Molecular Toxicology In Caenorhabditis Elegans

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Molecular Toxicology in Caenorhabditis elegans

Author : Dayong Wang
Publisher : Springer
ISBN 13 : 9811336334
Total Pages : 447 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Molecular Toxicology in Caenorhabditis elegans by : Dayong Wang

Download or read book Molecular Toxicology in Caenorhabditis elegans written by Dayong Wang and published by Springer. This book was released on 2019-01-24 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will focus on the molecular basis of oxidative stress induced by toxicants or stresses and various molecular signalling pathways in regulating the toxicity of toxicants or stresses in Caenorhabditis elegans. It will also cover the discussion on the aspects of response signals, G-protein coupled receptors and ion channels, specific molecular signals, and epigenetic signals involved in the regulation of toxicity from toxicants or stresses. The molecular basis for adaptive response for transgenerational toxicity of environmental toxicants or stresses will be further discussed. Nematode Caenorhabditis elegans is a classic model animal with well-described genetic and developmental backgrounds based on the study of life science, and has been further successfully and widely used in both toxicity assessment and toxicological study of various environmental toxicants or stresses. Based on related available data, this book aims at providing a systematic understanding of the knowledge system of molecular toxicology in C. elegans.

Exposure Toxicology in Caenorhabditis Elegans

Author : Dayong Wang
Publisher :
ISBN 13 : 9789811561306
Total Pages : 692 pages
Book Rating : 4.5/5 (613 download)

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Book Synopsis Exposure Toxicology in Caenorhabditis Elegans by : Dayong Wang

Download or read book Exposure Toxicology in Caenorhabditis Elegans written by Dayong Wang and published by . This book was released on 2020 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on exposure toxicology in C. elegans. The nematode Caenorhabditis elegans is sensitive to various environmental toxicants and stresses, and has proven to be an important animal model in both molecular and target-organ toxicology. As a result, over the past 30 years, there has been extensive research on the exposure to environmental toxicants or stresses in nematodes. Based on the available data, the book offers an introduction to the exposure system established in nematodes, discussing various aspects of endpoints that can potentially be used to assess the toxicity of environmental toxicants or stresses. Also exploring various factors affecting toxicity induction, and exposure to environmental toxicants and stresses, it allows readers to gain a systematic understanding of exposure toxicology in C. elegans.

Nanotoxicology in Caenorhabditis Elegans

Author : Dayong Wang
Publisher :
ISBN 13 : 9789811302343
Total Pages : pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Nanotoxicology in Caenorhabditis Elegans by : Dayong Wang

Download or read book Nanotoxicology in Caenorhabditis Elegans written by Dayong Wang and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the toxicity of engineered nanomaterials (ENMs) and their underlying physicochemical, cellular, physiological, and molecular mechanisms. Further, it covers ENMs' translocation and their targeted organ toxicology, and discusses chemical and pharmacological strategies used to combat nanotoxicity. Engineered nanomaterials (ENMs) are defined as materials with one or more dimensions of less than 100 nm, and have shown considerable promise in several areas of development. At the same time, the potential toxicity of ENMs for human health and environmental organisms is increasingly attracting attention. In addition to the typical properties of model animals, Caenorhabditis elegans is extremely sensitive to environmental toxicants, which makes it the ideal in vivo assay system for toxicological studies. C. elegans has been widely used in toxicity assessment and toxicological studies of environmental toxicants and stresses. This book provides a comprehensive summary of nanotoxicology research on C. elegans.

Toxicology at Environmentally Relevant Concentrations in Caenorhabditis elegans

Author : Dayong Wang
Publisher : Springer Nature
ISBN 13 : 9811667462
Total Pages : 371 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Toxicology at Environmentally Relevant Concentrations in Caenorhabditis elegans by : Dayong Wang

Download or read book Toxicology at Environmentally Relevant Concentrations in Caenorhabditis elegans written by Dayong Wang and published by Springer Nature. This book was released on 2022-01-20 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: “This book uses Caenorhabditis elegans as model animal to introduce the toxicity induction of toxicants at environmentally relevant concentrations under different conditions. It also discusses the systematic introduction of different molecular signaling pathways, as well as G protein coupled receptors and ion channels, in regulating the toxicity of toxicants at environmentally relevant concentrations. The intestinal, neuronal, and germline molecular networks required for the regulation of toxicity of toxicants at environmentally relevant concentrations is further introduced and discussed. This book aims at providing a systematic understanding of the knowledge system on toxicology at environmentally relevant concentrations in Caenorhabditis elegans. ”

Toxicology of Nanomaterials

Author : Yuliang Zhao
Publisher : John Wiley & Sons
ISBN 13 : 3527337970
Total Pages : 434 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Toxicology of Nanomaterials by : Yuliang Zhao

Download or read book Toxicology of Nanomaterials written by Yuliang Zhao and published by John Wiley & Sons. This book was released on 2016-12-12 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with a comprehensive view of analytical methods for nanotoxicology studies. After an introduction to nanomaterials and toxicological studies, the book discusses various characterization methods of nanomaterials and continues with the detection of nanoparticles in vivo as well as in vitro. A variety of techniques in molecular toxicology of nanomaterials is presented, followed by a detailed explanation of interaction between nanoparticles and biomacromolecules, including the structure-toxicity relationships of nanomaterials. Finally, the book concludes with the advantages and challenges of the analytical methods for nanotoxicology.

Environmental Toxicology and Toxicogenomics

Author : Xiaoping Pan
Publisher : Humana
ISBN 13 : 9781071615133
Total Pages : 366 pages
Book Rating : 4.6/5 (151 download)

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Book Synopsis Environmental Toxicology and Toxicogenomics by : Xiaoping Pan

Download or read book Environmental Toxicology and Toxicogenomics written by Xiaoping Pan and published by Humana. This book was released on 2021-07-09 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book provides an accessible compendium of up-to-date methods in the fields of environmental toxicology, molecular toxicology, and toxicogenomics. Organized into four major sections, the volume examines methods utilizing model animal species, such as nematode, fruit fly, mice, chicken, and amphibians, methods using plants to study chemical toxicity, applying the Ames assay to chemical mutagenicity study, as well as methods for environmental chemical analysis. Although this book is divided into these parts, the methods can be used across species. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Environmental Toxicology and Toxicogenomics: Principles, Methods, and Applications serves as a valuable resource for the scientific community, particularly for young scientists and graduate and undergraduate students, inspiring more research in the vitally important field of environmental toxicity, molecular toxicology, and toxicogenomics.

Reviews of Environmental Contamination and Toxicology Volume 237

Author : W.P. de Voogt
Publisher : Springer
ISBN 13 : 3319235737
Total Pages : 204 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Reviews of Environmental Contamination and Toxicology Volume 237 by : W.P. de Voogt

Download or read book Reviews of Environmental Contamination and Toxicology Volume 237 written by W.P. de Voogt and published by Springer. This book was released on 2015-11-27 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

Scientific Frontiers in Developmental Toxicology and Risk Assessment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309070864
Total Pages : 348 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Scientific Frontiers in Developmental Toxicology and Risk Assessment by : National Research Council

Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Caenorhabditis Elegans as a Model to Study Molecular Mechanisms of Methylmercury Toxicity

Author : Kirsten Jeanne Helmcke
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (857 download)

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Book Synopsis Caenorhabditis Elegans as a Model to Study Molecular Mechanisms of Methylmercury Toxicity by : Kirsten Jeanne Helmcke

Download or read book Caenorhabditis Elegans as a Model to Study Molecular Mechanisms of Methylmercury Toxicity written by Kirsten Jeanne Helmcke and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methylmercury (MeHg), a known neurotoxicant, is found in seafood, leading to regular exposure of humans to this compound. Many of the molecular targets and detoxifying components of MeHg toxicity, including glutathione (GSH), metallothioneins (MTs), and heat shock proteins (HSPs) have been identified; however, the molecular mechanisms of MeHg neurotoxicity are largely unknown. We used the model organism, Caenorhabditis elegans, to elucidate some of these mechanisms. We found that, although MeHg accumulated within C. elegans and caused a delay in development and a decrease in pharyngeal pumping rate, many endpoints, including life span, brood size, thrashing rate, and, most surprisingly, nervous system morphology, were unaffected. This finding led to the hypothesis that C. elegans has unique mechanisms for protecting its nervous system from MeHg neurotoxicity. We examined the involvement of GSH, MTs, and HSPs in MeHg toxicity in C. elegans and found that GSH levels were altered upon MeHg exposure, a glutathione s-transferase was highly upregulated upon exposure, and that the lack of MTs in MT knockout animals resulted in increased sensitivity to this toxicant. We also demonstrated that MeHg can induce hormesis in C. elegans, likely at least partially due to the involvement of GSTs in MeHg toxicity. As a result of our findings, we began to elucidate some of the molecular mechanisms of MeHg neuroprotection in the C. elegans model system. Our findings are highly valuable to the field of human health due to the regular exposure of humans to MeHg.

C. Elegans II

Author : Donald L. Riddle
Publisher : Firefly Books
ISBN 13 : 9780879695323
Total Pages : 1252 pages
Book Rating : 4.6/5 (953 download)

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Book Synopsis C. Elegans II by : Donald L. Riddle

Download or read book C. Elegans II written by Donald L. Riddle and published by Firefly Books. This book was released on 1997 with total page 1252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR

Developmental Toxicology

Author : Craig Harris
Publisher : Humana Press
ISBN 13 : 9781617798665
Total Pages : 0 pages
Book Rating : 4.7/5 (986 download)

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Book Synopsis Developmental Toxicology by : Craig Harris

Download or read book Developmental Toxicology written by Craig Harris and published by Humana Press. This book was released on 2012-05-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discipline of developmental toxicology is an integration of concepts, models, and methodologies based heavily on the superimposition of toxicology principles upon the science of developmental biology. The science of developmental toxicology also borrows from other research areas that are concerned with regulation of cell growth, migration, differentiation and cell death, as such are central to the study of stem cells, cancer, and chronic diseases. In Developmental Toxicology: Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to study developmental toxicology highlighting the evolution of methods from classical teratology approaches to the dynamic, state-of-the-art molecular methods, systems biology, and next generation models and procedures. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Developmental Toxicology: Methods and Protocols is a valuable resource to those planning experiments to investigate consequences of environmental, nutritional, or chemical effects caused during development.

Fluorescent Nanodiamonds

Author : Huan-Cheng Chang
Publisher : John Wiley & Sons
ISBN 13 : 1119477085
Total Pages : 294 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Fluorescent Nanodiamonds by : Huan-Cheng Chang

Download or read book Fluorescent Nanodiamonds written by Huan-Cheng Chang and published by John Wiley & Sons. This book was released on 2018-11-12 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most comprehensive reference on fluorescent nanodiamond physical and chemical properties and contemporary applications Fluorescent nanodiamonds (FNDs) have drawn a great deal of attention over the past several years, and their applications and development potential are proving to be manifold and vast. The first and only book of its kind, Fluorescent Nanodiamonds is a comprehensive guide to the basic science and technical information needed to fully understand the fundamentals of FNDs and their potential applications across an array of domains. In demonstrating the importance of FNDs in biological applications, the authors bring together all relevant chemistry, physics, materials science and biology. Nanodiamonds are produced by powerful cataclysmic events such as explosions, volcanic eruptions and meteorite impacts. They also can be created in the lab by high-pressure high-temperature treatment of graphite or detonating an explosive in a reactor vessel. A single imperfection can give a nanodiamond a specific, isolated color center which allows it to function as a single, trapped atom. Much smaller than the thickness of a human hair, a nanodiamond can have a huge surface area that allows it to bond with a variety of other materials. Because of their non-toxicity, nanodiamonds may be useful in biomedical applications, such as drug delivery and gene therapy. The most comprehensive reference on a topic of rapidly increasing interest among academic and industrial researchers across an array of fields Includes numerous case studies and practical examples from many areas of research and industrial applications, as well as fascinating and instructive historical perspectives Each chapter addresses, in-depth, a single integral topic including the fundamental properties, synthesis, mechanisms and functionalisation of FNDs The first book published by the key patent holder with his research group in the field of FNDs Fluorescent Nanodiamonds is an important working resource for a broad range of scientists and engineers in industry and academia. It will also be a welcome reference for instructors in chemistry, physics, materials science, biology and related fields.

The Nematode Caenorhabditis Elegans

Author : Jason C. Tew
Publisher :
ISBN 13 :
Total Pages : 238 pages
Book Rating : 4.3/5 (129 download)

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Book Synopsis The Nematode Caenorhabditis Elegans by : Jason C. Tew

Download or read book The Nematode Caenorhabditis Elegans written by Jason C. Tew and published by . This book was released on 2008 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Caenorhabditis Elegans

Author : Joel H. Rothman
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (765 download)

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Book Synopsis Caenorhabditis Elegans by : Joel H. Rothman

Download or read book Caenorhabditis Elegans written by Joel H. Rothman and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mixture Toxicity

Author : Cornelis A. M. van Gestel
Publisher : CRC Press
ISBN 13 : 1439830096
Total Pages : 312 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Mixture Toxicity by : Cornelis A. M. van Gestel

Download or read book Mixture Toxicity written by Cornelis A. M. van Gestel and published by CRC Press. This book was released on 2016-04-19 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an

Exposure Toxicology in Caenorhabditis elegans

Author : Dayong Wang
Publisher : Springer Nature
ISBN 13 : 981156129X
Total Pages : 682 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Exposure Toxicology in Caenorhabditis elegans by : Dayong Wang

Download or read book Exposure Toxicology in Caenorhabditis elegans written by Dayong Wang and published by Springer Nature. This book was released on 2020-08-27 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on exposure toxicology in C. elegans. The nematode Caenorhabditis elegans is sensitive to various environmental toxicants and stresses, and has proven to be an important animal model in both molecular and target-organ toxicology. As a result, over the past 30 years, there has been extensive research on the exposure to environmental toxicants or stresses in nematodes. Based on the available data, the book offers an introduction to the exposure system established in nematodes, discussing various aspects of endpoints that can potentially be used to assess the toxicity of environmental toxicants or stresses. Also exploring various factors affecting toxicity induction, and exposure to environmental toxicants and stresses, it allows readers to gain a systematic understanding of exposure toxicology in C. elegans.

Target Organ Toxicology in Caenorhabditis elegans

Author : Dayong Wang
Publisher : Springer
ISBN 13 : 9811360103
Total Pages : 337 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Target Organ Toxicology in Caenorhabditis elegans by : Dayong Wang

Download or read book Target Organ Toxicology in Caenorhabditis elegans written by Dayong Wang and published by Springer. This book was released on 2019-02-12 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to intestinal and epidermal barriers, and to toxicity induction of environmental toxicants or stresses in the intestine, epidermis, neurons, muscle, and reproductive organs in Caenorhabditis elegans. In addition, it discusses the protective responses of various organs and nematodes’ avoidance behaviour with regard to environmental toxicants or stresses. The intestinal, epidermal, neuronal, and germline signalling pathways required for the regulation of toxicity of environmental toxicants or stresses are also introduced and discussed. As a classic model animal with well-described genetic and developmental backgrounds, the nematode Caenorhabditis elegans has been successfully and widely used in both toxicity assessments and toxicological studies on various environmental toxicants and stresses. Once exposure to certain environmental toxicants has occurred, the toxicants can enter into the primary targeted organs (such as intestinal cells), and even be translocated into secondary targeted organs (such as reproductive organs and neurons). Based on related available data, this book provides a systematic understanding of target organ toxicology in C. elegans.