Multiscale Modeling Of Cardiac Electrophysiology Adaptation To Atrial And Ventricular Rhythm Disorders And Pharmacological Treatment

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Multiscale Modeling of Cardiac Electrophysiology: Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment

Author : Mathias Wilhelms
Publisher : KIT Scientific Publishing
ISBN 13 : 3731500450
Total Pages : 206 pages
Book Rating : 4.7/5 (315 download)

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Book Synopsis Multiscale Modeling of Cardiac Electrophysiology: Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment by : Mathias Wilhelms

Download or read book Multiscale Modeling of Cardiac Electrophysiology: Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment written by Mathias Wilhelms and published by KIT Scientific Publishing. This book was released on 2014-05-22 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.AbstractEnglisch = Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.

Multiscale Cohort Modeling of Atrial Electrophysiology : Risk Stratification for Atrial Fibrillation through Machine Learning on Electrocardiograms

Download Multiscale Cohort Modeling of Atrial Electrophysiology : Risk Stratification for Atrial Fibrillation through Machine Learning on Electrocardiograms PDF Online Free

Author : Nagel, Claudia
Publisher : KIT Scientific Publishing
ISBN 13 : 3731512815
Total Pages : 280 pages
Book Rating : 4.7/5 (315 download)

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Book Synopsis Multiscale Cohort Modeling of Atrial Electrophysiology : Risk Stratification for Atrial Fibrillation through Machine Learning on Electrocardiograms by : Nagel, Claudia

Download or read book Multiscale Cohort Modeling of Atrial Electrophysiology : Risk Stratification for Atrial Fibrillation through Machine Learning on Electrocardiograms written by Nagel, Claudia and published by KIT Scientific Publishing. This book was released on 2023-04-24 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: An early detection and diagnosis of atrial fibrillation sets the course for timely intervention to prevent potentially occurring comorbidities. Electrocardiogram data resulting from electrophysiological cohort modeling and simulation can be a valuable data resource for improving automated atrial fibrillation risk stratification with machine learning techniques and thus, reduces the risk of stroke in affected patients.

Modeling Human Atrial Patho-Electrophysiology from Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves

Author : Loewe, Axel
Publisher : KIT Scientific Publishing
ISBN 13 : 3731505282
Total Pages : 342 pages
Book Rating : 4.7/5 (315 download)

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Book Synopsis Modeling Human Atrial Patho-Electrophysiology from Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves by : Loewe, Axel

Download or read book Modeling Human Atrial Patho-Electrophysiology from Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves written by Loewe, Axel and published by KIT Scientific Publishing. This book was released on 2016-08-03 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Half of the patients suffering from atrial fibrillation (AF) cannot be treated adequately, today. This book presents multi-scale computational methods to advance our understanding of patho-mechanisms, to improve the diagnosis of patients harboring an arrhythmogenic substrate, and to tailor therapy. The modeling pipeline ranges from ion channels on the subcellular level up to the ECG on the body surface. The tailored therapeutic approaches carry the potential to reduce the burden of AF.

A Multiscale In Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation : A Translational Study to Guide Ablation Therapy

Download A Multiscale In Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation : A Translational Study to Guide Ablation Therapy PDF Online Free

Author : Sánchez Arciniegas, Jorge Patricio
Publisher : KIT Scientific Publishing
ISBN 13 : 3731511703
Total Pages : 162 pages
Book Rating : 4.7/5 (315 download)

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Book Synopsis A Multiscale In Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation : A Translational Study to Guide Ablation Therapy by : Sánchez Arciniegas, Jorge Patricio

Download or read book A Multiscale In Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation : A Translational Study to Guide Ablation Therapy written by Sánchez Arciniegas, Jorge Patricio and published by KIT Scientific Publishing. This book was released on 2022-05-30 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: The atrial substrate undergoes electrical and structural remodeling during atrial fibrillation. Detailed multiscale models were used to study the effect of structural remodeling induced at the cellular and tissue levels. Simulated electrograms were used to train a machine-learning algorithm to characterize the substrate. Also, wave propagation direction was tracked from unannotated electrograms. In conclusion, in silico experiments provide insight into electrograms' information of the substrate.

Characterizing Cardiac Electrophysiology during Radiofrequency Ablation : An Integrative Ex vivo, In silico, and In vivo Approach

Author : Pollnow, Stefan
Publisher : KIT Scientific Publishing
ISBN 13 : 3731508869
Total Pages : 296 pages
Book Rating : 4.7/5 (315 download)

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Book Synopsis Characterizing Cardiac Electrophysiology during Radiofrequency Ablation : An Integrative Ex vivo, In silico, and In vivo Approach by : Pollnow, Stefan

Download or read book Characterizing Cardiac Electrophysiology during Radiofrequency Ablation : An Integrative Ex vivo, In silico, and In vivo Approach written by Pollnow, Stefan and published by KIT Scientific Publishing. This book was released on 2019-04-23 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Formation of Intracardiac Electrograms under Physiological and Pathological Conditions

Author : Keller, Matthias
Publisher : KIT Scientific Publishing
ISBN 13 : 3731502283
Total Pages : 264 pages
Book Rating : 4.7/5 (315 download)

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Book Synopsis Formation of Intracardiac Electrograms under Physiological and Pathological Conditions by : Keller, Matthias

Download or read book Formation of Intracardiac Electrograms under Physiological and Pathological Conditions written by Keller, Matthias and published by KIT Scientific Publishing. This book was released on 2014-09-09 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents methods to advance electrophysiological simulations of intracardiac electrograms (IEGM). An experimental setup is introduced, which combines electrical measurements of extracellular potentials with a method for optical acquisition of the transmembrane voltage in-vitro. Thereby, intracardiac electrograms can be recorded under defined conditions. Using experimental and clinical signals, detailed simulations of IEGMs are parametrized, which can support clinical diagnosis.

ECG Imaging of Ventricular Activity in Clinical Applications

Author : Schulze, Walther H. W.
Publisher : KIT Scientific Publishing
ISBN 13 : 3731503743
Total Pages : 238 pages
Book Rating : 4.7/5 (315 download)

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Book Synopsis ECG Imaging of Ventricular Activity in Clinical Applications by : Schulze, Walther H. W.

Download or read book ECG Imaging of Ventricular Activity in Clinical Applications written by Schulze, Walther H. W. and published by KIT Scientific Publishing. This book was released on 2015-08-12 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: ECG imaging was performed in humans to reconstruct ventricular activation patterns and localize their excitation origins. The precision of the non-invasive reconstructions was evaluated against invasive measurements and found to be in line with the state-of-the-art literature. Statistics were produced for various excitation origins and reveal the beat-to-beat robustness of the imaging method.

Cardiac Electrophysiology: From Cell to Bedside E-Book

Author : Douglas P. Zipes
Publisher : Elsevier Health Sciences
ISBN 13 : 0323448887
Total Pages : 1429 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Cardiac Electrophysiology: From Cell to Bedside E-Book by : Douglas P. Zipes

Download or read book Cardiac Electrophysiology: From Cell to Bedside E-Book written by Douglas P. Zipes and published by Elsevier Health Sciences. This book was released on 2017-05-13 with total page 1429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid advancements in cardiac electrophysiology require today’s health care scientists and practitioners to stay up to date with new information both at the bench and at the bedside. The fully revised 7th Edition of Cardiac Electrophysiology: From Cell to Bedside, by Drs. Douglas Zipes, Jose Jalife, and William Stevenson, provides the comprehensive, multidisciplinary coverage you need, including the underlying basic science and the latest clinical advances in the field. An attractive full-color design features color photos, tables, flow charts, ECGs, and more. All chapters have been significantly revised and updated by global leaders in the field, including 19 new chapters covering both basic and clinical topics. New topics include advances in basic science as well as recent clinical technology, such as leadless pacemakers; catheter ablation as a new class I recommendation for atrial fibrillation after failed medical therapy; current cardiac drugs and techniques; and a new video library covering topics that range from basic mapping (for the researcher) to clinical use (implantations). Each chapter is packed with the latest information necessary for optimal basic research as well as patient care, and additional figures, tables, and videos are readily available online. New editor William G. Stevenson, highly regarded in the EP community, brings a fresh perspective to this award-winning text. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.

Encyclopedia of Cell Biology

Author :
Publisher : Academic Press
ISBN 13 : 0123947960
Total Pages : 2972 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Encyclopedia of Cell Biology by :

Download or read book Encyclopedia of Cell Biology written by and published by Academic Press. This book was released on 2015-08-07 with total page 2972 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Cell Biology, Four Volume Set offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences

Multiscale Modelling and Simulation

Author : Sabine Attinger
Publisher : Springer Science & Business Media
ISBN 13 : 9783540211808
Total Pages : 304 pages
Book Rating : 4.2/5 (118 download)

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Book Synopsis Multiscale Modelling and Simulation by : Sabine Attinger

Download or read book Multiscale Modelling and Simulation written by Sabine Attinger and published by Springer Science & Business Media. This book was released on 2004-07-12 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: In August 2003, ETHZ Computational Laboratory (CoLab), together with the Swiss Center for Scientific Computing in Manno and the Università della Svizzera Italiana (USI), organized the Summer School in "Multiscale Modelling and Simulation" in Lugano, Switzerland. This summer school brought together experts in different disciplines to exchange ideas on how to link methodologies on different scales. Relevant examples of practical interest include: structural analysis of materials, flow through porous media, turbulent transport in high Reynolds number flows, large-scale molecular dynamic simulations, ab-initio physics and chemistry, and a multitude of others. Though multiple scale models are not new, the topic has recently taken on a new sense of urgency. A number of hybrid approaches are now created in which ideas coming from distinct disciplines or modelling approaches are unified to produce new and computationally efficient techniques.

Heart Rate and Rhythm

Author : Onkar N. Tripathi
Publisher : Springer Science & Business Media
ISBN 13 : 3642175759
Total Pages : 676 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Heart Rate and Rhythm by : Onkar N. Tripathi

Download or read book Heart Rate and Rhythm written by Onkar N. Tripathi and published by Springer Science & Business Media. This book was released on 2011-05-02 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.

Cardiac Mechano-Electric Coupling and Arrhythmias

Author : Peter Kohl
Publisher : OUP Oxford
ISBN 13 : 0191636231
Total Pages : 512 pages
Book Rating : 4.1/5 (916 download)

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Book Synopsis Cardiac Mechano-Electric Coupling and Arrhythmias by : Peter Kohl

Download or read book Cardiac Mechano-Electric Coupling and Arrhythmias written by Peter Kohl and published by OUP Oxford. This book was released on 2011-08-25 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Mechano-Electric Coupling and Arrhythmias offers a thoroughly reviewed compendium written by leading experts in the field on the mechanism and consequences of cardiac mechano-electrical coupling. Its coverage ranges from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction. Information is grouped into logical sections, from molecular mechanisms, to cell, tissue and whole organ responses, right through to patient-based observations and insight emerging from clinical trials. The information provided carefully highlights both consensus insight and current shortcomings in our understanding of cardiac mechano-electric coupling. The book has been thoroughly revised and expanded since publication of the first edition in 2005, extensively updated to reflect recent developments in the field, and now offers a more balanced view of mechano-electrical interactions in the heart and develops a more clinical focus. Written with the practising cardiologist and junior doctor in mind, it offers interesting new insight for the established physician with an interest in cardiac arrhythmogenesis and heart rhythm management.

Electrocardiographic Imaging

Author : Maria S. Guillem
Publisher : Frontiers Media SA
ISBN 13 : 2889636712
Total Pages : 178 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Electrocardiographic Imaging by : Maria S. Guillem

Download or read book Electrocardiographic Imaging written by Maria S. Guillem and published by Frontiers Media SA. This book was released on 2020-04-17 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrical activity in the myocardium coordinates the contraction of the heart, and its knowledge could lead to a better understanding, diagnosis, and treatment of cardiac diseases. This electrical activity generates an electromagnetic field that propagates outside the heart and reaches the human torso surface, where it can be easily measured. Classical electrocardiography aims to interpret the 12-lead electrocardiogram (ECG) to determine cardiac activity and support the diagnosis of cardiac pathologies such as arrhythmias, altered activations, and ischemia. More recently, a higher number of leads is used to reconstruct a more detailed quantitative description of the electrical activity in the heart by solving the so-called inverse problem of electrocardiography. This technique is known as ECG imaging. Today, clinical applications of ECG imaging are showing promising results in guiding a variety of electrophysiological interventions such as catheter ablation of atrial fibrillation and ventricular tachycardia. However, in order to promote the adoption of ECG imaging in the routine clinical practice, further research is required regarding more accurate mathematical methods, further scientific validation under different preclinical scenarios and a more extensive clinical validation

Multiscale Mechanobiology of Bone Remodeling and Adaptation

Author : Peter Pivonka
Publisher : Springer
ISBN 13 : 3319588451
Total Pages : 295 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Multiscale Mechanobiology of Bone Remodeling and Adaptation by : Peter Pivonka

Download or read book Multiscale Mechanobiology of Bone Remodeling and Adaptation written by Peter Pivonka and published by Springer. This book was released on 2017-06-20 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.

Cardiovascular Mechanics

Author : Michel R. Labrosse
Publisher : CRC Press
ISBN 13 : 1315280280
Total Pages : 386 pages
Book Rating : 4.3/5 (152 download)

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Book Synopsis Cardiovascular Mechanics by : Michel R. Labrosse

Download or read book Cardiovascular Mechanics written by Michel R. Labrosse and published by CRC Press. This book was released on 2018-09-13 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this book is to illustrate in specific detail how cardiovascular mechanics stands as a common pillar supporting such different clinical successes as drugs for high blood pressure, prosthetic heart valves and coronary artery bypass grafting, among others. This information is conveyed through a comprehensive treatment of the overarching principles and theories that are behind mechanobiological processes, aortic and arterial mechanics, atherosclerosis, blood and microcirculation, hear valve mechanics, as well as medical devices and drugs. Examines all major theoretical and practical aspects of mechanical forces related to the cardiovascular system. Discusses a unique coverage of mechanical changes related to an aging cardiovascular system. Provides an overview of experimental methods in cardiovascular mechanics. Written by world-class researchers from Canada, the US and EU. Extensive references are provided at the end of each chapter to enhance further study. Michel R. Labrosse is the founder of the Cardiovascular Mechanics Laboratory at the University of Ottawa, where he is a full professor within the Department of Mechanical Engineering. He has been an active researcher in academia along with being heavily associated with the University of Ottawa Heart Institute. He has authored or co-authored over 90 refereed communications, and supervised or co-supervised over 40 graduate students and post-docs.

Modeling and Simulating Cardiac Electrical Activity

Author : David J. Christini
Publisher :
ISBN 13 : 9780750320641
Total Pages : 0 pages
Book Rating : 4.3/5 (26 download)

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Book Synopsis Modeling and Simulating Cardiac Electrical Activity by : David J. Christini

Download or read book Modeling and Simulating Cardiac Electrical Activity written by David J. Christini and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a thorough introduction to the topic of mathematical modeling of electrical activity in the heart, from molecular details of ionic channel dynamics to clinically derived patient-specific models. It discusses how cellular ionic models are formulated, introduces commonly used models and explains why there are so many different models available. The chapters cover modeling of the intracellular calcium handling that underlies cellular contraction as well as modeling molecular-level details of cardiac ion channels, and also focus on specialized topics such as cardiomyocyte energetics and signalling pathways. It is an excellent resource for experienced and specialised researchers in the field, but also biological scientists with a limited background in mathematical modelling and computational methods. Part of Biophysical Society-IOP series.

Drug Discovery and Evaluation: Pharmacological Assays

Author : Hans Vogel
Publisher : Springer Science & Business Media
ISBN 13 : 3540714200
Total Pages : 2118 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Drug Discovery and Evaluation: Pharmacological Assays by : Hans Vogel

Download or read book Drug Discovery and Evaluation: Pharmacological Assays written by Hans Vogel and published by Springer Science & Business Media. This book was released on 2007-10-30 with total page 2118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.