New Research On Pharmacogenetics

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New Research on Pharmacogenetics

Author : Linda P. Barnes
Publisher : Nova Publishers
ISBN 13 : 9781600210563
Total Pages : 636 pages
Book Rating : 4.2/5 (15 download)

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Book Synopsis New Research on Pharmacogenetics by : Linda P. Barnes

Download or read book New Research on Pharmacogenetics written by Linda P. Barnes and published by Nova Publishers. This book was released on 2007 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: The terms pharmacogenomics and pharmacogenetics tend to be used interchangeably, and a precise, consensus definition of either remains elusive. Pharmacogenetics is generally regarded as the study of genetic variation that gives rise to differing response to drugs, while pharmacogenomics is the broader application of genomic technologies to new drug discovery and further characterization of older drugs. Pharmacogenetics considers one or at most a few genes of interest, while pharmacogenomics considers the entire genome. Much of current clinical interest is at the level of pharmacogenetics, involving variation in genes involved in drug metabolism with a particular emphasis on improving drug safety. This new book presents leading-edge research in this dynamic field.

Pharmacogenomics

Author : Yui-Wing Francis Lam
Publisher : Academic Press
ISBN 13 : 0123983037
Total Pages : 515 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Pharmacogenomics by : Yui-Wing Francis Lam

Download or read book Pharmacogenomics written by Yui-Wing Francis Lam and published by Academic Press. This book was released on 2013-02-12 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference. Multi-contributed book and chapters are written by contributors who are experts in their field Provides perspectives from those involved in all aspects of pharmacogenomics—including academic, regulatory, economic, industry and medical—to illustrate how all of the pieces fit together and where the challenges may be Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

Principles of Pharmacogenetics and Pharmacogenomics

Author : Russ B. Altman
Publisher : Cambridge University Press
ISBN 13 : 1107377471
Total Pages : 283 pages
Book Rating : 4.1/5 (73 download)

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Book Synopsis Principles of Pharmacogenetics and Pharmacogenomics by : Russ B. Altman

Download or read book Principles of Pharmacogenetics and Pharmacogenomics written by Russ B. Altman and published by Cambridge University Press. This book was released on 2012-01-23 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. Recent progress in clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or less likely to respond to individual therapies. The aim is to improve personalised medicine - not simply to prescribe the right medicine, but to deliver the right drug at the right dose at the right time. This textbook brings together leading experts to discuss the latest information on how human genetics impacts drug response phenotypes. It presents not only the basic principles of pharmacogenetics, but also clinically valuable examples that cover a broad range of specialties and therapeutic areas. This textbook is an invaluable introduction to pharmacogenetics and pharmacogenomics for health care professionals, medical students, pharmacy students, graduate students and researchers in the biosciences.

Textbook of Personalized Medicine

Author : Kewal K. Jain
Publisher : Humana Press
ISBN 13 : 1493925539
Total Pages : 762 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Textbook of Personalized Medicine by : Kewal K. Jain

Download or read book Textbook of Personalized Medicine written by Kewal K. Jain and published by Humana Press. This book was released on 2015-03-17 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.

Big Data, Pharmacogenomics and Real-World Research in Pharmacology

Author : James Cheng-Chung Wei
Publisher : Frontiers Media SA
ISBN 13 : 2889660664
Total Pages : 165 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Big Data, Pharmacogenomics and Real-World Research in Pharmacology by : James Cheng-Chung Wei

Download or read book Big Data, Pharmacogenomics and Real-World Research in Pharmacology written by James Cheng-Chung Wei and published by Frontiers Media SA. This book was released on 2020-10-12 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Concepts in Pharmacogenomics

Author : Martin M. Zdanowicz
Publisher : ASHP
ISBN 13 : 1585282340
Total Pages : 425 pages
Book Rating : 4.5/5 (852 download)

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Book Synopsis Concepts in Pharmacogenomics by : Martin M. Zdanowicz

Download or read book Concepts in Pharmacogenomics written by Martin M. Zdanowicz and published by ASHP. This book was released on 2010 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new science of pharmacogenomics aims to understand how an individual's genetic composition affects his/her response to a specific drug or class of drugs. By studying such characteristics as drug metabolizing enzymes, drug transporter activity, and receptor sensitivity, a pharmacist is better able to prescribe the right drug the first time.If you are pharmacist, resident, or student curious about this new field, start withConcepts in Pharmacogenomics. In this practical guide, you will find an overview of the science behind pharmacogenomics, followed by detailed chapters related to its clinical application and implementation.Features include: case studies in each chapter clinical pearls illustrations of key concepts figures, diagrams, and flow charts for visual learners key points summarized.

Pharmacogenomics and Personalized Medicine

Author : Erika Cecchin
Publisher : MDPI
ISBN 13 : 3039367307
Total Pages : 208 pages
Book Rating : 4.0/5 (393 download)

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Book Synopsis Pharmacogenomics and Personalized Medicine by : Erika Cecchin

Download or read book Pharmacogenomics and Personalized Medicine written by Erika Cecchin and published by MDPI. This book was released on 2021-01-20 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics is one of the emerging approaches to precision medicine, tailoring drug selection and dosing to the patient’s genetic features. In recent years, several pharmacogenetic guidelines have been published by international scientific consortia, but the uptake in clinical practice is still poor. Many coordinated international efforts are ongoing in order to overcome the existing barriers to pharmacogenomic implementation. On the other hand, existing validated pharmacogenomic markers can explain only a minor part of the observed clinical variability in the therapeutic outcome. New investigational approaches are warranted, including a study of the pharmacogenomic role of the immune system genetics and of previously neglected rare genetic variants, reported to account for a large part of inter-individual variability in drug metabolism. In this book, we have collected a series of articles covering many aspects of pharmacogenomics. These include clinical implementation of pharmacogenomics in clinical practice, development of tools or infrastructures to support this process, research of new pharmacogenomics markers to increase drug efficacy and safety, and the impact of rare genetic variants in pharmacogenomics.

Pharmacogenomics

Author : Yui-Wing Francis Lam
Publisher : Academic Press
ISBN 13 : 0128126272
Total Pages : 444 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Pharmacogenomics by : Yui-Wing Francis Lam

Download or read book Pharmacogenomics written by Yui-Wing Francis Lam and published by Academic Press. This book was released on 2018-11-27 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation, Second Edition, provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of pharmacogenomics from academic, regulatory, pharmaceutical, socio-ethical and economic perspectives. While emphasis is on the limitations in moving the science into drug development and direct therapeutic applications, this book also focuses on clinical areas with successful applications and important initiatives that have the ability to further advance the discipline. New chapters cover important topics such as pharmacogenomic data technologies, clinical testing strategies, cost-effectiveness, and pharmacogenomic education and practice guidelines. The importance of ethnicity is also discussed, which highlights phar,acogenomic diversity across Latin American populations.With chapters written by interdisciplinary experts and insights into the future direction of the field, this book is an indispensable resource for academic and industry scientists, graduate students and clinicians engaged in pharmacogenomics research and therapeutic implementation. Provides viewpoints that focus on the scientific and translational challenges and opportunities associated with advancing the field of pharmacogenomics Highlights progress in both the research and clinical areas of pharmacogenomics, as well as relevant implementation experience, challenges, and perspectives on direct-to-consumer genetic testing Includes, where applicable, discussion points, review questions, and cases for self-assessment purposes and to facilitate in-depth discussion

Pharmacogenomics

Author : Julio Licinio
Publisher : John Wiley & Sons
ISBN 13 : 3527616306
Total Pages : 599 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Pharmacogenomics by : Julio Licinio

Download or read book Pharmacogenomics written by Julio Licinio and published by John Wiley & Sons. This book was released on 2009-07-30 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work represents the first comprehensive publication in the innovative field of pharmacogenomics, a field which is set to revolutionize pharmaceutical research. In addition to renowned editors, the list of contributors is a "who-is-who" in the field. Broad coverage of all aspects of pharmacogenomics with a full presentation of applications to disease conditions is featured. Anyone involved in pharmaceutical research and drug development needs this book to keep up with this new and revolutionary approach

Pharmacogenetics: Making cancer treatment safer and more effective

Author : William G. Newman
Publisher : Springer Science & Business Media
ISBN 13 : 9048186188
Total Pages : 190 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Pharmacogenetics: Making cancer treatment safer and more effective by : William G. Newman

Download or read book Pharmacogenetics: Making cancer treatment safer and more effective written by William G. Newman and published by Springer Science & Business Media. This book was released on 2010-07-20 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemotherapy has made a dramatic difference to improved survival in patients with cancer. However, not all patients respond and some experience serious side effects. "Pharmacogenetics: Making cancer treatment safer and more effective" is an up to date summary of the exciting new field of how genetic testing can tailor more effective prescription in oncology. It is targeted at oncologists and professionals involved in the treatment of patients with cancer. It provides a core background in genetics and pharmacological principles before providing chapters from acknowledged experts in the field on genetic tests in specific cancer types, including breast, bowel and lung cancer. Clinical cases are used to illustrate the practical application of this knowledge. Chapters on ethics, health economics and the industry aspects of pharmacogenetics set out the challenges and opportunities afforded by this new science.

Pharmacogenomics in Drug Discovery and Development

Author : Qing Yan
Publisher : Springer Nature
ISBN 13 : 107162573X
Total Pages : 618 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Pharmacogenomics in Drug Discovery and Development by : Qing Yan

Download or read book Pharmacogenomics in Drug Discovery and Development written by Qing Yan and published by Springer Nature. This book was released on 2022-09-06 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

Pharmacogenetics and Pharmacogenomics in Latin America: Ethnic Variability, New Insights in Advances and Perspectives: A RELIVAF-CYTED Initiative

Download Pharmacogenetics and Pharmacogenomics in Latin America: Ethnic Variability, New Insights in Advances and Perspectives: A RELIVAF-CYTED Initiative PDF Online Free

Author : Luis Abel Quiñones
Publisher : Frontiers Media SA
ISBN 13 : 2889744159
Total Pages : 165 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Pharmacogenetics and Pharmacogenomics in Latin America: Ethnic Variability, New Insights in Advances and Perspectives: A RELIVAF-CYTED Initiative by : Luis Abel Quiñones

Download or read book Pharmacogenetics and Pharmacogenomics in Latin America: Ethnic Variability, New Insights in Advances and Perspectives: A RELIVAF-CYTED Initiative written by Luis Abel Quiñones and published by Frontiers Media SA. This book was released on 2022-02-17 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biopharmaceutics and Pharmacokinetics Considerations

Author :
Publisher : Academic Press
ISBN 13 : 0128144262
Total Pages : 754 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Biopharmaceutics and Pharmacokinetics Considerations by :

Download or read book Biopharmaceutics and Pharmacokinetics Considerations written by and published by Academic Press. This book was released on 2021-07-07 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopharmaceutics and Pharmacokinetics Considerations examines the history of biopharmaceutics and pharmacokinetics. The book provides a biopharmaceutics and pharmacokinetics approach to addressing issues in formulation development and ethical considerations in handling animals. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biopharmaceutics and pharmacokinetics within drug discovery and drug development. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to study the chemical and physical properties of drugs and the biological effects they produce. Examines the most recent developments in biopharmaceutics and pharmacokinetics for pharmaceutical sciences Covers the principles, methodologies and technologies of biopharmaceutics and pharmacokinetics Focuses on the pharmaceutical sciences, but also encompasses aspects of toxicology, neuroscience, environmental sciences and nanotechnology

Encyclopedia of Pharmacy Practice and Clinical Pharmacy

Author :
Publisher : Academic Press
ISBN 13 : 0128127368
Total Pages : 2370 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Encyclopedia of Pharmacy Practice and Clinical Pharmacy by :

Download or read book Encyclopedia of Pharmacy Practice and Clinical Pharmacy written by and published by Academic Press. This book was released on 2019-06-28 with total page 2370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Pharmacy Practice and Clinical Pharmacy, Three Volume Set covers definitions, concepts, methods, theories and applications of clinical pharmacy and pharmacy practice. It highlights why and how this field has a significant impact on healthcare. The work brings baseline knowledge, along with the latest, most cutting-edge research. In addition, new treatments, algorithms, standard treatment guidelines, and pharmacotherapies regarding diseases and disorders are also covered. The book's main focus lies on the pharmacy practice side, covering pharmacy practice research, pharmacovigilance, pharmacoeconomics, social and administrative pharmacy, public health pharmacy, pharmaceutical systems research, the future of pharmacy, and new interventional models of pharmaceutical care. By providing concise expositions on a broad range of topics, this book is an excellent resource for those seeking information beyond their specific areas of expertise. This outstanding reference is essential for anyone involved in the study of pharmacy practice. Provides a ‘one-stop’ resource for access to information written by world-leading scholars in the field Meticulously organized, with articles split into three clear sections, it is the ideal resource for students, researchers and professionals to find relevant information Contains concise and accessible chapters that are ideal as an authoritative introduction for non-specialists and readers from the undergraduate level upwards Includes multimedia options, such as hyperlinked references and further readings, cross-references and videos

Pharmacogenomics An Introduction and Clinical Perspective

Author : Joseph S. Bertino
Publisher : McGraw Hill Professional
ISBN 13 : 0071813713
Total Pages : 289 pages
Book Rating : 4.0/5 (718 download)

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Book Synopsis Pharmacogenomics An Introduction and Clinical Perspective by : Joseph S. Bertino

Download or read book Pharmacogenomics An Introduction and Clinical Perspective written by Joseph S. Bertino and published by McGraw Hill Professional. This book was released on 2012-10-12 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: A COMPLETE INTRODUCTORY TEXT TO THE FIELD OF PHARMACOGENOMICS The only pharmacogenomics resource to feature a global author team comprised of PharmDs, MDs, PhDs and social scientists, Pharmacogenomics offers an essential, highly accessible survey of this dynamic discipline. You will find thorough coverage of all need-to-know topics, from individual molecules to systemic diseases, plus an examination of the latest technologies that are constantly reshaping the field. Pharmacogenomics is cohesively organized into two sections, the first of which reviews basic aspects of pharmacogenomics, including ethics, regulatory, science, and drug metabolism, along with a "mini" course in molecular genetics and testing. The second section highlights the practical application of pharmacogenomics in cardiovascular medicine, immunology, neurology, and other specialties. FEATURES Important overview of general pharmacogenomics and pharmacogenetics concepts, including genetic variation in signal transduction and targets, plus a review of the genetic concepts of pharmacogenomics Discussion of regulatory considerations in pharmacogenomics Focus on the role of health care professionals along with a review of related privacy issues, as well as broader ethical, legal, and social considerations In-depth chapters on drug metabolism and transporters Practical, step-by-step guidance on public access to pharmacogenomic testing and patient counseling Up-to-date coverage of non-genetic influences on pharmacogenomics Emphasis on gene-drug interactions Numerous tables and figures Chapter-ending references Concise learning objectives at the beginning of each chapter Case studies to familiarize you with the clinical relevance of pharmacogenomics in each specialty

Psychiatric Pharmacogenomics

Author : David Mrazek
Publisher : Oxford University Press
ISBN 13 : 0195367294
Total Pages : 276 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis Psychiatric Pharmacogenomics by : David Mrazek

Download or read book Psychiatric Pharmacogenomics written by David Mrazek and published by Oxford University Press. This book was released on 2010-06-10 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychiatric Pharmacogenomics is a book written to help clinicians to use pharmacogenomic testing to improve the pharmacotherapy that they provide for their patients. It is designed to teach clinicians how to order pharmacogenomic tests and interpret the results. Clinical examples are used to underscore the specific indications for pharmacogenomic testing and to clarify the clinical usefulness of identifying atypical genotypes that result in problematic responses to medication. The first section of the book begins with a basic review of molecular genetics. Additionally, the book also includes an extensive glossary of technical terms associated with molecular genetics and pharmacogenomics. The clinical utility of pharmacogenomic testing is demonstrated throughout the book by describing the implications of genetic variations for the care of individual patients. The second section of the book is organized into fourteen chapters that each focus on the clinical implications of testing for specific genes for which variants have been associated with either therapeutic response or side effects of psychotropic medications. Each of these chapters is structured in the same manner and involves a description of the gene and its significant variants. Each chapter also includes one or more clinical vignettes. The third section of the book discusses the clinical usefulness of pharmacogenomic testing, ethical issues associated with pharmacogenomic testing, and provides predictions for the future development of more sophisticated pharmacogenomic testing.

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response

Author : Federico Innocenti
Publisher : Springer Science & Business Media
ISBN 13 : 1603270884
Total Pages : 379 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response by : Federico Innocenti

Download or read book Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response written by Federico Innocenti and published by Springer Science & Business Media. This book was released on 2008-10-30 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response provides the most comprehensive body of knowledge available on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients. As a consequence of the intrinsic chromosomal and genetic instability of the tumor genome, it is generally believed that tailoring of chemotherapy in cancer - tients might be achieved by molecular analysis of patient tumor DNA. In addition, to reduce the toxicity risk of patients, the tumor DNA information should be in- grated with the available data on polymorphic drug-metabolizing enzyme and tra- porter genes mediating the exposure of patients to active drugs and/or their active metabolites. The chapters of this book clearly show how DNA information from both the host (germline) and the tumor should be taken into account for rational selection of drug therapies in cancer patients, an aspect that received little attention, despite its importance. The availability of new molecular approaches to the selection of drug therapy is an emerging need, because the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. Many treated patients do not experience signi?cant bene?ts from the treatment, while they often experience moderate to severe toxicities. In addition, the development and clinical use of novel molecularly targeted agents (alone or in combination with classical cytotoxic therapy) requires the und- standing of the molecular features of the tumors and the identi?cation of tumor markers of response.