Murine Norovirus Abrogates Chlamydia Pneumoniae Accelerated Atherosclerosis In Apoe Mice

Download Murine Norovirus Abrogates Chlamydia Pneumoniae Accelerated Atherosclerosis In Apoe Mice full books in PDF, epub, and Kindle. Read online Murine Norovirus Abrogates Chlamydia Pneumoniae Accelerated Atherosclerosis In Apoe Mice ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Murine Norovirus Abrogates Chlamydia Pneumoniae Accelerated Atherosclerosis in ApoE-/- Mice

Author : Karuna Patil
Publisher :
ISBN 13 :
Total Pages : 23 pages
Book Rating : 4.:/5 (932 download)

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Book Synopsis Murine Norovirus Abrogates Chlamydia Pneumoniae Accelerated Atherosclerosis in ApoE-/- Mice by : Karuna Patil

Download or read book Murine Norovirus Abrogates Chlamydia Pneumoniae Accelerated Atherosclerosis in ApoE-/- Mice written by Karuna Patil and published by . This book was released on 2015 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chlamydia pneumoniae (Cpn), a common respiratory pathogen of humans, has a strong seroepidemiologic association with cardiovascular disease as well as the ability to accelerate atherosclerosis in hyperlipidemic animal models. Our laboratory recently demonstrated that murine norovirus (MNV), a highly prevalent infection of laboratory mice, can variably alter atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice. Given that MNV has a tropism for macrophages and has been shown to exacerbate atherogenesis under particular conditions, we investigated whether concurrent MNV and Cpn infection could alter macrophage phenotypes in vitro and atherosclerosis in ApoE-/- mice. In the presence of oxidized low-density lipoprotein (oxLDL), co-infection of ApoE-/- bone marrow derived macrophages (BMDM) with MNV and Cpn resulted in increases in gene expression of IL-6, MCP-1, iNOS, and TNF-[unknown scientific symbol] as compared with Cpn mono-infected BMDM. Based on these findings, we hypothesized that concurrent MNV infection would exacerbate vascular inflammation and increase plaque lesion size in Cpn infected ApoE-/- mice. As demonstrated previously, Cpn infection alone resulted in significantly larger plaques (64% increase in mean size) as compared with uninfected mice. In mice co-infected with MNV and Cpn however, there was a 54% decrease in mean lesion size compared with Cpn mono-infected mice. Mechanisms by which MNV could elicit this unexpected abrogation in Cpn infected ApoE-/- mice were investigated. There were significant increases (P

Dorland's Dictionary of Medical Acronyms and Abbreviations E-Book

Author : Dorland
Publisher : Elsevier Health Sciences
ISBN 13 : 0323442544
Total Pages : 488 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Dorland's Dictionary of Medical Acronyms and Abbreviations E-Book by : Dorland

Download or read book Dorland's Dictionary of Medical Acronyms and Abbreviations E-Book written by Dorland and published by Elsevier Health Sciences. This book was released on 2015-07-24 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical acronyms and abbreviations offer convenience, but those countless shortcuts can often be confusing. Now a part of the popular Dorland’s suite of products, this reference features thousands of terms from across various medical specialties. Its alphabetical arrangement makes for quick reference, and expanded coverage of symbols ensures they are easier to find. Effective communication plays an important role in all medical settings, so turn to this trusted volume for nearly any medical abbreviation you might encounter. Symbols section makes it easier to locate unusual or seldom-used symbols. Convenient alphabetical format allows you to find the entry you need more intuitively. More than 90,000 entries and definitions. Many new and updated entries including terminology in expanding specialties, such as Nursing; Physical, Occupational, and Speech Therapies; Transcription and Coding; Computer and Technical Fields. New section on abbreviations to avoid, including Joint Commission abbreviations that are not to be used. Incorporates updates suggested by the Institute for Safe Medication Practices (ISMP).

Laboratory Assessment of Vitamin Status

Author : Dominic J. Harrington
Publisher : Academic Press
ISBN 13 : 0128130512
Total Pages : 340 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Laboratory Assessment of Vitamin Status by : Dominic J. Harrington

Download or read book Laboratory Assessment of Vitamin Status written by Dominic J. Harrington and published by Academic Press. This book was released on 2018-11-28 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Laboratory Assessment of Vitamin Status provides a comprehensive understanding of the limitations of commonly used approaches used for the evaluation of vitamin status, reducing harm in the general health setting. It outlines the application of ‘Best Practice’ approaches to the evaluation of vitamin status, giving physicians and other healthcare professionals the opportunity to make evidence-based interventions. Nearly every metabolic and developmental pathway in the human body has a dependency on at least one micronutrient. Currently, the clinical utility of approaches taken by laboratories for the assessment of vitamin status is generally poorly understood, missing the opportunity to diagnosis vitamin deficiencies. This essential reference gives clinical and biomedical scientists an understanding of the limitations of commonly used approaches to the evaluation of vitamin status in the general health setting through change in practice. Nutritionists and dietitians gain an understanding of more sophisticated markers of vitamin status. Describes specialist assays in sufficient detail to enable laboratories to replicate what is being performed by expert groups Provides detailed information that supports laboratories in the setting up of methods for the evaluation of vitamin status Informs laboratories looking for third party providers of specialist investigations Provides an essential overview of reference ranges for each vitamin

Co-signal Molecules in T Cell Activation

Author : Miyuki Azuma
Publisher : Springer Nature
ISBN 13 : 9813297174
Total Pages : 326 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Co-signal Molecules in T Cell Activation by : Miyuki Azuma

Download or read book Co-signal Molecules in T Cell Activation written by Miyuki Azuma and published by Springer Nature. This book was released on 2019-11-22 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.

Lanzkowsky's Manual of Pediatric Hematology and Oncology

Author : Jonathan D. Fish
Publisher : Academic Press
ISBN 13 : 0323997600
Total Pages : 826 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Lanzkowsky's Manual of Pediatric Hematology and Oncology by : Jonathan D. Fish

Download or read book Lanzkowsky's Manual of Pediatric Hematology and Oncology written by Jonathan D. Fish and published by Academic Press. This book was released on 2021-06-01 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lanzkowsky’s Manual of Pediatric Hematology and Oncology, Seventh Edition remains the go-to clinical manual for the treatment and management of childhood cancers and blood disorders. It is a comprehensive book on patient management, replete with algorithms and flow diagrams, and includes a new section on vascular anomalies. Reflecting the considerable advances in the treatment and management of hematologic and oncologic diseases in children, the seventh edition of this successful clinical manual is entirely updated to incorporate all current treatment protocols, new drugs, and management approaches. Its concise and easy-to-read format, again, enables readers to make accurate diagnoses and treatment decisions without having to reference larger medical textbooks. Designed to be easily readable and highly practical with over 400 illustrative tables, along with color diagrams and figures New chapter on Pediatric Vascular Anomalies New content on ‘blood avoidance’ programs to honor religious preferences Discussions of new drugs and immunological therapies for cancers, along with discussions of increasing use of cytokine stimulants for hematologic disorders Includes practical genetic evaluations providing a deeper understanding and advances in management of bone marrow failure diseases

Neuroendocrine-immune Interactions

Author : Rolf C. Gaillard
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805572824
Total Pages : 144 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Neuroendocrine-immune Interactions by : Rolf C. Gaillard

Download or read book Neuroendocrine-immune Interactions written by Rolf C. Gaillard and published by Karger Medical and Scientific Publishers. This book was released on 2002 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interactions between the immune, endocrine and nervous systems seldom appear as main issues in the neurosciences and in immunology. So far this was most likely due to the need to focus on the molecular and cellular bases of single neural, endocrine and immune processes. But hormones, neurotransmitters and neuropeptides can also influence more subtle mechanisms underlying immune cell activity. The contents of this volume aim at listing some aspects which show that not only the bases for neuroendocrine control of more refined mechanisms related to the organization and functioning of the immune systems to exist, but also that the immune system can actively communicate with neuroendocrine structures. The evidence is divided into three categories: - Anatomical, cellular and molecular bases for the exchange of information between immune, endocrine and neural cells, - reciprocal effects between immune and neuroendocrine mechanisms, and - immune-neuroendocrine regulatory circuits. Immunologically triggered neuroendocrine responses can be either beneficial or deleterious for the host. A systematic approach would imply the simultaneous evaluation of neuroendocrine and immune parameters and thus provide the basis for therapeutic interventions based on antagonizing or blocking undesirable effects.

Dacie and Lewis Practical Haematology E-Book

Author : Barbara J. Bain
Publisher : Elsevier Health Sciences
ISBN 13 : 0702069256
Total Pages : 600 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Dacie and Lewis Practical Haematology E-Book by : Barbara J. Bain

Download or read book Dacie and Lewis Practical Haematology E-Book written by Barbara J. Bain and published by Elsevier Health Sciences. This book was released on 2016-08-11 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 65 years, this best-selling text by Drs. Barbara J. Bain, Imelda Bates, and Mike A. Laffan has been the worldwide standard in laboratory haematology. The 12th Edition of Dacie and Lewis Practical Haematology continues the tradition of excellence with thorough coverage of all of the techniques used in the investigation of patients with blood disorders, including the latest technologies as well as traditional manual methods of measurement. You’ll find expert discussions of the principles of each test, possible causes of error, and the interpretation and clinical significance of the findings. A unique section on haematology in under-resourced laboratories. Ideal as a laboratory reference or as a comprehensive exam study tool. Each templated, easy-to-follow chapter has been completely updated, featuring new information on haematological diagnosis, molecular testing, blood transfusion- and much more. Complete coverage of the latest advances in the field. An expanded section on coagulation now covers testing for new anticoagulants and includes clinical applications of the tests.

Fresh from the Farm 6pk

Author : Rigby
Publisher :
ISBN 13 : 9781418914219
Total Pages : 0 pages
Book Rating : 4.9/5 (142 download)

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Book Synopsis Fresh from the Farm 6pk by : Rigby

Download or read book Fresh from the Farm 6pk written by Rigby and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Yvain

Author : Chretien de Troyes
Publisher : Yale University Press
ISBN 13 : 0300038380
Total Pages : 244 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Yvain by : Chretien de Troyes

Download or read book Yvain written by Chretien de Troyes and published by Yale University Press. This book was released on 1987-09-10 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: A twelfth-century poem by the creator of the Arthurian romance describes the courageous exploits and triumphs of a brave lord who tries to win back his deserted wife's love

Alcohol and Its Biomarkers

Author : Amitava Dasgupta
Publisher : Elsevier
ISBN 13 : 0128004096
Total Pages : 313 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Alcohol and Its Biomarkers by : Amitava Dasgupta

Download or read book Alcohol and Its Biomarkers written by Amitava Dasgupta and published by Elsevier. This book was released on 2015-02-18 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcohol and Its Biomarkers: Clinical Aspects and Laboratory Determination is a concise guide to all currently known alcohol biomarkers, their clinical application, and the laboratory methods used to detect them. Pathologists can use this resource to understand the limitations and cost factors associated with each method for determining certain alcohol biomarkers. In addition, interferences in these determinations are discussed, so that clinicians can understand the causes of falsely elevated biomarkers and pathologists and laboratory scientists can potentially eliminate them. The book focuses on the analytical methods used to detect alcohol in blood and urine, the limitations of alcohol determination using enzymatic methods, and the differences between clinical and forensic alcohol measurement. Chapters also cover cutting-edge alcohol biomarkers for potential use. Focuses on the analytical methods used for detecting alcohol in blood and urine along with the pitfalls and limitations of alcohol determination using enzymatic methods Explains the difference between clinical and forensic alcohol measurement Includes a brief overview of the benefits of consuming alcohol in moderation and the hazards of heavy drinking

Inorganic Biomaterials

Author : Wolfram Höland
Publisher : Frontiers Media SA
ISBN 13 : 2889198014
Total Pages : 119 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Inorganic Biomaterials by : Wolfram Höland

Download or read book Inorganic Biomaterials written by Wolfram Höland and published by Frontiers Media SA. This book was released on 2016-04-04 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inorganic biomaterials include materials for e.g. dental restorations, biocompatible materials for orthopedic appliances and bioactive materials. However, inorganic biomaterials are also developed for use in tissue regeneration, e.g. wound healing. These products either consist of crystalline phases, such as Al2O3 or ZrO2, which makes them suitable for use in hip bone replacement or they are composed of tricalcium phosphate and used as resorbable biomaterials. Or, they contain glassy phases, such as BIOGLASS®, and are employed as bioactive biomaterials to bond to living bone. Inorganic biomaterials are also used to develop inorganic – organic composites which are suitable for use as bioactive products or to produce dental filling materials. In general, the development of composites is state of the art. However, it is also a future technology. Biomaterials for dental restorations consist of glassy or crystalline phases. Glass-ceramics represent a special group of inorganic biomaterials for dental restorations. Glass-ceramics are composed of at least one inorganic glassy phase and at least one crystalline phase. These products demonstrate a combination of properties, which include excellent aesthetics and the ability to mimic the optical properties of natural teeth, as well as high strength and toughness. They can be processed using special processing procedures, e.g. machining, moulding and sintering, to fabricate high quality products. Sintered oxide ceramics, such as Al2O3 or ZrO2, are also used for the fabrication of dental restorations. These products can be veneered with other biomaterials, or they can be polished to achieve the best possible surface quality. The manuscripts dealing with inorganic biomaterials should focus on the development of the products, especially on their chemical nature, the phase formation processes and all the details related to their processing. Very important are the mechanisms of phase formation. The reader of the manuscript should understand all of these reactions in detail. As far as application is concerned, it is important to describe the main properties of the developed products based on the valid standards, e.g. the ISO standards. The papers published should show that the products comply with these standards. It is very important to understand the relationship between biomass and biomaterials. This will help young scientists to follow the development of biomaterials with new, unexpected properties. He manuscripts published in "Frontiers" should also focus on the application of the biomaterials. Every manuscript should show the most important application of the material presented. There are different journals that deal with specific product categories, eg "Dental Materials". However, "Frontiers" should allow young scientists to publish their research results using all kinds of inorganic biomaterials. On the other hand, fundamental discussion and analysis of the findings should be encouraged and conclusions about possible applications in the field of medicine and dentistry should be drawn.

Kumba Africa

Author : Sampson Ejike Odum
Publisher : iUniverse
ISBN 13 : 1663205043
Total Pages : 123 pages
Book Rating : 4.6/5 (632 download)

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Book Synopsis Kumba Africa by : Sampson Ejike Odum

Download or read book Kumba Africa written by Sampson Ejike Odum and published by iUniverse. This book was released on 2020-11-03 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: ‘KUMBA AFRICA’, is a compilation of African Short Stories written as fiction by Sampson Ejike Odum, nostalgically taking our memory back several thousands of years ago in Africa, reminding us about our past heritage. It digs deep into the traditional life style of the Africans of old, their beliefs, their leadership, their courage, their culture, their wars, their defeat and their victories long before the emergence of the white man on the soil of Africa. As a talented writer of rich resource and superior creativity, armed with in-depth knowledge of different cultures and traditions in Africa, the Author throws light on the rich cultural heritage of the people of Africa when civilization was yet unknown to the people. The book reminds the readers that the Africans of old kept their pride and still enjoyed their own lives. They celebrated victories when wars were won, enjoyed their New yam festivals and villages engaged themselves in seasonal wrestling contest etc; Early morning during harmattan season, they gathered firewood and made fire inside their small huts to hit up their bodies from the chilling cold of the harmattan. That was the Africa of old we will always remember. In Africa today, the story have changed. The people now enjoy civilized cultures made possible by the influence of the white man through his scientific and technological process. Yet there are some uncivilized places in Africa whose people haven’t tested or felt the impact of civilization. These people still maintain their ancient traditions and culture. In everything, we believe that days when people paraded barefooted in Africa to the swarmp to tap palm wine and fetch firewood from there farms are almost fading away. The huts are now gradually been replaced with houses built of blocks and beautiful roofs. Thanks to modern civilization. Donkeys and camels are no longer used for carrying heavy loads for merchants. They are now been replaced by heavy trucks and lorries. African traditional methods of healing are now been substituted by hospitals. In all these, I will always love and remember Africa, the home of my birth and must respect her cultures and traditions as an AFRICAN AUTHOR.

Blood and Bone Marrow Pathology

Author : Anna Porwit
Publisher :
ISBN 13 : 9780702031472
Total Pages : 0 pages
Book Rating : 4.0/5 (314 download)

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Book Synopsis Blood and Bone Marrow Pathology by : Anna Porwit

Download or read book Blood and Bone Marrow Pathology written by Anna Porwit and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Already a standard reference work in the field, the new edition of Blood and Bone Marrow Pathology incorporates the latest WHO classification schemes and the latest ancillary diagnostic techniques in immunohistochemistry and molecular biology in order to provide a comprehensive, well balanced and authoritative guide to the interpretation and diagnosis of neoplastic and non-neoplastic diseases of blood and bone marrow. The text is lavishly illustrated with high quality colour images that demonstrate the relevant pathological,features and immunohistochemical and molecular markers. The text features a well-organized approach that incorporates practical tips and clues to help avoid pitfalls and to ensure optimal diagnosis The book is lavishly illustrated with high quality color images that demonstrate the relevant pathological features and immunohistochemical and molecular markers. The text features a well-organized approach that incorporates practical tips and clues to help avoid pitfalls and to ensure optimal diagnosis. Chapters have been totally rewritten and new chapters have been added, especially on myeloid malignancies. The chapters on hematological malignancies have been written so that the reader can apply the latest WHO Classifications in their routine daily practice (especially the 2008 WHO Classification of Tumors of Hemopoietic and Lymphoid Tissues) All chapters have been revised to include new aspects of molecular biology and flow cytometry diagnostics. Many new schematic diagrams and color illustrations have been added to illustrate blood and bone marrow pathology. Access the full text online and download images via Expert Consult. Chapters have been totally rewritten and some new chapters have been added especially on myeloid malignancies, in line with the WHO 2008 Classification All chapters have been revised to include new aspects of molecular biology and updated concerning flow cytometry diagnostics Greater emphasis on practical diagnostic aspects for all disorders Brand new editorial and contributing author team. Full Online text through Expert Consult. Full downloadable Image Bank Already a standard reference work in the field, the new edition of Blood and Bone Marrow Pathology incorporates the latest WHO classification schemes and the latest ancillary diagnostic techniques in immunohistochemistry and molecular biology in order to provide a comprehensive, well balanced and authoritative guide to the interpretation and diagnosis of neoplastic and non-neoplastic diseases of blood and bone marrow. The text is lavishly illustrated with high quality colour images that demonstrate the relevant pathological,features and immunohistochemical and molecular markers. The text features a well-organized approach that incorporates practical tips and clues to help avoid pitfalls and to ensure optimal diagnosis

KUMAR AND CLARK'S CLINICAL MEDICINE, INTERNATIONAL EDITION.

Author :
Publisher :
ISBN 13 : 9780702078699
Total Pages : pages
Book Rating : 4.0/5 (786 download)

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Book Synopsis KUMAR AND CLARK'S CLINICAL MEDICINE, INTERNATIONAL EDITION. by :

Download or read book KUMAR AND CLARK'S CLINICAL MEDICINE, INTERNATIONAL EDITION. written by and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Charles Pettigrew, First Bishop-elect of the North Carolina Episcopal Church

Author : Bennett H Wall
Publisher : Hassell Street Press
ISBN 13 : 9781015031500
Total Pages : 32 pages
Book Rating : 4.0/5 (315 download)

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Book Synopsis Charles Pettigrew, First Bishop-elect of the North Carolina Episcopal Church by : Bennett H Wall

Download or read book Charles Pettigrew, First Bishop-elect of the North Carolina Episcopal Church written by Bennett H Wall and published by Hassell Street Press. This book was released on 2021-09-10 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Neurobiology of the Immune System

Author : Angela Clow
Publisher : Elsevier
ISBN 13 : 008049160X
Total Pages : 457 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Neurobiology of the Immune System by : Angela Clow

Download or read book Neurobiology of the Immune System written by Angela Clow and published by Elsevier. This book was released on 2003-01-08 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. Provides solid scientific basis to our understanding of the associations between the brain and the immune system the importance of these connections Presents coherent development from cellular and molecular neuroimmune communication to social and health considerations, including psychological intervention Addresses the theory that there is a neurobiology of the immune system

Structural Biology in Immunology

Author : Chaim Putterman
Publisher : Academic Press
ISBN 13 : 0128033703
Total Pages : 192 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Structural Biology in Immunology by : Chaim Putterman

Download or read book Structural Biology in Immunology written by Chaim Putterman and published by Academic Press. This book was released on 2018-05-14 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease. Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship Features a collaborative editorial effort, involving clinical immunologists and structural biologists Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology Gives interested parties a bridge to learn about computer modeling and structure based design principles