Neural Transplantation In Neurodegenerative Disease

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Neural Transplantation in Neurodegenerative Disease

Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 0470870826
Total Pages : 334 pages
Book Rating : 4.4/5 (78 download)

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Book Synopsis Neural Transplantation in Neurodegenerative Disease by : Derek J. Chadwick

Download or read book Neural Transplantation in Neurodegenerative Disease written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2003-10-31 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease nearing completion and novel, alternative approaches to fetal transplantation being developed. This timely book brings together leading neuroscientists, clinicians, and cell and developmental biologists to discuss the use of neural transplants in neurodegenerative disorders, such as Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential alternatives to freshly derived fetal tissue as the source of transplants, for example xenografts, encapsulated cells and immortalized stem cells. With authoritative contributions and lively discussion sections, this book presents much new and exciting work in this field and identifies promising new research directions.

Functional Neural Transplantation IV

Author :
Publisher : Academic Press
ISBN 13 : 012811813X
Total Pages : 382 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Functional Neural Transplantation IV by :

Download or read book Functional Neural Transplantation IV written by and published by Academic Press. This book was released on 2017-05-25 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides a survey of the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science to an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair. Selected chapters review the latest advances in translating the new technologies to a broader range of neurodegenerative diseases, stroke, spinal cord injury, glial and retinal disease and pain than had hitherto been considered possible, with the realization that the opportunities of off-the-shelf cell therapy may fast be approaching a plausible reality. Comprehensive set of critical reviews covering the field Presents state-of-the-art topics in science and translational medicine Written by international leaders in the field of neural transplantation

Functional Neural Transplantation III

Author :
Publisher : Newnes
ISBN 13 : 0444595457
Total Pages : 405 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Functional Neural Transplantation III by :

Download or read book Functional Neural Transplantation III written by and published by Newnes. This book was released on 2012-12-31 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on Functional Neural Transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Functional Neural Transplantation IV

Author :
Publisher : Academic Press
ISBN 13 : 0128138807
Total Pages : 316 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Functional Neural Transplantation IV by :

Download or read book Functional Neural Transplantation IV written by and published by Academic Press. This book was released on 2017-06-07 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Neural Transplantation IV: Translation to Clinical Application, Part B, Volume 231 provides the current status of cell transplantation in the nervous system, focusing on the conditions for achieving structural repair and functional recovery after brain damage or disease. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments in cellular and molecular science, providing the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, and also addressing the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair. Selected chapters review the latest advances in translating new technologies to a broader range of neurodegenerative diseases, stroke, spinal cord injury, glial and retinal disease and pain than had hitherto been considered impossible, with a realization that the opportunities of off-the-shelf cell therapy may fast be approaching a plausible reality. Provides a comprehensive set of critical reviews covering the field Presents state-of-the-art topics in science and translational medicine Written by international leaders in the field of neural transplantation

Neural Transplantation

Author : William J. Freed
Publisher : MIT Press
ISBN 13 : 9780262062084
Total Pages : 590 pages
Book Rating : 4.0/5 (62 download)

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Book Synopsis Neural Transplantation by : William J. Freed

Download or read book Neural Transplantation written by William J. Freed and published by MIT Press. This book was released on 2000 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: After providing basic background on transplantation, brain structure, and development, the book discusses Parkinson's disease, the use of transplants to influence localized brain functions, circuit reconstruction, and genetic engineering and other future technologies.

Cell Transplantation for Neurological Disorders

Author : Thomas B. Freeman
Publisher : Springer Science & Business Media
ISBN 13 : 159259476X
Total Pages : 361 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Cell Transplantation for Neurological Disorders by : Thomas B. Freeman

Download or read book Cell Transplantation for Neurological Disorders written by Thomas B. Freeman and published by Springer Science & Business Media. This book was released on 1998-05-29 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Distinguished medical researchers from around the world review novel neural reconstructive techniques that appear to be beneficial for Parkinson's disease and hold promise for treating Huntington's disease, pain, demyelinating diseases, and stroke. The contributors focus on those diseases for which clinical trials are either ongoing or likely to occur in the near future. Among the topics reviewed are results and rationale for some of the leading transplant programs for the treatment of Parkinson's disease, the use of PET scanning for patient evaluation, autopsy studies of transplant recipients, transplant immunology, fetal tissue transplantation for Huntington's disease, cellular transplantation for the treatment of pain and stroke, and transplantation of myelinating cells. A full discussion of the important ethical issues surrounding the use of fetal tissue for transplantation purposes is also included.

Functional Neural Transplantation IV

Author :
Publisher : Academic Press
ISBN 13 : 9780128117385
Total Pages : 0 pages
Book Rating : 4.1/5 (173 download)

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Book Synopsis Functional Neural Transplantation IV by :

Download or read book Functional Neural Transplantation IV written by and published by Academic Press. This book was released on 2017-05-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. New to this release are chapters that delve into the Mechanisms and Use of Neural Transplants for Brain Repair, Reprogramming of Somatic Cells: iPS and iN Cells, Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons, and Ex Vivo Gene Therapy for the Treatment of Neurological Disorders, Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantation. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science, providing an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, and also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.

Neurological Rehabilitation

Author : Stephen B. Dunnett
Publisher : Elsevier Inc. Chapters
ISBN 13 : 012807793X
Total Pages : 680 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Neurological Rehabilitation by : Stephen B. Dunnett

Download or read book Neurological Rehabilitation written by Stephen B. Dunnett and published by Elsevier Inc. Chapters. This book was released on 2013-01-10 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transplants of cells and tissues to the central nervous system of adult mammals can, under appropriate conditions, survive, integrate, and function. In particular, the grafted cells can sustain functional recovery in animal models of a range of neurodegenerative conditions including genetic and idiopathic neurodegenerative diseases of adulthood and aging, ischemic stroke, and brain and spinal cord trauma. In a restricted subset of such conditions, cell transplantation has progressed to application in humans in early-stage clinical trials. At the present stage of play, there is clear evidence of clinical efficacy of fetal cell transplants in Parkinson disease (notwithstanding a range of technical difficulties still to be fully resolved), and preliminary claims of promising outcomes in several other severe neurodegenerative conditions, including Huntington disease and stroke. Moreover, the experimental literature is increasingly suggesting that the experience and training of the graft recipient materially affects the functional outcome. For example, environmental enrichment, behavioral activity, and specific training can enhance the recovery process to maximize functional recovery. There are even circumstances where the grafted cells have been demonstrated to restore the neural substrate for new learning. Consequently, it is not sufficient to replace lost cells anatomically; rather, for the grafts to be effective, they need to be integrated functionally into the host circuitry, and the host animal requires training and rehabilitation to maximize function of the reconstructed graft−host circuitry. Such observations require reconsideration of the design of the next generation of clinical trials and subsequent service delivery, to include physiotherapists, cognitive therapists, and rehabilitation experts as core members of the transplant team, along with the neurologists and neurosurgeons that have conventionally led the field.

Neural Stem Cells in Health and Disease

Author : Ashok K Shetty
Publisher : World Scientific Publishing Company
ISBN 13 : 9814623199
Total Pages : 572 pages
Book Rating : 4.8/5 (146 download)

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Book Synopsis Neural Stem Cells in Health and Disease by : Ashok K Shetty

Download or read book Neural Stem Cells in Health and Disease written by Ashok K Shetty and published by World Scientific Publishing Company. This book was released on 2015-08-28 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide on neural stem cell behavior in health and disease. The book confers the altered behavior of endogenous neural stem cells in neurodegenerative disease conditions and the prospects of neural stem cell therapy for alleviating brain dysfunction in a variety of neurodegenerative disorders. Neural stem cell activity and neurogenesis in the adult brain is now confirmed in virtually all mammalian species including humans. Hence, a series of chapters in the first half of the book discusses the current knowledge on mechanisms of neural stem cell activity, the extent and functional significance of neurogenesis in the adult brain under normal, aged and disease environments, the susceptibility of neural stem cells and the plasticity of neurogenesis to alcohol, drugs of abuse and anesthetic agents, and advanced techniques that trigger neurogenesis in non-neurogenic regions. A second series of chapters in this book are focused on discussing the promise and efficacy of grafting of neural stem cells and/or other stem cells for treating neurological disorders such as Parkinson's disease, stroke, temporal lobe epilepsy, Alzheimer's disease and spinal cord injury. The final chapter confers on advances that are made in manufacturing a variety of neural cell types from human pluripotent stem cells that can be used as donor cells for cell transplantation.

Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease

Author : Lazaros C. Triarhou
Publisher : Springer Science & Business Media
ISBN 13 : 1461506999
Total Pages : 152 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease by : Lazaros C. Triarhou

Download or read book Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease written by Lazaros C. Triarhou and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the culmination of fifteen years of research on the transplantation of dopaminergic neurons in the striatum of the weaver mouse (wv/wv), a neurological mutant characterized by genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the only available laboratory model with a chronic disorder that mimics Parkinson's disease. Structural and functional aspects of intrastriatal mesencephalic neuron grafting into the weaver model are reviewed, including histochemical correlates of graft survival and integration, numerical aspects of donor cell survival, ultrastructural findings on synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor related molecules, levels of striatal amino acid receptors, and behavioural effects of unilateral and bilateral neuronal transplantations.

Neural Transplantation Methods

Author : Stephen B. Dunnett
Publisher : Springer Science & Business Media
ISBN 13 : 0896037932
Total Pages : 554 pages
Book Rating : 4.8/5 (96 download)

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Book Synopsis Neural Transplantation Methods by : Stephen B. Dunnett

Download or read book Neural Transplantation Methods written by Stephen B. Dunnett and published by Springer Science & Business Media. This book was released on 1999-10-20 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: we might seek alternative sources of donor tissues. Genetic en- neering, expansion of precursor cells, generation of immortalized cell lines, and transplantation between species are all under active investigation. Although significant difficulties remain for each of these alternatives, the problems appear soluble and relevant knowledge is expanding rapidly. As we enter the twenty-first century, the place of neural tra- plantation in experimental neuroscience is continuing to evolve. Rather than being a topic in its own right, neural transplantation increasingly serves as just another technique in the researcher's armory--alongside lesions, pharmaceuticals, gene transfer, and a variety of other techniques--for the experimental manipulation of brain structure and function. This is particularly true for studies of degeneration, plasticity, regeneration, and recovery of function in the nervous system, topics of increasing importance as experimental neurobiology is required to serve the higher needs of neurological and mental health in aging societies. Within this evolving context, Neural Transplantation Methods seeks to serve a particular need: to provide experimental neu- scientists with a source book of information to enable them to select and adapt transplantation techniques to their own expe- mental programs. All authors have been asked to address prac- cal issues, to enable the reader to assess what is available, what are the alternatives, what are the practical issues to be resolved in applying a particular protocol and getting it to work reliably in their unique experimental context.

Stem Cells in Neurodegeneration: Disease Modeling and Therapeutics

Author : Kim A. Staats
Publisher : Frontiers Media SA
ISBN 13 : 288971182X
Total Pages : 183 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Stem Cells in Neurodegeneration: Disease Modeling and Therapeutics by : Kim A. Staats

Download or read book Stem Cells in Neurodegeneration: Disease Modeling and Therapeutics written by Kim A. Staats and published by Frontiers Media SA. This book was released on 2021-08-17 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Functional Neural Transplantation III

Author :
Publisher : Elsevier
ISBN 13 : 9780444595751
Total Pages : 0 pages
Book Rating : 4.5/5 (957 download)

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Book Synopsis Functional Neural Transplantation III by :

Download or read book Functional Neural Transplantation III written by and published by Elsevier. This book was released on 2012-12-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on functional neural transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.

Neural Transplantation, CNS Neuronal Injury, and Regeneration

Author : Joe Marwah
Publisher : CRC Press
ISBN 13 : 9780849386831
Total Pages : 304 pages
Book Rating : 4.3/5 (868 download)

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Book Synopsis Neural Transplantation, CNS Neuronal Injury, and Regeneration by : Joe Marwah

Download or read book Neural Transplantation, CNS Neuronal Injury, and Regeneration written by Joe Marwah and published by CRC Press. This book was released on 1994-02-23 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique reference presents studies from leading laboratories that are studying the effects of CNS transplants on neuronal plasticity and recovery of function after CNS injury. Topics covered include tropic influences, reinnervation patterns, and prevention of cell death that range from pre-clinical models of Parkinson's disease in primates to studies of restoration of circadian rhythms in rats. Techniques of neurotransplantation are presented, including current limitations and future projections of advancement.

The Emerging Field of Human Neural Organoids, Transplants, and Chimeras

Author : National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Ethical, Legal, and Regulatory Issues Associated with Neural Chimeras and Organoids
Publisher :
ISBN 13 :
Total Pages : 136 pages
Book Rating : 4.:/5 (131 download)

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Book Synopsis The Emerging Field of Human Neural Organoids, Transplants, and Chimeras by : National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Ethical, Legal, and Regulatory Issues Associated with Neural Chimeras and Organoids

Download or read book The Emerging Field of Human Neural Organoids, Transplants, and Chimeras written by National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Ethical, Legal, and Regulatory Issues Associated with Neural Chimeras and Organoids and published by . This book was released on 2021 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each year, tens of millions of individuals in the U.S. suffer from neurological and psychiatric disorders including neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease, and psychiatric disorders such as autism spectrum disorder, depression and schizophrenia. Treatments for these diseases are often completely lacking or only partially effective, due in large part to the difficulty of conducting brain research and the complexity of the brain itself. Researchers in recent years have developed new models to better represent and study the human brain. The three models considered in this report, all of which generate and use pluripotent stem cells from healthy individuals and patients, are human neural organoids, human neural transplants, and human-animal neural chimeras. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance reviews the status of research, considers its benefits and risks, discusses associated ethical issues, and considers governance mechanisms for this type of research.

Neurodegenerative Diseases

Author : Shamim I. Ahmad
Publisher : Springer Science & Business Media
ISBN 13 : 1461406536
Total Pages : 421 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Neurodegenerative Diseases by : Shamim I. Ahmad

Download or read book Neurodegenerative Diseases written by Shamim I. Ahmad and published by Springer Science & Business Media. This book was released on 2012-03-12 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.

Neural Repair, Transplantation, and Rehabilitation

Author : Roger A. Barker
Publisher : Psychology Press
ISBN 13 : 9780863776281
Total Pages : 356 pages
Book Rating : 4.7/5 (762 download)

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Book Synopsis Neural Repair, Transplantation, and Rehabilitation by : Roger A. Barker

Download or read book Neural Repair, Transplantation, and Rehabilitation written by Roger A. Barker and published by Psychology Press. This book was released on 1999 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book begins with a synopsis of experimental work underlying degeneration and recovery in the nervous system, which is then discussed in the context of strategies to repair the central nervous system (CNS) and peripheral nervous system (PNS). The major part of the book is given over to the approach involving the use of transplanted tissues to replace and restore disrupted neural networks. This experimental work has formed the basis for the emerging clinical trials employing neural grafts for diseases such as Parkinson's and Huntington's, which are discussed in detail. The book then goes on to discuss newer cellular strategies involving the manipulation of neural cells both in culture and genetically, an approach that may ultimately be employed in the clinical situation. Neural Repair, Transplantation and Rehabilitation is unique in bridging the gap from experimental studies to clinical trials, whilst also providing the non-specialist with a background in rehabilitation strategies as well as basic neuroscience. It is recommended for all those involved in the management of patients with degenerative and traumatic injuries to the nervous system.