Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Neurochemical Aspects Of Alzheimers Disease
Download Neurochemical Aspects Of Alzheimers Disease full books in PDF, epub, and Kindle. Read online Neurochemical Aspects Of Alzheimers Disease ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Neurochemical Aspects of Alzheimer's Disease by : Akhlaq A. Farooqui
Download or read book Neurochemical Aspects of Alzheimer's Disease written by Akhlaq A. Farooqui and published by Academic Press. This book was released on 2017-05-25 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists, and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders. Provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for Alzheimer's disease Written for researchers, clinicians, and advanced graduate students in neurology, neuroscience, neurochemistry, and neuropharmacology Acts as the first book to provide a comprehensive description of the signal transduction processes associated with pathogenesis of Alzheimer's disease
Book Synopsis A Multidisciplinary Approach to Capability in Age and Ageing by : Hanna Falk Erhag
Download or read book A Multidisciplinary Approach to Capability in Age and Ageing written by Hanna Falk Erhag and published by Springer Nature. This book was released on 2022-01-10 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides insight on how to interpret capability in ageing – one’s individual ability to perform actions in order to reach goals one has reason to value – from a multidisciplinary approach. With for the first time in history there being more people in the world aged 60 years and over than there are children below the age of 5, the book describes this demographic trends as well as the large global challenges and important societal implications this will have such as a worldwide increase in the number of persons affected with dementia, and in the ratio of retired persons to those still in the labor market. Through contributions from many different research areas, it discussed how capability depends on interactions between the individual (e.g. health, genetics, personality, intellectual capacity), environment (e.g. family, friends, home, work place), and society (e.g. political decisions, ageism, historical period). The final chapter summarizes the differences and similarities in these contributions. As such this book provides an interesting read for students, teachers and researchers at different levels and from different fields interested in capability and multidisciplinary research.
Book Synopsis Animal Models of Dementia by : Joseph T. Coyle
Download or read book Animal Models of Dementia written by Joseph T. Coyle and published by . This book was released on 1987 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biological Aspects of Alzheimer's Disease by : Robert Katzman
Download or read book Biological Aspects of Alzheimer's Disease written by Robert Katzman and published by . This book was released on 1983 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neurobiology of Alzheimer's Disease by : David Dawbarn
Download or read book Neurobiology of Alzheimer's Disease written by David Dawbarn and published by . This book was released on 2007 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable introduction to the disease, from molecular pathology to clinical practice. The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice and molecular neurobiology; appendices detail disease-associate proteins, their sequences, familial mutations and known structures. It will be essential reading for students interested in neurodegeneration and for researchers and clinicians, giving a coherent and cohesive approach to the whole area of research, and allowing access at different levels. For those in the pharmaceutical industry it describes the underlying molecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.
Book Synopsis Neurochemical Changes in Normal Aging and Alzheimer's Disease by : Shelley Jane Allen
Download or read book Neurochemical Changes in Normal Aging and Alzheimer's Disease written by Shelley Jane Allen and published by . This book was released on 1985 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neurotransmitter and Dementia by : C.G. Gottfries
Download or read book Neurotransmitter and Dementia written by C.G. Gottfries and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurotransmitter changes taking place in the brain of patients with dementia disorders, mainly Alzheimer type dementia, are reported. Their role in the pathogenesis of Alzheimer's disease is discussed; and the neurochemical changes are considered as a base for formulating treatment strategies. By studying markers in the cerebrospinal fluid, diagnostic methods may be achieved that will aid in diagnosing subgroups of dememtia.
Book Synopsis Neurochemical Diagnosis of Alzheimer's Disease by : Piotr Lewczuk
Download or read book Neurochemical Diagnosis of Alzheimer's Disease written by Piotr Lewczuk and published by . This book was released on 2003 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biological Markers of Alzheimer’s Disease by : Francois Boller
Download or read book Biological Markers of Alzheimer’s Disease written by Francois Boller and published by Springer. This book was released on 2012-03-01 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the proceedings of the symposium held in Toulouse on April 24, 1989, on the topic "Biological Markers of Alzheimer's Disease. " This sym posium was the fourth of a continuing and successful series of Colloques Medecine et Recherche organized by the Fondation IPSEN pour la Recherche Therapeutique, addressing various aspects of contemporary research in the field of Alzheimer's disease (AD). The series started in September 1987 with "Im munology and Alzheimer's Disease," followed 6 months later in Paris by "Gene tics and Alzheimer's Disease" and in September 1988 in Montpellier by "Neuronal Grafting and Alzheimer's Disease. " The present symposium was organized for the purpose of gathering the most current ideas concerning biological markers of AD. The papers presented at this symposium may be roughly subdivided into three groups. The first deals with the markers of AD at the level of the brain itself. These markers are studied either through the cerebrospinal fluid or through techniques such as nuclear magnetic resonance (NMR) - approaches which respectively aim at demonstrating the cerebral changes indicated by the debris resulting from the disease, or studying the possible neurochemical abnormalities that occur in the earlier stages of AD.
Book Synopsis Pharmacological Mechanisms in Alzheimer's Therapeutics by : A. Claudio Cuello
Download or read book Pharmacological Mechanisms in Alzheimer's Therapeutics written by A. Claudio Cuello and published by Springer Science & Business Media. This book was released on 2007-12-22 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need for effective therapy to treat Alzheimer’s disease is greater than ever, but there is still no drug therapy that can stop or reverse the progression of the disease. There is, however, a great deal of anticipation over the imminent development of effective therapies as a result of the identification of promising targets for drug development. This book investigates these targets and examines ongoing strategies to develop effective therapies for this devastating neurodegenerative condition.
Book Synopsis Handbook of Psychopharmacology by : Leslie L. Iversen
Download or read book Handbook of Psychopharmacology written by Leslie L. Iversen and published by Springer. This book was released on 2013-11-11 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Psychopharmacology of the Aging Nervous System" was selected as the topic for Volume 20 of the Handbook of PsychopharmacoloffY. Senile dementia is now widely recognized as a medical and social problem likely to reach epidemic proportions by the turn of the century. By that time it is esti mated that almost 20% of the population in most developed countries will be over the age of 65 and at a conservative estimate 1 in 10 of them will suffer from a dementing illness. Many symposia have appeared over the last few years describing the neuropathological and neurochemical deficiencies in Alzheimer's and other forms of dementia, the neuropsychological features of the disease, and attempts to treat it. In this volume, we have selected topics and authors who are beginning to question some of the earlier assumptions and to ask different questions about dementia. In the first four chapters the neuropathology and neu rochemistry of dementia are reevaluated. It is important to understand the relationship between the formation of amyloid plaques and neurofibrillary tangles, the progressive degeneration in cortex, and the neurochemical deafferentation of cortex. In particular, the possibility is considered that the most severe pathology is seen in a well-defined limbo/cortical circuitry known to be involved in mnemonic processing. The growing interest in the genetic determinants of familial Alz heimer's is reviewed. It is also recognized that detailed comparisons of the neural and psychological characteristics of the various degenerative dis eases that impair cognitive processing may be valuable.
Book Synopsis Quantifying Neurochemical Changes in Early Alzheimer’s Disease by : Katrina Cruickshank
Download or read book Quantifying Neurochemical Changes in Early Alzheimer’s Disease written by Katrina Cruickshank and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Alzheimer’s disease (AD) is a neurodegenerative disorder that advances through a unique cascade of characteristic neuropathological features. Distinguishing features include the accumulation of amyloid beta plaques and neurofibrillary tangles (NFTs) in the brain, accompanied by learning and memory impairments. The disease is projected to begin years-to-decades before clinical diagnosis. Accordingly, prodromal biomarkers are a necessity with early diagnosis as the goal. Neurochemical measures obtained via non-invasive brain imaging have potential to serve as early, AD biomarkers. Evidence suggests that alterations in the concentrations of certain metabolites are related to inflammation. It is known that while inflammation is ubiquitous in the progressed disease state, it is also apparent during initial stages. Of interest, a paradoxical increase in neuronal activity during early stages of AD has been noted, with a suspected link to an initial inflammatory response via proinflammatory cytokines. Early evidence suggests that alongside their role in immune mediation, cytokines play a critical part in maintaining optimal synaptic activity, and that early deviations from this role may contribute directly to downstream AD pathogenesis. Therefore, as magnetic resonance spectroscopy (MRS) has the capacity to noninvasively quantify neurochemical concentrations, it is an appropriate tool to pinpoint early fluctuations associated with inflammation and elevated cytokine activation.A greater understanding of AD requires an improved appreciation for its initial evolution. This requires, not only investigation into potential preclinical, neurochemical biomarkers, but furthermore, an examination into any parallel cognitive deficits. This project investigated prodromal AD in a transgenic (Tg) rodent model from early adulthood to middle age. It utilized in vivo proton magnetic resonance spectroscopy (1H MRS) to assess longitudinal changes in neurochemistry and the Barnes maze (BM) to evaluate spatial learning and memory. The central research objective was the longitudinal characterization of neurochemistry and behaviour in the TgF344-AD rodent model during the initial disease state, to highlight abnormalities that precede diagnosable AD.The study was conducted from approximately 4 to 10 months of age, in both TgF344-AD rats and their wildtype (WT) controls. Five evenly spaced magnetic resonance (MR) scans were acquired during this time (1 every 6 weeks), in addition to three sessions of behavioural testing (1 every 2 months). The BM was implemented to test spatial learning and memory ability, and longitudinal changes in metabolic levels were evaluated through linear mixed effects modeling.Altered neurochemistry was recorded between genotypes and across time in prodromal stages of AD. More specifically, Tg rats had significantly lower levels of glutamine (Gln), a precursor to glutamate (Glu), following disease initiation and increasing with age. In addition, with time Glu levels fell and myo-inositol (Ins) levels rose, independent of genotype. N-acetyl aspartate (NAA), reportedly reduced at later stages of AD, remained unchanged in Tg relative to WT rats. Neurochemical changes were not accompanied by a significant loss in cognitive ability, and thus appear to precede characteristic cognitive impairments.This research demonstrates that altered neurochemistry materializes in early AD and occurs before the onset of measurable behavioural deficits. A better understanding of preclinical AD requires further investigation into the relationship between neurochemistry, cognition, neuroanatomy, and the concentrations of proinflammatory mediators. Consequently, this could contribute to novel diagnostic and treatment techniques through the identification of reliable, early biomarkers"--
Book Synopsis Treatment of Dementias by : Edwin M. Meyer
Download or read book Treatment of Dementias written by Edwin M. Meyer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease is one the foremost health problems facing every society fortunate enough to attain a level of medical care that ensures an average lifespan of over 70 years of age. The cause of the disease remains unknown, and no single therapeutic approach has yet been found highly efficacious. Indeed, as the complexity of its effects on brain neuronal systems becomes elucidated, the concept emerges that Alzheimer's disease may be an umbrella term for multiple Alzheimer's-type syndromes that can be differentiated based on etiology (hereditary versus sporadic), neurochemical deficits, and extent of pathology. Whether one or more disease processes is involved, it seems increasingly unlikely that any single drug will provide efficacious relief across the broad spectrum of symptoms reflected in large subject populations. Rational therapeutic approaches may yield long term amelioration of many symptoms in selected groups of patients; and individual symptoms may be ameliorated in larger populations. Multiple approaches may be combined to optimize therapeutic effects. For example, a variety of approaches remain focused on restoration of cholinergic neurodegeneration and enhancing cholinergic neurotransmission, whereas other approaches attempt to retard the of the brain that occurs during Alzheimer's disease. Chapters cover continuous degeneration topics from growth factor secretion of proteases, which could modify amyloid processing, to neuronal gene delivery using viral vectors. The breadth and thoroughness of the chapters truly embrace a broad spectrurn of models, pathological mechanisms and therapeutic approaches.
Author :Study Group on the Pharmacology of Memory Disorders Associated with Aging. Meeting Publisher : ISBN 13 : Total Pages :460 pages Book Rating :4.X/5 (4 download)
Book Synopsis The Neurobiology of Alzheimer's Disease by : Study Group on the Pharmacology of Memory Disorders Associated with Aging. Meeting
Download or read book The Neurobiology of Alzheimer's Disease written by Study Group on the Pharmacology of Memory Disorders Associated with Aging. Meeting and published by . This book was released on 1996 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall goal of the International Study Group on the Pharmacology of Memory Disorders Associated with Ageing is to point out discoveries that shed light on the potential causes of Alzheimer's disease, its pathogenesis, and the biological mechanisms that could underlie its cure. This eighth meeting in the series, aims to stimulate research in dementia and increase the transfer of information from the basic sciences to physicians and the pharmaceutical industry."
Book Synopsis Dementia with Lewy Bodies by : Robert Perry
Download or read book Dementia with Lewy Bodies written by Robert Perry and published by Cambridge University Press. This book was released on 1996-11-28 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dementia with Lewy bodies (DLB) is perhaps the second most common cause of degenerative dementia after Alzheimer's disease. This book, which represents the first authoritative statement about DLB, arises from a workshop held in Newcastle, England, in October 1995, which brought together leading investigators with clinical and research experience of this condition. It includes review articles, case studies and recent research findings from the main centres studying DLB. Covering the classification, cognitive manifestations, clinical diagnosis, epidemiology, genetics, neuropathology, neurochemistry and treatment of DLB, this is a landmark publication in clinical neuroscience. It presents new operational criteria for research on DLB, and will interest all concerned with the problem of dementia in the elderly.
Book Synopsis Pre- and Postsynaptic Neurochemical Alterations in Alzheimer's Disease by : Terry D. Reisine
Download or read book Pre- and Postsynaptic Neurochemical Alterations in Alzheimer's Disease written by Terry D. Reisine and published by . This book was released on 1978 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Basic, Clinical, and Therapeutic Aspects of Alzheimer's and Parkinson's Diseases by : Toshiharu Nagatsu
Download or read book Basic, Clinical, and Therapeutic Aspects of Alzheimer's and Parkinson's Diseases written by Toshiharu Nagatsu and published by . This book was released on 1990 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt:
