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Molecular Signaling Of Mammalian Inner Ear Development
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Book Synopsis Molecular Signaling of Mammalian Inner Ear Development by : Dorothy A. Frenz
Download or read book Molecular Signaling of Mammalian Inner Ear Development written by Dorothy A. Frenz and published by . This book was released on 2013 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inner ear originates from an ectodermal thickening, the otic placode, which lies adjacent to the developing hindbrain. Complex interactions between regulatory signaling molecules guide development of the simple otic placode into the elaborate, multifunctional organs of hearing and balance. This book delves into recent research in the field, focusing on successive stages of inner ear development and how they are influenced by the coordinate activity of signaling molecules. This book begins with an overview of the evolutionary adaptation of the organ of Corti (organ of hearing) and the molecular signals that characterize ancestral development of the inner ear. Following this, the topics addressed include the complex signaling interactions underlying induction of the otic placode, key molecular mediators influencing inner ear development and patterning, genetic signaling of the vestibular (balance) system and clinical correlations to human balance disorders, commitment to auditory hair cell fate, and reliance of the inner ear on retinoic acid, a biologically-active derivative of vitamin A, for appropriate development. This timely and comprehensive book provides an excellent resource for researchers, clinician-scientists and students alike.
Book Synopsis Development of Auditory and Vestibular Systems-3: Molecular Development of the Inner Ear by : Raymond Romand
Download or read book Development of Auditory and Vestibular Systems-3: Molecular Development of the Inner Ear written by Raymond Romand and published by Elsevier. This book was released on 2003-12-15 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thanks to advances in genetics and genomics, research on inner ear development has flourished. Better approaches and experimental models have shed light on the function of a variety of vertebrate genes and their related proteins. This latest volume of Current Topics in Developmental Biology delves into this new research to show how the discovery of more genes involved in the development of the inner ear leads to the generation of new models that examine a wealth of issues -- from the origins of human deafness to the roles of genes during inner ear induction, development and differentiation. The wide variety of experimental approaches will help readers to understand the broad range of issues related to inner ear morphogenesis and other concepts from complementary areas of investigation. This state-of-the-art overview will be essential reading for researchers, clinicians and students alike. * Scores of high-quality, full- color figures* Detailed schemes on the structure and timing of ear development* Current Topics in Developmental Biology is the longest-running forum for contemporary issues in developmental biology
Book Synopsis Development of the Inner Ear by : Matthew Kelley
Download or read book Development of the Inner Ear written by Matthew Kelley and published by Springer Science & Business Media. This book was released on 2006-03-04 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Springer Handbook of Auditory Research presents a series of compreh- sive and synthetic reviews of the fundamental topics in modern auditory - search. The volumes are aimed at all individuals with interests in hearing research including advanced graduate students, postdoctoral researchers, and clinical investigators. The volumes are intended to introduce new investigators to important aspects of hearing science and to help established investigators to betterunderstandthefundamentaltheoriesanddatain?eldsofhearingthatthey may not normally follow closely. Each volume presents a particular topic comprehensively, and each servesas a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in peer-reviewed journals. The volumes focus on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beginning to develop. New research areas will be covered on a timely basis in the series as they begin to mature. Eachvolumeintheseriesconsistsofafewsubstantialchaptersonaparticular topic. In some cases, the topics will be ones of traditional interest for which there is a substantial body of data and theory, such as auditory neuroanatomy (Vol. 1) and neurophysiology (Vol. 2). Other volumes in the series deal with topics that have begun to mature more recently, suchasdevelopment,plasticity, and computational models of neural processing. In many cases, the series - itorsarejoinedbyaco-editorhavingspecialexpertiseinthetopicofthevolume.
Book Synopsis Development of Auditory and Vestibular Systems by : Raymond Romand
Download or read book Development of Auditory and Vestibular Systems written by Raymond Romand and published by Academic Press. This book was released on 2014-05-23 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development of Auditory and Vestibular Systems fourth edition presents a global and synthetic view of the main aspects of the development of the stato-acoustic system. Unique to this volume is the joint discussion of two sensory systems that, although close at the embryological stage, present divergences during development and later reveal conspicuous functional differences at the adult stage. This work covers the development of auditory receptors up to the central auditory system from several animal models, including humans. Coverage of the vestibular system, spanning amphibians to effects of altered gravity during development in different species, offers examples of the diversity and complexity of life at all levels, from genes through anatomical form and function to, ultimately, behavior. The new edition of Development of Auditory and Vestibular Systems will continue to be an indispensable resource for beginning scientists in this area and experienced researchers alike. Full-color figures illustrate the development of the stato-acoustic system pathway Covers a broad range of species, from drosophila to humans, demonstrating the diversity of morphological development despite similarities in molecular processes involved at the cellular level Discusses a variety of approaches, from genetic-molecular biology to psychophysics, enabling the investigation of ontogenesis and functional development
Book Synopsis The Primary Auditory Neurons of the Mammalian Cochlea by : Alain Dabdoub
Download or read book The Primary Auditory Neurons of the Mammalian Cochlea written by Alain Dabdoub and published by Springer. This book was released on 2015-10-06 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details the essential role of the spiral ganglion neurons. The volume elucidates and characterizes their development, their environment, their electrophysiological characteristics, their connectivity to their targets in the inner ear and the brain, and discusses the potential for their regeneration. A comprehensive review about the spiral ganglion neurons is important for researchers not only in the inner ear field but also in development, neuroscience, biophysics as well as neural networks researchers. The chapters are authored by leading researchers in the field.
Book Synopsis Molecular Analyses of Mouse Inner Ear Development by : Bernhard M. Saeger
Download or read book Molecular Analyses of Mouse Inner Ear Development written by Bernhard M. Saeger and published by . This book was released on 2011 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Dynamic Role of SOX2 in Mammalian Inner Ear Development by : Aleta R. Steevens
Download or read book The Dynamic Role of SOX2 in Mammalian Inner Ear Development written by Aleta R. Steevens and published by . This book was released on 2018 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intricate neuroanatomical structures within our inner ears confer humans with the ability to detect sound and balance information with exquisite detail. These abilities are mediated by six sensory organs and the specialized sensory cells that make up these regions: mechanosensory hair cells, supporting cells, and inner ear neurons. Hair cells and supporting cells derive from a common sensory progenitor, and in some cases, all three cell types arise from a common neurosensory progenitor. Generating a better understanding of how sensory cells develop from a progenitor stage will further therapeutic strategies aimed at regenerating damaged sensory areas in hearing and balance disorders, in which cellular deficits are permanent. The transcription factor SOX2 is firmly established to be required for inner ear sensory progenitor formation. Additionally, overexpression studies have suggested that SOX2 may promote the generation of both neuronal and sensory inner ear lineages. However, it is not known when SOX2 is required nor in which cells types. Thus, an outstanding question remains: is SOX2 exclusive to sensory progenitors from the earliest times? In order to determine when and in which cell types SOX2 acts during inner ear development, I used a genetic system in the mouse to fate map early SOX2 expressing progeny and to test the requirements of SOX2 activity during critical inner ear development stages. I discovered several novel and previously unrecognized roles for SOX2 in inner ear development that includes the following: (1) SOX2 is required for inner ear neurogenesis and acts upstream in a cascade of proneural signaling events. (2) SOX2 initially is required for non-sensory development in the cochlea and for vestibular formation. (3) Loss and gain-of-function approaches indicate an early role for SOX2 in promoting inner ear progenitor proliferation. Moreover, I showed that SOX2 does not mark the sensory lineage from the earliest times, but rather sensory specification is a later function of SOX2. Interestingly, short harvest fate mapping experiments captured the dynamics in SOX2 expression and function, as the entire domain of SOX2 inverted within a 48-hour window. Likely this reflects its switch from promoting non-sensory formation and proliferation to sensory development in the cochlea. These studies reveal the dynamic role for SOX2 in inner ear development and outline the parameters in which SOX2 promotes different otic lineages.
Book Synopsis The Fibroblast Growth Factor Family by : Andrew Baird
Download or read book The Fibroblast Growth Factor Family written by Andrew Baird and published by . This book was released on 1991 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mammalian Development by : Patrick P. L. Tam
Download or read book Mammalian Development written by Patrick P. L. Tam and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A subject collection from Cold Spring Harbor perspectives in biology."
Book Synopsis Vertebrate Hair Cells by : Ruth Eatock
Download or read book Vertebrate Hair Cells written by Ruth Eatock and published by Springer Science & Business Media. This book was released on 2006-07-01 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Springer Handbook of Auditory Research presents a series of compreh- sive and synthetic reviews of the fundamental topics in modern auditory - search. The volumes are aimed at all individuals with interests in hearing research including advanced graduate students, postdoctoral researchers, and clinical investigators. The volumes are intended to introduce new investigators to important aspects of hearing science and to help established investigators to better understand the fundamental theories and data in ?elds of hearing that they may not normally follow closely. Each volume presents a particular topic comprehensively, and each serves as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in peer-reviewed journals. The volumes focus on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beginning to develop. New research areas will be covered on a timely basis in the series as they begin to mature.
Book Synopsis Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics by : Srdjan M Vlajkovic
Download or read book Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics written by Srdjan M Vlajkovic and published by . This book was released on 2021-10-25 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sense of hearing is vulnerable to environmental challenges, such as exposure to noise. More than 1.5 billion people experience some decline in hearing ability during their lifetime, of whom at least 430 million will be affected by disabling hearing loss. If not identified and addressed in a timely way, hearing loss can severely reduce the quality of life at various stages. Some causes of hearing loss can be prevented, for example from occupational or leisure noise. The World Health Organization estimates that more than 1 billion young people put themselves at risk of permanent hearing loss by listening to loud music over long periods of time. Mitigating such risks through public health action is essential to reduce the impact of hearing loss in the community. The etiology of sensorineural hearing loss is complex and multifactorial, arising from congenital and acquired causes. This book highlights the diverse range of approaches to sensorineural hearing loss, from designing new animal models of age-related hearing loss, to the use of microRNAs as biomarkers of cochlear injury and drug repurposing for the therapy of agerelated and noise-induced hearing loss. Further investigation into the underlying molecular mechanisms of sensorineural hearing loss and the integration of the novel drug, cell, and gene therapy strategies into controlled clinical studies will permit significant advances in a field where there are currently many unmet needs.
Download or read book GM3 Signaling written by Cheorl-Ho Kim and published by Springer Nature. This book was released on 2020-07-10 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells. GM3 is the simplest of the gangliosides and the precursor of other gangliosides. It is expressed in the outer leaflet of plasma cell membranes and has roles in the recognition, interaction, binding, adhesion, and motility of cells. In addition, GM3 has been documented to have functional roles in cell migration, proliferation, senescence, and apoptosis. The full range of topics of interest are addressed in the book. The early chapters discuss the synthesis of GM3, its molecular localization in cells, and its basic function as an interacting molecule. The ways in which GM3 exerts its effects via various growth factor receptors are fully explored. Current knowledge of the part played by GM3 in health and disease is discussed in depth. For example, its roles in preventing inflammation, inhibiting tumor angiogenesis and tumor growth, and suppressing arthritis are highlighted, and attention drawn to the significance of GM3 as a driver of impaired wound healing in diabetics. The book will be of interest to all who want a comprehensive update on research in this field.
Download or read book Your Inner Fish written by Neil Shubin and published by Vintage. This book was released on 2008-01-15 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: The paleontologist and professor of anatomy who co-discovered Tiktaalik, the “fish with hands,” tells a “compelling scientific adventure story that will change forever how you understand what it means to be human” (Oliver Sacks). By examining fossils and DNA, he shows us that our hands actually resemble fish fins, our heads are organized like long-extinct jawless fish, and major parts of our genomes look and function like those of worms and bacteria. Your Inner Fish makes us look at ourselves and our world in an illuminating new light. This is science writing at its finest—enlightening, accessible and told with irresistible enthusiasm.
Book Synopsis Molecular Signaling in Spermatogenesis and Male Infertility by : Rajender Singh
Download or read book Molecular Signaling in Spermatogenesis and Male Infertility written by Rajender Singh and published by CRC Press. This book was released on 2019-11-06 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spermatogenesis involves the coordination of a number of signaling pathways, which culminate into production of sperm. Its failure results in male factor infertility, which can be due to hormonal, environmental, genetic or other unknown factors. This book includes chapters on most of the signaling pathways known to contribute to spermatogenesis. Latest research in germ cell signaling like the role of small RNAs in spermatogenesis is also discussed. This book aims to serve as a reference for both clinicians and researchers, explaining possible causes of infertility and exploring various treatment methods for management through the basic understanding of the role of molecular signaling. Key Features Discusses the signaling pathways that contribute to successful spermatogenesis Covers comprehensive information about Spermatogenesis at one place Explores the vital aspects of male fertility and infertility Explains the epigenetic regulation of germ cell development and fertility Highlights the translational opportunities in molecular signaling in testis
Book Synopsis Auriculotherapy Manual by : Terry Oleson
Download or read book Auriculotherapy Manual written by Terry Oleson and published by . This book was released on 2003 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health professionals from a wide range of backgrounds apply auriculotherapy to successfully relieve chronic pain and treat addictions. The most popular book on the subject, this practical handbook combines information on Chinese and French systems of ear acupuncture to offer treatment plans for over 250 medical conditions. Presenting the ear reflex points based on extensive research conducted at the UCLA Pain Management Center, it provides a standardized auricular nomenclature system for designating different anatomical zones of the ear, and it represents each ear reflex point with both a number and an auricular zone location.
Book Synopsis Vestibular System Part 1: Basic Mechanisms by : H.H. Kornhuber
Download or read book Vestibular System Part 1: Basic Mechanisms written by H.H. Kornhuber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: The details of the receptor mechanism are not yet fully understood for any sensory system. However, sufficient data are available (for the vestibular system and for other systems) to permit meaningful tracking of the sensory messages through the nervous system and via conscious experience. The reception, process ing, storage and output of information in man and other animals, as done by means of receptors, neurons, secretory cells and muscle fibers, are collectively referred to as mind. Sensory physiologists tend to disbelieve in extrasensory perception. Sensory physiology in general is an area upon which different sciences and methods converge. Anatomists, physiologists, psychologists, physicists, chemists, and engineers have made important contributions to sensory physiology. What is special about vestibular physiology is the fact that many research workers are clinicians, living under the constant pressure of their patient's demands. This is a disadvantage when it comes to writing handbooks, but an advantage for the pa tient, since research is guided by clinical practice and can be quickly applied. Modern methods, such as recording from single nerve units and the correlation of electrophysiological and psychophysical data, have greatly contributed to our knowledge, yet the study of lesions is still important, especially in the vestibular field.
Book Synopsis Ion Channels in Health and Sickness by : Fatima Shad Kaneez
Download or read book Ion Channels in Health and Sickness written by Fatima Shad Kaneez and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.
