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Monte Carlo Studies Of The Effects Of Protein Cholesterol And Curvature On Lipid Order Parameters
Download Monte Carlo Studies Of The Effects Of Protein Cholesterol And Curvature On Lipid Order Parameters full books in PDF, epub, and Kindle. Read online Monte Carlo Studies Of The Effects Of Protein Cholesterol And Curvature On Lipid Order Parameters ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Monte Carlo Studies of the Effects of Protein, Cholesterol and Curvature on Lipid Order Parameters by : Sheau-Lin Sharon Cherng
Download or read book Monte Carlo Studies of the Effects of Protein, Cholesterol and Curvature on Lipid Order Parameters written by Sheau-Lin Sharon Cherng and published by . This book was released on 1978 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Simulations of the Effect of Cholesterol on Membrane-Mediated Protein-Protein Interactions by : Frédérick Jean-Marie De Meyer
Download or read book Molecular Simulations of the Effect of Cholesterol on Membrane-Mediated Protein-Protein Interactions written by Frédérick Jean-Marie De Meyer and published by . This book was released on 2010 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this work we use molecular simulations to investigate how cholesterol affects membrane-mediated protein-protein interactions. We consider a typical hydrated biological model membrane containing saturated phospholipids (for example, dimyris- toylphosphatidylcholine or DMPC), cholesterol, and trans-membrane proteins. We introduce a model in which the different molecules are coarse-grained, retaining their hydrophobic and hydrophilic properties together with their main structure and flexi- bility. The system is studied using a hybrid Monte-Carlo dissipative particle dynamics method. First we study lipid-mediated protein-protein interactions in a pure hydrated sat- urated phospholipid bilayer. The potential of mean force between the proteins show that hydrophobic forces drive long-range lipid-mediated protein-protein interactions and that the nature of these interactions depends on the length of the protein hy- drophobic segment, on the three-dimensional structure of the protein and on the properties of the lipid bilayer. The concept of hydrophilic shielding is introduced to gain insight into the nature of the computed potentials of mean force. To study the effect of cholesterol on the properties of a membrane, we extend our model to cholesterol. Structural and mechanical properties of the hydrated bi- layer containing a saturated lipid and cholesterol are studied at various temperatures and cholesterol concentrations. The properties studied are the area per lipid, con- densation, bilayer thickness, tail order parameters, bending modulus, and area com- pressibility. The model quantitatively reproduces most of the experimental effects of cholesterol on these properties and reproduces the main features of the experi- mental temperature-composition phase diagram. Based on the changes in structural properties a temperature-composition structure diagram is proposed, which is com- pared with the experimental phase and structure diagrams. The lateral organization of cholesterol in the bilayer is also discussed. In a second part, modifications of the cholesterol model are made to allow a better understanding of the cholesterol condensation effect. This condensation effect is further discussed in relation to the DMPC-cholesterol phase behavior. Finally, the effect of cholesterol on lipid-mediated protein-protein interactions is investigated. This is done in accordance with the results concerning the effect of cholesterol on the phase behavior of lipid bilayers. The calculations of the potential of mean force between proteins and protein clusters show that the addition of choles- terol gradually reduces repulsive lipid-mediated interactions between certain proteins. At a given cholesterol concentration, the interactions even become attractive. Hence, cholesterol significantly promotes protein aggregation. The role of protein-induced dynamical cholesterol-enriched and cholesterol-depleted shells in these effects is dis- cussed in detail.
Book Synopsis Reviews in Computational Chemistry, Volume 5 by : Kenny B. Lipkowitz
Download or read book Reviews in Computational Chemistry, Volume 5 written by Kenny B. Lipkowitz and published by John Wiley & Sons. This book was released on 2009-09-22 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Führende Experten auf dem Gebiet der Computer-Chemie präsentieren in dem fünften Band der erfolgreichen Reihe 'Reviews in Computational Chemistry' die neuesten Entwicklungen. Um den interessierten Chemiker auf dem aktuellen Stand zu halten, ist der Reihe im Anhang eine Liste mit der Software zum Thema beigefügt
Book Synopsis Masters Theses in the Pure and Applied Sciences by : Wade H. Shafer
Download or read book Masters Theses in the Pure and Applied Sciences written by Wade H. Shafer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Masters Theses in the Pure and Applied Sciences was first conceived, published, and dis seminated by the Center for Information and Numerical Data Analysis and Synthesis (CINDAS) * at Purdue University in 1957, starting its coverage of theses with the academic year 1955. Beginning with Volume 13, the printing and dissemination phases of the ac tivity were transferred to University Microfilms/Xerox of Ann Arbor, Michigan, with the thought that such an arrangement would be more beneficial to the academic and general scientific and technical community. After five years of this joint undertaking we had concluded that it was in the interest of all concerned if the printing and distribution of the volume were handled by an international publishing house to assure improved service and broader dissemination. Hence, starting with Volume 18, Masters Theses in the Pure and Applied Sciences has been disseminated on a worldwide basis by Plenum Publishing Corporation of New York, and in the same year the coverage was broadened to include Canadian universities. All back issues can also be ordered from Plenum. We have reported in Volume 23 (thesis year 1978) a total of 10,148 theses titles from 27 Canadian and 220 United States universities. We are sure that this broader base for theses titles reported will greatly enhance the value of this important annual reference work. While Volume 23 reports these submitted in 1978, on occasion, certain universities do report theses submitted in previous years but not reported at the time.
Download or read book Lipid Domains written by and published by Academic Press. This book was released on 2015-06-08 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up to date presentation of current knowledge in the field of Lipid Domains. Written by leading experts Contains original material, both textual and illustrative, that should become a very relevant reference material The material is presented in a very comprehensive manner Both researchers in the field and general readers should find relevant and up-to-date information
Book Synopsis AMolecular Description of Biological Membrane Components by Computer Aided Conformational Analysis by : Robert Brasseur
Download or read book AMolecular Description of Biological Membrane Components by Computer Aided Conformational Analysis written by Robert Brasseur and published by CRC Press. This book was released on 2019-07-18 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1990, the goal of these two volumes is to help fill the gap between theory and experiment in membrane science. Those involved with biochemistry, biophysics, pharmacology, and biology will find these volumes interesting and informative.
Book Synopsis Structure and Dynamics of Membranes by : R. Lipowsky
Download or read book Structure and Dynamics of Membranes written by R. Lipowsky and published by Elsevier. This book was released on 1995-06-15 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first volume of the Handbook deals with the amazing world of biomembranes and lipid bilayers. Part A describes all aspects related to the morphology of these membranes, beginning with the complex architecture of biomembranes, continues with a description of the bizarre morphology of lipid bilayers and concludes with technological applications of these membranes. The first two chapters deal with biomembranes, providing an introduction to the membranes of eucaryotes and a description of the evolution of membranes. The following chapters are concerned with different aspects of lipids including the physical properties of model membranes composed of lipid-protein mixtures, lateralphase separation of lipids and proteins and measurement of lipid-protein bilayer diffusion. Other chapters deal with the flexibility of fluid bilayers, the closure of bilayers into vesicles which attain a large variety of different shapes, and applications of lipid vesicles and liposomes. Part B covers membrane adhesion, membrane fusion and the interaction of biomembranes withpolymer networks such as the cytoskeleton. The first two chapters of this part discuss the generic interactions of membranes from the conceptual point of view. The following two chapters summarize the experimental work on two different bilayer systems. The next chapter deals with the process ofcontact formation, focal bounding and macroscopic contacts between cells. The cytoskeleton within eucaryotic cells consists of a network of relatively stiff filaments of which three different types of filaments have been identified. As explained in the next chapter much has been recently learned aboutthe interaction of these filaments with the cell membrane. The final two chapters deal with membrane fusion.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1998 with total page 1646 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lipid Rafts written by Thomas J. McIntosh and published by Humana. This book was released on 2007-07-06 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many unanswered questions concerning the composition, structure, and dynamics of lateral microdomains (rafts) in biological membranes. Thus, sophisticated techniques have been used to study intact cell membranes as well as model systems composed of specific lipids and proteins thought to be in rafts. Using biochemical, biophysical, and computational methods, "Lipid Rafts" provides the most up-to-date information on the subject.
Book Synopsis Berichte über die wissenschaftliche Biologie by :
Download or read book Berichte über die wissenschaftliche Biologie written by and published by . This book was released on 1979 with total page 1138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Nonmedical Applications of Liposomes by : Danilo D. Lasic
Download or read book Handbook of Nonmedical Applications of Liposomes written by Danilo D. Lasic and published by CRC Press. This book was released on 2023-01-27 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1996, liposomes have become an important model in fundamental biomembrane research, including biophysical, biochemical, and cell biological studies of membranes and cell function. They are thoroughly studied in several applications, such as drug delivery systems in medical applications and as controlled release systems, microencapsulating media, signal carriers, support matrices, and solubilizers in other applications. While medical applications have been extensively reviewed in recent literature, there is a need for easily accessible information on applications for liposomes beyond pharmacology and medicine. The Handbook of Nonmedical Applications of Liposomes fills this void. This unique new handbook series presents recent developments in the use of liposomes in many scientific disciplines, from studies on the origin of life, protein function, and vesicle shapes, to applications in cosmetics, diagnostics, ecology, bioreclamation, and the food industry. In these volumes many of the top experts contribute extensive reviews of their work.
Book Synopsis Bioactive Spin Labels by : Renat I. Zhdanov
Download or read book Bioactive Spin Labels written by Renat I. Zhdanov and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Spin Labels is a collection of contributions by leading experts on nitroxyl radicals and their application in biomedicine. These compounds are used as side specific contrast agents for in-vivo EPR techniques. Their potential as drugs is investigated. Bioactive Spin Labels is a must for researchers in bioorganic chemistry, pharmacology and biomedicine.
Book Synopsis Membrane Reconstitution by : George Poste
Download or read book Membrane Reconstitution written by George Poste and published by North-Holland. This book was released on 1982 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Computational Biochemistry and Biophysics by : Oren M. Becker
Download or read book Computational Biochemistry and Biophysics written by Oren M. Becker and published by CRC Press. This book was released on 2001-02-09 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering theoretical methods and computational techniques in biomolecular research, this book focuses on approaches for the treatment of macromolecules, including proteins, nucleic acids, and bilayer membranes. It uses concepts in free energy calculations, conformational analysis, reaction rates, and transition pathways to calculate and interpret b
Book Synopsis The Giant Vesicle Book by : Rumiana Dimova
Download or read book The Giant Vesicle Book written by Rumiana Dimova and published by CRC Press. This book was released on 2019-11-19 with total page 1144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Giant vesicles are widely used as a model membrane system, both for basic biological systems and for their promising applications in the development of smart materials and cell mimetics, as well as in driving new technologies in synthetic biology and for the cosmetics and pharmaceutical industry. The reader is guided to use giant vesicles, from the formation of simple membrane platforms to advanced membrane and cell system models. It also includes fundamentals for understanding lipid or polymer membrane structure, properties and behavior. Every chapter includes ideas for further applications and discussions on the implications of the observed phenomena towards understanding membrane-related processes. The Giant Vesicle Book is meant to be a road companion, a trusted guide for those making their first steps in this field as well as a source of information required by experts. Key Features • A complete summary of the field, covering fundamental concepts, practical methods, core theory, and the most promising applications • A start-up package of theoretical and experimental information for newcomers in the field • Extensive protocols for establishing the required preparations and assays • Tips and instructions for carefully performing and interpreting measurements with giant vesicles or for observing them, including pitfalls • Approaches developed for investigating giant vesicles as well as brief overviews of previous studies implementing the described techniques • Handy tables with data and structures for ready reference
Book Synopsis Free Energy Calculations by : Christophe Chipot
Download or read book Free Energy Calculations written by Christophe Chipot and published by Springer Science & Business Media. This book was released on 2007-01-08 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free energy constitutes the most important thermodynamic quantity to understand how chemical species recognize each other, associate or react. Examples of problems in which knowledge of the underlying free energy behaviour is required, include conformational equilibria and molecular association, partitioning between immiscible liquids, receptor-drug interaction, protein-protein and protein-DNA association, and protein stability. This volume sets out to present a coherent and comprehensive account of the concepts that underlie different approaches devised for the determination of free energies. The reader will gain the necessary insight into the theoretical and computational foundations of the subject and will be presented with relevant applications from molecular-level modelling and simulations of chemical and biological systems. Both formally accurate and approximate methods are covered using both classical and quantum mechanical descriptions. A central theme of the book is that the wide variety of free energy calculation techniques available today can be understood as different implementations of a few basic principles. The book is aimed at a broad readership of graduate students and researchers having a background in chemistry, physics, engineering and physical biology.
Book Synopsis Advances in Planar Lipid Bilayers and Liposomes by : Ales Iglic
Download or read book Advances in Planar Lipid Bilayers and Liposomes written by Ales Iglic and published by Academic Press. This book was released on 2012-09-04 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Planar Lipid Bilayers and Liposomes volumes cover a broad range of topics, including main arrangements of the reconstituted system, namely planar lipid bilayers as well as spherical liposomes. The invited authors present the latest results of their own research groups in this exciting multidisciplinary field. Incorporates contributions from newcomers and established and experienced researchers Explores the planar lipid bilayer systems and spherical liposomes from both theoretical and experimental perspectives Serves as an indispensable source of information for new scientists
