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Na K Atpase And Related Atpases
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Book Synopsis Na/K-ATPase and Related ATPases by : Kazuya Taniguchi
Download or read book Na/K-ATPase and Related ATPases written by Kazuya Taniguchi and published by . This book was released on 2000 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1997, J.C. Skou was awarded the Nobel Prize in Chemistry for his discovery of Na/K-ATPase, which has led to widespread appreciation of this enzyme in the scientific community. This volume contains the latest findings and insights in the field and acts as a reference source containing a comprehensive overview of the present state of knowledge. It includes a proposal that Na/K-ATPase plays a role as a tranducer of signal transduction, and, amongst other topics, covers the oligomericity of the enzyme, the site directed mutagenesis of P-type ATPases and the role of g-subunit. The book will serve as an important resouce, not only for work on Na/K-ATPase, but also for the investigation of other P-type ATPases.
Book Synopsis Na/K-ATPase and Related Transport ATPases by : L. Beaugé
Download or read book Na/K-ATPase and Related Transport ATPases written by L. Beaugé and published by . This book was released on 1997 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume disseminates the most recent advances in understanding of the molecular structure, transport mechanism, and regulatory properties of the sodium/potassium adenosine triphosphatase. Recent knowledge gained from other transport ATPases is incorporated as well. The volume also provides contributions from crystallographers, cryoelectronmicroscopists, biochemists, cell biologists, biophysicists, physiologists, and pharmacologists.
Book Synopsis Na, K-ATPase and Related Cation Pumps by : Peter Leth Jørgensen
Download or read book Na, K-ATPase and Related Cation Pumps written by Peter Leth Jørgensen and published by . This book was released on 2003 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text focuses on research on the structure, molecular mechanisms, physiological regulation, and involvement in disease of Na, K-ATPase and other members of the family of cation pumps. Prominent members of this family include gastric H, K-ATPase, Ca-ATPase of sarcoplasmic and endoplasmic reticulum, plasma membrane Ca-ATPase, and plasma membrane of H-ATPase of fungi and higher plants, as well as heavy metal pumps. The volume includes details of the first high-resolution structure ever obtained of a P-type pump, the sarcoplasmic reticulum Ca-ATPase; this structure has great predictive power relative to all P-type pumps. There are 50 papers and 97 poster papers altogethe
Book Synopsis The Na, K-ATPase by : Jean-Daniel Horisberger
Download or read book The Na, K-ATPase written by Jean-Daniel Horisberger and published by R. G. Landes. This book was released on 1994 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text addresses the question, How does the sodium pump pump'. A variety of primary structure information is available, and progress has been made in the functional characterization of the Na, K-pump, making the answer to this question possible, within reach of currently used techniques
Book Synopsis Basic Neurochemistry by : Scott Brady
Download or read book Basic Neurochemistry written by Scott Brady and published by Academic Press. This book was released on 2011-11-02 with total page 1120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking; Stem cells, adult neurogenesis, regeneration; Lipid messengers; Expanded coverage of all major neurodegenerative and psychiatric disorders; Neurochemistry of addiction; Neurochemistry of pain; Neurochemistry of hearing and balance; Neurobiology of learning and memory; Sleep; Myelin structure, development, and disease; Autism; and Neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475
Book Synopsis P-type ATPases in Health and Disease by : Sigrid A. Langhans
Download or read book P-type ATPases in Health and Disease written by Sigrid A. Langhans and published by Frontiers Media SA. This book was released on 2019-01-11 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Sodium Pump written by Ernst Bamberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sodium of animal cell membranes converts the chemical energy obtained from the hydrolysis of adenosine 5' -triphosphate into a movement of the cations Na + and K + against an electrochemical gradient. The gradient is used subse quently as an energy source to drive the uptake of metabolic substrates in polar epithelial cells and to use it for purposes of communications in excitable cells. The biological importance of the sodium pump is evident from the fact that be tween 20-70% of the cell's metabolic energy is consumed for the pumping pro cess. Moreover, the sodium pump is an important biological system involved in regulatory processes like the maintenance of the cells' and organism's water me tabolism. It is therefore understandable that special cellular demands are han dled better by special isoforms of the sodium pump, that the expression of the sodium pump and their isoforms is regulated by hormones as is the activity of the sodium pump via hormone-regulated protein kinases. Additionally, the sodium pump itself seems to be a receptor for a putative new group of hormones, the endogenous digitalis-like substances, which still have to be defined in most cases in their structure. This group of substances has its chemically well known coun terpart in steroids from plant and toad origin which are generally known as "car diac glycosides". They are in medical use since at least 200 years in medicine in the treatment of heart diseases.
Book Synopsis P-type ATPases in Health and Disease by :
Download or read book P-type ATPases in Health and Disease written by and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: P-type ATPases are a large group of evolutionary related ion and lipid pumps that have in common that they catalyze a transient phosphorylated intermediate at a key conserved aspartate residue within the pump in order to function. While all the P-type ATPases perform active transport across cellular membranes, they have different transport specificities and serve diverse physiological functions. The ion pumps of the P-type ATPase family create electrochemical gradients that are essential for transepithelial transport, nutrient uptake and membrane potential. They mediate cellular signaling and provide the ligands for metalloenzymes. Phospholipid flippases, also members of the P-type ATPase superfamily, regulate the asymmetric lipid distribution across the lipid bilayer and are critical for the biogenesis of cell membranes. Since all of these ATPases serve fundamental cellular functions, malfunctioning is associated with various pathophysiological processes and dysfunctions of P-type ATPases are known to contribute to cardiovascular, neurological, renal and metabolic diseases. However, with the ever growing knowledge about the diseases associated with the malfunction of P-type ATPases, they are also promising targets for future drug development. In eukaryotes the most prominent examples of P-type ATPases are the Na+,K+-ATPase (sodium pump), the H+-ATPase (proton pump), the H+,K+-ATPase (proton-potassium pump) and the Ca2+-ATPases (calcium pumps). Mutations in the alpha2 and alpha3 subunit of Na,K-ATPase have been associated with neurological diseases, including rapid-onset dystonia-parkinsonism, familial hemiplegic migraine and alternating hemiplegia of childhood. Dysregulation and loss of expression of Na,K-ATPase and plasma membrane Ca-ATPases may be involved in cancer progression. Malfunctioning of the Ca-ATPases is also thought to contribute to hypertension and neurodegenerative diseases and mutations can cause cardiac dysfunction, deafness, hypertension and cerebellar ataxia. Mutations in the SERCA calcium pumps can cause heart failure, Brody myopathy and Darier disease and mutations in the Cu-ATPase genes cause Menkes and Wilson disease. Deficiencies in phospholipid flippases have been linked to progressive familial intrahepatic cholestasis, obesity, diabetes, hearing loss and neurological diseases.
Book Synopsis Regulation of Membrane Na+-K+ ATPase by : Sajal Chakraborti
Download or read book Regulation of Membrane Na+-K+ ATPase written by Sajal Chakraborti and published by Springer. This book was released on 2015-12-16 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Na+-K+ ATPase or Na-pump ATPase, a member of “P”-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it’s α- and β- subunits. At present four different α- (α-1,α-2,α-3 and α-4) and three β- (β-1, β-2, and β-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+-K+ ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+-K+ ATPase is either mediated by changes in intracellular Na+ concentrations that directly affect the Na+-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na+-K+ ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of α- and β- subunits leading to an increased expression in the level of Na+-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra ne domain adjacent to the isoform(s) of α-β subunits of Na+-K+ ATPase. Considering the extraordinary importance of Na+-K+ ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled “Regulation of Membrane Na+-K+ ATPase” for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na+-K+ ATPase regulation in health and disease.
Author :Katharina L. Dürr Publisher :Sudwestdeutscher Verlag Fur Hochschulschriften AG ISBN 13 :9783838113494 Total Pages :120 pages Book Rating :4.1/5 (134 download)
Book Synopsis Functional Significance of Na,K- and H,K-Atpase ß-Subunits by : Katharina L. Dürr
Download or read book Functional Significance of Na,K- and H,K-Atpase ß-Subunits written by Katharina L. Dürr and published by Sudwestdeutscher Verlag Fur Hochschulschriften AG. This book was released on 2010-01 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Na, K-ATPase and gastric H, K-ATPase are primary active transporters that belong to the superfamily of P-type ATPases. These membrane proteins utilize the energy released by the hydrolysis of ATP to transport their cationic substrates against electrochemical gradients. Despite more than 50 years of extensive research on P-type ATPases, the molecular details of their ion transport mechanisms are not fully understood. Especially for oligomeric P-type ATPases, such as Na, K- and H, K-ATPases, which require an accessory -subunit for their transport activity, many open questions remain, since only recently structural information became available. This thesis encompasses a comprehensive analysis of Na, K- and H, K-ATPase mutations in conserved -subunit regions and other domains that may be relevant for interactions to the respective -subunit according to the recently available structural data. Therefore, this work contributes to the understanding of how -subunits influence the transport activity of P2C-type ATPases and provides a clue to the question whether similar molecular mechanisms are responsible for this kind of cation transport modulation of the two related ion pumps.
Book Synopsis Metal Transporters by : Jose M. Arguello
Download or read book Metal Transporters written by Jose M. Arguello and published by Academic Press. This book was released on 2012-10-25 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise
Book Synopsis Cardiac Glycosides 1785–1985 by : E. Erdmann
Download or read book Cardiac Glycosides 1785–1985 written by E. Erdmann and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bicentenary of William Withering's now famous medical report entitled "An Account of the Foxglove and Some of its Medical Uses" has given us the occasion to analyze the state of the art. Cardiac glycosides in 1985 are considered tobe the basis for medical treatment of myocardial failure, together with diuretics and vasodilators in the more severe cases. Nevertheless, the controversy as to their exact place in the treatment of heart failure with sinus rhythm has never ceased. Although cardiac glycosides are of unquestionable value in tachycardia caused by atrial fibrillation or atrial flutter, the chronic use of these drugs in sinus rhythm is not generally accepted. The development of tolerance has been reported. It is of interest that Withering hirnself wrote: "-let it (foxglove) be continued until it either acts on the kidneys, the stomach, the pulse, or the bowels; Iet it be stopped upon the first appearance of any of these effects, and I will maintain that the patient will not suffer from its exhibition, nor the practitioner be disappointed in any reasonable expectation. " In West Germany alone, more than three million patients (about 5% of the total population) are constantly taking cardiac glycosides. These drugs are the most prescribed medicaments in many countries. Thus, we considered it worthwhile and necessary to review in a critical way today's knowledge about the foxglove; to report new findings and to evaluate old Statements.
Book Synopsis Handbook of ATPases by : Masamitsu Futai
Download or read book Handbook of ATPases written by Masamitsu Futai and published by John Wiley & Sons. This book was released on 2006-01-24 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: ATP-dependent active ion transport enables cells to regulate their pH value and to control their ion composition. The reverse process, transforming an ion imbalance into chemical energy, drives mitochondrial and chloroplast ATP synthesis. The mediators of these fundamental processes are ion-motive ATPases, highly conserved enzymes that play key roles in cell physiology from bacteria to man. As the first comprehensive overview of this important class of enzymes, this handbook summarizes recent knowledge about the molecular mechanism of ATPases, relating this information to the physiology and pathopyhsiology of ion transport, mitochondrial function, vesicle transport and lysosomal acidification. All important P-type, F-type and V-type ATPases are treated systematically, complemented by a special section on the cell biology and physiology of acidic compartments, and backed by an extensive bibliography and index. This premier reference source for physiologists, molecular biologists, biophysicists and clinical researchers contains contributions by the world's foremost ATPase research groups.
Book Synopsis Cell Physiology Source Book by : Nicholas Sperelakis
Download or read book Cell Physiology Source Book written by Nicholas Sperelakis and published by Elsevier. This book was released on 2012-12-02 with total page 1262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors Includes broad coverage of both animal and plant cells Appendixes review basics of the propagation of action potentials, electricity, and cable properties Authored by leading experts in the field Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics
Download or read book The ATPases written by Thomas A. Pressley and published by S Karger Ag. This book was released on 1996-01-01 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, researchers have learned much about the regulation and structure of the ion pumps most relevant to renal function. This issue provides a comprehensive summary of current knowledge on these critical transport enzymes with particular emphasis on the kidney. The Na,K-pump is examined in six reviews which discuss structure-function relationships, expression and distribution of the pump's various forms within the nephron, its regulation by corticosteroids and the influence of second messengers on its function. Also discussed is the controversy surrounding endogenous circulating inhibitors of the Na,K-ATPase, Na,K-pump inhibition, and the pump's role in ammonium transport within the nephron. Issues relating to calcium transport mechanisms are examined in three reviews, one of which looks at the characteristics of the Ca-ATPase in vascular smooth muscle. The final section contains five reviews which address questions relating to renal acid-base balance and which seek to give new clinical insights by integrating molecular, biochemical, and histologic data.
Author :Society of General Physiologists. Symposium Publisher :Rockefeller Univ. Press ISBN 13 :9780874700497 Total Pages :700 pages Book Rating :4.7/5 (4 download)
Book Synopsis The Sodium Pump by : Society of General Physiologists. Symposium
Download or read book The Sodium Pump written by Society of General Physiologists. Symposium and published by Rockefeller Univ. Press. This book was released on 1991 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Na+, K+-pump: Cellular aspects by : J. C. Skou
Download or read book The Na+, K+-pump: Cellular aspects written by J. C. Skou and published by . This book was released on 1988 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt:
