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Molecular Mechanisms Of The Unconventional Secretion Of Macrophage Migration Inhibitory Factor Mif
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Book Synopsis Molecular Mechanisms of the Unconventional Secretion of Macrophage Migration Inhibitory Factor (MIF) by : Melanie Merk
Download or read book Molecular Mechanisms of the Unconventional Secretion of Macrophage Migration Inhibitory Factor (MIF) written by Melanie Merk and published by . This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Unconventional protein secretion: From basic mechanisms to dysregulation in disease by : Vivek Malhotra
Download or read book Unconventional protein secretion: From basic mechanisms to dysregulation in disease written by Vivek Malhotra and published by Frontiers Media SA. This book was released on 2023-01-02 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cellular Trafficking of Cell Stress Proteins in Health and Disease by : Brian Henderson
Download or read book Cellular Trafficking of Cell Stress Proteins in Health and Disease written by Brian Henderson and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.
Book Synopsis Protein Secretion in Bacteria by : Maria Sandkvist
Download or read book Protein Secretion in Bacteria written by Maria Sandkvist and published by John Wiley & Sons. This book was released on 2020-07-02 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein transport into and across membranes is a fundamental process in bacteria that touches upon and unites many areas of microbiology, including bacterial cell physiology, adhesion and motility, nutrient scavenging, intrabacterial signaling and social behavior, toxin deployment, interbacterial antagonism and collaboration, host invasion and disruption, and immune evasion. A broad repertoire of mechanisms and macromolecular machines are required to deliver protein substrates across bacterial cell membranes for intended effects. Some machines are common to most, if not all bacteria, whereas others are specific to Gram-negative or Gram-positive species or species with unique cell envelope properties such as members of Actinobacteria and Spirochetes. Protein Secretion in Bacteria, authored and edited by an international team of experts, draws together the many distinct functions and mechanisms involved in protein translocation in one concise tome. This comprehensive book presents updated information on all aspects of bacterial protein secretion encompassing: Individual secretory systems–Sec, Tat, and T1SS through the newly discovered T9SS Mechanisms, structures, and functions of bacterial secretion systems Lipoprotein sorting pathways, outer membrane vesicles, and the sortase system Structures and roles of surface organelles, including flagella, pili, and curli Emerging technologies and translational implications Protein Secretion in Bacteria serves as both an introductory guide for students and postdocs and a ready reference for seasoned researchers whose work touches on protein export and secretion. This volume synthesizes the diversity of mechanisms of bacterial secretion across the microbial world into a digestible resource to stimulate new research, inspire continued identification and characterization of novel systems, and bring about new ways to manipulate these systems for biotechnological, preventative, and therapeutic applications.
Book Synopsis HSF1 and Molecular Chaperones in Biology and Cancer by : Marc Laurence Mendillo
Download or read book HSF1 and Molecular Chaperones in Biology and Cancer written by Marc Laurence Mendillo and published by Springer Nature. This book was released on 2020-04-15 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Book Synopsis Proceedings of the National Academy of Sciences of the United States of America by : National Academy of Sciences (U.S.).
Download or read book Proceedings of the National Academy of Sciences of the United States of America written by National Academy of Sciences (U.S.). and published by . This book was released on 2006 with total page 1148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mesenchymal Stem Cell Derived Exosomes by : Yaoliang Tang
Download or read book Mesenchymal Stem Cell Derived Exosomes written by Yaoliang Tang and published by Academic Press. This book was released on 2015-09-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies
Author :Inger Helene Madshus Publisher :Springer Science & Business Media ISBN 13 :9783540210382 Total Pages :208 pages Book Rating :4.2/5 (13 download)
Book Synopsis Signalling from Internalised Growth Factor Receptors by : Inger Helene Madshus
Download or read book Signalling from Internalised Growth Factor Receptors written by Inger Helene Madshus and published by Springer Science & Business Media. This book was released on 2004-07-09 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book will concentrate on how growth factor receptors are down-regulated by endocytosis and intracellular trafficking. The authors will further discuss what is currently understood about the effect of cellular microenvironments on signal transduction.
Book Synopsis Herbal Medicine in Depression by : Clara Grosso
Download or read book Herbal Medicine in Depression written by Clara Grosso and published by Springer. This book was released on 2016-05-30 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is written for researchers, undergraduate students and postgraduate students, physicians and traditional medicine practitioners who develop research in the field of neurosciences, phytochemistry and ethnopharmacology or can be useful for their practice. Topics discussed include the description of depression, its biochemical causes, the targets of antidepressant drugs, animal and cell models commonly used in the research of this pathology, medicinal plants and bioactive compounds with antidepressant activity used in traditional medicine, advances in nanotechnology for drug delivery to the brain and finally the future challenges for researchers studying this pathology.
Book Synopsis Microorganisms and Bioterrorism by : Burt Anderson
Download or read book Microorganisms and Bioterrorism written by Burt Anderson and published by Springer Science & Business Media. This book was released on 2007-05-26 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to bring together, in a single volume, the most up-to-date information concerning microbes with potential as bioterrorist weapons. The primary audience includes microbiologists, including bacteriologists, virologists and mycologists, in academia, government laboratories and research institutes at the forefront of studies concerning microbes which have potential as bioterrorist weapons, public health physicians and researchers and scientists who must be trained to deal with bioterrorist attacks as well as laboratory investigators who must identify and characterize these microorganisms from the environment and from possibly infected patients.
Book Synopsis Perinatal Neuropathology by : Mirna Lechpammer
Download or read book Perinatal Neuropathology written by Mirna Lechpammer and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "1 Clinical history, clinical correlations with placental pathology and prematurity The initial steps in the process of perinatal nervous system evaluation, namely the planning of the optimal approach and choice of samples to be obtained, are driven by the clinical context. Of key importance are the following data: a. Gestational age at time of demise (if stillborn); or gestational age and postnatal age (if liveborn), for comparison with normative standards of development (see Appendix); b. State of maternal health (age, parity, pre-existing medical conditions or ones appearing during gestation or around the time of delivery, exposure to medications/toxins/infections), and of health of siblings or other family members: - Concerns for inherited (i.e., genetic) conditions, metabolic disorders, congenital infections, etc., may indicate the need for special testing; c. Details of prenatal course, including any imaging, amniocentesis, or monitoring: - Prenatal imaging modalities most commonly consist of transabdominal ultrasonography, generally done at the time of the first prenatal visit (to confirm pregnancy) or more usually in the mid-second-trimester for detection of fetal or placental anomalies"--
Book Synopsis Introduction to Psychoneuroimmunology by : Jorge H. Daruna
Download or read book Introduction to Psychoneuroimmunology written by Jorge H. Daruna and published by Academic Press. This book was released on 2012-02-24 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health is maintained by the coordinated operation of all the biological systems that make up the individual. The Introduction to Psychoneuroimmunology, Second Edition, presents an overview of what has been discovered by scientists regarding how bodily systems respond to environmental challenges and intercommunicate to sustain health. The book touches on the main findings from the current literature without being overly technical and complex. The result is a comprehensive overview of psychoneuroimmunology, which avoids oversimplification, but does not overwhelm the reader. Single authored for consistency of breadth and depth, with no redundancy of coverage between chapters Covers endocrine-immune modulation, neuro-immune modulation, and the enhancing or inhibiting processes of one or more systems on the others Expanded use of figures, tables, and text boxes
Download or read book Dmso written by Morton Walker D.P.M. and published by Penguin. This book was released on 1993-01-01 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: An easy-to-understand, up-to-date guide on the highly publicized drug, DMSO DMSO—dimethyl sulfoxide—is a simple by-product of wood and has been called a “miracle” drug, capable of relieving pain, diminishing swelling, reducing inflammation, encouraging healing, and restoring normal function. In this groundbreaking work, award-winning health science writer Dr. Morton Walker examines the powerful and compelling case for the use of DMSO in the treatment of many debilitating disease and health-related problems. In DMSO: Nature’s Healer, Dr. Walker cites documented cases of its astounding use in healing and prevention of a host of health disorders, including arthritis, stroke, cancer, mental retardation, and sports and auto injuries. He also recounts the dramatic story of the long struggle to gain FDA approval of DMSO.
Book Synopsis Craniofacial Muscles by : Linda K. McLoon
Download or read book Craniofacial Muscles written by Linda K. McLoon and published by Springer Science & Business Media. This book was released on 2012-09-13 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the approximately 640 muscles in the human body, over 10% of them are found in the craniofacial region. The craniofacial muscles are involved in a number of crucial non-locomotor activities, and are critical to the most basic functions of life, including vision, taste, chewing and food manipulation, swallowing, respiration, speech, as well as regulating facial expression and controlling facial aperture patency. Despite their importance, the biology of these small skeletal muscles is relatively unexplored. Only recently have we begun to understand their unique embryonic development and the genes that control it and characteristic features that separate them from the skeletal muscle stereotype. This book is the most comprehensive reference to date on craniofacial muscle development, structure, function, and disease. It details the state-of-the-art basic science of the craniofacial muscles, and describes their unique response to major neuromuscular conditions. Most importantly, the text highlights how the craniofacial muscles are different from most skeletal muscles, and why they have been viewed as a distinct allotype. In addition, the text points to major gaps in our knowledge about these very important skeletal muscles and identified key gaps in our knowledge and areas primed for further study and discovery.
Book Synopsis Unusual Secretory Pathways: From Bacteria to Man by : Karl Kuchler
Download or read book Unusual Secretory Pathways: From Bacteria to Man written by Karl Kuchler and published by Springer. This book was released on 2013-11-13 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the first comprehensive discussion and collection of facts and functions of unconventional secretory pathways, some of which are of importance in human disease and pathology. The function of ABC transporters in these processes is also discussed. This comparison of common aspects and similarities in all living cells - from bacteria to man - is an excellent reference book with "textbook" character.
Book Synopsis Pediatric Allergy, Asthma and Immunology by : Arnaldo Cantani
Download or read book Pediatric Allergy, Asthma and Immunology written by Arnaldo Cantani and published by Springer Science & Business Media. This book was released on 2008-01-23 with total page 1634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Easy to understand and easy to use, this essential book reflects the rapid progress in one of the most intriguing fields of medicine. It offers state-of-the-art information on basic immunology, fetal-neonatal immunology, and many more fascinating areas.
Book Synopsis Mif: A Most Interesting Factor by : Richard Bucala
Download or read book Mif: A Most Interesting Factor written by Richard Bucala and published by World Scientific. This book was released on 2007-07-27 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, researchers have identified a pivotal, upstream role for macrophage migration inhibitory factor (MIF) in the innate immune response. This pioneering book describes this renaissance of knowledge in the biology of MIF. Topics covered include MIF's molecular mechanism of action, its counterregulatory action on the immunosuppressive properties of glucocorticoids, its role in the production of proinflammatory mediators as shown in cell-based and animal studies; and its central role in human inflammation. Human genetic studies have identified allelic forms of the MIF gene, and high-expression alleles have been associated with rheumatoid arthritis, asthma severity, sarcoidosis, atopy, inflammatory bowel disease, and other inflammatory and infectious maladies. The book also discusses the role of MIF as a therapeutic target. Unique structural features of the protein, such as an intrinsic catalytic activity and the recent discovery of its cell surface receptor, offer attractive opportunities for therapeutic intervention. Such approaches are presently in clinical development.
