New Advances In Histamine Research

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New Advances in Histamine Research

Author : Kenji Tasaka
Publisher : Springer Science & Business Media
ISBN 13 : 4431682635
Total Pages : 341 pages
Book Rating : 4.4/5 (316 download)

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Book Synopsis New Advances in Histamine Research by : Kenji Tasaka

Download or read book New Advances in Histamine Research written by Kenji Tasaka and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent research has given great insight into the physiological and pharmaceutical effects of histamine on the central nervous system and especially on the brain. This volume focuses on these many new findings, including the role of brain histamine in the arousal system, learning, and memory. Also featured are the mechanisms of histamine release in bone marrow and mast cells and the role of histamine in neutrophil differentiation. These are analyzed using the most up-to-date techniques of molecular pharmacology and refined immunoelectroscopy. In addition, the pharmacological profiles of newly developed H1 antagonists are described, making this book invaluable to those who want to understand the very latest advances in histamine research.

Histamine in the brain

Author : Jian-Sheng Lin
Publisher : Frontiers Media SA
ISBN 13 : 2889194345
Total Pages : 100 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Histamine in the brain by : Jian-Sheng Lin

Download or read book Histamine in the brain written by Jian-Sheng Lin and published by Frontiers Media SA. This book was released on 2015-03-18 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.

Biomedical Aspects of Histamine

Author : Nancy Khardori
Publisher : Springer Science & Business Media
ISBN 13 : 9048193494
Total Pages : 451 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Biomedical Aspects of Histamine by : Nancy Khardori

Download or read book Biomedical Aspects of Histamine written by Nancy Khardori and published by Springer Science & Business Media. This book was released on 2010-09-30 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its identification by Sir Henry H. Dale a century ago, histamine has become one of the most important multifunctional biogenic amines in the field of biomedicine. The pharmacological effects of histamine are mediated through four types of membrane histamine receptors; H1R, H2R, H3R and H4R, which are all heptahelical G-protein-coupled receptors. It has been known to play the broadest spectrum of activities in various physiological and pathological conditions including cell proliferation, differentiation, hematopoiesis, embryonic development, regeneration, wound healing, aminergic neurotransmission and numerous brain functions, secretion of pituitary hormones, regulation of gastrointestinal and circulatory functions, cardiovascular system, as well as inflammatory reactions, modulation of the immune response, endocrine function and homeostasis, and other important areas. This book is a compendium of the current state of established and investigational literature on Histamine, its receptors and their Agonists and antagonists. It provides a comprehensive overview of histamine biology in the field of biochemistry, cell biology, molecular biology, immunology, allergy, neurobiology, pharmacology, microbiology and reproductive biology. The first section on Histamine biology and physiology leads into subsequent sections on enzymology, pharmacology, regulation of the immune system and cell proliferation and role in allergic and other diseases including acid peptic diseases, inflammatory diseases, autoimmune and cancer diseases, nervous system, reproductive functions and hematopoiesis. The compilation of chapters in the book presents the most recent advances in histamine research and bridges the basic and clinical aspects of histamine biology.

The Functional Roles of Histamine Receptors

Author : Kazuhiko Yanai
Publisher : Springer Nature
ISBN 13 : 3031169972
Total Pages : 463 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis The Functional Roles of Histamine Receptors by : Kazuhiko Yanai

Download or read book The Functional Roles of Histamine Receptors written by Kazuhiko Yanai and published by Springer Nature. This book was released on 2022-09-28 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in the field of histamine receptors over the past 100 years went hand-in-hand with the development of modern pharmacology. Advances in histamine research led by outstanding scientists was so incisive that the clinical approach to treat allergies and gastrointestinal ailments was revolutionized. The pharmacological treatment of peptic ulcer and gastroesophageal reflux was indeed a revolution, as it ended the surgical intervention. Interest in histamine pharmacology was resurrected by the discovery of another histamine receptor, number 4, using genomics-based reverse pharmacological approaches for screening orphan GPCRs. This receptor is preferentially expressed by immune cells and its discovery raised hopes for its translational exploitation as a new therapeutic target for unmet medical needs ranging from asthma to cancer. However, several drawbacks emerged and dramatically slowed down research in the field. A better understanding of receptor intra-and interspecies heterogeneity will certainly improve and accelerate the translation of experimental data into clinical practice. Also, the plethora of data on brain histamine is hinting at a fundamental role of this system as a hub that receives internal and peripheral stimuli to allocate the necessary excitation to specific brain circuits that preside the appropriate behavioral responses. The development of new histaminergic ligands is an ongoing process that constantly provide new preclinical tools. The aim of this book is to cover the most important aspects of histamine receptor function and pharmacology in the central nervous system and to provide a comprehensive overview of the preclinical and clinical advances made in recent decades and the exciting prospects for the future. It highlights the clinical areas where there is a great need for new therapeutic approaches and where novel histaminergic agents may be useful for personalized medicine.

New Perspectives in Histamine Research

Author : H. Timmermann
Publisher : Birkhäuser
ISBN 13 :
Total Pages : 452 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis New Perspectives in Histamine Research by : H. Timmermann

Download or read book New Perspectives in Histamine Research written by H. Timmermann and published by Birkhäuser. This book was released on 1991-02 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Histamine is an intriguing compound; the same is true for the several classes of anti-histaminergic compounds. The classical anti-histamines, now known as H -antagonists have 1 been the result of intensive research in the 1950s and 1960s. The new, so-called non-sedating H1-antagonists, which became available in the 1980s, could be d'eveloped mainly due to insights into structural features causing the sedating effects of the older compounds. In the 1970s the H2-receptors became important targets for developing new anti-ulcer agents. The H2-antagonist story is a stimulating example of modern research on pharmacology and medicinal chemistry. Unknown and new properties of histamine and histaminergic systems came to the attention of the pharmacologists and medicinal chemists in the 1980s. The role of histamine as a neurotransmitter, the existence of a presynaptic receptor (H ) controlling the release of histamine 3 and other neurotransmitters, and the particular character of this receptor became important as the possibilities to design new therapeutic agents were realized. Recently, other roles of the histaminergic systems have been suggested. Is there a distinct histamine receptor involved in immunological features of histamine? Is histamine involved in the prolactin axis? Are histamine receptors intracellularly present in certain cells and what is their possible role? For these reasons it was the right time to discuss "New Perspectives in Histamine Research" during a scientific meeting. Therefore a symposium was organized as a satellite of the XIth International Congress of Pharmacology of IUPHAR in Amsterdam in 1990.

Histamine in Inflammation

Author : Robin Thurmond
Publisher : Springer Science & Business Media
ISBN 13 : 1441980563
Total Pages : 153 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Histamine in Inflammation by : Robin Thurmond

Download or read book Histamine in Inflammation written by Robin Thurmond and published by Springer Science & Business Media. This book was released on 2011-06-29 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.

Histamine Receptors—Advances in Research and Application: 2012 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481633279
Total Pages : 24 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Histamine Receptors—Advances in Research and Application: 2012 Edition by :

Download or read book Histamine Receptors—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: Histamine Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Histamine Receptors in a compact format. The editors have built Histamine Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Histamine Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Histamine Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Advances in Histamine Research

Author : Börje Uvnäs
Publisher : Pergamon
ISBN 13 :
Total Pages : 280 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Advances in Histamine Research by : Börje Uvnäs

Download or read book Advances in Histamine Research written by Börje Uvnäs and published by Pergamon. This book was released on 1982 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. This book reviews the knowledge of the various fields of histamine research and discusses the basic mechanisms involved in histamine action. It covers histamine release, the central nervous system, gastric secretion and histamine receptors, heart and ultramicrodetermination.

Frontiers in Histamine Research

Author : C. Robin Ganellin
Publisher : Pergamon
ISBN 13 : 9780080319896
Total Pages : 470 pages
Book Rating : 4.3/5 (198 download)

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Book Synopsis Frontiers in Histamine Research by : C. Robin Ganellin

Download or read book Frontiers in Histamine Research written by C. Robin Ganellin and published by Pergamon. This book was released on 1985 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. Focuses on recent studies into the actions and roles of histamine in the gastrointestinal, cardiovascular, central nervous and immune systems. Recent advances herald another major breakthrough in histamine research and include new histochemical approaches to visualisation of histamine-synthesising and storing cells, more specific enzyme inhibitors and new methods for studying histamine biosynthesis and metabolism. Drugs to block the effect of histamine have a well established place in such clinical areas as allergy, inflammation, and gastroenterology. Current research anticipates new exciting opportunities for therapy in neurobiology and immunology.

Histamine and Histamine Antagonists

Author : Börje Uvnäs
Publisher : Springer Science & Business Media
ISBN 13 : 3642758401
Total Pages : 782 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Histamine and Histamine Antagonists by : Börje Uvnäs

Download or read book Histamine and Histamine Antagonists written by Börje Uvnäs and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt: Together with the two previous volumes of the Handbook of Experimental Pharmacology on histamine and antihistamines the present publication yields a picture of a still rapidly developing field of research. New techniques and new experimental approaches have brought us new knowledge and deeper insight into the biomedical significance of histamine, even if many questions remain to be answered about the functional and medical implications of this old biogenic amine. The present volume covers the progress in histamine research during the past two decades. A significant chapter concerns techniques for histamine determination. As the result of a consensus meeting in Munich in December 1988, a panel of eminent specialists arrived at common recommendations as to the usefulness of the available histamine assays for the most common experimental biomedical conditions. The heterogeneity of mast cells, with great differences in their reactivity to various stimuli, has become apparent, not only among species but also among the tissues of a species. New informa tion is presented about the mechanism of exocytosis. The old questions about the role of histamine in the mechanism of gastric secretion and in cardio vascular and respiratory functions have been studied with new techniques, and the role of HI and H2 receptors discussed. New observations have been made on the occurrence and possible functions of histaminergic neurons and histamine receptors in CNS where a new type of receptor, the H , seems to 3 be widely represented.

Recent Advances in Histamine Research

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (497 download)

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Book Synopsis Recent Advances in Histamine Research by :

Download or read book Recent Advances in Histamine Research written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Third Histamine Receptor

Author : Divya Vohora
Publisher : CRC Press
ISBN 13 : 1420053922
Total Pages : 408 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis The Third Histamine Receptor by : Divya Vohora

Download or read book The Third Histamine Receptor written by Divya Vohora and published by CRC Press. This book was released on 2008-11-14 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reveals an Emerging Avenue of Potential Treatments for a Host of Challenging Diseases and Disorders The H3 receptor is known to play a major role in a range of CNS disorders, including those affecting cognitive functions such as ADHD and Alzheimer’s disease, as well as sleep disorders, obesity, epilepsy, schizophrenia, depression, and neurodegeneration. In light of dramatic advances in research at the molecular level, supported by impressive clinical studies, optimism remains high that an H3 receptor-related drug could hit the market soon. The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders provides a thorough grounding in advances made over the last two decades. It brings together an elite group of 30 pioneering researchers. In writing about their own work, these scientists report on the cutting-edge investigations that are now being conducted across a variety of disciplines. This text is designed to aid researchers and inform those involved in the treatment and clinical aspects of a number of histamine-related diseases. Presents Several Disease-Specific Chapters Certainly, the most comprehensive and cutting-edge volume in the field, this text includes material drawn from groundbreaking research techniques and patent literature. Put together with great thought and passion, it is written to serve as a primary resource for anyone involved with or interested in the identification and localization of H3 receptors and the ligands being developed as therapeutic agents to treat a wide range of diseases including some that were once considered intractable.

Histamine

Author : András Falus
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 368 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Histamine by : András Falus

Download or read book Histamine written by András Falus and published by S. Karger AG (Switzerland). This book was released on 2004 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Histamine, discovered in 1910 by the British physiologist Sir Henry H. Dale, has become one of the most important biogenic amines in medicine and biology. In addition to the three well-known functions such as the contraction of smooth muscles, the increase in vascular permeability, and the stimulation of gastric acid secretion, histamine has been known to play various roles in neurotransmission, immunomodulation, the regulation of cell proliferation, etc. This book provides a comprehensive overview of histamine biology including structure, anabolic and catabolic enzymes, receptors and their ligands. It outlines the details of histamine physiology such as its role in the immune response, nutrition and neuro/psychobiology, and covers medical fields like allergy, gastroenterology, oncology, sepsis, posttraumatic stress, embryonic development and hematopoiesis. Also considered is the structural and functional genomics of histamine. Presenting the most recent advances in histamine research from basic science to clinical medicine, this book is a valuable source for students, graduates and postgraduates in medicine and the life sciences, and to anyone interested in this multifaceted molecule.

Pharmacology of Histamine Receptors

Author : C. R. Ganellin
Publisher : Elsevier
ISBN 13 : 1483193411
Total Pages : 540 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Pharmacology of Histamine Receptors by : C. R. Ganellin

Download or read book Pharmacology of Histamine Receptors written by C. R. Ganellin and published by Elsevier. This book was released on 2013-10-22 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology of Histamine Receptors presents a summary of the pharmacology of histamine receptors. It discusses the research and developments made in the use of histamine. It addresses the biological actions of the drug in various pathological instances. Some of the topics covered in the book are the classification of histamine receptors; mepyramine and related histamine antagonists; activity relationships of drugs acting at histamine receptors; chemical structure of histamine; effects of methyl substituents in histamine; enzymes involved in histamine metabolism; and histamine in body fluids. The cellular sources of histamine in tissues and blood are fully covered. The relationship of the mast cell to basophil is discussed in detail. The text describes in depth the urinary excretion of histamine and metabolites. The pathological conditions in man are presented completely. A chapter is devoted to the fundamental properties of adenylate cyclase and its measurement. The book can provide useful information to pharmacists, doctors, chemists, students, and researchers.

History of Allergy

Author : K.-C. Bergmann
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318021954
Total Pages : 445 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis History of Allergy by : K.-C. Bergmann

Download or read book History of Allergy written by K.-C. Bergmann and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-27 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prevalence of allergic diseases has increased dramatically over recent decades, both in terms of the number of sufferers and the number of allergies. This is a trend that has frequently been referred to as 'the epidemic of the 21st century'. As described in ancient texts, allergies have been known for over 2,000 years, but the term 'allergy' was only coined at the beginning of the 20th century when doctors began to understand their pathophysiological basis. This book presents a detailed and varied historical overview of the field of allergology. Beginning with insights on allergy from antiquity to the 20th century and the development of the associated terminology, it compiles historical reflections on the understanding of the most common allergic diseases. Important milestones in the discovery of mechanisms of allergy are described, followed by historical accounts of the detection of allergens such as pollen, dust mites, peanuts and latex, and of environmental influences such as pollution and the relationship between farmers and their environment. Several chapters illustrate the progress made in allergy management to date. Particular highlights of this book are the personal reflections of and interviews with a number of pioneers of allergy, including F. Austen, J. Bienenstock, K. Blaser, A. de Weck, A.W. Frankland, K. Ishizaka, and many more. Concluding with portrayals of allergy societies and collections, as well as being supplemented by two films, this book represents a veritable treasure trove of fascinating and richly illustrated information. Not only researchers, physicians and medical historians, but also students and even non-scientists will find History of Allergy a scientific adventure well worth reading.

Itch

Author : E. Carstens
Publisher : CRC Press
ISBN 13 : 1466505435
Total Pages : 482 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Itch by : E. Carstens

Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Abstracts Presented at the 39th Annual Meeting of the European Histamine Research Society with COST Action BM0806 ["Recent Advances in Histamine Receptor H4R Research"], 2010

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Author : European Histamine Research Society
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (751 download)

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Book Synopsis Abstracts Presented at the 39th Annual Meeting of the European Histamine Research Society with COST Action BM0806 ["Recent Advances in Histamine Receptor H4R Research"], 2010 by : European Histamine Research Society

Download or read book Abstracts Presented at the 39th Annual Meeting of the European Histamine Research Society with COST Action BM0806 ["Recent Advances in Histamine Receptor H4R Research"], 2010 written by European Histamine Research Society and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: