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Author : EEC Concerted Action on Extracorporeal Oxygenation
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (857 download)
Download or read book Molecular Mechanisms of Oxygen Toxicity written by EEC Concerted Action on Extracorporeal Oxygenation and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. Hakim
Publisher :
ISBN 13 : 9780080280011
Total Pages : 288 pages
Book Rating : 4.2/5 (8 download)
Download or read book International Conference on Molecular Mechanisms of Oxygen Toxicity written by J. Hakim and published by . This book was released on 1981 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Osamu Hayaishi
Publisher : Elsevier
ISBN 13 : 0323143261
Total Pages : 697 pages
Book Rating : 4.3/5 (231 download)
Download or read book Molecular Mechanisms Of Oxygen Activation written by Osamu Hayaishi and published by Elsevier. This book was released on 2012-12-02 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Mechanisms of Oxygen Activation reviews some of the major advances that have been made in our understanding of the molecular mechanisms underlying oxygen activation, with emphasis on the role of oxygen activation in contemporary biological processes. The biological role of oxygenases in the metabolism of fatty acids and steroids is discussed, along with the functions of heme-containing dioxygenases, a-ketoglutarate-coupled dioxygenases, and pterin-requiring aromatic amino acid hydroxylases. This book is comprised of 14 chapters and begins with an overview of the general properties and biological functions of oxygenases, along with the chemical aspects of oxygen fixation reactions. The reader is then introduced to research concerning fatty acid and steroid oxygenases which has appeared in the literature since 1962, paying particular attention to the mechanism of oxygenation and the biosynthesis and metabolism of steroids. Subsequent chapters explore the biological functions of a variety of oxygenases such as heme-containing dioxygenases, copper-containing oxygenases, flavoprotein oxygenases, and pterin-requiring aromatic amino acid hydroxylases. Superoxide dismutase, cytochrome c oxidase, peroxidase, and bacterial monoxygenases are also considered. This monograph should serve as a valuable reference for biochemists as well as undergraduate and graduate students of biochemistry.
Author : Lewis L. Smith
Publisher : CRC Press
ISBN 13 : 100000600X
Total Pages : 235 pages
Book Rating : 4.0/5 ( download)
Download or read book Molecular and Cellular Mechanisms of Toxicity written by Lewis L. Smith and published by CRC Press. This book was released on 2019-06-04 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1995: Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins. The second section discusses the interactions of carcinogens with DNA, and other targets, and their relevance to both molecular dosimetry of exposure and development of cancer. The final part is concerned with cellular and genetic aspects and includes coverage of some of the most recent and rapidly developing problems in toxicology.
Author : Roland N. Pittman
Publisher : Biota Publishing
ISBN 13 : 1615047212
Total Pages : 117 pages
Book Rating : 4.6/5 (15 download)
Download or read book Regulation of Tissue Oxygenation, Second Edition written by Roland N. Pittman and published by Biota Publishing. This book was released on 2016-08-18 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Author : Taylor & Francis Group
Publisher : CRC Press
ISBN 13 : 9780367229146
Total Pages : 224 pages
Book Rating : 4.2/5 (291 download)
Download or read book Molecular and Cellular Mechanisms of Toxicity written by Taylor & Francis Group and published by CRC Press. This book was released on 2020-12-12 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1995: Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins. The second section discusses the interactions of carcinogens with DNA, and other targets, and their relevance to both molecular dosimetry of exposure and development of cancer. The final part is concerned with cellular and genetic aspects and includes coverage of some of the most recent and rapidly developing problems in toxicology.
Author : Nariyoshi Shinomiya
Publisher : Springer Nature
ISBN 13 : 9811378363
Total Pages : 152 pages
Book Rating : 4.8/5 (113 download)
Download or read book Hyperbaric Oxygenation Therapy written by Nariyoshi Shinomiya and published by Springer Nature. This book was released on 2019-10-09 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on hyperbaric oxygenation (HBO) therapy from the molecular biology perspective and its clinical applications, including molecular mechanisms of HBO’s positive effect on cellular function in hypoxic tissues. HBO is a therapeutic tool that enhances oxygen supply to hypoxic tissues and improves wound healing/tissue remodeling. Currently HBO therapy is applied to a wide range of clinical cases, which include not only acute hypoxic diseases but also many chronic and refractory diseases involving tissue hypoxia or intractable infection. HBO therapy is a well-recognized regimen for many researchers and clinicians. The first half of the book outlines basic molecular mechanisms of HBO and their potential applications for clinical activities, while the second half describes the rationale behind introducing HBO therapy into suitable clinical cases and presents successful clinical reports. It is primarily written for HBO clinicians, physiologists and basic research scientists, but is also of interest to clinicians who have an interest in this field considering introducing HBO therapy.
Author : Urs A. Boelsterli
Publisher : CRC Press
ISBN 13 : 9780849372728
Total Pages : 424 pages
Book Rating : 4.3/5 (727 download)
Download or read book Mechanistic Toxicology written by Urs A. Boelsterli and published by CRC Press. This book was released on 2007-03-23 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk. New aspects, major advances, and new areas in molecular and cellular biology and toxicology demand updated sources of information to elucidate the functional mechanics of human toxicology. Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition retains the accessible format of the original to present the general principles that link xenobiotic-induced toxicity with the molecular pathways that underlie these toxic effects. Extensively illustrated, this book forms a conceptual bridge between multiple events at the molecular level and the determinants of toxicity at the physiological and cellular level. Specific examples of drugs, environmental pollutants, and other chemicals are carefully chosen to illustrate and highlight the fundamental mechanisms of toxicity at different toxicokinetic and toxicodynamic levels. The book includes references and review articles at the end of each chapter, as well as boxed text for relevant review information on biological, biochemical, molecular, and toxicological background. Linking molecular pathways to more general biomedical contexts, the author ensures that the reader is not lost in the details and instead receives a broad understanding of the processes underlying xenobiotic toxicity. New in the Second Edition Updated chapters Types of toxic responses Disruption of signal transduction by xenobiotics Disruption of mitochondrial function Novel mechanisms derived from systems toxicology
Author : Joseph Priestley
Publisher :
ISBN 13 :
Total Pages : 112 pages
Book Rating : 4.:/5 (42 download)
Download or read book The Discovery of Oxygen written by Joseph Priestley and published by . This book was released on 1894 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Xianglin Shi
Publisher : Springer Science & Business Media
ISBN 13 : 1461507936
Total Pages : 232 pages
Book Rating : 4.4/5 (615 download)
Download or read book Molecular Mechanisms of Metal Toxicity and Carcinogenesis written by Xianglin Shi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: These proceedings focus on the latest research in molecular mechanisms of metal-induced toxicity and carcinogenesis. The conference promoted a multidisciplinary investigative approach and included presentations from international experts on state-of-the-art information in this field.
Author : Eduardo Bancalari
Publisher : Elsevier Health Sciences
ISBN 13 : 0323568750
Total Pages : 464 pages
Book Rating : 4.3/5 (235 download)
Download or read book The Newborn Lung written by Eduardo Bancalari and published by Elsevier Health Sciences. This book was released on 2018-06-19 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Richard Polin’s Neonatology Questions and Controversies series highlights the most challenging aspects of neonatal care, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today’s practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient. Stay fully up to date in this fast-changing field with The Newborn Lung, 3rd Edition. The most current clinical information throughout, including key management strategies that may reduce some of the chronic sequelae of neonatal respiratory failure. New content on the role of microbiome in lung injury and lung development. Current coverage of non-invasive respiratory support, perinatal events and their influence on lung development and injury, cell-based lung therapy, automation of respiratory support, and oxygenation targeting in preterm infants. Consistent chapter organization to help you find information quickly and easily. The most authoritative advice available from world-class neonatologists who share their knowledge of new trends and developments in neonatal care. Purchase each volume individually, or get the entire 7-volume set! Gastroenterology and Nutrition Hematology, Immunology and Genetics Hemodynamics and Cardiology Infectious Disease and Pharmacology New Volume! Nephrology and Fluid/Electrolyte Physiology Neurology The Newborn Lung
Author : Francesco De Matteis
Publisher : Springer
ISBN 13 : 1349087599
Total Pages : 305 pages
Book Rating : 4.3/5 (49 download)
Download or read book Selectivity and Molecular Mechanisms of Toxicity written by Francesco De Matteis and published by Springer. This book was released on 1987-06-18 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Giuseppe Buonocore
Publisher : Springer
ISBN 13 : 9783319294872
Total Pages : 0 pages
Book Rating : 4.2/5 (948 download)
Download or read book Neonatology written by Giuseppe Buonocore and published by Springer. This book was released on 2018-10-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This landmark book, a reference work now in its second edition, provides healthcare practitioners in neonatology with an up-to-date, comprehensive source of readily accessible practical advice that will assist in the expert management of patients and their diverse illnesses. Leading experts in their fields discuss the underlying causes and mechanisms and all aspects of the treatment of the full range of neonatal diseases and abnormalities, citing the evidence base whenever appropriate. In addition, detailed information is provided on epidemiology and fetal medicine; therapeutic issues such as the organization of care, transport services, and home care after discharge; legal issues; nutrition; and the consequences of medication use during pregnancy, maternal drug abuse and smoking, and maternal diabetes. The inclusion of summaries, tables, and carefully selected guidelines and recommendations will supply practitioners with quick references and instant solutions during daily practice. The book will be a superb resource for all involved in the care of newborn babies, including neonatologists, pediatricians, pediatric surgeons, anesthesiologists, midwives, and nursing staff. It is published within the SpringerReference program, which delivers access to living editions constantly updated through a dynamic peer-review publishing process.
Author : Olen R. Brown
Publisher :
ISBN 13 :
Total Pages : 34 pages
Book Rating : 4.:/5 (227 download)
Download or read book Mechanisms of Oxygen Toxicity at the Cellular Level written by Olen R. Brown and published by . This book was released on 1980 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant progress occurred in four areas: (1) Effect of hyperoxia on reverse glycolysis: We concluded that glucose protects Escherichia coli against hyperoxia better than other intermediates later in glycolysis and in the Krebs cycle but not because of a specific inhibition of reverse glycolysis. There was no significant impairment of the three enzymes of reverse glycolysis: fructose-1,6-diphosphatase, phosphoenolpyruvate synthase, or phosphoenolpyruvate carboxykinase. (2) Effect of hyperoxia on synthesis of RNA, DNA and pyridine nucleotide coenzymes: Evidence was obtained for direct inhibition of RNA synthesis in cells poisoned by hyperoxia, while protein synthesis was not directly affected. DNA synthesis is impaired but it is not proven whether this is direct or indirect. NAD and NADH were severly decreased in cells during poisoning by hyperoxia. This decrease was prevented by niacin, but not quinolinate which is consistent with poisoning of quinolinate phosphoribosyltransferase (QPT), as previously reported. PRPP does not protect against oxygen poisoning, PRPP synthetase is not affected by hyperoxia, but PRPP accumulates in oxygen poisoned cells which is in agreement with inhibiton of QPT. (3) Relationship of thiamine to oxygen toxicity.
Author : Morris D. Faiman
Publisher :
ISBN 13 :
Total Pages : 6 pages
Book Rating : 4.:/5 (139 download)
Download or read book Mechanisms of Oxygen Toxicity and Methods of Protection written by Morris D. Faiman and published by . This book was released on 1984 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanism by which oxygen causes convulsions is not clear. Although man biochemical changes in brain have been reported to occur as a result of oxygen exposure, these changes are not necessarily the cause of oxygen-induced convulsions. From in vivo studies in mice, inhibition of brain energy metabolism was not found. Furthermore, although oxygen caused an increased oxidation of pyridine nucleotides, the decrease in both NADPH and NADH in cerebral cortex was not-related to the susceptibility fo mice to oxygen convulsions. GABA in brain cortex was decreased by oxygen, however, this decrease did not influence the susceptibility of mice to oxygen convulsions. The most effective CNS protectants seem to be those agents containing a disulfide bridge in their molecular structure, and which can be reduced to thiols. Since thiols are good free radical scavengers, free radicals may be the initial event in provoking the insult to produce oxygen convulsions.
Author : Olen R. Brown
Publisher :
ISBN 13 :
Total Pages : 36 pages
Book Rating : 4.:/5 (227 download)
Download or read book Mechanisms of Oxygen Toxicity at the Cellular Level written by Olen R. Brown and published by . This book was released on 1972 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most significant finding has been the demonstration that even five minute exposures to oxygen at four atmospheres produces a severe, but reversible (upon removal from hyperoxia), inhibition of active transport of glucose, using Escherichia coli as a model cell system. Experimental data is so far consistent with the current operating theory that a site in membrane transport is the primary target in acute oxygen toxicity at the cell level. The inhibition of transport apparently is not due to lack of energy (ATP) for transport, nor to oxidative destruction of the membrane, but the true mechanism is unknown. (Modified author abstract).
Author : Jaspal Singh
Publisher : Academic Press
ISBN 13 : 0323886027
Total Pages : 428 pages
Book Rating : 4.3/5 (238 download)
Download or read book Hazardous Gases written by Jaspal Singh and published by Academic Press. This book was released on 2021-07-17 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hazardous Gases: Risk Assessment on Environment and Human Health examines all relevant routes of exposure, inhalation, skin absorption and ingestion, and control measures of specifics hazardous gases resulting from workplace exposure from industrial processes, traffic fumes, and the degradation of waste materials and how they impacts the health and environment of workers. The book examines the risk assessment and effect of poisonous gases on the environment human health. It also covers necessary emergency guidelines, safety measures, physiological impact, hazard control measures, handling and storage of hazardous gases. Each chapter is formatted to include an introduction, historical background, physicochemical properties, physiological role discussing mechanisms of toxicity, its effect on human health as well as environment, followed by case studies and recent research on toxic gases. Hazardous Gases: Risk Assessment on Environment and Human Health is a helpful resource for academics and researchers in toxicology, occupational health and safety, and environmental sciences as well as those in the field who work to assess and mitigate the impact of toxic gases on the work environment and the health of the workforce. - Emphasizes the environmental monitoring in the workplace of hazardous materials - Includes all relevant storage and handling information required for detailing all personnel on the hazards and risks from the substances with which they work - Offers practical examples and case studies related to toxic gases and their impact on health
