Nanobiomaterials in Galenic Formulations and Cosmetics

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Author :
Publisher : William Andrew
ISBN 13 : 0323428916
Total Pages : 460 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Nanobiomaterials in Galenic Formulations and Cosmetics by : Alexandru Grumezescu

Download or read book Nanobiomaterials in Galenic Formulations and Cosmetics written by Alexandru Grumezescu and published by William Andrew. This book was released on 2016-05-12 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanobiomaterials in Galenic Formulations and Cosmetics: Applications of Nanobiomaterials is one of the first books on the market related to the application of nanotechnology in galenic formulations and cosmetics. This book provides the results of current research for those working in an applied setting. The advantage of having all this information in one coherent text is the focused nature of the chapters and the ease of which this information can be accessed. This collection of titles brings together many of the novel applications these materials have in biology, and discusses the advantages and disadvantages of each application and the perspectives of the technologies based on these findings. At the moment there is no other comparable book series covering all the subjects approached in this set of titles. Offers an updated and highly structured reference material for students, researchers, and practitioners working in biomedical, biotechnological, and engineering fields Serves as a valuable resource of recent scientific progress, along with most known applications of nanomaterials in the biomedical field Features novel opportunities and ideas for developing or improving technologies in nanomedicine and nanobiology

Nanocosmetics

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Author :
Publisher : Springer
ISBN 13 : 3030165736
Total Pages : 363 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Nanocosmetics by : Jean Cornier

Download or read book Nanocosmetics written by Jean Cornier and published by Springer. This book was released on 2019-06-14 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the application of nanotechnology to cosmetics. Edited by three respected experts in the field, the book begins with a general overview of the science behind cosmetics and skin care today, and of the status quo of nanotechnology in cosmetics. Subsequent chapters provide detailed information on the different nanoparticles currently used in cosmetics; the production and characterization of nanoparticles and nanocosmetics; and regulatory, safety and commercialization aspects. Given its scope, the book offers an indispensable guide for scientists in academia and industry, technicians and students, as well as a useful resource for decision-makers in the field and consumer organizations. Chapter 6 of this book is available open access under a CC BY 4.0 licence at link.springer.com.

Nanocosmetics and Nanomedicines

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642197922
Total Pages : 368 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Nanocosmetics and Nanomedicines by : Ruy Beck

Download or read book Nanocosmetics and Nanomedicines written by Ruy Beck and published by Springer Science & Business Media. This book was released on 2011-04-06 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book "Nanocosmetics and nanomedicines: new approaches for skin care” contains a summary of the most important nanocarriers for skin delivery. Although “nanocosmetics” is a subject widely commented in the academy and the beauty industry, a book covering the skin care treatments using nanotechnological approaches with cosmetics and nanomedicines is still missing, therefore the need for this publication. This book is divided in three parts: The first one (Part A) is devoted to a brief review on the main topics related to the skin delivery and to the introduction of the subject “nanocosmetics”. The second part (Part B) presents different types of nanocarriers applied as skin delivery systems for cosmetics or drugs. The last part (Part C) shows a wide range of applications of nanotechnology on the skin care area as well as on dermatocosmetic and dermatological fields.

Nanotechnology for the Preparation of Cosmetics using Plant-Based Extracts

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Author :
Publisher : Elsevier
ISBN 13 : 012822939X
Total Pages : 410 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Nanotechnology for the Preparation of Cosmetics using Plant-Based Extracts by : Siti Hamidah Mohd Setapar

Download or read book Nanotechnology for the Preparation of Cosmetics using Plant-Based Extracts written by Siti Hamidah Mohd Setapar and published by Elsevier. This book was released on 2022-02-18 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cosmetic manufacturers use nanoscale size ingredients to provide better UV protection, deeper skin penetration, long-lasting effects, increased color and finish quality. This approach enables the forming of nanoscale cosmetic ingredients, which can possess active components readily absorbed into the skin, repair damage easily, and promote improved product outcomes. Nanotechnology for the Preparation of Cosmetics using Plant-Based Extracts explores the various applications of nanotechnology in the cosmetic industry. Techniques for the development of cosmetic are a topic of increasing interest with widespread opportunities for potential applications in a broad range of industrial applications. The book covers a variety of techniques and processes, focusing on its potential applications in the field of skincare and makeup cosmetics. The book will cover not only conventional processes but also innovative and efficient techniques for the preparation of cosmetics exhibiting unique applications in the field. Nanotechnology for the Preparation of Cosmetics using Plant-Based Extracts is an important reference source for materials scientists, engineers and pharmaceutical scientists who want to learn more about the use of cosmetics prepared through nanotechnology to achieve the materials characteristics and enhancements in the mechanism and properties of makeup and skincare. Presents techniques for the design and manufacture of high-performance skincare products using nanotechnology Demonstrates systematic approaches and investigations for the design, synthesis, characterization and applications of various plant-based extracts in order to make them effective ingredients for cosmetics creation Assesses the major challenges of using plant-based materials in the manufacture of cosmetic products

Nanocosmetics

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Author :
Publisher : Elsevier
ISBN 13 : 0128222867
Total Pages : 520 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Nanocosmetics by : Arun Nanda

Download or read book Nanocosmetics written by Arun Nanda and published by Elsevier. This book was released on 2020-05-19 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology is key to the design and manufacture of the new generation of cosmetics. Nanotechnology can enhance the performance and properties of cosmetics, including colour, transparency, solubility, texture, and durability. Sunscreen products, such as UV nano-filters, nano-TiO2 and nano-ZnO particles, can offer an advantage over their traditional counterparts due to their broad UV-protection and non-cutaneous side effects. For perfumes, nano-droplets can be found in cosmetic products including Eau de Toilette and Eau de Parfum. Nanomaterials can also be used in cosmetics as transdermal drug delivery systems. By using smart nanocontainers, active compounds such as vitamins, antioxidants, nutrients, and anti-inflammatory, anti-infective agents, can be delivered effectively. These smart nanocontainers are typically related with the smart releasing property for their embedded active substances. These smart releases could be obtained by using the smart coatings as their outer nano-shells. These nano-shells could prevent the direct contact between these active agents and the adjacent local environments. Nanocosmetics: Fundamentals, Applications and Toxicity explores the formulation design concepts and emerging applications of nanocosmetics. The book also focuses on the mitigation or prevention of their potential nanotoxicity, potential global regulatory challenges, and the technical challenges of mass implementation. It is an important reference source for materials scientists and pharmaceutical scientists looking to further their understanding of how nanotechnology is being used for the new generation of cosmetics. Outlines the major fabrication and formulation design concepts of nanoscale products for cosmetic applications Explores how nanomaterials can safely be used for various applications in cosmetic products Assesses the major challenges of using nanomaterials for cosmetic applications on a large scale

Nanocosmetics

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Author :
Publisher : CRC Press
ISBN 13 : 1000931447
Total Pages : 423 pages
Book Rating : 4.0/5 (9 download)

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Book Synopsis Nanocosmetics by : Prashant Kesharwani

Download or read book Nanocosmetics written by Prashant Kesharwani and published by CRC Press. This book was released on 2023-09-21 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an explicit account of vital aspects of various nanocosmetics drug delivery approaches, thereby providing a next-generation cosmetic product Brings together novel applications of nanocosmetics approaches in a biological milieu Explores preparation, applications, toxicity, and regulatory prospects Includes a dedicated chapter on Niosomal drug-delivery system in cosmetics Discusses the perspectives of the technologies explored so far based upon the findings outlined in highly organized tables, illustrative figures, and flow charts

Nanocosmeceuticals

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Author :
Publisher : Academic Press
ISBN 13 : 0323910785
Total Pages : 590 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Nanocosmeceuticals by : Malay K. Das

Download or read book Nanocosmeceuticals written by Malay K. Das and published by Academic Press. This book was released on 2022-08-23 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cosmetics are a fast-growing segment in the global personal care industry and the application of nanocosmeceuticals are on the rise. Conventional cosmetics greatly lack specific delivery systems, prolong effects and relatively heavy doses may be necessary. One of the common complaints of consumers is rather short-term activity of cosmetics, especially in face care products. Nanocosmeceuticals, having more advanced nutrient delivery mechanisms, carry more task specific nutrients to the skin deep where it can be metabolized and used to nourish cells. It can help to increase the aesthetic appeal of a product influencing the purchase decision of a consumer. Nanocosmeceuticals: Innovation, Application and Safety highlights the trends and applications of nanotechnology in cosmeceuticals for more advance and task specific nutrients delivery and long term effects of personal care products using liposome, solid lipid nanoparticles, nanostructured lipid carriers, transferosomes, niosomes, phytosomes, nanoemulsions, silver nanoparticles, chitin nanofibrils etc. It also provides the detailed information on regulatory laws, safety and marketing aspects of cosmeceuticals. This book offers an indispensable guide for professors, researchers, students, formulation chemists as well as formulation scientists in academia and industry; beauticians and decision-makers in consumer organizations. First book on ‘Nanocosmeceuticals’ Serves as a valuable resource of scientific innovations, novel applications, safety and regulations of Nanocosmeceuticals Offers an updated and highly structured reference material for students, researchers, professors, formulation chemists and scientists

Nanocosmetics

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Author :
Publisher :
ISBN 13 : 9783030165741
Total Pages : pages
Book Rating : 4.1/5 (657 download)

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Book Synopsis Nanocosmetics by : Jean Cornier

Download or read book Nanocosmetics written by Jean Cornier and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the application of nanotechnology to cosmetics. Edited by three respected experts in the field, the book begins with a general overview of the science behind cosmetics and skin care today, and of the status quo of nanotechnology in cosmetics. Subsequent chapters provide detailed information on the different nanoparticles currently used in cosmetics; the production and characterization of nanoparticles and nanocosmetics; and regulatory, safety and commercialization aspects. Given its scope, the book offers an indispensable guide for scientists in academia and industry, technicians and students, as well as a useful resource for decision-makers in the field and consumer organizations. Chapter 6 of this book is available open access under a CC BY 4.0 license at link.springer.com.

Biopolymeric Nanomaterials

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Author :
Publisher : Elsevier
ISBN 13 : 0323853285
Total Pages : 732 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Biopolymeric Nanomaterials by : Shamsher S. Kanwar

Download or read book Biopolymeric Nanomaterials written by Shamsher S. Kanwar and published by Elsevier. This book was released on 2021-09-24 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopolymeric Nanomaterials: Fundamentals and Applications outlines the fundamental design concepts and emerging applications of biopolymeric nanomaterials. The book also provides information on emerging applications of biopolymeric nanomaterials, including in biomedicine, manufacturing and water purification, as well as assessing their physical, chemical and biological properties. This is an important reference source for materials scientists, engineers and biomedical scientists who are seeking to increase their understanding of how polymeric nanomaterials are being used for a range of biomedical and industrial applications. Biopolymeric nanomaterials refer to biocompatible nanomaterials, consisting of biopolymers, such as protein (silk, collagen, gelatin, ß-casein, zein, and albumin), protein-mimicked polypeptides and polysaccharides (chitosan, alginate, pullulan, starch, and heparin). Biopolymeric nanomaterials may be used as i) delivery systems for bioactive compounds in food application, (ii) for delivery of therapeutic molecules (drugs and genes), or for (iii) tissue engineering. Provides information on the design concepts and synthesis of biopolymeric nanomaterials in biomedical and industrial applications Highlights the major properties and processing methods for biopolymeric nanomaterials Assesses the major challenges of producing biopolymeric nanomaterials on an industrial scale

Pharmaceutical, Cosmetic and Personal Care Formulations

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Author :
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110587599
Total Pages : 362 pages
Book Rating : 4.1/5 (15 download)

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Book Synopsis Pharmaceutical, Cosmetic and Personal Care Formulations by : Tharwat F. Tadros

Download or read book Pharmaceutical, Cosmetic and Personal Care Formulations written by Tharwat F. Tadros and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-05-22 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 3 of Formulation Science and Technology is a survey of the applications of formulations in a variety of fields, based on the theories presented in Volumes 1 and 2. It offers in-depth explanations and a wealth of real-world examples for research scientists, universities, and industry practitioners in the fields of Pharmaceuticals, Cosmetics and Personal Care.

Nanocosmetics

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Author :
Publisher : Elsevier
ISBN 13 : 0128222859
Total Pages : 521 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Nanocosmetics by : Arun Nanda

Download or read book Nanocosmetics written by Arun Nanda and published by Elsevier. This book was released on 2020-05-06 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology is key to the design and manufacture of the new generation of cosmetics. Nanotechnology can enhance the performance and properties of cosmetics, including colour, transparency, solubility, texture, and durability. Sunscreen products, such as UV nano-filters, nano-TiO2 and nano-ZnO particles, can offer an advantage over their traditional counterparts due to their broad UV-protection and non-cutaneous side effects. For perfumes, nano-droplets can be found in cosmetic products including Eau de Toilette and Eau de Parfum. Nanomaterials can also be used in cosmetics as transdermal drug delivery systems. By using smart nanocontainers, active compounds such as vitamins, antioxidants, nutrients, and anti-inflammatory, anti-infective agents, can be delivered effectively. These smart nanocontainers are typically related with the smart releasing property for their embedded active substances. These smart releases could be obtained by using the smart coatings as their outer nano-shells. These nano-shells could prevent the direct contact between these active agents and the adjacent local environments. Nanocosmetics: Fundamentals, Applications and Toxicity explores the formulation design concepts and emerging applications of nanocosmetics. The book also focuses on the mitigation or prevention of their potential nanotoxicity, potential global regulatory challenges, and the technical challenges of mass implementation. It is an important reference source for materials scientists and pharmaceutical scientists looking to further their understanding of how nanotechnology is being used for the new generation of cosmetics. Outlines the major fabrication and formulation design concepts of nanoscale products for cosmetic applications Explores how nanomaterials can safely be used for various applications in cosmetic products Assesses the major challenges of using nanomaterials for cosmetic applications on a large scale

Nanotoxicology in Safety Assessment of Nanomaterials

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Author :
Publisher : Springer Nature
ISBN 13 : 3030880710
Total Pages : 439 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Nanotoxicology in Safety Assessment of Nanomaterials by : Henriqueta Louro

Download or read book Nanotoxicology in Safety Assessment of Nanomaterials written by Henriqueta Louro and published by Springer Nature. This book was released on 2022-05-18 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its advent, nanotechnologies are considered key enabling technologies that take advantage of a wide array of nanomaterials (NMs) for biomedical and industrial applications generating significant societal and economic benefits. However, such innovation increases human exposure to these substances through inhalation, ingestion or dermal contact raising public health concerns. Furthermore, the NMs’ specific physicochemical properties, that confer them unique beneficial characteristics, can also elicit nano-bio interactions leading to toxicity and concerns for public health. In addition, such properties can be affected by the surrounding matrix, particularly when incorporated in complex matrices such as food products, leading to secondary features potentially more relevant than primary characteristics for determining their toxicological outcome. These nano specific issues raise the question of whether the NMs may produce adverse outcomes that are not accounted for when using conventional toxicological approaches to assess their safety. Such uncertainties about the safety of NMs for human health and the environment may hamper a faster and more widespread exploration of their potentials. In response, the NMs definition has evolved, and nanotoxicology has developed towards new and more integrative approach methods to support regulatory and policy actions. This book provides a perspective on recent developments in the synthesis, application, and characterization of NMs and the related nanotechnologies, focusing on nanotoxicology for their accurate safety assessment early in the product development stage. The use of complex in vitro models, including multicellular systems and organoids, and “omics-based” approaches, such as transcriptomics or epigenomics, have greatly contributed to an in-depth understanding of the cellular and molecular mechanisms behind some NMs toxicity. Such mechanistic knowledge is equally addressed in this book and has set the basis for a predictive nanotoxicology approach building on adverse outcome pathways. In addition, considering the knowledge provided by the above-mentioned approaches, insights into risk assessment, standardization, and regulation of NMs are also included. Incorporating adequate nanosafety assessment early in the life-cycle of NMs will allow the implementation of the safe and sustainable-by-design paradigm enabling safety to keep pace with innovation. Chapters 10 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Skin 3-D Models and Cosmetics Toxicity

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Author :
Publisher : Springer Nature
ISBN 13 : 9819928044
Total Pages : 266 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Skin 3-D Models and Cosmetics Toxicity by : Aditya Bhushan Pant

Download or read book Skin 3-D Models and Cosmetics Toxicity written by Aditya Bhushan Pant and published by Springer Nature. This book was released on 2023-08-28 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Efforts are being made by research organizations and cosmetic industries worldwide to develop more precise and targeted 3D models that mimic humans for testing cosmetic and personal health care product ingredients, following a complete ban on animal testing. This book includes several subtopics dedicated to the progress made, challenges faced, roadblocks encountered, and future prospects in the development and validation of 3D models for testing these products. The book consist of an editorial and 14 themed chapters that will showcase the significant progress made so far, challenges encountered, and future prospects in the development of 3D reconstruct models.

Ethics in Nanotechnology

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Author :
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110701979
Total Pages : 266 pages
Book Rating : 4.1/5 (17 download)

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Book Synopsis Ethics in Nanotechnology by : Marcel Van de Voorde

Download or read book Ethics in Nanotechnology written by Marcel Van de Voorde and published by Walter de Gruyter GmbH & Co KG. This book was released on 2021-09-07 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: With nanotechnology being a relatively new field, the questions regarding safety and ethics are steadily increasing with the development of the research. This book aims to give an overview on the ethics associated with employing nanoscience for products with everyday applications. The risks as well as the regulations are discussed, and an outlook for the future of nanoscience on a manufacturer’s scale and for the society is provided. Ethics in nanotechnology is a valuable resource for, philosophers, academicians and scientist, as well as all other industry professionals and researchers who interact with emerging social and philosophical ethical issues on routine bases. It is especially for deep learners who are enthusiastic to apprehend the challenges related to nanotechnology and ethics in philosophical and social education. This book presents an overview of new and emerging nanotechnologies and their societal and ethical implications. It is meant for students, academics, scientists, engineers, policy makers, ethicist, philosophers and all stakeholders involved in the development and use of nanotechnology.

Advances in Smart Nanomaterials and their Applications

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Author :
Publisher : Elsevier
ISBN 13 : 0323995675
Total Pages : 681 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Advances in Smart Nanomaterials and their Applications by : Azamal Husen

Download or read book Advances in Smart Nanomaterials and their Applications written by Azamal Husen and published by Elsevier. This book was released on 2023-03-25 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Smart Nanomaterials and their Applications brings together the latest advances and novel methods in the preparation of smart nanomaterials for cutting-edge applications. The book covers fundamental concepts of nanomaterials, including fabrication methods, processing, application areas, specific applications of smart nanomaterials across a range of areas, such as biomedicine, pharmaceuticals, food science and packaging, sensing, cosmetics and dermatology, gas, oil, energy, wastewater and environment, textiles, agriculture, and forestry sectors. In each case, possible challenges, recent trends, and potential future developments are addressed in detail. The book also discusses various considerations for the utilization of smart nanomaterials, including environmental safety and legal requirements. The book is suitable for graduate students as a textbook and simultaneously be useful for both novices and experienced scientists or researchers, medical biologists, nanobiotechnologists, nanoengineers, agricultural scientists, and general biologists as a reference book as well as inspires some industrialists and policy makers involved in the investigation of smart nanomaterials. Introduces fundamentals of smart nanomaterials, including theory, fabrication methods, processing and properties Opens the door to a broad range of multifaceted applications across agriculture, food science, biomedicine, energy and other areas Considers environmental safety, risk assessment, legal requirements and sustainability issues

Green Nanomaterials for Industrial Applications

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Author :
Publisher : Elsevier
ISBN 13 : 0128236221
Total Pages : 580 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Green Nanomaterials for Industrial Applications by : Uma Shanker

Download or read book Green Nanomaterials for Industrial Applications written by Uma Shanker and published by Elsevier. This book was released on 2021-09-29 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green Nanomaterials for Industrial Applications explores the applications of nanomaterials for a variety of industry sectors, along with their environmental impacts, lifecycle analysis, safety and sustainability. This book brings together the industrial applications of nanomaterials, covering new trends and challenges. Significant properties, safety and sustainability and environmental impacts of synthesis routes are also explored, as are major industrial applications, including agriculture, medicine, communications, construction, energy, and in the military. This book is an important information source for those in research and development who want to gain a greater understanding of how nanotechnology is being used to create cheaper, more efficient products. Green nanomaterials have significant advantages including low cost, high efficiency, neutral environmental impact, and stability. Green Nanomaterials for Industrial Applications provides comprehensive information about green nanomaterials, their types, and methods for generation, characterization as well as their properties. Furthermore, this book also provides coverage of industrial scale fabrication methods for green nanomaterials and their applications for various industrial sectors at both experimental and theoretical models scales. This book is an important reference source for materials scientists, engineers and environmental scientists who want to learn more about how sustainable nanomaterials are being used in a range of industrial applications. Explores industrial scale fabrication of green nanomaterials Assesses environmental, legal, health and safety aspects Discusses how green nanomaterials can be manufactured on an industrial scale

Natural Bio-active Compounds

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Author :
Publisher : Springer Nature
ISBN 13 : 9811372055
Total Pages : 492 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Natural Bio-active Compounds by : Mallappa Kumara Swamy

Download or read book Natural Bio-active Compounds written by Mallappa Kumara Swamy and published by Springer Nature. This book was released on 2019-09-19 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nature has consistently provided human beings with bioactive compounds that can be used directly as drugs or indirectly as drug leads. Some of the major classes of natural bioactive compounds include phenolics, alkaloids, tannins, saponins, lignin, glycosides, terpenoids, and many more. They possess a broad range of biological activities and are primarily useful in the treatment of various health issues. At the same time, the search for new and novel drugs is never-ending and, despite major advances in synthetic chemistry, nature remains an essential resource for drug discovery. Therefore, more and more researchers are interested in understanding the chemistry, clinical pharmacology, and beneficial effects of bioactive compounds in connection with solving human health problems. This book presents a wealth of information on natural metabolites that have been or are currently being used as drugs or leads for the discovery of new drugs. In addition, it highlights the importance of natural products against various human diseases, and their applications in the drug, nutraceuticals, cosmetics and herbal industries. Accordingly, the book offers a valuable resource for all students, educators, and healthcare experts involved in natural product research, phytochemistry, and pharmacological research.