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Download or read book New developments in the treatment of chronic rheumatoid arthritis written by and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lazaros Sakkas
Publisher : BoD – Books on Demand
ISBN 13 : 9535129694
Total Pages : 166 pages
Book Rating : 4.5/5 (351 download)
Download or read book New Developments in the Pathogenesis of Rheumatoid Arthritis written by Lazaros Sakkas and published by BoD – Books on Demand. This book was released on 2017-02-22 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA. MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.
Author : K. D. Rainsford
Publisher : Springer Science & Business Media
ISBN 13 : 9400912536
Total Pages : 331 pages
Book Rating : 4.4/5 (9 download)
Download or read book New Developments in Antirheumatic Therapy written by K. D. Rainsford and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: At present we may be at the cross-roads in the therapeutic approaches we have for the treatment of the 100 or more rheumatic conditions. This is be cause we now recognise that although some advances have been made with the development of a large range of non-steroidal and steroidal drugs during the past two decades or so, we now recognise that many, if not all, of these have rather limited effects on many of the disease processes which underlie the manifestations of the various rheumatic states. Advances in molecular bi- 010gy in the past 5-10 years have enabled these tools to be applied extensive ly for developing further our understanding of the rheumatic disease processes. In some cases these molecular tools (e. g. ,),-interferon, interleukin- 2, T-cell antibodies) have been directly employed as therapies themselves. While the outcome from trials with such agents in rheumatoid arthritis in particular has not been as would have been hoped, these results as with cy closporin A and low-dose methotrexate in the therapy of rheumatoid arth ritis have given us important indications for the approach employing what are generally described as "immunomodulators" to control this disease. But this may not be the same type of approach which is desirable for all types of rheumatic conditions. Indeed, even the way which the present range of drugs and other therapies are applied may not be the most effective and safe means of treating different types of arthritic conditions.
Author : Paul-Peter Tak
Publisher : Springer Science & Business Media
ISBN 13 : 3764382384
Total Pages : 233 pages
Book Rating : 4.7/5 (643 download)
Download or read book New Therapeutic Targets in Rheumatoid Arthritis written by Paul-Peter Tak and published by Springer Science & Business Media. This book was released on 2009-05-14 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on therapeutic targets that were identified after TNF blockade. All these targets have recently been registered or are currently under development for the treatment of rheumatoid arthritis. Each chapter explores the biological rationale of a distinct therapeutic target in great detail. Readers will discover the latest in vitro work, animal models, and results from clinical trials.
Author : David L. Scott
Publisher : Oxford University Press
ISBN 13 : 0192567101
Total Pages : 576 pages
Book Rating : 4.1/5 (925 download)
Download or read book Oxford Textbook of Rheumatoid Arthritis written by David L. Scott and published by Oxford University Press. This book was released on 2020-09-18 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brand new textbook of rheumatoid arthritis (RA) is an important addition to the Oxford Textbooks in Rheumatology series, and provides a comprehensive overview of both the scientific and clinical aspects of the disease. Divided into eight sections - from the history, diagnosis, and epidemiology of the disease, through the pathogenesis, clinical presentation, and assessment to treatments and management strategies, both drug- and non-drug based - each chapter is written by leading clinicians and scientists in the field to deliver a contemporary view of RA. During the past two decades there have been revolutionary changes in the understanding and management of rheumatoid arthritis, in particular the development of biological treatments. This has had wide-ranging effects on almost all aspects of treatment, from effectiveness and intensity to the nature and the cost. Providing a comprehensive account of the modern ideas about the disease, the Oxford Textbook of Rheumatoid Arthritis is a key new addition to the literature, with each chapter providing a detailed background, key recent advances, and areas of doubt and future developments. Featuring over 170 photographs, radiological images, and clinical charts to aid both diagnosis and illustrate the rationale behind key scientific studies, this new title will prove an indispensable resource for specialist rheumatologists, trainees in rheumatology, and other members of the multi-disciplinary team.
Author : John J. Cush
Publisher :
ISBN 13 : 1932610286
Total Pages : 368 pages
Book Rating : 4.9/5 (326 download)
Download or read book Rheumatoid Arthritis written by John J. Cush and published by . This book was released on 2008-01-01 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizes the importance of early intervention in RA with focus on pharmacologic treatment of RA. Detailed information on the various medications employed in treatment, including corticosteroids, NSAIDs DMARDs, biologic agents, and combination therapy is reviewed, including evidence based data on efficacy, safety, side effects, and monitoring requirements. Clinical evaluation is presented, including lab findings, joint scoring, diagnostic criteria, and radiographic outcomes. Surgical options and the management of advanced RA are disussed.
Author : John D. Isaacs
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 1905832915
Total Pages : 118 pages
Book Rating : 4.9/5 (58 download)
Download or read book Fast Facts: Rheumatoid Arthritis written by John D. Isaacs and published by Karger Medical and Scientific Publishers. This book was released on 2011-05-01 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly updated second edition of 'Fast Facts: Rheumatoid Arthritis' provides an easy-to-read overview of how the condition is thought to develop and how it is diagnosed, monitored and treated. Written by two leading UK and US rheumatologists, it covers the many recent developments in this field, including: • Recently published classification criteria • The emerging role of anti-CCP autoantibodies • The latest developments in ultrasound and MRI • The association between RA and cardiovascular disease and lung disease • New concepts of undifferentiated arthritis and treatment to remission • The importance of early referral and new biological therapies 'Fast Facts: Rheumatoid Arthritis' provides a well-referenced international perspective on this condition. It is a 'must read' for all healthcare professionals caring for patients with this debilitating inflammatory joint disease. Contents: • The normal joint • Etiology • Pathogenesis • Epidemiology • Clinical features • Investigation • Assessment • Management - traditional measures • Management - biological therapies • Therapeutic developments
Author : Hubert Baumgartner
Publisher : Thieme Medical Publishers
ISBN 13 :
Total Pages : 306 pages
Book Rating : 4.3/5 (91 download)
Download or read book Rheumatoid Arthritis written by Hubert Baumgartner and published by Thieme Medical Publishers. This book was released on 1995 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work covers the latest developments in diagnosis & treatment of this widespread disease. It integrates the knowledge & experience of renowned rheumatologists, neurologists, neurosurgeons, orthopedic surgeons & physical therapists.
Author :
Publisher :
ISBN 13 : 9789535129707
Total Pages : pages
Book Rating : 4.1/5 (297 download)
Download or read book New Developments in the Pathogenesis of Rheumatoid Arthritis written by and published by . This book was released on 19?? with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : George C. Tsokos
Publisher : Springer Science & Business Media
ISBN 13 : 1592592392
Total Pages : 648 pages
Book Rating : 4.5/5 (925 download)
Download or read book Modern Therapeutics in Rheumatic Diseases written by George C. Tsokos and published by Springer Science & Business Media. This book was released on 2001-11-08 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309174988
Total Pages : 472 pages
Book Rating : 4.3/5 (91 download)
Download or read book Vaccines for the 21st Century written by Institute of Medicine and published by National Academies Press. This book was released on 2001-02-21 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccines have made it possible to eradicate the scourge of smallpox, promise the same for polio, and have profoundly reduced the threat posed by other diseases such as whooping cough, measles, and meningitis. What is next? There are many pathogens, autoimmune diseases, and cancers that may be promising targets for vaccine research and development. This volume provides an analytic framework and quantitative model for evaluating disease conditions that can be applied by those setting priorities for vaccine development over the coming decades. The committee describes an approach for comparing potential new vaccines based on their impact on morbidity and mortality and on the costs of both health care and vaccine development. The book examines: Lessons to be learned from the polio experience. Scientific advances that set the stage for new vaccines. Factors that affect how vaccines are used in the population. Value judgments and ethical questions raised by comparison of health needs and benefits. The committee provides a way to compare different forms of illness and set vaccine priorities without assigning a monetary value to lives. Their recommendations will be important to anyone involved in science policy and public health planning: policymakers, regulators, health care providers, vaccine manufacturers, and researchers.
Author : Paul Emery
Publisher :
ISBN 13 : 9781416027676
Total Pages : 0 pages
Book Rating : 4.0/5 (276 download)
Download or read book Early Rheumatoid Arthritis written by Paul Emery and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue covers the latest developments in the understanding of rheumatoid arthritis at the early stage. Treatments such as with newer biologic agents and conventional disease-modifying antirheumatic drugs are reviewed. Also included are articles on imaging modalities as a means of identifying those in the early stages and monitoring response to treatment.
Author : Henry Scammell
Publisher : Rowman & Littlefield
ISBN 13 : 0871318431
Total Pages : 331 pages
Book Rating : 4.8/5 (713 download)
Download or read book The New Arthritis Breakthrough written by Henry Scammell and published by Rowman & Littlefield. This book was released on 1998 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines the minocycline in rheumatoid arthritis clinical trials in dramatic detail.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309175070
Total Pages : 252 pages
Book Rating : 4.3/5 (91 download)
Download or read book Changing Health Care Systems and Rheumatic Disease written by Institute of Medicine and published by National Academies Press. This book was released on 1997-01-09 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Market forces are driving a radical restructuring of health care delivery in the United States. At the same time, more and more people are living comparatively long lives with a variety of severe chronic health conditions. Many such people are concerned about the trend toward the creation of managed care systems because their need for frequent, often complex, medical services conflicts with managed care's desires to contain costs. The fear is that people with serious chronic disorders will be excluded from or underserved by the integrated health care delivery networks now emerging. Responding to a request from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, this book reflects the results of a workshop that focused on the following questions: Does the model of managed care or an integrated delivery system influence the types of interventions provided to patients with chronic conditions and the clinical and health status outcomes resulting from those interventions? If so, are these effects quantitatively and clinically significant, as compared to the effects that other variables (e.g., income, education, ethnicity) have on patient outcomes? If the type of health care delivery system appears to be related to patient care and outcomes, can specific organizational, financial, or other variables be identified that account for the relationships? If not, what type of research should be pursued to provide the information needed about the relationship between types of health care systems and the processes and outcomes of care provided to people with serious chronic conditions?
Author : John H. Stone
Publisher : Springer Science & Business Media
ISBN 13 : 1848009348
Total Pages : 489 pages
Book Rating : 4.8/5 (48 download)
Download or read book A Clinician's Pearls & Myths in Rheumatology written by John H. Stone and published by Springer Science & Business Media. This book was released on 2009-10-03 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: Important strides have been made in understanding the pathophysiologic basis of many inflammatory conditions in recent years, but rheumatology remains a discipline in which diagnosis is rooted in the medical history skillfully extracted from the patient, the careful physical examination, and the discriminating use of laboratory tests and imaging. Moreover, selection of the most appropriate therapy for patients with rheumatic diseases also remains heavily reliant upon clinical experience. Medical disciplines such as rheumatology that depend significantly upon clinical wisdom are prone to the development of systems of ‘Pearls’ and ‘Myths,’ related to the diseases they call their own, a ‘Pearl’ being a nugget of truth about the diagnosis or treatment of a particular disease that has been gained by dint of clinical experience and a ‘Myth’ being a commonly held belief that influences the practice of many clinicians – but is false. This book will pool together the clinical wisdom of seasoned, expert rheumatologists who participate in the care of patients with autoimmune diseases, systemic inflammatory disorders, and all other rheumatic conditions.
Author : Cheryl Koehn
Publisher : Oxford University Press, USA
ISBN 13 : 0195130561
Total Pages : 284 pages
Book Rating : 4.1/5 (951 download)
Download or read book Rheumatoid Arthritis written by Cheryl Koehn and published by Oxford University Press, USA. This book was released on 2002 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest therapies and medications, diet and exercise, controlling pain, building a health care team, finding support and much more.
Author : Fabia Nathalie Doll
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (896 download)
Download or read book Development of Therapeutic Proteins for the Treatment of Rheumatoid Arthritis and Chronic Cardiac Rejection written by Fabia Nathalie Doll and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
