New Developments In Alternative Splicing Research

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New Developments in Alternative Splicing Research

Author : Samuel DiMaggio
Publisher : Nova Science Publishers
ISBN 13 : 9781628087208
Total Pages : 0 pages
Book Rating : 4.0/5 (872 download)

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Book Synopsis New Developments in Alternative Splicing Research by : Samuel DiMaggio

Download or read book New Developments in Alternative Splicing Research written by Samuel DiMaggio and published by Nova Science Publishers. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alternative splicing occurs in most human genes and contributes to protein diversity by producing multiple mRNAs from each gene. In this book, the authors present new developments in alternative splicing research. Topics discussed include alternative splicing alterations in Alzheimer's disease; plant RNA-binding proteins implicate mRNA processing in abscisic acid (ABA) responses; comprehensive analyses of alternative exons in neuronally differentiated P19 cells; an epigenetic view on alternative splicing; identification of genuine alternative splicing variants for rare or long-sized transcripts; alternative RNA splicing and regulation of nitric oxide signalling; alternative splicing by analysing human mRNA diversity using data of FLJ human cDNAs; alternative splicing in human immune systems and auto-immune diseases; and poly (ADP-Ribosyl)ation regulation in alternative splicing.

New Developments in Robotics Research

Author : John X. Liu
Publisher : Nova Publishers
ISBN 13 : 9781594545931
Total Pages : 270 pages
Book Rating : 4.5/5 (459 download)

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Book Synopsis New Developments in Robotics Research by : John X. Liu

Download or read book New Developments in Robotics Research written by John X. Liu and published by Nova Publishers. This book was released on 2005 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Robotics began as a science fiction creation which has become quite real, first in assembly line operations such as automobile manufacturing, aeroplane construction etc. They have now reached such areas as the Internet, ever-multiplying-medical uses and sophisticated military applications. Control of today's robots is often remote which requires even more advanced computer vision capabilities as well as sensors and interface techniques. Learning has become crucial for modern robotic systems as well. This new book brings together leading research in this exciting field.

Alternative Splicing in Brain Function

Author : Kif Liakath-Ali
Publisher : Frontiers Media SA
ISBN 13 : 2832540732
Total Pages : 171 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Alternative Splicing in Brain Function by : Kif Liakath-Ali

Download or read book Alternative Splicing in Brain Function written by Kif Liakath-Ali and published by Frontiers Media SA. This book was released on 2023-12-13 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional and structural intricacies of biological systems emerge from the complex nature of the genome. A key aspect of genome complexity can be attributed to the process of alternative splicing of precursor mRNA (or pre-mRNA), during which introns are removed and exons are selectively spliced together. This highly regulated process generates different mature mRNA transcripts from a single gene and is widespread throughout the eukaryotic evolution. The majority of the genes expressed in the mammalian central nervous system undergo extensive alternative splicing. Some genes can generate more than a thousand isoforms resulting in diverse proteoforms that can differ in their function, binding preference, catalytic activity, and localization. Perturbation in alternative splicing has been linked to many neurological disorders. Despite its significance, we still lack a comprehensive understanding of its role in neuronal function. Recent studies suggest that alternative splicing is a regulator of tissue identity and development. This is particularly relevant to the brain where developmental regulation and heterogenous cell population play a crucial role in shaping its function. For a long time, technological limitations in detecting and measuring alternatively spliced transcripts hindered the progress in understanding the biology of alternative splicing. Recent advances in long-read and native mRNA sequencing and robust computational tools allow us to capture and quantify in their full-length form. Public transcriptomics datasets can be utilized for the meta-analysis of alternative splicing landscapes of various experimental conditions and disease samples. In addition, protein isoform detection complements mRNA isoform levels. Given its biological significance and recent advances, the objective of this Research Topic is to assemble current knowledge, views, and challenges in the studies of alternative splicing in brain function.

RNA Splicing and Backsplicing: Disease and Therapy

Author : Rosanna Asselta
Publisher : Frontiers Media SA
ISBN 13 : 2889662357
Total Pages : 197 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis RNA Splicing and Backsplicing: Disease and Therapy by : Rosanna Asselta

Download or read book RNA Splicing and Backsplicing: Disease and Therapy written by Rosanna Asselta and published by Frontiers Media SA. This book was released on 2020-12-24 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Alternative Splicing Regulation in Plants

Author : Ezequiel Petrillo
Publisher : Frontiers Media SA
ISBN 13 : 2889639746
Total Pages : 175 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Alternative Splicing Regulation in Plants by : Ezequiel Petrillo

Download or read book Alternative Splicing Regulation in Plants written by Ezequiel Petrillo and published by Frontiers Media SA. This book was released on 2020-09-02 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Alternative Splicing and Disease

Author : Philippe Jeanteur
Publisher : Springer Science & Business Media
ISBN 13 : 3540344497
Total Pages : 265 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Alternative Splicing and Disease by : Philippe Jeanteur

Download or read book Alternative Splicing and Disease written by Philippe Jeanteur and published by Springer Science & Business Media. This book was released on 2006-10-04 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. This is the first book to highlight the medical implications, i.e. diseases, caused by alternative splicing. Alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences. The book also outlines possible targets for therapy.

New Developments in Metastasis Suppressor Research

Author : Paul Jackson
Publisher : Nova Publishers
ISBN 13 : 9781600216039
Total Pages : 340 pages
Book Rating : 4.2/5 (16 download)

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Book Synopsis New Developments in Metastasis Suppressor Research by : Paul Jackson

Download or read book New Developments in Metastasis Suppressor Research written by Paul Jackson and published by Nova Publishers. This book was released on 2007 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: The spread of cancer cells from their organ of origin to distant tissues is called metastasis. Cancer metastasis is the main cause of death from cancer, and in many cases is difficult to detect or treat. The process by which tumour cells become metastatic is complex and involves many stages, including detachment of cells from the main tumour mass, degradation of the surrounding extra-cellular matrix, invasion into nearby blood vessels, travel and survival through the circulatory system, attachment to a vessel wall, extra-vasation, degradation of the extra-cellular matrix into a distant tissue/organ, and the development of a novel blood supply. In order to accomplish this process, the cells acquire characteristics which are important for each stage. Recently, a class of genes known as metastasis suppressors' has been the subject of intense investigation. For some metastasis suppressor genes, there is strong evidence from both in vitro and in vivo studies to demonstrate key roles in the metastatic process, for others data is much more limited, and their importance uncertain. In this book, chapters are devoted to providing up-to-date summaries of our understanding of individual metastasis suppressor genes. Each is written by a leading authority in the study of that gene. Topics covered include discussions on how each metastasis suppressor was discovered, the mechanisms underlying their loss of expression in tumours and tumour cell lines, their proposed molecular functions, and the consequences to a tumour cell of the loss of this function. This compilation aims to provide, in a single volume, comprehensive information that will be valuable to all scientists working in cancer research, to students needing to understand molecular events that regulate tumour progression and the acquisition of metastasis, and to clinicians who might wish to know more of the roles of potentially new markers for cancer diagnosis and prognosis.

New Developments in Epstein-Barr Virus Research

Author : Constantine S. Umar
Publisher : Nova Publishers
ISBN 13 : 9781594548604
Total Pages : 332 pages
Book Rating : 4.5/5 (486 download)

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Book Synopsis New Developments in Epstein-Barr Virus Research by : Constantine S. Umar

Download or read book New Developments in Epstein-Barr Virus Research written by Constantine S. Umar and published by Nova Publishers. This book was released on 2006 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epstein-Barr virus, frequently referred to as EBV, is a member of the herpes virus family and one of the most common human viruses. The virus occurs world-wide, and most people become infected with EBV sometime during their lives. In the United States, as many as 95 per cent of adults between 35 and 40 years of age have been infected. Infants become susceptible to EBV as soon as maternal antibody protection (present at birth) disappears. Many children become infected with EBV, and these infections usually cause no symptoms or are indistinguishable from the other mild, brief illnesses of childhood. In the United States and in other developed countries, many persons are not infected with EBV in their childhood years. When infection with EBV occurs during adolescence or young adulthood, it causes infectious mononucleosis 35 per cent to 50 per cent of the time. EBV also establishes a lifelong dormant infection in some cells of the body's immune system. A late event in a very few carriers of this virus is the emergence of Burkitt's lymphoma and nasopharyngeal carcinoma. This new book presents leading research from around the world in this field.

Global Analyses of Alternative Splicing in Evolution and Nervous System Development

Author : John Anthony Calarco
Publisher :
ISBN 13 : 9780494781418
Total Pages : 460 pages
Book Rating : 4.7/5 (814 download)

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Book Synopsis Global Analyses of Alternative Splicing in Evolution and Nervous System Development by : John Anthony Calarco

Download or read book Global Analyses of Alternative Splicing in Evolution and Nervous System Development written by John Anthony Calarco and published by . This book was released on 2011 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological advancements have sparked discovery in biology, enabling important questions to be addressed experimentally at unprecedented depth and scale. One such advance, the development of large-scale approaches to study gene expression, has transformed the way we view the transcriptome. In recent years, these approaches have been applied to studies of alternative RNA splicing, a process where multiple distinct messenger RNAs can be generated from precursor transcripts to produce extensive transcriptomic diversity from a limited repertoire of genes. Global analyses have not only reinforced models initially based on single gene studies, they have also led to numerous insights into general principles governing the regulation and evolution of alternative splicing. In this thesis, I describe how I have combined both large-scale and focused approaches to study alternative splicing regulation during development and in an evolutionary context. Using microarray profiling and comparative genomics approaches, I describe the first large-scale comparative analysis of alternative splicing patterns between humans and chimpanzees. Next, I describe the discovery of a novel neural-specific RS domain splicing factor and the network of alternative exons it regulates to promote nervous system development in vertebrates. Finally, I describe the profiling of alternative splicing patterns during C. elegans development using splicing microarrays and high-throughput sequencing. In this latter study, I also describe two resources that facilitate the analysis of tissue- or cell type-specific splicing events, and enable the function of isoforms to be assessed in vivo . Collectively, these studies have shed light on how differential regulation of alternative splicing has contributed to the evolution of complexity and diversity in biological systems.

Transcription and Splicing

Author : B. D. Hames
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 238 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Transcription and Splicing by : B. D. Hames

Download or read book Transcription and Splicing written by B. D. Hames and published by Oxford University Press, USA. This book was released on 1988 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a co-ordinated review of our present knowledge of eukaryotic RNA synthesis.

Tropomyosin

Author : Peter Gunning
Publisher : Springer Science & Business Media
ISBN 13 : 0387857664
Total Pages : 323 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Tropomyosin by : Peter Gunning

Download or read book Tropomyosin written by Peter Gunning and published by Springer Science & Business Media. This book was released on 2009-09-30 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: A recent review of one of my grant applications commented on the ‘rediscovery of tropomyosin’. I was tempted to write back in my rebuttal to the reviewer that I didn’t realise it had been lost. Uncharacteristic maturity prevailed and I resisted the temptation, but I was struck by the underlying observation that research on the str- ture and function of tropomyosin has been somewhat invisible, particularly in terms of the cytoskeleton isoforms. So, how can it be that one of the two major components of the actin filament has been so thoroughly overlooked? I suspect that the answer is disappointingly pedestrian. Whereas the biochemistry of the 1980s revealed the potential of tropomyosin isoforms to diversify the function of actin filaments, the subsequent disenchantment with isoform biology in general in the 1990s inhibited growth of this field. With the development of more sophisticated experimental - proaches we are now seeing a growing realisation of the importance of tropomyosin in regulating actin filaments beyond its pivotal role in muscle contraction. The opportunity to edit this book came at a time when we had written several reviews on different aspects of tropomyosin function and I had just finished the background reading for a comprehensive review of tropomyosin biology. I realised that the field was simply beyond the capacity of any one person to do the field j- tice.

Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension

Author : Toshio Nakanishi
Publisher : Springer Nature
ISBN 13 : 9811511853
Total Pages : 374 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension by : Toshio Nakanishi

Download or read book Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension written by Toshio Nakanishi and published by Springer Nature. This book was released on 2020-02-28 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.

Alternative Splicing in the Postgenomic Era

Author : Benjamin J. Blencowe
Publisher : Springer Science & Business Media
ISBN 13 : 9780387773735
Total Pages : 260 pages
Book Rating : 4.7/5 (737 download)

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Book Synopsis Alternative Splicing in the Postgenomic Era by : Benjamin J. Blencowe

Download or read book Alternative Splicing in the Postgenomic Era written by Benjamin J. Blencowe and published by Springer Science & Business Media. This book was released on 2008-01-23 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Yet again Springer has reached the market before everyone. This is the first book that is solely dedicated to the topic of alternative splicing. The book contains chapters by experts in the field that cover nearly all aspects of this hugely important subject. The purpose of the text is to provide a single, authoritative source of information on alternative splicing that is accessible to researchers in diverse fields. It is suitable for beginners and experts alike.

Regulation of Alternative Splicing

Author : Philippe Jeanteur
Publisher :
ISBN 13 : 9783662097298
Total Pages : 266 pages
Book Rating : 4.0/5 (972 download)

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Book Synopsis Regulation of Alternative Splicing by : Philippe Jeanteur

Download or read book Regulation of Alternative Splicing written by Philippe Jeanteur and published by . This book was released on 2014-01-15 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Bioinformatics in the Era of Post Genomics and Big Data

Author : Ibrokhim Y. Abdurakhmonov
Publisher : BoD – Books on Demand
ISBN 13 : 1789232686
Total Pages : 190 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Bioinformatics in the Era of Post Genomics and Big Data by : Ibrokhim Y. Abdurakhmonov

Download or read book Bioinformatics in the Era of Post Genomics and Big Data written by Ibrokhim Y. Abdurakhmonov and published by BoD – Books on Demand. This book was released on 2018-06-20 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinformatics has evolved significantly in the era of post genomics and big data. Huge advancements were made toward storing, handling, mining, comparing, extracting, clustering and analysis as well as visualization of big macromolecular data using novel computational approaches, machine and deep learning methods, and web-based server tools. There are extensively ongoing world-wide efforts to build the resources for regional hosting, organized and structured access and improving the pre-existing bioinformatics tools to efficiently and meaningfully analyze day-to-day increasing big data. This book intends to provide the reader with updates and progress on genomic data analysis, data modeling and network-based system tools.

The Human Hypothalamus

Author : Dick F. Swaab
Publisher : Elsevier
ISBN 13 : 0128199741
Total Pages : 520 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Human Hypothalamus by : Dick F. Swaab

Download or read book The Human Hypothalamus written by Dick F. Swaab and published by Elsevier. This book was released on 2021-07-07 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer’s, Parkinson’s, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more. Summarizes research on how the hypothalamus relates to neurological disorders Contains neuropsychiatric, neurodegenerative, periodic and autonomic disorders Includes the neurobiology of, and treatment for, each disorder Covers depression, anxiety, OCD, PTSD, schizophrenia, autism, aggression, addiction, and more Provides coverage of sleep and pain

Armadillo Domain Proteins: Advances in Research and Application: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464930481
Total Pages : 157 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Armadillo Domain Proteins: Advances in Research and Application: 2011 Edition by :

Download or read book Armadillo Domain Proteins: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Armadillo Domain Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Armadillo Domain Proteins. The editors have built Armadillo Domain Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Armadillo Domain Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Armadillo Domain Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.