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Molecular Pharming
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Book Synopsis Molecular Pharming by : Allison R. Kermode
Download or read book Molecular Pharming written by Allison R. Kermode and published by John Wiley & Sons. This book was released on 2018-03-12 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant specialized metabolites, and plants as model organisms to study human disease processes. Molecular Pharming: Applications, Challenges and Emerging Areas offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology. Broad ranging coverage of a key area of plant biotechnology Describes efforts to produce pharmaceutical and industrial proteins in plants Provides reviews of recent advances and technology breakthroughs Assesses realities of regulatory and cost hurdles Forward looking with coverage of small molecule technologies and the use of plants as models of human disease processes Providing wide-ranging and unique coverage, Molecular Pharming: Applications, Challenges and Emerging Areas will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities.
Book Synopsis Molecular Pharming by : Allison R. Kermode
Download or read book Molecular Pharming written by Allison R. Kermode and published by John Wiley & Sons. This book was released on 2018-05-08 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant specialized metabolites, and plants as model organisms to study human disease processes. Molecular Pharming: Applications, Challenges and Emerging Areas offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology. Broad ranging coverage of a key area of plant biotechnology Describes efforts to produce pharmaceutical and industrial proteins in plants Provides reviews of recent advances and technology breakthroughs Assesses realities of regulatory and cost hurdles Forward looking with coverage of small molecule technologies and the use of plants as models of human disease processes Providing wide-ranging and unique coverage, Molecular Pharming: Applications, Challenges and Emerging Areas will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities.
Book Synopsis Molecular Farming by : Rainer Fischer
Download or read book Molecular Farming written by Rainer Fischer and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here, authors from academia and industry provide an exciting overview of current production technologies and the fascinating possibilities for future applications. Topics include chloroplast-derived antibodies, biopharmaceuticals and edible vaccines, production of antibodies in plants and plant cell suspension cultures, production of spider silk proteins in plants, and glycosylation of plant produced proteins. The whole is rounded off by chapters on the demands and expectations made on molecular farming by pharmaceutical corporations and the choice of crop species in improving recombinant protein levels. Of interest to biotechnologists, gene technologists, molecular biologists and protein biochemists in university as well as the biotechnological and pharmaceutical industries.
Book Synopsis Frontiers in Molecular Pharming by : Muhammad Sarwar Khan
Download or read book Frontiers in Molecular Pharming written by Muhammad Sarwar Khan and published by Bentham Science Publishers. This book was released on 2021-12-09 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of large-scale production and clinical trials of drugs developed through diverse production routes - involving viruses, microbes, plants, and animals - has increased the demand for an expanded capacity for pharmaceutical manufacturing. The production and purification of expressed proteins accounts for the bulk of the manufacturing costs for new therapeutics. Several pharmaceutical proteins have been synthesized by exploiting plant genetics allowing producers to override conventional approaches used to manufacture pharmaceuticals. The process of inserting a gene into a host organism for the purpose of harvesting a bioactive molecule for therapeutic use is known as molecular pharming. Frontiers in Molecular Pharming covers an array of topics relevant to understanding the structure, function, regulation, and mechanisms of action, biochemical significance, and usage of proteins and peptides as biomarkers, therapeutics, and vaccines for animals and humans. The contributions aim to highlight current progress in three areas, including system biology (in vivo characterization of proteins and peptides), molecular pharming for animals and molecular pharming for humans. The book gives special attention to computational biology tools, production platforms and fields (such as immunoinformatics) and applications of molecular pharming (such as veterinary therapeutics). A balance of theoretical concepts and practical applications is provided through 13 chapters. Frontiers in Molecular Pharming is an invaluable resource for students and researchers of biochemistry, molecular biology, and biotechnology. The book also serves as a springboard for understanding the process of how discoveries in protein and peptide research and its applications are coming to fruition.
Book Synopsis Frontiers in Molecular Pharming by : Muhammad Sarwar Khan
Download or read book Frontiers in Molecular Pharming written by Muhammad Sarwar Khan and published by Bentham Science Publishers. This book was released on 2021-12-09 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of large-scale production and clinical trials of drugs developed through diverse production routes - involving viruses, microbes, plants, and animals - has increased the demand for an expanded capacity for pharmaceutical manufacturing. The production and purification of expressed proteins accounts for the bulk of the manufacturing costs for new therapeutics. Several pharmaceutical proteins have been synthesized by exploiting plant genetics allowing producers to override conventional approaches used to manufacture pharmaceuticals. The process of inserting a gene into a host organism for the purpose of harvesting a bioactive molecule for therapeutic use is known as molecular pharming. Frontiers in Molecular Pharming covers an array of topics relevant to understanding the structure, function, regulation, and mechanisms of action, biochemical significance, and usage of proteins and peptides as biomarkers, therapeutics, and vaccines for animals and humans. The contributions aim to highlight current progress in three areas, including system biology (in vivo characterization of proteins and peptides), molecular pharming for animals and molecular pharming for humans. The book gives special attention to computational biology tools, production platforms and fields (such as immunoinformatics) and applications of molecular pharming (such as veterinary therapeutics). A balance of theoretical concepts and practical applications is provided through 13 chapters. Frontiers in Molecular Pharming is an invaluable resource for students and researchers of biochemistry, molecular biology, and biotechnology. The book also serves as a springboard for understanding the process of how discoveries in protein and peptide research and its applications are coming to fruition.
Book Synopsis Sustainable Food Production by : Paul Christou
Download or read book Sustainable Food Production written by Paul Christou and published by Springer. This book was released on 2012-12-05 with total page 1869 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gathering some 90 entries from the Encyclopedia of Sustainability Science and Technology, this book covers animal breeding and genetics for food, crop science and technology, ocean farming and sustainable aquaculture, transgenic livestock for food and more.
Book Synopsis Molecular Pharming by : Allison R. Kermode
Download or read book Molecular Pharming written by Allison R. Kermode and published by John Wiley & Sons. This book was released on 2018-03-12 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant specialized metabolites, and plants as model organisms to study human disease processes. Molecular Pharming: Applications, Challenges and Emerging Areas offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology. Broad ranging coverage of a key area of plant biotechnology Describes efforts to produce pharmaceutical and industrial proteins in plants Provides reviews of recent advances and technology breakthroughs Assesses realities of regulatory and cost hurdles Forward looking with coverage of small molecule technologies and the use of plants as models of human disease processes Providing wide-ranging and unique coverage, Molecular Pharming: Applications, Challenges and Emerging Areas will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities.
Book Synopsis Molecular Farming of Plants and Animals for Human and Veterinary Medicine by : L. Erickson
Download or read book Molecular Farming of Plants and Animals for Human and Veterinary Medicine written by L. Erickson and published by Springer Science & Business Media. This book was released on 2013-04-18 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular farming has been hailed as the "third wave" of genetically-modified organisms produced through biotechnology for the bio-based economy of the future. Unlike products of the first wave, such as herbicide resistant crop plants, which were perceived to benefit only the farmers who used them and the agrochemical companies who developed them, products of molecular farming are designed specifically for the benefit of the consumer. Such products could be purified from food or non-food organisms for a range of applications in industry, as well as animal and human health. Alternatively, the products of this technology could be consumed more directly in some edible format, such as milk, eggs, fruits or vegetables. There is a rapidly-growing interest Qn the part of the public as well as in the medical community in the role food plays in health, especially in the immunophysiological impact of food over and above the role of basic nutrition.
Book Synopsis Molecular Farming in Plants: Recent Advances and Future Prospects by : Aiming Wang
Download or read book Molecular Farming in Plants: Recent Advances and Future Prospects written by Aiming Wang and published by Springer Science & Business Media. This book was released on 2011-10-14 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular farming in plants is a relatively young subject of sciences. As plants can offer an inexpensive and convenient platform for the large-scale production of recombinant proteins with various functions, the driven force from the giant market for recombinant protein pharmaceuticals and industrial enzymes makes this subject grow and advance very quickly. To summarize recent advances, current challenges and future directions in molecular farming, international authorities were invited to write this book for researchers, teachers and students who are interested in this subject. This book, with the focus on the most advanced cutting-edge breakthroughs, covers all the essential aspects of the field of molecular farming in plants: from expression technologies to downstream processing, from products to safety issues, and from current advances and holdups to future developments.
Book Synopsis Plant Bioactive Molecules by : Massimo Maffei
Download or read book Plant Bioactive Molecules written by Massimo Maffei and published by Cambridge Scholars Publishing. This book was released on 2019-01-18 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants have always been a source of nourishment and healing for living things. Their dual task of producing nutrients and medicines has played a key role in the evolution of herbivore and omnivore organisms. The so-called secondary metabolites are molecules with well-defined functional roles. These compounds are produced to defend plants from abiotic and biotic stresses. The complexity of the molecular structures produced by plants is only equal to their versatility and chemical diversity, while the harmonic intertwining of biosynthetic and metabolic pathways offers a perfect picture of the adaptive plasticity of plants to changing environmental conditions. This book is divided into three parts designed to provide the reader with a general overview, a biochemical and a biotechnological approach to plant bioactive molecules. The first part analyses the concepts of chemical diversity, sustainability and functional role of bioactive molecules, by exploring the sites of synthesis and accumulation, the plant defence strategies and the use of bioactive molecules as food supplements and as a source for natural products to fight diseases. The first part ends with the study of chemotaxonomy. The second part is dedicated to plant biochemistry, with the detailed description of the main biosynthetic pathways leading to the synthesis of phenols and flavonoids, terpenes, oxylipins and nitrogen-containing substances. The third and final part describes plant biotechnology and production of bioactive molecules with industrial processes, both in vivo and in vitro. Special attention is paid to cell and tissue cultures, roots and shoots cultures, technological aspects describing bioreactors, biofermenters and photobioreactors. The book concludes with a chapter describing the genetic engineering strategies for the production of plant bioactive molecules, facing with ethical problems, risks and benefits of using recombinant DNA in genetically modified organisms (GMOs) and the use of molecular pharming, with a general discussion on food safety.
Download or read book Pharming written by Eckard Rehbinder and published by Springer Science & Business Media. This book was released on 2008-09-27 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: A recently established technique termed pharming uses genetically modified plants and animals for the production of biopharmaceuticals. The present interdisciplinary study comprises an extended overview of the state of the art of pharming, as well as in depth analyses of the environmental risks and other ethical and legal issues of pharming. Public attitudes to pharming are investigated on the basis of an original survey in 15 countries worldwide. The study concludes with specific recommendations addressed towards science, industry and politics.
Book Synopsis Biotechnologies of Crop Improvement, Volume 2 by : Satbir Singh Gosal
Download or read book Biotechnologies of Crop Improvement, Volume 2 written by Satbir Singh Gosal and published by Springer. This book was released on 2018-07-09 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past 15 years, cellular and molecular approaches have emerged as valuable adjuncts to supplement and complement conventional breeding methods for a wide variety of crop plants. Biotechnology increasingly plays a role in the creation, conservation, characterization and utilization of genetic variability for germplasm enhancement. For instance, anther/microspore culture, somaclonal variation, embryo culture and somatic hybridization are being exploited for obtaining incremental improvement in the existing cultivars. In addition, genes that confer insect- and disease-resistance, abiotic stress tolerance, herbicide tolerance and quality traits have been isolated and re-introduced into otherwise sensitive or susceptible species by a variety of transgenic techniques. Together these transformative methodologies grant access to a greater repertoire of genetic diversity as the gene(s) may come from viruses, bacteria, fungi, insects, animals, human beings, unrelated plants or even be artificially derived. Remarkable achievements have been made in the production, characterization, field evaluation and commercialization of transgenic crop varieties worldwide. Likewise, significant advances have been made towards increasing crop yields, improving nutritional quality, enabling crops to be raised under adverse conditions and developing resistance to pests and diseases for sustaining global food and nutritional security. The overarching purpose of this 3-volume work is to summarize the history of crop improvement from a technological perspective but to do so with a forward outlook on further advancement and adaptability to a changing world. Our carefully chosen “case studies of important plant crops” intend to serve a diverse spectrum of audience looking for the right tools to tackle complicated local and global issues.
Book Synopsis Tools & Techniques of Plant Molecular Farming by : Chittaranjan Kole
Download or read book Tools & Techniques of Plant Molecular Farming written by Chittaranjan Kole and published by Springer Nature. This book was released on 2023-11-22 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book is an in-depth compilation of recent tools and techniques, concepts and strategies used globally in plant molecular farming (PMF) for the cost-effective bulk production of recombinant proteins, secondary metabolites, and other biomolecules. The book presents an overview of success stories of PMF applications from developing countries to address poverty, achieve zero hunger, good health and well-being, thus achieving the UN SDGs 1, 2, and 3. The book deep dives into recent extraction and downstream processing methodologies, its co-existence with conventional agriculture, global governance and finally opportunities, challenges, and future perspectives in plant molecular farming. It focuses on plastid/chloroplast transformation (transplastomics) and its application in plant molecular farming. The books highlight recent advances in genome editing, synthetic biology, glycosylation and glyco-engineering for improved plant molecular farming by marker-free and tissue-specific systems via cisgenic and transgenic crops. In depth discussions on biosafety issues and bio-containment strategies have also been included. The book has 15 chapters authored by globally leading experts on the subject, presenting opportunities & challenges for bio-industrial researchers and entrepreneurs. It is useful to researchers, industrialists, entrepreneurs, policy planners, academician, and students across the disciplines.
Book Synopsis Molecular Farming in Plants: Recent Advances and Future Prospects by : Aiming Wang
Download or read book Molecular Farming in Plants: Recent Advances and Future Prospects written by Aiming Wang and published by Springer. This book was released on 2011-10-21 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular farming in plants is a relatively young subject of sciences. As plants can offer an inexpensive and convenient platform for the large-scale production of recombinant proteins with various functions, the driven force from the giant market for recombinant protein pharmaceuticals and industrial enzymes makes this subject grow and advance very quickly. To summarize recent advances, current challenges and future directions in molecular farming, international authorities were invited to write this book for researchers, teachers and students who are interested in this subject. This book, with the focus on the most advanced cutting-edge breakthroughs, covers all the essential aspects of the field of molecular farming in plants: from expression technologies to downstream processing, from products to safety issues, and from current advances and holdups to future developments.
Book Synopsis Proceedings of ISPMF 2018 - Plant Molecular Farming by : Anneli Ritala
Download or read book Proceedings of ISPMF 2018 - Plant Molecular Farming written by Anneli Ritala and published by Frontiers Media SA. This book was released on 2020-06-16 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Plant Molecular Farming for the Production of Next-Generation Vaccines and Biologics – Prospects and Challenges by :
Download or read book Plant Molecular Farming for the Production of Next-Generation Vaccines and Biologics – Prospects and Challenges written by and published by Frontiers Media SA. This book was released on 2024-03-11 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are still a major threat to public health. The vaccine remains the most important and safer way of combating infectious diseases. Therefore, there is an urgent need to look for new ways of vaccine generation that can cut down production costs and processing time. The development of rDNA technology allows the expression and purification of proteins in unlimited quantity, thus opening an avenue for the development of protein-based vaccines as a prophylactic measure against infectious diseases. Recombinant therapeutic proteins derived from biological sources, including mammalian cells, microorganisms, suspension cultures, or genetically modified organisms by employing biotechnological processes, are widely used in clinical applications, especially for the treatment and prevention of human or veterinary infections. Since the development of human insulin by utilizing recombinant DNA technology in E. coli in the 1980s, the recombinant therapeutic protein production field has significantly grown and gained major attention. Plant molecular farming, the production of biologics in plant cells or transgenic plants, could offer a cost-effective adaptable strategy to produce biologics, particularly in low-resource settings. Molecular farming-based strategies could provide an alternative strategy to traditional biologics or vaccine production, enabling rapid development, effective deployment, and safe administration of vaccines. The concept of PMF was initially documented three decades back when recombinant growth hormone was produced in tobacco and sunflower plants. Even with such a long history of significant advantages and several proof-of-concept studies, very few plant-derived therapeutic products have been clinically translated. However, the recent progress around the approval of the plant-based biopharmaceutical ZMapp by the FDA, Medicago’s COVID-19 vaccine by Health Canada, and the safety of a few plant-derived vaccines in clinical trials have displayed the potential of a plant platform for biopharmaceutical production. Furthermore, constant efforts are being made with respect to the optimization of expression techniques, downstream processing, and defining standard guidelines for plant products to make an impact of plant-derived products on an array of applications.
Book Synopsis Transgenesis and Secondary Metabolism by : Sumita Jha
Download or read book Transgenesis and Secondary Metabolism written by Sumita Jha and published by Springer. This book was released on 2017-05-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides comprehensive reference information on the efficient production of secondary metabolites from plants by transgenesis and other genetic manipulation strategies. It reviews and summarizes selected important case studies in genetic methods applied to enhance the production of a given metabolite or a group of related or derived compounds. Readers will find reference information on a multitude of techniques and methods, including traditional breeding and screening; over-expression of genes encoding key enzymes; functional genomics approaches; metabolic engineering of the relevant biosynthetic pathways; indirect genetic approaches to improve metabolite production, including Agrobacterium mediated transformations. Furthermore, combinatorial biochemistry approaches to engineer secondary metabolic pathways are summarized, which can offer access to new structures or to the design of novel compounds. Since many commercially valuable substances are still extracted from plants, being largely inaccessible to efficient modern laboratory synthesis methods, this book provides a valuable resource of information for biotechnological approaches that can help to find alternative and more efficient methods for the production of natural secondary metabolites. Thus adjusted production methods, with the help of tailored plant systems, can potentially help to release the stress on plants, which are currently suffering from extensive human harvesting, and to conserve global biodiversity. Readers will find comprehensive reference information on plant genetic manipulation toward more efficient synthesis, accumulation and production of target secondary metabolites. The handbook will appeal to researchers and professionals, but also graduate students and scholars working in the fields of biotechnology, genetic engineering, medicinal plant research, pharmacy, and phytochemistry.
