Neglected Tropical Diseases - Latin America and the Caribbean

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Author :
Publisher : Springer
ISBN 13 : 3709114225
Total Pages : 243 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Neglected Tropical Diseases - Latin America and the Caribbean by : Carlos Franco-Paredes

Download or read book Neglected Tropical Diseases - Latin America and the Caribbean written by Carlos Franco-Paredes and published by Springer. This book was released on 2015-05-08 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the major neglected tropical diseases (NTDs) – based on their prevalence and the years of healthy life lost to disability – in Latin American and Caribbean countries. These include Chagas disease, leishmaniasis, hookworm infection, and other soil-transmitted helminth infections, followed by dengue, schistosomiasis, leishmaniasis, leprosy, cysticercosis, bartonellosis, Plasmodium vivax malaria, and onchocerciasis. Topics like disease burden, major manifestations and approaches to the control and elimination of NTDs in Latin America and the Caribbean are discussed in detail. As such, the book will be of general interest to basic researchers and clinicians engaged in infectious disease, tropical medicine, and parasitology, and a must-have for scientists specialized in the characteristics of this region of the world.​

Infectious Tropical Diseases and One Health in Latin America

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Author :
Publisher : Springer Nature
ISBN 13 : 303099712X
Total Pages : 239 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Infectious Tropical Diseases and One Health in Latin America by : Heinz Mehlhorn

Download or read book Infectious Tropical Diseases and One Health in Latin America written by Heinz Mehlhorn and published by Springer Nature. This book was released on 2022-06-23 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers current aspects of important infectious diseases affecting human and animal health in Latin American countries. Readers are equipped with details on arthropod vectors as well as on neglected health problems. Diseases covered include Neglected Tropical Diseases such as Chagas Disease, schistosomiasis, tungiasis, myiasis and leishmaniasis, but also Zika and Chikungunya viral infections, plague and yellow fever. One focus is given on parasitic transmission routes. In addition, the authors describe current therapeutic options and sustainable control measures, considering both human and animal health. By highlighting options within the interdisciplinary One Health approach, they round off this work into a cutting-edge reference for diverse expert readers. Scientists and clinicians concerned on public health, entomology, tropical medicine and parasitology not only in Latin America will find this collection particularly valuable. Finally, these contributions are essential in the framework of the Sustainable Development Goals and the targets of SDG 3 (Good Health and Well-being) in order to combat and end epidemics of Neglected Tropical Diseases.

Investing to Overcome the Global Impact of Neglected Tropical Diseases

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Author :
Publisher : World Health Organization
ISBN 13 : 9241564865
Total Pages : 211 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Investing to Overcome the Global Impact of Neglected Tropical Diseases by : World Health Organization

Download or read book Investing to Overcome the Global Impact of Neglected Tropical Diseases written by World Health Organization and published by World Health Organization. This book was released on 2015-08-05 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The presence, or absence, of neglected tropical diseases (NTDs) can be seen as a proxy for poverty and for the success of interventions aimed at reducing poverty. Today, coverage of the public-health interventions recommended by the World Health Organization (WHO) against NTDs may be interpreted as a proxy for universal health coverage and shared prosperity - in short, a proxy for coverage against neglect. As the world's focus shifts from development to sustainable development, from poverty eradication to shared prosperity, and from disease-specific goals to universal health coverage, control of NTDs will assume an important role towards the target of achieving universal health coverage, including individual financial risk protection. Success in overcoming NTDs is a "litmus test" for universal health coverage against NTDs in endemic countries. The first WHO report on NTDs (2010) set the scene by presenting the evidence for how these interventions had produced results. The second report (2013) assessed the progress made in deploying them and detailed the obstacles to their implementation. This third report analyses for the first time the investments needed to achieve the scale up of implementation required to achieve the targets of the WHO Roadmap on NTDs and universal coverage against NTDs. INVESTING TO OVERCOME THE GLOBAL IMPACT OF NEGLECTED TROPICAL DISEASES presents an investment strategy for NTDs and analyses the specific investment case for prevention, control, elimination and eradication of 12 of the 17 NTDs. Such an analysis is justified following the adoption by the Sixty-sixth World Health Assembly in 2013 of resolution WHA6612 on neglected tropical diseases, which called for sufficient and predictable funding to achieve the Roadmap's targets and sustain control efforts. The report cautions, however, that it is wise investment and not investment alone that will yield success. The report registers progress and challenges and signals those that lie ahead. Climate change is expected to increase the spread of several vector-borne NTDs, notably dengue, transmission of which is directly influenced by temperature, rainfall, relative humidity and climate variability primarily through their effects on the vector. Investments in vector-borne diseases will avoid the potentially catastrophic expenditures associated with their control. The presence of NTDs will thereby signal an early warning system for climate-sensitive diseases. The ultimate goal is to deliver enhanced and equitable interventions to the most marginalized populations in the context of a changing public-health and investment landscape to ensure that all peoples affected by NTDs have an opportunity to lead healthier and wealthier lives."--Publisher's description.

Emerging Infectious Diseases from the Global to the Local Perspective

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Author :
Publisher : National Academies Press
ISBN 13 : 0309171105
Total Pages : 134 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Emerging Infectious Diseases from the Global to the Local Perspective by : Institute of Medicine

Download or read book Emerging Infectious Diseases from the Global to the Local Perspective written by Institute of Medicine and published by National Academies Press. This book was released on 2001-03-29 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: In October 1999, the Forum on Emerging Infections of the Institute of Medicine convened a two-day workshop titled "International Aspects of Emerging Infections." Key representatives from the international community explored the forces that drive emerging infectious diseases to prominence. Representatives from the Americas, Africa, Asia and the Pacific, and Europe made formal presentations and engaged in panel discussions. Emerging Infectious Diseases from the Global to the Local Perspective includes summaries of the formal presentations and suggests an agenda for future action. The topics addressed cover a wide range of issues, including trends in the incidence of infectious diseases around the world, descriptions of the wide variety of factors that contribute to the emergence and reemergence of these diseases, efforts to coordinate surveillance activities and responses within and across borders, and the resource, research, and international needs that remain to be addressed.

One Health and Neglected Tropical Diseases

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Author :
Publisher : Mdpi AG
ISBN 13 : 9783036502861
Total Pages : 160 pages
Book Rating : 4.5/5 (28 download)

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Book Synopsis One Health and Neglected Tropical Diseases by : Claire J Standley

Download or read book One Health and Neglected Tropical Diseases written by Claire J Standley and published by Mdpi AG. This book was released on 2021-08-18 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: "One Health" is defined as an approach to achieve better health outcomes for humans, animals, and the environment through collaborative and interdisciplinary efforts. The One Health framework is increasingly being applied to the management, control, and even elimination of neglected tropical diseases (NTDs), a set of infectious diseases that, collectively, affect more than one billion people across almost 150 countries. NTDs are some of the most common infections in the world; they cause substantial morbidity and mortality, particularly in regions with little access to medical care and other resources. Although there is increasing recognition of the major public health threat presented by NTDs, the ecological complexities of their transmission continue to pose challenges for their control and elimination. Some NTDs are zoonotic, meaning that they can be transmitted between humans and animals and, as such, present obstacles for public health and veterinary services in addition to concerns for wildlife conservation. Vector-borne NTDs necessitate measures that integrate consideration of the environment into public health strategies in order to sustainably reduce disease transmission. This book presents a collection of papers that explore various aspects of how the One Health concept is being applied to NTD control around the world, from genomics and diagnostic tools to improved surveillance and disease management. Encompassing research from Central America, the Caribbean, Asia, and sub-Saharan Africa, the collection emphasizes the diversity of NTDs as well as the critical importance of multisectoral collaboration for their control and elimination.

The NET-Heart Book

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Publisher : Academic Press
ISBN 13 : 0323911234
Total Pages : 290 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis The NET-Heart Book by : Clara Saldarriaga

Download or read book The NET-Heart Book written by Clara Saldarriaga and published by Academic Press. This book was released on 2021-10-12 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neglected Tropical Diseases and other Infectious Diseases Affecting the Heart provides a comprehensive and systematic review on the literature surrounding Neglected Tropical Diseases and infectious diseases and how they affect the heart. Written by Emerging Leaders of the Interamerican Society of Cardiology (SIAC), the book includes the latest research findings, covering the cardiac involvement of a range of viral, bacterial and parasitic diseases, including COVID19, HIV, Zika, Lyme Disease, and more. Chapters cover epidemiology, the physiopathology of cardiovascular involvement, symptoms, diagnosis, and treatment options for each disease, making the book suitable to researchers, scientists, clinicians and physicians in the field. Covers the cardiac involvement of a range of viral, bacterial and parasitic diseases, including COVID19, HIV, Influenza, Lyme Disease, and more Explains the diagnosis and management of cardiovascular ailments in neglected tropical diseases Written in an easy to read manner with figures, illustrations and tables to aid understanding Contains chapter formatted with an Introduction, Epidemiology, Physiopathology of Cardiovascular (CV) involvement, Symptoms, Diagnosis, Treatment, Discussion and Conclusions

Forgotten People, Forgotten Diseases

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Publisher : John Wiley & Sons
ISBN 13 : 1555818757
Total Pages : 275 pages
Book Rating : 4.5/5 (558 download)

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Book Synopsis Forgotten People, Forgotten Diseases by : Peter J. Hotez

Download or read book Forgotten People, Forgotten Diseases written by Peter J. Hotez and published by John Wiley & Sons. This book was released on 2020-07-24 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forgotten People, Forgotten Diseases Second Edition The neglected tropical diseases (NTDs) are the most common infections of the world's poor, but few people know about these diseases and why they are so important. This second edition of Forgotten People, Forgotten Diseases provides an overview of the NTDs and how they devastate the poor, essentially trapping them in a vicious cycle of extreme poverty by preventing them from working or attaining their full intellectual and cognitive development. Author Peter J. Hotez highlights a new opportunity to control and perhaps eliminate these ancient scourges, through alliances between nongovernmental development organizations and private-public partnerships to create a successful environment for mass drug administration and product development activities. Forgotten People, Forgotten Diseases also Addresses the myriad changes that have occurred in the field since the previous edition. Describes how NTDs have affected impoverished populations for centuries, changing world history. Considers the future impact of alliances between nongovernmental development organizations and private-public partnerships. Forgotten People, Forgotten Diseases is an essential resource for anyone seeking a roadmap to coordinate global advocacy and mobilization of resources to combat NTDs.

Promoting Safety of Medicines for Children

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Publisher : World Health Organization
ISBN 13 : 9241563435
Total Pages : 65 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Promoting Safety of Medicines for Children by : World Health Organization

Download or read book Promoting Safety of Medicines for Children written by World Health Organization and published by World Health Organization. This book was released on 2007 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monitoring the safety of medicine use in children is of paramount importance since during the clinical development of medicines only limited data on this aspect are generated through clinical trials. Use of medicines outside the specifications described in the license (e.g. in terms of formulation indications contraindications or age) constitutes off-label and off-license use and these are a major area of concern. These guidelines are intended to improve awareness of medicine safety issues among everyone who has an interest in the safety of medicines in children and to provide guidance on effective systems for monitoring medicine safety in pediatric populations. This book will be of interest to all health care professionals medicine regulatory authorities pharmacovigilance centres academia the pharmaceutical industry and policy-makers. Systems for monitoring medicine safety are described in Annex 1. Pharmacovigilance methods and some examples of recent information on adverse reactions to marketed medicines are discussed in Annex 2.

Current Topics in Neglected Tropical Diseases

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1789238897
Total Pages : 166 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Current Topics in Neglected Tropical Diseases by :

Download or read book Current Topics in Neglected Tropical Diseases written by and published by BoD – Books on Demand. This book was released on 2019-12-04 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neglected tropical diseases (NTDs) is a diverse group of communicable diseases that prevail in tropical and subtropical conditions in 149 countries. NTDs affect more than one billion people and cost developing economies billions of dollars every year. According to the World Health Organization (WHO), NTDs mainly affect populations living in poverty, without adequate sanitation, and in close contact with infectious vectors, domestic animals, and livestock. Migration, as well as climate change and variability, are key factors in NTD prevalence. Therefore, NTDs deserve more study. Recently, viruses transmitted by vectors (arboviruses) that affect not only people living in the tropics, but also travelers and migrating populations, have been causing epidemics. Examples of these viruses include Dengue, Chikungunya, Zika, Mayaro, and encephalitis viruses. These viruses emerge and reemerge in multiple regions of the world, as occurred in the Americas recently (2013-2017) with Chikungunya and Zika. This book aims to update the significant epidemiological and clinical research of NTDs in many aspects with a multinational perspective.

Working to Overcome the Global Impact of Neglected Tropical Diseases

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Author :
Publisher : World Health Organization
ISBN 13 : 9241564091
Total Pages : 184 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Working to Overcome the Global Impact of Neglected Tropical Diseases by : World Health Organization. Department of Control of Neglected Tropical Diseases

Download or read book Working to Overcome the Global Impact of Neglected Tropical Diseases written by World Health Organization. Department of Control of Neglected Tropical Diseases and published by World Health Organization. This book was released on 2010 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Neglected tropical diseases (NTDs) blight the lives of a billion people worldwide and threaten the health of millions more. These ancient companions of poverty weaken impoverished populations, frustrate the achievement of health in the Millennium Development Goals and impede global health and economies has convinced governments, donors, the pharmaceutical industry and other agencies, including nongovernmental organizations (NGOs), to invest in preventing and controlling this diverse group of diseases. Global efforts to control "hidden" diseases, such as dracunculiasis (guinea-worm disease), leprosy, gains including the imminent eradication of dracunculiasis. Since 1989 (when most endemic countries began reporting monthly from each endemic village), the number of new dracunculiasis cases has fallen from 892 055 in 12 endemic countries to 3190 in 4 countries in 2009, a decrease of more than 99%. The World Health Organization (WHO) recommends five public-health strategies for the prevention and control of NTDs: preventive chemotherapy; intensified case-management; vector control; the provision of safe water, sanitation and hygiene; and veterinary public health (that is, applying veterinary sciences to ensure the health and well-being of humans). Although one approach and delivered locally." - p. vii

CDC Yellow Book 2020

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Publisher : Oxford University Press, USA
ISBN 13 : 0190065974
Total Pages : 721 pages
Book Rating : 4.1/5 (9 download)

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Book Synopsis CDC Yellow Book 2020 by : CENTERS FOR DISEASE CONTROL AND PREVENTION. (CDC)

Download or read book CDC Yellow Book 2020 written by CENTERS FOR DISEASE CONTROL AND PREVENTION. (CDC) and published by Oxford University Press, USA. This book was released on 2019-06-11 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive reference for travel medicine, updated for 2020! "A beloved travel must-have for the intrepid wanderer." -Publishers Weekly "A truly excellent and comprehensive resource." -Journal of Hospital Infection The CDC Yellow Book offers everything travelers and healthcare providers need to know for safe and healthy travel abroad. This 2020 edition includes: · Country-specific risk guidelines for yellow fever and malaria, including expert recommendations and 26 detailed, country-level maps · Detailed maps showing distribution of travel-related illnesses, including dengue, Japanese encephalitis, meningococcal meningitis, and schistosomiasis · Guidelines for self-treating common travel conditions, including altitude illness, jet lag, motion sickness, and travelers' diarrhea · Expert guidance on food and drink precautions to avoid illness, plus water-disinfection techniques for travel to remote destinations · Specialized guidelines for non-leisure travelers, study abroad, work-related travel, and travel to mass gatherings · Advice on medical tourism, complementary and integrative health approaches, and counterfeit drugs · Updated guidance for pre-travel consultations · Advice for obtaining healthcare abroad, including guidance on different types of travel insurance · Health insights around 15 popular tourist destinations and itineraries · Recommendations for traveling with infants and children · Advising travelers with specific needs, including those with chronic medical conditions or weakened immune systems, health care workers, humanitarian aid workers, long-term travelers and expatriates, and last-minute travelers · Considerations for newly arrived adoptees, immigrants, and refugees Long the most trusted book of its kind, the CDC Yellow Book is an essential resource in an ever-changing field -- and an ever-changing world.

Neglected Tropical Diseases and Their Impact on Global Health

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Author :
Publisher : American Medical Publishers
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.8/5 (874 download)

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Book Synopsis Neglected Tropical Diseases and Their Impact on Global Health by : Cyrus Hank

Download or read book Neglected Tropical Diseases and Their Impact on Global Health written by Cyrus Hank and published by American Medical Publishers. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neglected tropical diseases (NTDs) are a group of bacterial and parasitic diseases commonly found in various nations in Africa, Asia and Latin America. NTDs are caused by different kinds of pathogens and transmitted by vectors such as mosquitoes and black flies. Some of the common NTDs are schistosomiasis, leishmaniasis, lymphatic filariasis, mycetoma, onchocerciasis, trachoma, etc. There are several factors such as the lack of accessibility to clean water and hygienic sanitary conditions that contribute to the spread of NTDs. These diseases mainly affect the poor and are a source of tremendous suffering because of their disfiguring, debilitating, and sometimes deadly impact. NTDs also impair physical and cognitive development. This book investigates the neglected tropical diseases and their impact on global health in detail. Its aim is to present researches that have transformed the study of these diseases. The book will provide comprehensive knowledge to the readers.

Infectious Diseases

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1119971624
Total Pages : 532 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Infectious Diseases by : Eskild Petersen

Download or read book Infectious Diseases written by Eskild Petersen and published by John Wiley & Sons. This book was released on 2011-04-22 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise and practical guide describes infections in geographical areas and provides information on disease risk, concomitant infections (such as co-prevalence of HIV and tuberculosis) and emerging bacterial, viral and parasitic infections in a given geographical area of the world. Infectious Diseases: A Geographic Guide is divided according to United Nations world regions and addresses geographic disease profiles, presenting symptoms and incubation periods of infections. Each chapter contains a section on the coverage of the childhood vaccination programs in the countries included in that region. Chapters also include descriptions of infectious disease risk and problems with resistant bacteria in each region (e.g. antibiotic resistance in Salmonella infections in Southeast Asia). For the clinician, this book is a tool to generate differential diagnoses by considering the geographical history, as well the presenting symptoms and duration of illness. For the travel medicine specialist, this book provides information on risks of different diseases at various destinations and is particularly useful in advising long-term travelers.

Communicable Diseases in Developing Countries

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Author :
Publisher : Springer
ISBN 13 : 113735478X
Total Pages : 219 pages
Book Rating : 4.1/5 (373 download)

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Book Synopsis Communicable Diseases in Developing Countries by : John Malcolm Dowling

Download or read book Communicable Diseases in Developing Countries written by John Malcolm Dowling and published by Springer. This book was released on 2014-10-05 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This books provides an essential study of communicable diseases, by integrating the diagnosis, treatment and cure of communicable diseases in developing countries with the practical aspects of delivery of these services to the public.

Integrated Management Strategy for Arboviral Disease Prevention and Control in the Americas

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Author :
Publisher : Pan American Health Organization
ISBN 13 : 9789275220498
Total Pages : 95 pages
Book Rating : 4.2/5 (24 download)

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Book Synopsis Integrated Management Strategy for Arboviral Disease Prevention and Control in the Americas by : Pan American Pan American Health Organization

Download or read book Integrated Management Strategy for Arboviral Disease Prevention and Control in the Americas written by Pan American Pan American Health Organization and published by Pan American Health Organization. This book was released on 2020-07-20 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, conditions in the Region of the Americas have been highly favorable for the introduction and spread of arthropod-borne viral infections (arboviral diseases). Although dengue has been circulating for over 400 years, the number of cases reported since the year 2000 represents an unprecedented increase, with four serotypes in circulation. Since that year, 19.6 million cases of dengue have been reported to PAHO/WHO, including more than 800,000 severe cases and over 10,000 deaths. In 2015 and 2016 alone, more than 4.8 million cases were reported, 17,000 of them severe, resulting in 2,000 deaths. Despite a 23% reduction in the dengue case-fatality rate in the last six years (from 0.069% to 0.053%), the continued risk of severe disease and even death poses a serious public health problem in the Americas. Today, arboviruses present an extremely complex and unstable epidemiological situation, given the simultaneous epidemic circulation of three arboviral diseases and the risk that others could become epidemics, for example, Mayaro fever. Countries are aware that this complex situation can only be addressed with a comprehensive and multidisciplinary approach. The development of IMS-arbovirus is part of a history of technical cooperation between PAHO/WHO and the countries and territories of the Americas. It is based on the lessons learned during the development and implementation of national IMS-dengue programs in recent years. This history of cooperation is not new. It dates back to October 1947, with the adoption of Resolution CD1.R1 during the first Directing Council of PAHO. This resolution stated that the solution to the problem of urban yellow fever would be the eradication of Ae. aegypti in the entire hemisphere. The success of that campaign was demonstrated in 1962, with the eradication of this vector in 18 countries in the Region and several Caribbean islands.

Current Topics in Tropical Emerging Diseases and Travel Medicine

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1789848245
Total Pages : 179 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Current Topics in Tropical Emerging Diseases and Travel Medicine by : Alfonso J. Rodriguez-Morales

Download or read book Current Topics in Tropical Emerging Diseases and Travel Medicine written by Alfonso J. Rodriguez-Morales and published by BoD – Books on Demand. This book was released on 2018-12-19 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tropical emerging diseases pose a significant risk for the circulation of old and new pathogens in areas previously unknown, also implying the possibility of new morbidities and mortalities and new consequences for naïve populations. Globalization, migration and travel are key factors for tropical diseases, and represent the need for integration of tropical medicine, travel medicine and epidemiology in the understanding of such complex situations. Neglected tropical diseases such as leprosy or Chagas disease, arboviral diseases, HIV, Ebola, and arenaviral infections are just a few examples. This book tries to update significant epidemiological and clinical research in many aspects with a multinational perspective.

Addressing Emerging Infectious Disease Threats

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Author :
Publisher :
ISBN 13 :
Total Pages : 56 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Addressing Emerging Infectious Disease Threats by :

Download or read book Addressing Emerging Infectious Disease Threats written by and published by . This book was released on 1994 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: This plan addresses the need to improve our ability to identify infectious disease threats and respond to them effectively by improving the public health infrastructure at the local, state and federal levels. The goals of the plan are surveillance (detect, promptly investigate, and monitor emerging pathogens, the diseases they cause, and the factors influencing their emergence); applied research (integrate laboratory science and epidemiology to optimize public health practice); prevention and control (enhance communication of public health information about emerging diseases and ensure prompt implementation of prevention strategies); and infrastructure (strengthen local, state, and federal public health infrastructures to support surveillance and implement prevention and control programs).