Mouse Behavioral Testing

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Mouse Behavioral Testing

Author : Douglas Wahlsten
Publisher : Academic Press
ISBN 13 : 0123756758
Total Pages : 305 pages
Book Rating : 4.1/5 (237 download)

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Book Synopsis Mouse Behavioral Testing by : Douglas Wahlsten

Download or read book Mouse Behavioral Testing written by Douglas Wahlsten and published by Academic Press. This book was released on 2010-11-25 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience provides detailed explanations of how to conduct an experiment on mouse behavior from the initial planning of the research design through every step of the process until the data analysis phase. The book discusses the practical matters that need to be considered carefully when working with any species of animal, such as how many animals need to be tested. It describes the tests and techniques devised specifically for work with mice. Every step of the research process is illustrated with real situations encountered in previous studies. All examples are based on real experiments, and extensive details of several published experiments are provided. The essential features of a behavioral test protocol are outlined, and several complete protocols are provided. Methods to balance the order of tests and determine throughput are described, then a completely balanced order of tests in a complex experiment is presented. The book will be useful for those already familiar with the general principles of research but are new to the realm of behavioral testing of live mice. It will also serve as a text for a formal course, most likely at the graduate level. A guide to running a behavioral testing lab, including the many aspects of mouse research beyond the confines of the specific test Diagrams and photographs are shown for many kinds of apparatus and test situations with sufficient details such as dimensions to enable building of replicas Provides step-by-step instructions on planning and executing behavioral experiments in order to run them successfully

Methods of Behavior Analysis in Neuroscience

Author : Jerry J. Buccafusco
Publisher : CRC Press
ISBN 13 : 1420041819
Total Pages : 341 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Methods of Behavior Analysis in Neuroscience by : Jerry J. Buccafusco

Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes

Author : Wim E. Crusio
Publisher : Cambridge University Press
ISBN 13 : 1107355575
Total Pages : 361 pages
Book Rating : 4.1/5 (73 download)

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Book Synopsis Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes by : Wim E. Crusio

Download or read book Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes written by Wim E. Crusio and published by Cambridge University Press. This book was released on 2013-04-25 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

Animal Models of Cognitive Impairment

Author : Edward D. Levin
Publisher : CRC Press
ISBN 13 : 1420004336
Total Pages : 395 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Animal Models of Cognitive Impairment by : Edward D. Levin

Download or read book Animal Models of Cognitive Impairment written by Edward D. Levin and published by CRC Press. This book was released on 2006-06-22 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen

Mood and Anxiety Related Phenotypes in Mice

Author : Todd D. Gould
Publisher :
ISBN 13 : 9781617793134
Total Pages : pages
Book Rating : 4.7/5 (931 download)

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Book Synopsis Mood and Anxiety Related Phenotypes in Mice by : Todd D. Gould

Download or read book Mood and Anxiety Related Phenotypes in Mice written by Todd D. Gould and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Rodent Models of Stroke

Author : Ulrich Dirnagl
Publisher : Humana Press
ISBN 13 : 9781607617495
Total Pages : 0 pages
Book Rating : 4.6/5 (174 download)

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Book Synopsis Rodent Models of Stroke by : Ulrich Dirnagl

Download or read book Rodent Models of Stroke written by Ulrich Dirnagl and published by Humana Press. This book was released on 2010-07-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In view of the numerous failures of clinical trials aimed at improving stroke therapy, the role and potential benefit of experimentally modeling focal cerebral ischemia in rodents has been debated. When methods of systematic review and metaanalyis are applied, however, it turns out that experimental models actually faithfully predicted the negative outcomes of clinical trials. In addition, thrombolysis and neuroprotection by hypothermia, first described in animal models, are key examples of treatment modalities that have made it successfully into clinical practice. In Rodent Models of Stroke, an international consortium of authors aims at critically addressing the issues on a very practical level, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. The structure and content of the book reflect both the authors’ longstanding expertise in experimental and clinical stroke research and their roles in training the scientific community in the tools of the trade. As a volume in the successful Neuromethods series, the chapters provide authoritative reviews of the most commonly used, well-honed approaches in the field today. Stimulating and easy-to-use, Rodent Models of Stroke will help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments.

What's Wrong With My Mouse?

Author : Jacqueline N. Crawley
Publisher : John Wiley & Sons
ISBN 13 : 0471471925
Total Pages : 540 pages
Book Rating : 4.4/5 (714 download)

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Book Synopsis What's Wrong With My Mouse? by : Jacqueline N. Crawley

Download or read book What's Wrong With My Mouse? written by Jacqueline N. Crawley and published by John Wiley & Sons. This book was released on 2007-03-23 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030916785X
Total Pages : 223 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by : National Research Council

Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Animal Models in Psychopharmacology

Author : Olivier
Publisher : Birkhäuser
ISBN 13 : 3034864191
Total Pages : 447 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Animal Models in Psychopharmacology by : Olivier

Download or read book Animal Models in Psychopharmacology written by Olivier and published by Birkhäuser. This book was released on 2013-11-21 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pre-Clinical Models

Author : Paul C. Guest
Publisher : Humana Press
ISBN 13 : 9781493989935
Total Pages : 343 pages
Book Rating : 4.9/5 (899 download)

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Book Synopsis Pre-Clinical Models by : Paul C. Guest

Download or read book Pre-Clinical Models written by Paul C. Guest and published by Humana Press. This book was released on 2019-02-04 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details reviews and protocols on the development and analysis of both cellular and animal-based pre-clinical models in a number of medical areas, including metabolic disorders, longevity, cancer, heart disease and psychiatric disorders. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Pre-Clinical Models: Techniques and Protocols aims to provide methods that describe the context of specific disease or therapeutic areas.

Animal Models of Neurological Disorders

Author : Puneet Kumar Bansal
Publisher : Springer
ISBN 13 : 9811059810
Total Pages : 350 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Animal Models of Neurological Disorders by : Puneet Kumar Bansal

Download or read book Animal Models of Neurological Disorders written by Puneet Kumar Bansal and published by Springer. This book was released on 2018-01-17 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins/chemicals. It also includes numerous protocols for inducing single neurological diseases, thus fulfilling an urgent need for a book that makes specific procedures for neurological disorders available, so that specific disease can be induced in laboratories according to the availability of resources. Further, it acquaints readers with the pathological changes that occur in a particular neurological disorder, which reflect specific signs and symptoms of any particular disease, and examines how they affect everyday life. It is a valuable resource for researchers aiming to eradicate or improve neurological disorders by testing the benefits of different drugs.

Mood and Anxiety Related Phenotypes in Mice

Author : Todd D Gould
Publisher : Humana Press
ISBN 13 : 9781493962372
Total Pages : 382 pages
Book Rating : 4.9/5 (623 download)

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Book Synopsis Mood and Anxiety Related Phenotypes in Mice by : Todd D Gould

Download or read book Mood and Anxiety Related Phenotypes in Mice written by Todd D Gould and published by Humana Press. This book was released on 2016-08-23 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preclinical research related to mood and anxiety disorders relies extensively upon mouse behavioral tests and models, the use of which continues to increase as a greater number of underlying susceptibility genes are discovered, new targets for medications are identified, and clinical studies reveal novel neurobiological risk factors. Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Volume II serves as a complement to the previous volume in order to offer a comprehensive resource for the behavioral approaches that are valuable for the characterization of mood and anxiety disorder-related behaviors in mice and the techniques that are utilized in the development of effective medications. As a collection presented in the Neuromethods series, each chapter provides a brief background and review of the test or model as well as a complete and up-to-date protocol narrative. Authoritative and comprehensive, Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Volume II is an ideal resource for scientists actively pursuing or interested in establishing vital behavioral protocols in their laboratories.

Micro-, Meso- and Macro-Dynamics of the Brain

Author : György Buzsáki
Publisher : Springer
ISBN 13 : 3319288024
Total Pages : 181 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Micro-, Meso- and Macro-Dynamics of the Brain by : György Buzsáki

Download or read book Micro-, Meso- and Macro-Dynamics of the Brain written by György Buzsáki and published by Springer. This book was released on 2016-05-02 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The individual chapters cover several fascinating facets of contemporary neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Each of these topics require appropriate levels of analyses with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks, supplemented by models and theories to explain how different levels of brain dynamics interact with each other and how the failure of such interactions results in neurologic and mental disease. While such complex questions cannot be answered exhaustively by a dozen or so chapters, this volume offers a nice synthesis of current thinking and work-in-progress on micro-, meso- and macro- dynamics of the brain.

Mood and Anxiety Related Phenotypes in Mice

Author : Todd D Gould
Publisher : Humana Press
ISBN 13 : 9781607613022
Total Pages : 0 pages
Book Rating : 4.6/5 (13 download)

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Book Synopsis Mood and Anxiety Related Phenotypes in Mice by : Todd D Gould

Download or read book Mood and Anxiety Related Phenotypes in Mice written by Todd D Gould and published by Humana Press. This book was released on 2009-10-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Affecting approximately twenty percent of the world population, mood and anxiety disorders have been the subject of ever-increasing research. This increased research parallels a remarkable growth in the use of the laboratory mouse as a tool to understand the biological and genetic basis of mood and anxiety disorders as well as to develop improved treatments. In Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, world-renowned researchers provide an overview of behavioral approaches utilized in the characterization of mood and anxiety related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds. As a volume in the successful NeuromethodsTM series, the chapters provide authoritative reviews including up-to-date detailed protocols of the most commonly used approaches in the field. Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests is an ideal resource for scientists actively pursuing or interested in establishing behavioral protocols in their laboratories, while also serving as a reference for those students, scientists, and practitioners who have an interest in better understanding the preclinical behavioral methods used in mood and anxiety research.

Animal-friendly methods for rodent behavioral testing in neuroscience research

Author : Raffaele d’Isa
Publisher : Frontiers Media SA
ISBN 13 : 2832551157
Total Pages : 229 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Animal-friendly methods for rodent behavioral testing in neuroscience research by : Raffaele d’Isa

Download or read book Animal-friendly methods for rodent behavioral testing in neuroscience research written by Raffaele d’Isa and published by Frontiers Media SA. This book was released on 2024-07-03 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rodent behavioral testing has been used to study brain functions since the 1890s and has become a gold-standard model in modern neuroscience. Up to the 1950s, most behavioral tests on laboratory rodent models were based on punishments and rewards. Both approaches can lead to a certain degree of animal pain or suffering. Punishments involved the employment of painful stimuli, typically electric shocks. Passive avoidance and fear conditioning tests, among the most widely used behavioral paradigms used to evaluate learning and memory in rodents, can be performed using only a single brief shock. Other tests, such as the active avoidance, might require up to tens or hundreds of shocks, strongly challenging the psychological welfare of the model animals. On the other hand, tests based on rewards, which apparently may seem more ethical, actually still induce suffering in the animals, as food rewards are almost always associated with a food restriction protocol, in order to motivate food-seeking behavior. Rodents are starved for days before starting the test and kept under food restriction for the whole duration of the test. The distress during the testing session is only a minimal part compared to the stress lived outside of the testing session, which is prolonged and continuous. Analogously, liquid rewards commonly rely on a previous water restriction protocol to use thirst as motivation. Animal stress is not only an ethical issue per se, but also an important factor potentially impacting on the reliability and reproducibility of experimental results.

Variation despite Standardization: Evidence for Animal Personality in Laboratory Mice?

Author : Mieke Heidenreich
Publisher : GRIN Verlag
ISBN 13 : 3656273898
Total Pages : 46 pages
Book Rating : 4.6/5 (562 download)

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Book Synopsis Variation despite Standardization: Evidence for Animal Personality in Laboratory Mice? by : Mieke Heidenreich

Download or read book Variation despite Standardization: Evidence for Animal Personality in Laboratory Mice? written by Mieke Heidenreich and published by GRIN Verlag. This book was released on 2012-09-18 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bachelor Thesis from the year 2011 in the subject Biology - Behaviour, grade: 1,7, University of Münster (Department of Behavioural Biology), language: English, abstract: It is generally assumed that human beings have personalities, while animals do not. This assumption is not only derived from common sense, but also a basic principle of western philosophy and social theory (Mead, 1934). Still, dog owners will not stop mumbling about their cute puppy's unique personality. And they find support from unexpected source: Biologists argue that humans are nothing more, nothing less than animals. So they, too, begin to take into consideration that animals – including humans – might have a personality. What seems like a solely philosophical question at first glance, has important practical impacts, because the existence of animal personality contradicts the assumption that animals used in biological experiments can be standardized, and have uniform properties. If despite all efforts of standardization a residual variation cannot be eliminated, pharmaceutical and medical experiments might lose part of their validity. Therefore the hypothesis that laboratory mice possess a personality was tested in an empirical study. In this study a set of standard behavior tests was performed with 40 female mice of the strain C57BL/6N. The data was then analyzed for correlations over time and across contexts, since this is a requirement for animal personality.

The Dancing Mouse: A Study in Animal Behavior

Author : Robert Mearns Yerkes
Publisher : DigiCat
ISBN 13 :
Total Pages : 265 pages
Book Rating : 4.8/5 (596 download)

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Book Synopsis The Dancing Mouse: A Study in Animal Behavior by : Robert Mearns Yerkes

Download or read book The Dancing Mouse: A Study in Animal Behavior written by Robert Mearns Yerkes and published by DigiCat. This book was released on 2022-09-04 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: DigiCat Publishing presents to you this special edition of "The Dancing Mouse: A Study in Animal Behavior" by Robert Mearns Yerkes. DigiCat Publishing considers every written word to be a legacy of humankind. Every DigiCat book has been carefully reproduced for republishing in a new modern format. The books are available in print, as well as ebooks. DigiCat hopes you will treat this work with the acknowledgment and passion it deserves as a classic of world literature.