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Author : Gildas Loussouarn
Publisher : Frontiers Media SA
ISBN 13 : 2889715884
Total Pages : 163 pages
Book Rating : 4.8/5 (897 download)
Download or read book Molecular Mechanisms of Voltage-Gating in Ion Channels written by Gildas Loussouarn and published by Frontiers Media SA. This book was released on 2021-11-03 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gildas Loussouarn
Publisher : Frontiers E-books
ISBN 13 : 288919115X
Total Pages : 211 pages
Book Rating : 4.8/5 (891 download)
Download or read book Mechanisms of ion channels voltage-dependency written by Gildas Loussouarn and published by Frontiers E-books. This book was released on with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Voltage-gated ion channels are transmembrane proteins in which at least one gate is controlled by the transmembrane potential. They are frequently very selectively permeable to sodium (Nav channels), potassium (Kv channels) or calcium (Cav channels) ions. Depending on the channels, opening of the activation gate is triggered by membrane depolarization (Kv, Nav and Cav channels) or hyperpolarization (HCN channels for instance). In addition, in many voltage-gated channels, a so-called inactivation gate is also present. Compared to the activation gate, the latter is oppositely coupled to the potential: In Kv, Nav and Cav channels, upon membrane depolarization, the inactivation gate closes whereas the activation gate opens. Depending on the cell types in which they are expressed and their physiological role, various voltage-dependent channels can be characterized by their conductance, ion selectivity, pharmacology and voltage-sensitivity. These properties are mainly dictated by the amino-acids sequence and structure of the pore forming subunit(s), presence of accessory subunit(s), membrane composition, intra- and extracellular ions concentration. Noteworthy, despite a profound variety of these ion channels characteristics, it seems that most of them obey to the same global, four-fold structure now obtained by several X-ray crystallography experiments. Given the wealth of electrophysiological, biochemical, optical, and structural data regarding ion channels voltage-dependency, we decided to put together in this e-book, up to date reviews describing the molecular details of these complex voltage-gated channels.
Author : Peter C. Ruben
Publisher : Springer Science & Business Media
ISBN 13 : 3642415881
Total Pages : 328 pages
Book Rating : 4.6/5 (424 download)
Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Author : Jie Zheng
Publisher : CRC Press
ISBN 13 : 1000857751
Total Pages : 331 pages
Book Rating : 4.0/5 (8 download)
Download or read book Textbook of Ion Channels Volume I written by Jie Zheng and published by CRC Press. This book was released on 2023-06-09 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Textbook of Ion Channels is a set of three volumes providing a wide-ranging reference source on ion channels for students, instructors and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells; mediate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. Volume I, Part 1 covers fundamental topics such as the basic principles of ion permeation and selectivity, voltage-dependent, ligand-dependent, and mechano-dependent ion channel activation mechanisms, the mechanisms for ion channel desensitization and inactivation, and basic ion channel pharmacology and inhibition. Volume I, Part 2 offers a practical guide of cardinal methods for researching ion channels, including heterologous expression and voltage-clamp and patch-clamp electrophysiology; isolation of native currents using patch clamping; modeling ion channel gating, structures, and its dynamics; crystallography and cryo-electron microscopy; fluorescence and paramagnetic resonance spectroscopy methods; and genetics approaches in model organisms. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels; a guide to the technical aspects of ion channel research; a modern guide to the properties of major ion channel families; and includes coverage of key examples of regulatory, physiological and disease roles for ion channels.
Author : Wolfgang B. Liedtke, MD, PH.D.
Publisher : CRC Press
ISBN 13 : 1420005847
Total Pages : 502 pages
Book Rating : 4.4/5 (2 download)
Download or read book TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades written by Wolfgang B. Liedtke, MD, PH.D. and published by CRC Press. This book was released on 2006-09-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Author : Christopher P. Fall
Publisher : Springer Science & Business Media
ISBN 13 : 0387224599
Total Pages : 468 pages
Book Rating : 4.3/5 (872 download)
Download or read book Computational Cell Biology written by Christopher P. Fall and published by Springer Science & Business Media. This book was released on 2007-06-04 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an introduction to dynamic modeling in molecular cell biology, taking a computational and intuitive approach. Detailed illustrations, examples, and exercises are included throughout the text. Appendices containing mathematical and computational techniques are provided as a reference tool.
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (939 download)
Download or read book Thermodynamics of Voltage-dependent Gating of Ion Channels written by and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Voltage-gated ion channels (VGICs) constitute an evolutionary diverse family of integral membrane proteins that transport ions across the hydrophobic membrane bilayers, when triggered by changes in membrane potential. This thesis examines the manifestations of the fundamental laws of thermodynamics on this family of proteins to understand how they operate at the molecular level. In the first few Chapters of this thesis, I describe an analytical approach to extract the energetics of voltage-dependent activation of ion channels and use it to determine the interaction energies between residues in the exemplar Shaker KV channel. The approach involves extracting a special parameter, the median voltage of activation (VM) from experimentally measured gating-charge displacement vs voltage (QV) curves. Next, I use this approach to determine the interaction energies between residues comprising an intersubunit gating nexus, which is likely to be crucial for the relay of structural and energetic information, from the voltage-sensors to the pore. Additionally, I describe how these thermodynamic principles can be extended to deconstruct the allosteric linkage pathways between voltage and ligand dependent activation pathways of polymodal allosteric channels. In the final chapter of this thesis, I study the mechanism by which temperature modulates voltage-dependent gating of ion channels. Gating of some members of the VGIC superfamily is exquisitely sensitive to changes in temperature, however we lack an understanding of the molecular mechanisms underlying temperature sensation and modulation of voltage-dependent channel function. I use a heuristic approach to systematically engineer mutations into the relatively temperature insensitive Shaker KV channel to design a temperature modulated voltage-dependent channel. From the characterization of the relative open probability vs voltage curves of over fifty mutants of the channel at two different temperatures, I propose that thermal sensitivity is mediated by state dependent changes in the solvation status of critical residues, which governs CP of channel gating. I also demonstrate that voltage-sensing charges play a crucial although indirect role in governing the effect of temperature on channel gating. These principles could be very useful to deconstruct the temperature sensing mechanisms of natively thermosensitive channels, such as the thermoTRPs and other structurally unrelated channels, such as Anoctamins.
Author : Valentin K. Gribkoff
Publisher : John Wiley & Sons
ISBN 13 : 0470429895
Total Pages : 505 pages
Book Rating : 4.4/5 (74 download)
Download or read book Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels written by Valentin K. Gribkoff and published by John Wiley & Sons. This book was released on 2008-12-09 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.
Author : Jie Zheng
Publisher : CRC Press
ISBN 13 : 1466551429
Total Pages : 682 pages
Book Rating : 4.4/5 (665 download)
Download or read book Handbook of Ion Channels written by Jie Zheng and published by CRC Press. This book was released on 2015-02-25 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce
Author : Mohamed Chahine
Publisher : Springer
ISBN 13 : 3319902849
Total Pages : 450 pages
Book Rating : 4.3/5 (199 download)
Download or read book Voltage-gated Sodium Channels: Structure, Function and Channelopathies written by Mohamed Chahine and published by Springer. This book was released on 2018-06-04 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.
Author : Fatima Shad Kaneez
Publisher : BoD – Books on Demand
ISBN 13 : 1789842271
Total Pages : 204 pages
Book Rating : 4.7/5 (898 download)
Download or read book Ion Channels in Health and Sickness written by Fatima Shad Kaneez and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.
Author : Shin-Ho Chung
Publisher : Springer
ISBN 13 : 9781441922076
Total Pages : 0 pages
Book Rating : 4.9/5 (22 download)
Download or read book Biological Membrane Ion Channels written by Shin-Ho Chung and published by Springer. This book was released on 2010-11-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.
Author : Bertil Hille
Publisher : Sinauer Associates, Incorporated
ISBN 13 :
Total Pages : 632 pages
Book Rating : 4.3/5 (91 download)
Download or read book Ionic Channels of Excitable Membranes written by Bertil Hille and published by Sinauer Associates, Incorporated. This book was released on 1992 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.
Author : William J. Brammar
Publisher : Academic Press
ISBN 13 : 0080535208
Total Pages : 905 pages
Book Rating : 4.0/5 (85 download)
Download or read book Ion Channel Factsbook written by William J. Brammar and published by Academic Press. This book was released on 1998-10-16 with total page 905 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Academic Press FactsBooks series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as 'a growing series of excellent manuals' by Molecular Medicine Today, and 'essential works of reference' by Trends in Biochemical Sciences, the FactsBooks have become the most popular comprehensive data resources available. As they are meticulously researched and use an easy-to-follow format, the FactsBooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties, and biological activity.In a set of four interrelated volumes, The Ion Channel FactsBook provides a comprehensive framework of facts about channel molecules central to electrical signaling phenomena in living cells. The fourth volume is devoted to Voltage-gated Channel Families, including those molecular complexes activated or modulated by calcium, potassium, and chloride. Nomenclature Expression Sequence Analyses Structure and function Electrophysiology Pharmacology Information retrieval
Author : Multiple authors
Publisher : BoD – Books on Demand
ISBN 13 : 953513857X
Total Pages : 244 pages
Book Rating : 4.5/5 (351 download)
Download or read book Evolutionary Physiology and Biochemistry written by Multiple authors and published by BoD – Books on Demand. This book was released on 2018-02-19 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2016, it was 60 years since the eminent Soviet researcher, a disciple and a successor of Ivan Pavlov, Leon Orbeli had proclaimed the birth of a new branch of physiology, evolutionary physiology. In the same year, his ideas were embodied in the foundation in Leningrad, now Saint Petersburg, of the present Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences. This anniversary book includes the selected works carried out recently by his followers at the same institute. While addressing some hot aspects of evolutionary physiology and biochemistry, they demonstrate that this branch of physiology really represents a discipline in its own right.
Author : Donald W. Pfaff
Publisher : Springer
ISBN 13 : 9781493934737
Total Pages : 0 pages
Book Rating : 4.9/5 (347 download)
Download or read book Neuroscience in the 21st Century written by Donald W. Pfaff and published by Springer. This book was released on 2016-10-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.
