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Molecular Investigation Of Endometrial Dysfunction
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Book Synopsis Molecular Investigation Of Endometrial Dysfunction by : Joy Kaush
Download or read book Molecular Investigation Of Endometrial Dysfunction written by Joy Kaush and published by . This book was released on 2023-11-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endometrial dysfunction refers to the disruption of normal endometrial physiology, leading to infertility, abnormal uterine bleeding, and other gynecological disorders. The molecular and signaling mechanisms that contribute to endometrial dysfunction are complex and multifactorial, involving a range of cellular and molecular pathways. As such, investigating these mechanisms requires a deep understanding of the molecular biology of the endometrium and the cellular processes that regulate its function. One key area of investigation in endometrial dysfunction is the role of hormones and their receptors in the regulation of endometrial physiology. The endometrium is sensitive to the effects of ovarian hormones such as estrogen and progesterone, which play critical roles in regulating the menstrual cycle and preparing the endometrium for implantation of a fertilized egg. Dysregulation of hormonal signaling pathways can lead to disruptions in endometrial function, contributing to infertility and other gynecological disorders. Another important area of investigation is the role of inflammatory and immune signaling pathways in the pathogenesis of endometrial dysfunction. Inflammatory cytokines and chemokines play a critical role in modulating endometrial function and regulating the immune response to implantation. Dysregulation of these pathways can lead to a range of gynecological disorders, including endometriosis, adenomyosis, and recurrent pregnancy loss. Molecular investigations into endometrial dysfunction have also focused on the role of epigenetic mechanisms in regulating gene expression and modulating cellular function. Epigenetic modifications such as DNA methylation and histone modifications can play critical roles in regulating endometrial function and influencing the pathogenesis of gynecological disorders. Studies have shown that alterations in DNA methylation patterns and histone modifications can lead to dysregulation of key genes involved in endometrial function, contributing to infertility and other reproductive disorders. Advances in molecular biology techniques have enabled researchers to investigate these pathways in greater detail, uncovering new insights into the molecular mechanisms underlying endometrial dysfunction. Techniques such as gene expression profiling, genome-wide association studies, and next-generation sequencing have enabled researchers to identify novel genes and pathways involved in the regulation of endometrial function and to identify potential targets for therapeutic intervention. In conclusion, molecular investigation of endometrial dysfunction is a rapidly evolving field that has the potential to provide new insights into the pathogenesis of gynecological disorders and to identify new therapeutic targets for their treatment. By gaining a better understanding of the molecular mechanisms underlying endometrial dysfunction, researchers can develop more targeted and effective treatments for infertility, abnormal uterine bleeding, and other gynecological disorders, ultimately improving the health and wellbeing of women worldwide.
Book Synopsis Molecular Research of Endometrial Pathophysiology by : Paola Viganò
Download or read book Molecular Research of Endometrial Pathophysiology written by Paola Viganò and published by MDPI. This book was released on 2019-10-14 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women’s health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.]
Book Synopsis Molecular Research of Endometrial Pathophysiology by : Paola Viganò
Download or read book Molecular Research of Endometrial Pathophysiology written by Paola Viganò and published by . This book was released on 2019 with total page 1 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women's health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.].
Book Synopsis The Human Endometrium by : Carlo Bulletti
Download or read book The Human Endometrium written by Carlo Bulletti and published by . This book was released on 1994 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structural, biochemical and clinical events related to menstruation, implantation, parturition, endometriosis, abnormal uterine bleeding and endometrial cancer are discussed in this comprehensive volume on the biological functions of the endometrium. New topics, such as the biochemical and molecular mechanisms regulating maternal embryonic interaction, are explored, and gynecologic endoscopy and therapeutic tools are discussed. The proceedings of the first conference is also available from the Academy, as volume 622 of The Annals of The New York Academy of Science.
Book Synopsis Endometrial Gene Expression by : Joanne Kwak-Kim
Download or read book Endometrial Gene Expression written by Joanne Kwak-Kim and published by Springer. This book was released on 2020-11-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endometrium goes through cyclical changes under the influence of hormones, and immune effectors in the endometrium change their populations cyclically as well. Dynamic changes in immune effectors determine endometrial cytokine and chemokine milieus and, consequently, the endometrial immune response. Endometrial immune responses have been shown to be important for trophoblast invasion and early pregnancy. Indeed, dysregulated endometrial inflammatory immune responses are associated with reproductive failures, such as recurrent pregnancy losses, repeated implantation failure, and gynecological diseases with oncogenic potential. Hence, the investigation of endometrial gene expression may predict infertility, gynecological and oncological conditions. This book presents the state of the art in endometrial gene expression as well as recent developmental findings relating to reproduction and reproductive disorders. It begins with a review of the genetic regulation of urogenital tract formation and molecular mechanism underlying the physiology of menstrual cycle before moving on to the current and emerging technological advances in molecular biology. Endometrial gene expressions of immune inflammatory conditions, viral infection, metabolic and nutritional conditions, and reproductive disorders are then presented in following chapters. Examples of the use and interpretation of gene expression in clinical scenarios including recurrent pregnancy losses, infertility and multiple implantation failures are presented with currently available endometrial gene analysis. Utilizing the latest evidence and clinical guidelines, Endometrial Gene Expression will be a cutting-edge resource for gynecologist, reproductive immunologist, reproductive endocrinologists, obstetrician, maternal fetal medicine specialist and other health care providers in the field of reproductive medicine.
Book Synopsis The Endometrium by : Stanley R. Glasser
Download or read book The Endometrium written by Stanley R. Glasser and published by CRC Press. This book was released on 2002-05-16 with total page 1079 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Endometrium is devoted to a comprehensive multi-disciplinary account of the uterine endometrium. This book is the first to define the regulatory biological interrelationships between epithelial and stromal cell phenotypes, endothelial cells, extracellular matrix and immunobiological elements. It highlights their relevance to clinical conditions
Book Synopsis Diagnostic Gynecologic and Obstetric Pathology E-Book by : Christopher P. Crum
Download or read book Diagnostic Gynecologic and Obstetric Pathology E-Book written by Christopher P. Crum and published by Elsevier Health Sciences. This book was released on 2017-10-13 with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and practice-oriented, the fully updated 3rd Edition of this easy-to-use text covers the full range of obstetric and gynecologic pathology, including information on treatment and patient management. Written largely by the pathology and clinical faculty at Harvard's Brigham and Women's Hospital, it covers the most up-to-date information available in the field, including molecular genetics and diagnostics. Drs. Christopher P. Crum and Marisa R. Nucci are joined by new editors Scott R. Granter, Brooke E. Howitt, Mana M. Parast, and Theonia K. Boyd, to provide complete, beautifully illustrated coverage of both neoplastic and non-neoplastic disorders of the female genital system, ideal for improving pathological diagnosis. Provides distinct diagnostic/differential diagnostic criteria for any potential obstetric/gynecologic specimen encountered in practice. Features more than 2,250 full-color images, key points at the end of each chapter, and an appendix with commonly used ICD-10 codes Covers topics not often found in gynecologic pathology textbooks, such as vulvodynia, and diseases of the anus. Approaches topics from a practice-oriented point of view, beginning with clinical presentation and progressing through histopathology, differential diagnosis, and treatment for each disorder. Emphasizes new practice issues and their biologic basis including approaches to vulvar, cervical and endometrial precursors as well as the underpinnings of cervical, endometrial and ovarian cancer. A comprehensive look at mesenchymal neoplasia, including not only lower genital tract and uterus but also the retroperitoneum.
Book Synopsis Molecular Genetics of Endometrial Carcinoma by : Lora Hedrick Ellenson
Download or read book Molecular Genetics of Endometrial Carcinoma written by Lora Hedrick Ellenson and published by Springer. This book was released on 2016-12-01 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.
Book Synopsis Atlas of Hysteroscopy by : Andrea Tinelli
Download or read book Atlas of Hysteroscopy written by Andrea Tinelli and published by Springer Nature. This book was released on 2020-02-28 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a wealth of detailed hysteroscopic images, illustrating the various gynecological pathologies that can be directly diagnosed by hysteroscopy. Providing comprehensive coverage, the book examines each pathology on the basis of concrete images, offering readers support with the diagnostic evaluation. This is especially important when there are recrudescent pathologies, such as TBC, which can often confuse physicians in the context of diagnosis, and with regard to oncological, infectious and infertility issues. Written by prominent experts in the field, this atlas offers an extremely useful and comprehensive tool for all gynecologists, which can support them to overcome any diagnostic doubts and arrive at an accurate diagnosis.
Book Synopsis Acute Care and Emergency Gynecology by : David Chelmow
Download or read book Acute Care and Emergency Gynecology written by David Chelmow and published by Cambridge University Press. This book was released on 2014-10-30 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents almost 100 common and uncommon gynecologic problems encountered in urgent and emergency settings with an emphasis on practical management.
Book Synopsis Blaustein's Pathology of the Female Genital Tract by : Ancel Blaustein
Download or read book Blaustein's Pathology of the Female Genital Tract written by Ancel Blaustein and published by Springer Science & Business Media. This book was released on 2011-01-10 with total page 1261 pages. Available in PDF, EPUB and Kindle. Book excerpt: New edition includes more than 350 new illustrations and 22 revised chapters Written by internationally recognized experts Each entry is structured the same way, from general to more specific information, which allows the reader to quickly access key information in every chapter Since the publication of the 1/e in 1977, Blaustein's Pathology of the Female Genital Tract has consolidated its position as the leading textbook of gynecological pathology. an essential reference for all pathologists and residents, this thoroughly updated Sixth Edition includes more than 1500 illustrations in color, i
Book Synopsis Chronic Pelvic Pain by : William Ledger
Download or read book Chronic Pelvic Pain written by William Ledger and published by Cambridge University Press. This book was released on 2014-12-11 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain is among the foremost complaints of women seeking gynecological consultation, yet the diagnosis is often limited to endometriosis. Chronic Pelvic Pain discusses how to diagnose a broad scope of underlying conditions presenting in relation to pelvic pain in women and their treatment. Starting with an anatomical review from a pain point of view, several chapters continue to explore specific conditions such as vulvodynia, the often overlooked painful bladder syndrome and pelvic inflammatory disease. Also covered are topics such as sexual dysfunction, psychological aspects of chronic pelvic pain and alternative treatment methods. Practical treatment tips for specific conditions which are readily applicable in everyday practice are provided throughout. Special attention is given to the use of sonography and MRI in diagnostics. With its comprehensive approach, addressing both body and mind, this is essential reading for medical specialists and consultants and specialist medical trainees in gynecology, pain medicine, and family practice.
Book Synopsis Biomarkers for Endometriosis by : Thomas D'Hooghe
Download or read book Biomarkers for Endometriosis written by Thomas D'Hooghe and published by Springer. This book was released on 2017-09-22 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem promising, more research is needed to translate these data into clinical benefit for patients and coordinate efforts internationally to standarize analysis, reports and operating procedures. The gold standard to diagnose endometriosis is currently through laparoscopic inspection with histological confirmation, a surgical procedure with rare but significant potential risks for the patients. A non-invasive test for endometriosis would be critical for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility with normal ultrasound. This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility. Such a test would also be useful in symptomatic women with ultrasound imaging suspicious for endometriosis, since it may be difficult to differentiate an ovarian endometrioma from other ovarian cysts and since the quality of ultrasound imaging is highly variable worldwide.
Book Synopsis Management of Endometrial Cancer by : Mansoor R. Mirza
Download or read book Management of Endometrial Cancer written by Mansoor R. Mirza and published by Springer. This book was released on 2019-08-26 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical reference book provides up-to-date, evidence-based multidisciplinary guidelines on the epidemiology, biology, diagnosis, and treatment of endometrial cancer. Individual chapters focus on topics such as hormonal interactions, cancer prevention, genetic classification and its clinical applications. Recent advances in diagnostic methods are described. The treatment-oriented chapters include coverage of the roles of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in early-stage disease. Treatment options in advanced disease, including hormonal therapy and targeted therapy, are considered separately, as is the management of rare tumor types. The authors are international key opinion leaders. Summaries of the ESMO/ESGO/ESTRO guidelines on management are included. Each clinical chapter ends with a summary of recommendations with the level of evidence.
Book Synopsis Diagnosis and Management of Ovarian Disorders by : Albert Altchek
Download or read book Diagnosis and Management of Ovarian Disorders written by Albert Altchek and published by Elsevier. This book was released on 2003-09-04 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders. KEY FEATURES* Includes updated information on early diagnosis of ovarian cancer* Reviews new diagnostic techniques for ovarian disorders* Discusses latest information on reproductive technology* Presents translational treatment linking laboratory research with clinical medicine
Book Synopsis Clinical Reproductive Medicine and Surgery by : Tommaso Falcone
Download or read book Clinical Reproductive Medicine and Surgery written by Tommaso Falcone and published by Elsevier Health Sciences. This book was released on 2007-01-01 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Reproductive Medicine and Surgery is the new, definitive resource in reproductive medicine. This unique text offers detailed discussion on both the medical and surgical management of reproductive disorders, as well as coverage of associated imaging modalities. Included are chapters on Reproductive Genetics, Management of Endometriosis (including interventional radiology), Ultrasonography and Sonohysterography, Preservation of Fertility, and Recurrent Pregnancy Loss. The book also features an accompanying DVD with additional images and video loops. A resource every practitioner interested in Reproductive Endocrinology and Infertility needs! Offers detailed discussion of medical and surgical management of reproductive disorders ... No other text offers coverage of both medical and surgical management in one resource. Covers gynecologic disorders that impact fertility--an important aspect of identifying fertility issues, not included in major competition Section on basic reproductive biology ... Not overly detailed -- Written for a clinician to understand how to practice reproductive medicine Section on reproductive imaging ... Unique to this text - includes US and MRI of the reproductive organs Algorithm in each chapter ... 4-color throughout ... Demonstrates the appropriate clinical investigation and management ... Offers attractive layout and best views of surgical procedures Perform reproductive surgery procedures with step-by-step guidance on intrauterine device insertion and laparoscopic surgery with detailed images and videos on the accompanying dvd
Book Synopsis Endometriosis in Adolescents by : Ceana H. Nezhat
Download or read book Endometriosis in Adolescents written by Ceana H. Nezhat and published by Springer Nature. This book was released on 2020-11-13 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adolescent endometriosis is a previously overlooked disease in children, the true prevalence of which is still unknown but has been estimated between 19-73%. There are numerous initial challenges faced by adolescents suffering from delayed or undiagnosed endometriosis apart from experiencing chronic pain, such as: school/work absenteeism, false diagnoses/treatments, erroneous physician referrals, unnecessary radiological studies, radiation exposure, and emergency room visits as well as early exposure to narcotic pain medications and subsequent drug tolerance, resistance or even addiction. This text presents a clear history of physician and patient understanding and awareness of endometriosis in adolescents. It lays the groundwork for this condition with background information on endometriosis in general followed by a more focused look at endometriosis in adolescents. Leading experts in the field provide chapters on the different locations where endometriotic lesions can present in adolescents as well as identified risk factors and concomitant diseases of which it is important to be aware. In addition to the clinical presentation, this book also provides information on breaking down existing barriers, such as stigma, and current activism and awareness of this condition. Adolescent Endometriosis is a first-of-its-kind text that focuses exclusively on endometriosis in the adolescent population. Written by experts in the field, this book is a comprehensive resource for clinicians in all medical disciplines that treat adolescent age girls.
