Nanoscale Imaging And Characterisation Of Amyloid

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Nanoscale Imaging and Characterisation of Amyloid-β

Author : Claire Louisa Tinker-Mill
Publisher : Springer
ISBN 13 : 3319395343
Total Pages : 165 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Nanoscale Imaging and Characterisation of Amyloid-β by : Claire Louisa Tinker-Mill

Download or read book Nanoscale Imaging and Characterisation of Amyloid-β written by Claire Louisa Tinker-Mill and published by Springer. This book was released on 2016-07-05 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents a method for reliably and robustly producing samples of amyloid-β (Aβ) by capturing them at various stages of aggregation, as well as the results of subsequent imaging with various atomic force microscopy (AFM) methods, all of which add value to the data gathered by collecting information on the peptide’s nanomechanical, elastic, thermal or spectroscopical properties. Amyloid-β (Aβ) undergoes a hierarchy of aggregation following a structural transition, making it an ideal subject of study using scanning probe microscopy (SPM), dynamic light scattering (DLS) and other physical techniques. By imaging samples of Aβ with Ultrasonic Force Microscopy, a detailed substructure to the morphology is revealed, which correlates well with the most advanced cryo-EM work. Early stage work in the area of thermal and spectroscopical AFM is also presented, and indicates the promise these techniques may hold for imaging sensitive and complex biological materials. This thesis demonstrates that physical techniques can be highly complementary when studying the aggregation of amyloid peptides, and allow the detection of subtle differences in their aggregation processes.

Peptide Catalysts, including Catalytic Amyloids

Author :
Publisher : Elsevier
ISBN 13 : 0443236682
Total Pages : 550 pages
Book Rating : 4.4/5 (432 download)

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Book Synopsis Peptide Catalysts, including Catalytic Amyloids by :

Download or read book Peptide Catalysts, including Catalytic Amyloids written by and published by Elsevier. This book was released on 2024-05-28 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Catalysts, including Catalytic Amyloids, Volume 697 in this esteemed series, highlights new advances in the field, with this new volume presenting interesting topics on Screening of oxidative behaviors in catalytic amyloid assemblies, Catalytic amyloids derived for natural proteins, AFM-IR studies of catalytic amyloids, MD structural studies of catalytic amyloids, Characterization of crystalline, amyloid-like amino acid assemblies, Computational modeling of supramolecular peptide assemblies, and Assembly and activity of short prion-inspired peptides. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Methods in Enzymology series - Updated release includes the latest information on Peptide Catalysts, including Catalytic Amyloids

Nanoscale Imaging

Author : Yuri L. Lyubchenko
Publisher : Humana Press
ISBN 13 : 9781493985906
Total Pages : 600 pages
Book Rating : 4.9/5 (859 download)

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Book Synopsis Nanoscale Imaging by : Yuri L. Lyubchenko

Download or read book Nanoscale Imaging written by Yuri L. Lyubchenko and published by Humana Press. This book was released on 2018-06-29 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents readers with the latest techniques to study nanoimaging and nanoprobing in application to a broad range of biological systems. The chapters in this book are divided into five parts, and cover topics such as imaging and probing of biomacromolecules including high-speed imaging and probing with AFM; probing chromatin structure with magnetic tweezers; and fluorescence correlation spectroscopy on genomic DNA in living cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and through, Nanoscale Imaging: Methods and Protocols is a valuable resource for anyone interested in learning more about this developing and expanding field.

Nanoimaging

Author : Beth A. Goins
Publisher : CRC Press
ISBN 13 : 9814267090
Total Pages : 308 pages
Book Rating : 4.8/5 (142 download)

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Book Synopsis Nanoimaging by : Beth A. Goins

Download or read book Nanoimaging written by Beth A. Goins and published by CRC Press. This book was released on 2011-09-07 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first resource of its kind, this book covers cutting-edge research on the use of nanoparticles for in vivo diagnostic medical imaging and therapy. It discusses a variety of nanoparticles, including quantum dots, carbon nanotubes, dendrimers, gold nanoshells, metal nanorods, micelles, liposomes, polymers, MRI iron oxide particles, and microbubbles. Examples in the book include multifunctional nanoparticles that designed for multimodality imaging and simultaneous diagnostic and therapy (theranostic) applications.

Bio-nanoimaging

Author : Vladimir N Uversky
Publisher : Academic Press
ISBN 13 : 0123978211
Total Pages : 556 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Bio-nanoimaging by : Vladimir N Uversky

Download or read book Bio-nanoimaging written by Vladimir N Uversky and published by Academic Press. This book was released on 2013-11-05 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bio-Nanoimaging: Protein Misfolding & Aggregation provides a unique introduction to both novel and established nanoimaging techniques for visualization and characterization of misfolded and aggregated protein species. The book is divided into three sections covering: - Nanotechnology and nanoimaging technology, including cryoelectron microscopy of beta(2)-microglobulin, studying amyloidogensis by FRET; and scanning tunneling microscopy of protein deposits - Polymorphisms of protein misfolded and aggregated species, including fibrillar polymorphism, amyloid-like protofibrils, and insulin oligomers - Polymorphisms of misfolding and aggregation processes, including multiple pathways of lysozyme aggregation, misfolded intermediate of a PDZ domain, and micelle formation by human islet amyloid polypeptide Protein misfolding and aggregation is a fast-growing frontier in molecular medicine and protein chemistry. Related disorders include cataracts, arthritis, cystic fibrosis, late-onset diabetes mellitus, and numerous neurodegenerative diseases like Alzheimer's and Parkinson's. Nanoimaging technology has proved crucial in understanding protein-misfolding pathologies and in potential drug design aimed at the inhibition or reversal of protein aggregation. Using these technologies, researchers can monitor the aggregation process, visualize protein aggregates and analyze their properties. - Provides practical examples of nanoimaging research from leading molecular biology, cell biology, protein chemistry, biotechnology, genetics, and pharmaceutical labs - Includes over 200 color images to illustrate the power of various nanoimaging technologies - Focuses on nanoimaging techniques applied to protein misfolding and aggregation in molecular medicine

Non-Destructive Material Characterization Methods

Author : Akira Otsuki
Publisher : Elsevier
ISBN 13 : 0323984789
Total Pages : 842 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Non-Destructive Material Characterization Methods by : Akira Otsuki

Download or read book Non-Destructive Material Characterization Methods written by Akira Otsuki and published by Elsevier. This book was released on 2023-09-01 with total page 842 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-Destructive Material Characterization Methods provides readers with a trove of theoretical and practical insight into how to implement different non-destructive testing methods for effective material characterization. The book starts with an introduction to the field before moving right into a discussion of a wide range of techniques that can be immediately implemented. Various imaging and microscopy techniques are first covered, with step-by-step insights on characterization using a polarized microscope, an atomic force microscope, computed tomography, ultrasonography, magnetic resonance imaging, infrared tomography, and more. Each chapter includes case studies, applications, and recent developments. From there, elemental assay and mapping techniques are discussed, including Raman spectroscopy, UV spectroscopy, atomic absorption spectroscopy, neutron activation analysis, and various others. The book concludes with sections covering displacement measurement techniques, large-scale facility techniques, and methods involving multiscale analysis and advanced analysis. - Provides an overview of a wide-range of NDT material characterization methods, strengths and weaknesses of these methods, when to apply them, and more - Includes eddy current sensing and imaging, ultrasonic sensing and imaging, RF and THz imaging, internet and cloud-based methods, among many others - Presents case studies, applications and other insights on putting these methods into practice

Advances in Imaging Technology Research and Application: 2013 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481682954
Total Pages : 1009 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Advances in Imaging Technology Research and Application: 2013 Edition by :

Download or read book Advances in Imaging Technology Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 1009 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Imaging Technology Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Atomic Force Microscopy. The editors have built Advances in Imaging Technology Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Atomic Force Microscopy in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Imaging Technology Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Bacterial Amyloids

Author : Véronique Arluison
Publisher : Springer Nature
ISBN 13 : 1071625292
Total Pages : 336 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Bacterial Amyloids by : Véronique Arluison

Download or read book Bacterial Amyloids written by Véronique Arluison and published by Springer Nature. This book was released on 2022-08-11 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume introduces different methods to assess the structure and folding of bacterial amyloids and analyze their functions, either in vitro or in vivo. Despite their initial association with neurodegenerative diseases, there is now increasing evidence of alternative roles for amyloids, with beneficial aspects for cells. In particular, prokaryotes use amyloids as functional assemblies, where they are key players in the cell's physiology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Bacterial Amyloids: Methods and Protocols is an ideal guide for experts and novices alike to further explore these crucial protein assemblies.

Advancing the Characterization of Neuronal Cyto-Architecture by X-ray Phase-Contrast Tomography

Author : Marina Eckermann
Publisher : Universitätsverlag Göttingen
ISBN 13 : 3863955285
Total Pages : 276 pages
Book Rating : 4.8/5 (639 download)

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Book Synopsis Advancing the Characterization of Neuronal Cyto-Architecture by X-ray Phase-Contrast Tomography by : Marina Eckermann

Download or read book Advancing the Characterization of Neuronal Cyto-Architecture by X-ray Phase-Contrast Tomography written by Marina Eckermann and published by Universitätsverlag Göttingen. This book was released on 2021 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: To bring physiology and pathology of the human brain into better micro-anatomical and histological context, studies with different methodologies are required. Established techniques such as electron microscopy or histology show limitations in view of invasiveness, labor-intense and artifact-prone sample preparation, as well as an adequate ratio between resolution and volume throughput. For this reason, X-ray phase-contrast tomography (PC-CT) has been proposed as a three-dimensional non-destructive imaging technique, which requires less effort in sample preparation and can assess larger volumes. Furthermore, it offers quantitative electron density based contrast even for unstained tissue. Up to now, however, PC-CT studies fell short in number of samples, so that structural alterations caused by neurodegenerative diseases cannot be distinguished from physiological inter-subject variations. In this thesis, the scalability of PC-CT with respect to the required number of samples and resolution-to-volume-throughput is demonstrated, and the methodology is advanced with respect to data acquisition, processing and segmentation. In addition to the human cerebellum, cortex and hippocampus are studied. Concerning quantification and analysis of PC-CT data, this work introduces optimal transport analysis to obtain quantitative metrics of the cyto-architecture and to identify changes due to neurodegenerative diseases. For the case of Alzheimer’s disease, this workflow reveals a yet undescribed compactification of granular cells in the human hippocampus. This thesis also provides optimized configurations to study neural tissues with laboratory instrumentation, and – finally – provides new correlative imaging approaches, in particular with scanning electron microscopy.

High-Speed Atomic Force Microscopy in Biology

Author : Toshio Ando
Publisher : Springer Nature
ISBN 13 : 3662647850
Total Pages : 327 pages
Book Rating : 4.6/5 (626 download)

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Book Synopsis High-Speed Atomic Force Microscopy in Biology by : Toshio Ando

Download or read book High-Speed Atomic Force Microscopy in Biology written by Toshio Ando and published by Springer Nature. This book was released on 2022-03-23 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first book on high-speed atomic force microscopy (HS-AFM) is intended for students and biologists who want to use HS-AFM in their research. It provides straightforward explanations of the principle and techniques of AFM and HS-AFM. Numerous examples of HS-AFM studies on proteins demonstrate how to apply this new form of microscopy to specific biological problems. Several precautions for successful imaging and the preparation of cantilever tips and substrate surfaces will greatly benefit first-time users of HS-AFM. In turn, the instrumentation techniques detailed in Chapter 4 can be skipped, but will be useful for engineers and scientists who want to develop the next generation of high-speed scanning probe microscopes for biology. The book is intended to facilitate the first-time use of this new technique, and to inspire students and researchers to tackle their own specific biological problems by directly observing dynamic events occurring in the nanoscopic world. Microscopy in biology has recently entered a new era with the advent of high-speed atomic force microscopy (HS-AFM). Unlike optical microscopy, electron microscopy, and conventional slow AFM, it allows us to directly observe biological molecules in physiological environments. Molecular “movies” created using HS-AFM can directly reveal how molecules behave and operate, without the need for subsequent complex analyses and roundabout interpretations. It also allows us to directly monitor morphological change in live cells, and dynamic molecular events occurring on the surfaces of living bacteria and intracellular organelles. As HS-AFM instruments were recently commercialized, in the near future HS-AFM is expected to become a common tool in biology, and will enhance and accelerate our understanding of biological phenomena.

Functional Bionanomaterials

Author : Devarajan Thangadurai
Publisher : Springer Nature
ISBN 13 : 3030414647
Total Pages : 497 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Functional Bionanomaterials by : Devarajan Thangadurai

Download or read book Functional Bionanomaterials written by Devarajan Thangadurai and published by Springer Nature. This book was released on 2020-07-08 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the application of nanotechnology in medicine and drug delivery, including diagnosis and therapy. Nanomedicine can contribute to the development of a personalized medicine both for diagnosis and therapy. By interacting with biological molecules at nanoscale level, nanotechnology opens up an immense field of research and applications. Interactions between artificial molecular assemblies or nanodevices and biomolecules can be understood both in the extracellular medium and inside human cells. Operating at nanoscale allows exploitation of physical properties different from those observed at microscale, such as the volume to surface area ratio. A number of clinical applications of nanobiotechnology, such as disease diagnosis, target-specific drug delivery, and molecular imaging are being investigated. Some promising new products are also undergoing clinical trials. Such advanced applications of this approach to biological systems will undoubtedly transform the foundations of diagnosis, treatment, and prevention of disease in the future. Nanomedicine sales reached $16 billion in 2015, with a minimum of $3.8 billion in nanotechnology R&D being invested each year. Global funding for emerging nanotechnology increased by 45% per year in recent years, with product sales exceeding $1 trillion in 2013. As the nanomedicine industry continues to grow, it is expected to have a significant impact on the global economy. This book provides clear, colorful and simple illustrations, tables, and case studies to clearly convey the content to a general audience and reader. This book also discusses the development of nanobiomaterials from biogenic (biological sources) systems for healthcare and disease therapies. This book, therefore, is useful for researchers and academicians in the fields of nanotechnology, medicine, nano-biotechnology and pharmacology.

The biochemistry of amyloids in neurodegenerative diseases, volume II

Author : Cláudio M. Gomes
Publisher : Frontiers Media SA
ISBN 13 : 2832529798
Total Pages : 193 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis The biochemistry of amyloids in neurodegenerative diseases, volume II by : Cláudio M. Gomes

Download or read book The biochemistry of amyloids in neurodegenerative diseases, volume II written by Cláudio M. Gomes and published by Frontiers Media SA. This book was released on 2023-07-19 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Scanning Probe Microscopy of Functional Materials

Author : Sergei V. Kalinin
Publisher : Springer Science & Business Media
ISBN 13 : 144197167X
Total Pages : 563 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Scanning Probe Microscopy of Functional Materials by : Sergei V. Kalinin

Download or read book Scanning Probe Microscopy of Functional Materials written by Sergei V. Kalinin and published by Springer Science & Business Media. This book was released on 2010-12-13 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this book is to provide a general overview of the rapidly developing field of novel scanning probe microscopy (SPM) techniques for characterization of a wide range of functional materials, including complex oxides, biopolymers, and semiconductors. Many recent advances in condensed matter physics and materials science, including transport mechanisms in carbon nanostructures and the role of disorder on high temperature superconductivity, would have been impossible without SPM. The unique aspect of SPM is its potential for imaging functional properties of materials as opposed to structural characterization by electron microscopy. Examples include electrical transport and magnetic, optical, and electromechanical properties. By bringing together critical reviews by leading researchers on the application of SPM to to the nanoscale characterization of functional materials properties, this book provides insight into fundamental and technological advances and future trends in key areas of nanoscience and nanotechnology.

Microbial Glycobiology

Author : Anthony P Moran
Publisher : Elsevier
ISBN 13 : 0080923240
Total Pages : 1037 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Microbial Glycobiology by : Anthony P Moran

Download or read book Microbial Glycobiology written by Anthony P Moran and published by Elsevier. This book was released on 2009-10-01 with total page 1037 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents in an easy-to-read format a summary of the important central aspects of microbial glycobiology, i.e. the study of carbohydrates as related to the biology of microorganisms. Microbial glycobiology represents a multidisciplinary and emerging area with implications for a range of basic and applied research fields, as well as having industrial, medical and biotechnological implications. - Individual chapters provided by leading international scientists in the field yield insightful, concise and stimulating reviews - Provides researchers with an overview and synthesis of the latest research - Each chapter begins with a brief 200 word Summary/Abstract detailing the topic and focus of the chapter, as well as the concepts to be addressed - Allows researchers to see at a glance what each chapter will cover - Each chapter includes a Research Focus Box - Identifies important problems that still need to be solved and areas that require further investigation

Raman Spectroscopy

Author : Dheeraj Kumar Singh
Publisher : Springer Nature
ISBN 13 : 9819717035
Total Pages : 388 pages
Book Rating : 4.8/5 (197 download)

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Book Synopsis Raman Spectroscopy by : Dheeraj Kumar Singh

Download or read book Raman Spectroscopy written by Dheeraj Kumar Singh and published by Springer Nature. This book was released on with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nanomaterials and Nanotechnology in Medicine

Author : Visakh P. M.
Publisher : John Wiley & Sons
ISBN 13 : 1119558093
Total Pages : 580 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Nanomaterials and Nanotechnology in Medicine by : Visakh P. M.

Download or read book Nanomaterials and Nanotechnology in Medicine written by Visakh P. M. and published by John Wiley & Sons. This book was released on 2022-09-12 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: NANOMATERIALS AND NANOTECHNOLOGY IN MEDICINE A comprehensive introduction to nanomaterials and their application in the field of medicine The use of nanotechnology and nanomaterials more generally is an emerging field that has generated a lot of interest in the last few years. To this point, there have been few books that deal with the recent advances in nanomaterials or nanocomposites in the medical discipline. Intended as a one-stop reference, Nanomaterials and Nanotechnology in Medicine provides the reader with the most-up-to-date and comprehensive exploration of the field of nanomedicine. The scope of the topic is huge, with nano applications in every medical specialization—from diagnostics to pharmaceuticals, from biological therapies to surgical devices, and from regenerative therapies to gene therapy. As such, this volume provides the most comprehensive coverage of this intriguing field of study. Nanomaterials and Nanotechnology in Medicine readers will also find: An application-oriented book dedicated towards helping researchers find solutions to both fundamental and applied problems Chapters written by leading researchers from industry, academy, government, and private research institutions across the globe Nanomaterials and Nanotechnology in Medicine is a useful reference for medical doctors, medical practitioners, post-doctoral research fellows, senior graduate students, and medical libraries.

Frontiers in Nanomedicine

Author : Maria Luisa Bondì
Publisher : Bentham Science Publishers
ISBN 13 : 168108046X
Total Pages : 270 pages
Book Rating : 4.6/5 (81 download)

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Book Synopsis Frontiers in Nanomedicine by : Maria Luisa Bondì

Download or read book Frontiers in Nanomedicine written by Maria Luisa Bondì and published by Bentham Science Publishers. This book was released on 2015-04-16 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Nanomedicine offers an up-to-date understanding of nanomaterials to readers having clinical or biomolecular research interests. Scientists, both aspiring and experienced, will find, in each volume, a comprehensive overview of current molecular strategies for using nanoscale materials in medicine. This volume explains the use of nanotechnology in medicine to improve the diagnosis of disease and the role of nanoparticles in targeted drug delivery systems for theranostic applications. This volume also covers the applications of nanoparticles in breast cancer research, liver disease therapy and Alzheimer’s disease treatment.