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Multiple Trait Multiple Interval Mapping Of Quantitative Trait Loci
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Book Synopsis Multiple-trait Multiple-interval Mapping of Quantitative-trait Loci by :
Download or read book Multiple-trait Multiple-interval Mapping of Quantitative-trait Loci written by and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: QTL (quantitative-trait locus) analysis aims to locate and estimate the effects of genes that are responsible for quantitative traits, such as grain protein content and yield, by means of statistical methods that evaluate the association of genetic variation with trait (phenotypic) variation. Quantitative traits are typically polygenic, i.e., controlled by multiple genes, with varying degrees of in uence on the phenotype. Several methods have been developed to increase the accuracy of QTL location and effect estimates. One of them, multiple interval mapping (MIM) (Kao et al. 1999), has been shown to be more accurate than conventional methods such as composite interval mapping (CIM) (Zeng 1994). Other QTL analysis methods have been developed to perform additional analyses that might be useful for breeders, such as of pleiotropy and QTL-by-environment (QxE) interaction. It has been shown (Jiang and Zeng 1995) that these analyses can be carried out with a multivariate extension of CIM (MT-CIM) that exploits the correlation structure in a set of traits. In doing so, this method also improves the accuracy of QTL location detection. This thesis describes the multivariate extension of MIM (MT-MIM) using ideas from MT-CIM. The development of additional multivariate tests, such as of pleiotropy and QxE interaction, and several methods pertinent to the development of MT-MIM are also described. A small simulation study shows that MT-MIM is more accurate than MT-CIM and univariate MIM. Results for real data show that MT-MIM is able to provide a more accurate and precise estimate of QTL location.
Book Synopsis Multiple Trait Multiple Interval Mapping of Quantitative Trait Loci from Inbred Line Crosses by :
Download or read book Multiple Trait Multiple Interval Mapping of Quantitative Trait Loci from Inbred Line Crosses written by and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Tremendous progress has been made in recent years on developing statistical methods for mapping quantitative trait loci (QTL) from crosses of inbred lines. Most of the recent research is focused on strategies for mapping multiple QTL and associated model selection procedures and criterion. In Chapter 1, we review the progress of research on QTL mapping on one and multiple trait by maximum likelihood and Bayesian methods. Although in many instances multiple trait are measured in the same subject, single traits analyses have been the main stream for the purpose of QTL identià ̄ÂƠ cation. However, single trait analyses do not take advantage of correlation between traits. Multiple trait analysis allows an investigator to assess the pattern of action of QTL on multiple trait, such as, testing the hypothesis of existence of pleiotropic QTL versus the hypothesis of close linked QTL aà ̄ÂƠâ'Ơecting multiple trait, and testing the hypothesis of QTL by environment interaction. In Chapter 2, we proposed a statistical model for mapping multiple QTL aà ̄ÂƠâ'Ơecting multiple trait, the multiple trait multiple interval mapping (MTMIM) model. We also developed a score-based threshold for assessing signià ̄ÂƠ cance level of QTL eà ̄ÂƠâ'Ơects on multiple trait. Our MTMIM model provides a comprehensive framework for QTL inference in multiple trait, in which the score-based threshold is built in as an essential and elegant tool for computing the signià ̄ÂƠ cance level of eà ̄ÂƠâ'Ơects of putative QTL in the genome-wide scan, therefore, allowing us to build a set of models containing multiple QTL. In Chapter 3, we empirically showed that the score-based threshold maintains the false discovery rate within acceptable levels and the multiple trait analysis can bring insights into the analysis of data for the purpose of QTL identià ̄ÂƠ cation. The analysis of data from an experiment with Drosophila showed the potential of our MTMIM model in delivering complementary information regarding the gen.
Book Synopsis Multiple Trait Multiple Interval Mapping of Quantitative Trait Loci from Inbred Line Crosses by : Luciana Da Costa E. Silva
Download or read book Multiple Trait Multiple Interval Mapping of Quantitative Trait Loci from Inbred Line Crosses written by Luciana Da Costa E. Silva and published by . This book was released on 2010 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keywords: quantitative trait loci, mapping, statistical method, multiple trait, inbred lines.
Book Synopsis Quantitative Trait Loci (QTL) by : Scott A. Rifkin
Download or read book Quantitative Trait Loci (QTL) written by Scott A. Rifkin and published by Humana Press. This book was released on 2016-08-23 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last two decades advances in genotyping technology, and the development of quantitative genetic analytical techniques have made it possible to dissect complex traits and link quantitative variation in traits to allelic variation on chromosomes or quantitative trait loci (QTLs). In Quantitative Trait Loci (QTLs):Methods and Protocols, expert researchers in the field detail methods and techniques that focus on specific components of the entire process of quantitative train loci experiments. These include methods and techniques for the mapping populations, identifying quantitative trait loci, extending the power of quantitative trait locus analysis, and case studies. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Quantitative Trait Loci (QTLs):Methods and Protocols aids scientists in the further study of the links between phenotypic and genotypic variation in fields from medicine to agriculture, from molecular biology to evolution to ecology.
Book Synopsis Quantitative Trait Loci by : Nicola J. Camp
Download or read book Quantitative Trait Loci written by Nicola J. Camp and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QTL). Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and variations in method ease the way to understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov Chain Monte Carlo method for joint linkage and segregation analysis.
Book Synopsis Contributions to the Design and Analysis of Quantitative Trait Loci Experiments by : Chunfang Jin
Download or read book Contributions to the Design and Analysis of Quantitative Trait Loci Experiments written by Chunfang Jin and published by . This book was released on 2004 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Guide to QTL Mapping with R/qtl by : Karl W. Broman
Download or read book A Guide to QTL Mapping with R/qtl written by Karl W. Broman and published by Springer. This book was released on 2011-12-02 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive discussion of QTL mapping concepts and theory Detailed instructions on the use of the R/qtl software, the most featured and flexible software for QTL mapping Two case studies illustrate QTL analysis in its entirety
Book Synopsis Genome-Wide Association Studies and Genomic Prediction by : Cedric Gondro
Download or read book Genome-Wide Association Studies and Genomic Prediction written by Cedric Gondro and published by Humana Press. This book was released on 2013-06-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the detailed genomic information that is now becoming available, we have a plethora of data that allows researchers to address questions in a variety of areas. Genome-wide association studies (GWAS) have become a vital approach to identify candidate regions associated with complex diseases in human medicine, production traits in agriculture, and variation in wild populations. Genomic prediction goes a step further, attempting to predict phenotypic variation in these traits from genomic information. Genome-Wide Association Studies and Genomic Prediction pulls together expert contributions to address this important area of study. The volume begins with a section covering the phenotypes of interest as well as design issues for GWAS, then moves on to discuss efficient computational methods to store and handle large datasets, quality control measures, phasing, haplotype inference, and imputation. Later chapters deal with statistical approaches to data analysis where the experimental objective is either to confirm the biology by identifying genomic regions associated to a trait or to use the data to make genomic predictions about a future phenotypic outcome (e.g. predict onset of disease). As part of the Methods in Molecular Biology series, chapters provide helpful, real-world implementation advice.
Book Synopsis Quantitative Trait Loci Analysis in Animals by : Joel Ira Weller
Download or read book Quantitative Trait Loci Analysis in Animals written by Joel Ira Weller and published by CABI. This book was released on 2009 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Trait Loci (QTL) is a topic of major agricultural significance for efficient livestock production. This book covers various statistical methods that have been used or proposed for detection and analysis of QTL and marker-and gene-assisted selection in animal genetics and breeding.
Book Synopsis Statistical Methods for QTL Mapping by : Zehua Chen
Download or read book Statistical Methods for QTL Mapping written by Zehua Chen and published by CRC Press. This book was released on 2016-04-19 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: While numerous advanced statistical approaches have recently been developed for quantitative trait loci (QTL) mapping, the methods are scattered throughout the literature. Statistical Methods for QTL Mapping brings together many recent statistical techniques that address the data complexity of QTL mapping. After introducing basic genetics topics an
Book Synopsis Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research by : Robert T. Gerlai
Download or read book Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research written by Robert T. Gerlai and published by Academic Press. This book was released on 2018-04-24 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior Written and edited by leading international experts
Book Synopsis Genetics and Analysis of Quantitative Traits by : Michael Lynch
Download or read book Genetics and Analysis of Quantitative Traits written by Michael Lynch and published by Sinauer Associates Incorporated. This book was released on 1998-01 with total page 980 pages. Available in PDF, EPUB and Kindle. Book excerpt: Professors Lynch and Walsh bring together the diverse array of theoretical and empirical applications of quantitative genetics in a work that is comprehensive and accessible to anyone with a rudimentary understanding of statistics and genetics.
Book Synopsis Quantitative Trait Loci Linkage Mapping for Dynamic Traits by : Hongjuan Liu
Download or read book Quantitative Trait Loci Linkage Mapping for Dynamic Traits written by Hongjuan Liu and published by . This book was released on 2006 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of Multiple Interval Mapping for Mapping QTL in Ordinal Traits by : Jian Li
Download or read book Development of Multiple Interval Mapping for Mapping QTL in Ordinal Traits written by Jian Li and published by . This book was released on 2004 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keywords: quantitative trait locus, QTL mapping, ordinal data, threshold model, maximum likelihood.
Book Synopsis The Maize Genome by : Jeffrey Bennetzen
Download or read book The Maize Genome written by Jeffrey Bennetzen and published by Springer. This book was released on 2018-11-24 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses advances in our understanding of the structure and function of the maize genome since publication of the original B73 reference genome in 2009, and the progress in translating this knowledge into basic biology and trait improvement. Maize is an extremely important crop, providing a large proportion of the world’s human caloric intake and animal feed, and serving as a model species for basic and applied research. The exceptionally high level of genetic diversity within maize presents opportunities and challenges in all aspects of maize genetics, from sequencing and genotyping to linking genotypes to phenotypes. Topics covered in this timely book range from (i) genome sequencing and genotyping techniques, (ii) genome features such as centromeres and epigenetic regulation, (iii) tools and resources available for trait genomics, to (iv) applications of allele mining and genomics-assisted breeding. This book is a valuable resource for researchers and students interested in maize genetics and genomics.
Book Synopsis A Guide to QTL Mapping with R/qtl by : Karl W. Broman
Download or read book A Guide to QTL Mapping with R/qtl written by Karl W. Broman and published by Springer Science & Business Media. This book was released on 2009-07-21 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive discussion of QTL mapping concepts and theory Detailed instructions on the use of the R/qtl software, the most featured and flexible software for QTL mapping Two case studies illustrate QTL analysis in its entirety
Book Synopsis Statistical Genetics of Quantitative Traits by : Rongling Wu
Download or read book Statistical Genetics of Quantitative Traits written by Rongling Wu and published by Springer Science & Business Media. This book was released on 2007-07-17 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the basic concepts and methods that are useful in the statistical analysis and modeling of the DNA-based marker and phenotypic data that arise in agriculture, forestry, experimental biology, and other fields. It concentrates on the linkage analysis of markers, map construction and quantitative trait locus (QTL) mapping, and assumes a background in regression analysis and maximum likelihood approaches. The strength of this book lies in the construction of general models and algorithms for linkage analysis, as well as in QTL mapping in any kind of crossed pedigrees initiated with inbred lines of crops.
