes the various underlying chemical, molecular and genetic mechanisms by which NO and NO reactive species mediate the anti-cancer activity, thus reducing the threshold of drug resistance and enabling chemo therapeutic drugs to induce their cytotoxic activity and reversal of resistance. This book exposes scientists and clinicians to this highly beneficial topic for research investigations and pharmaceutical companies to new avenues for R&D. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use Nitric Oxide as a sensitizing agent for chemotherapy. Brings updated information as reviewed by experts in the field Presents expert analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches that can be used in reader investigations
Book Synopsis Nitric Oxide Synthase by : Seyed Soheil Saeedi Saravi
Download or read book Nitric Oxide Synthase written by Seyed Soheil Saeedi Saravi and published by BoD – Books on Demand. This book was released on 2017-05-17 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric Oxide Synthase - Simple Enzyme-Complex Roles provides information on nitric oxide synthase, a biomolecule of key importance for the different biological systems, including central and peripheral nervous, cardiovascular, and reproductive systems. With recent links to the role of nitric oxide in the reactions that can impact cell signaling, and discoveries surrounding the complex role of nitric oxide synthase that have increased research attention across the fields of cell and molecular biology, physiology, pharmacology, toxicology, neuroscience, cardiology, urology, and endocrinology, this book tries to provide a comprehensive overview of biology/pathobiology of nitric oxide synthases and a perspective from possible therapeutic indication of the enzyme inhibitors.
Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Book Synopsis The Low Dose Nitric Oxide Donor Inhibits Tumor Progression Through Immune Modulation by :
Download or read book The Low Dose Nitric Oxide Donor Inhibits Tumor Progression Through Immune Modulation written by and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Role of Endothelial Nitric Oxide Synthase in Breast Cancer by : Tupurani Mohini Aiyengar
Download or read book Role of Endothelial Nitric Oxide Synthase in Breast Cancer written by Tupurani Mohini Aiyengar and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer (BC) is the most common form of carcinoma and a primary cause of morbidity and mortality globally. Oxidative stress represents as an important factor in carcinogenesis and may play a role in initiation and progression of tumors. Oxidative stress-induced NO• damage to DNA includes a multitude of lesions, many of which are mutagenic and have multiple roles in cancer and aging. It is caused by an unfavorable balance between reactive oxygen species/reactive nitrogen species (ROS/RNS) and antioxidant defenses. ROS/RNS are generated during normal cellular metabolism, as a result of the influence of various environmental factors, as well as during pathological processes. Nitric oxide (NO•) is a ubiquitous, short-lived free radical produced from L-arginine by nitric oxide synthases (NOSs), and isoforms of NOS exist, depending on the site of origin: endothelial (eNOS), neuronal (nNOS), mitochondrial (mtNOS), and inducible (iNOS). eNOS is responsible for the endothelial synthesis of NO• and has shown to modulate cancer-related events such as inflammation, angiogenesis, apoptosis, cell cycle, invasion, and metastasis. Genetic studies also showed that eNOS gene polymorphisms are associated with the development of breast cancer. Therefore, selective targeting of eNOS may prove a potential strategy for prevention and treatment of breast cancer.
Book Synopsis The Role of Nitric Oxide Synthase Dysregulation in Tumor Maintenance by : Christopher S. Rabender
Download or read book The Role of Nitric Oxide Synthase Dysregulation in Tumor Maintenance written by Christopher S. Rabender and published by . This book was released on 2013 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inflammatory nature of the tumor microenvironment provides a cytokine and chemokine rich proliferative environment. Much of the responsibility of this environment is due to the production of Reactive Oxygen Species (ROS). These studies examined the proliferative rich tumor environment from a new perspective of Nitric Oxide Synthase (NOS) dysregulation. NOS's have the ability to become uncoupled and generate superoxide in lieu of nitric oxide (NO). A requirement of NOS for the production of NO is the cofactor tetrahydrobiopterin (BH4) and when it is missing NOS becomes uncoupled and turns into a peroxynitrite synthase. Here I demonstrate that NOS is uncoupled in tumor cells due to depleted BH4 levels. This uncoupling leads to decreased NO signaling and increased pro-inflammatory, pro-survival, signaling as a result of the increased generation of ROS/RNS from uncoupled NOS activity. I was able to recouple NOS through exogenous BH4 both in vitro and in vivo, reducing ROS/RNS and reestablishing NO signaling through cGMP protein associated kinase. Reduction of ROS/RNS resulted in the reduced activity of two major constitutively active transcription factors in breast cancer cells, NF[kappa]B and STAT3. In MCF-7 and MDA231 cells I found that increased NO-dependent PKG signaling led to tumor cell toxicity mediated by downregulation of [beta]-catenin. Downregulation of [beta]-catenin led to increased protein levels of p21 in MCF-7 and p27 in MDA 231cells, ultimately resulting in cell death. These results suggest that there is potential for BH4 as a therapeutic agent since exogenous dietary BH4 ameliorates chemically induced colitis, and reduced azoxymethane (AOM) induced colon and spontaneously developing mammary carcinogenesis.
Book Synopsis Tumor Vascularization by : Domenico Ribatti
Download or read book Tumor Vascularization written by Domenico Ribatti and published by Academic Press. This book was released on 2020-01-21 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment
