Molecular Imaging Basic Principles And Applications In Biomedical Research

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Molecular Imaging: Basic Principles And Applications In Biomedical Research (2nd Edition)

Author : Markus Rudin
Publisher : World Scientific
ISBN 13 : 1783263172
Total Pages : 618 pages
Book Rating : 4.7/5 (832 download)

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Book Synopsis Molecular Imaging: Basic Principles And Applications In Biomedical Research (2nd Edition) by : Markus Rudin

Download or read book Molecular Imaging: Basic Principles And Applications In Biomedical Research (2nd Edition) written by Markus Rudin and published by World Scientific. This book was released on 2013-07-04 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied. The final chapter deals with visualization of cell migration, for example in the context of cell therapies.The second edition covers novel developments over recent years, in particular regarding imaging technologies (hybrid techniques) and novel reporter concepts. Novel biomedical applications have been included, where appropriate. All the chapters have been thoroughly reworked and the artwork updated.

Molecular Imaging: Basic Principles And Applications In Biomedical Research (3rd Edition)

Author : Markus Rudin
Publisher : World Scientific
ISBN 13 : 1786346869
Total Pages : 801 pages
Book Rating : 4.7/5 (863 download)

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Book Synopsis Molecular Imaging: Basic Principles And Applications In Biomedical Research (3rd Edition) by : Markus Rudin

Download or read book Molecular Imaging: Basic Principles And Applications In Biomedical Research (3rd Edition) written by Markus Rudin and published by World Scientific. This book was released on 2020-04-04 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied.The third edition has been extended considerably. This holds for the chapter on imaging modalities, which now includes sections on intravital microscopy and mass spectrometric imaging. All chapters have been updated and a new chapter on the challenges of translating molecular imaging solutions for clinical use has been added.

Molecular Imaging

Author : Markus Rudin
Publisher :
ISBN 13 : 9781848168565
Total Pages : 593 pages
Book Rating : 4.1/5 (685 download)

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Book Synopsis Molecular Imaging by : Markus Rudin

Download or read book Molecular Imaging written by Markus Rudin and published by . This book was released on 2013 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today. This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological or structural response of the organism studied. The final chapter deals with visualization of cell migration, for example in the context of cell therapies. The second edition covers novel developments over recent years, in particular regarding imaging technologies (hybrid techniques) and novel reporter concepts. Novel biomedical applications have been included, where appropriate. All the chapters have been thoroughly reworked and the artwork updated.

Molecular Imaging

Author : Jie Tian
Publisher : Springer Science & Business Media
ISBN 13 : 3642343031
Total Pages : 707 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Molecular Imaging by : Jie Tian

Download or read book Molecular Imaging written by Jie Tian and published by Springer Science & Business Media. This book was released on 2013-07-23 with total page 707 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Molecular Imaging: Fundamentals and Applications" is a comprehensive monograph which describes not only the theory of the underlying algorithms and key technologies but also introduces a prototype system and its applications, bringing together theory, technology and applications. By explaining the basic concepts and principles of molecular imaging, imaging techniques, as well as research and applications in detail, the book provides both detailed theoretical background information and technical methods for researchers working in medical imaging and the life sciences. Clinical doctors and graduate students will also benefit from this book. Jie Tian is a professor at the Institute of Automation, Chinese Academy of Sciences, China.

Molecular Imaging

Author : Jie Tian
Publisher : Springer
ISBN 13 : 9783642343049
Total Pages : 699 pages
Book Rating : 4.3/5 (43 download)

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Book Synopsis Molecular Imaging by : Jie Tian

Download or read book Molecular Imaging written by Jie Tian and published by Springer. This book was released on 2014-06-11 with total page 699 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Molecular Imaging: Fundamentals and Applications" is a comprehensive monograph which describes not only the theory of the underlying algorithms and key technologies but also introduces a prototype system and its applications, bringing together theory, technology and applications. By explaining the basic concepts and principles of molecular imaging, imaging techniques, as well as research and applications in detail, the book provides both detailed theoretical background information and technical methods for researchers working in medical imaging and the life sciences. Clinical doctors and graduate students will also benefit from this book. Jie Tian is a professor at the Institute of Automation, Chinese Academy of Sciences, China.

Molecular Imaging

Author : Brian D. Ross
Publisher : Academic Press
ISBN 13 : 0128163879
Total Pages : 1872 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Molecular Imaging by : Brian D. Ross

Download or read book Molecular Imaging written by Brian D. Ross and published by Academic Press. This book was released on 2021-08-03 with total page 1872 pages. Available in PDF, EPUB and Kindle. Book excerpt: The detection and measurement of the dynamic regulation and interactions of cells and proteins within the living cell are critical to the understanding of cellular biology and pathophysiology. The multidisciplinary field of molecular imaging of living subjects continues to expand with dramatic advances in chemistry, molecular biology, therapeutics, engineering, medical physics and biomedical applications. Molecular Imaging: Principles and Practice, Volumes 1 and 2, Second Edition provides the first point of entry for physicians, scientists, and practitioners. This authoritative reference book provides a comprehensible overview along with in-depth presentation of molecular imaging concepts, technologies and applications making it the foremost source for both established and new investigators, collaborators, students and anyone interested in this exciting and important field. - The most authoritative and comprehensive resource available in the molecular-imaging field, written by over 170 of the leading scientists from around the world who have evaluated and summarized the most important methods, principles, technologies and data - Concepts illustrated with over 600 color figures and molecular-imaging examples - Chapters/topics include, artificial intelligence and machine learning, use of online social media, virtual and augmented reality, optogenetics, FDA regulatory process of imaging agents and devices, emerging instrumentation, MR elastography, MR fingerprinting, operational radiation safety, multiscale imaging and uses in drug development - This edition is packed with innovative science, including theranostics, light sheet fluorescence microscopy, (LSFM), mass spectrometry imaging, combining in vitro and in vivo diagnostics, Raman imaging, along with molecular and functional imaging applications - Valuable applications of molecular imaging in pediatrics, oncology, autoimmune, cardiovascular and CNS diseases are also presented - This resource helps integrate diverse multidisciplinary concepts associated with molecular imaging to provide readers with an improved understanding of current and future applications

Molecular Imaging

Author : Ralph Weissleder
Publisher : PMPH-USA
ISBN 13 : 9781607950059
Total Pages : 1384 pages
Book Rating : 4.9/5 (5 download)

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Book Synopsis Molecular Imaging by : Ralph Weissleder

Download or read book Molecular Imaging written by Ralph Weissleder and published by PMPH-USA. This book was released on 2010 with total page 1384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of molecular imaging of living subjects have evolved considerably and have seen spectacular advances in chemistry, engineering and biomedical applications. This textbook was designed to fill the need for an authoritative source for this multi-disciplinary field. We have been fortunate to recruit over 80 leading authors contributing 75 individual chapters. Given the multidisciplinary nature of the field, the book is broken into six different sections: "Molecular Imaging technologies", "Chemistry", "Molecular Imaging in Cell and Molecular Biology", "Applications of Molecular Imaging", "Molecular Imaging in Drug Evaluation" with the final section comprised of chapters on computation, bioinformatics and modeling. The organization of this large amount of information is logical and strives to avoid redundancies among chapters. It encourages the use of figures to illustrate concepts and to provide numerous molecular imaging examples.

Biomedical Imaging

Author : Reiner Salzer
Publisher : John Wiley & Sons
ISBN 13 : 1118271920
Total Pages : 444 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Biomedical Imaging by : Reiner Salzer

Download or read book Biomedical Imaging written by Reiner Salzer and published by John Wiley & Sons. This book was released on 2012-04-11 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents and describes imaging technologies that can be used to study chemical processes and structural interactions in dynamic systems, principally in biomedical systems. The imaging technologies, largely biomedical imaging technologies such as MRT, Fluorescence mapping, raman mapping, nanoESCA, and CARS microscopy, have been selected according to their application range and to the chemical information content of their data. These technologies allow for the analysis and evaluation of delicate biological samples, which must not be disturbed during the profess. Ultimately, this may mean fewer animal lab tests and clinical trials.

Biomedical Imaging

Author : Reiner Salzer
Publisher : John Wiley & Sons
ISBN 13 : 0470648473
Total Pages : 444 pages
Book Rating : 4.4/5 (76 download)

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Book Synopsis Biomedical Imaging by : Reiner Salzer

Download or read book Biomedical Imaging written by Reiner Salzer and published by John Wiley & Sons. This book was released on 2012-05-22 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents and describes imaging technologies that can be used to study chemical processes and structural interactions in dynamic systems, principally in biomedical systems. The imaging technologies, largely biomedical imaging technologies such as MRT, Fluorescence mapping, raman mapping, nanoESCA, and CARS microscopy, have been selected according to their application range and to the chemical information content of their data. These technologies allow for the analysis and evaluation of delicate biological samples, which must not be disturbed during the profess. Ultimately, this may mean fewer animal lab tests and clinical trials.

Molecular Imaging

Author : Shankar Vallabhajosula
Publisher : Springer Science & Business Media
ISBN 13 : 3540767355
Total Pages : 379 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Molecular Imaging by : Shankar Vallabhajosula

Download or read book Molecular Imaging written by Shankar Vallabhajosula and published by Springer Science & Business Media. This book was released on 2009-07-13 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.

Molecular Imaging

Author : Alexei Bogdanov
Publisher : Springer Science & Business Media
ISBN 13 : 354026809X
Total Pages : 269 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Molecular Imaging by : Alexei Bogdanov

Download or read book Molecular Imaging written by Alexei Bogdanov and published by Springer Science & Business Media. This book was released on 2007-01-19 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continuous progress in the understanding of molecular processes of disease formation and progression attributes an increasing importance to biomedical molecular imaging methods. The purpose of this workshop was to discuss and overview multiple applications and emerging technologies in the area of diagnostic imaging including its fundamental capabilities in preclinical research, the opportunities for medical care, and the options involving therapeutic concepts. The book provides the reader with state-of-the-art information on the different aspects of diagnostic imaging, illuminating new developments in molecular biology, imaging agents and molecular probe design, and therapeutic techniques.

Imaging in Drug Discovery and Early Clinical Trials

Author : Markus Rudin
Publisher : Springer Science & Business Media
ISBN 13 : 9783764377809
Total Pages : 408 pages
Book Rating : 4.3/5 (778 download)

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Book Synopsis Imaging in Drug Discovery and Early Clinical Trials by : Markus Rudin

Download or read book Imaging in Drug Discovery and Early Clinical Trials written by Markus Rudin and published by Springer Science & Business Media. This book was released on 2006-07-11 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph examines the contribution of imaging modalities to the stages of drug discovery and development, from early target validation to their use in clinical development programs. Chapters are devoted to the description of the drug discovery process, to the various imaging modalities preclinically and clinically, to applications of imaging during the optimization of a lead compound, addressing issues such as bioavailability and efficacy, and during drug safety evaluation.

Principles And Advanced Methods In Medical Imaging And Image Analysis

Author : Atam P Dhawan
Publisher : World Scientific
ISBN 13 : 9814476064
Total Pages : 869 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Principles And Advanced Methods In Medical Imaging And Image Analysis by : Atam P Dhawan

Download or read book Principles And Advanced Methods In Medical Imaging And Image Analysis written by Atam P Dhawan and published by World Scientific. This book was released on 2008-03-17 with total page 869 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computerized medical imaging and image analysis have been the central focus in diagnostic radiology. They provide revolutionalizing tools for the visualization of physiology as well as the understanding and quantitative measurement of physiological parameters. This book offers in-depth knowledge of medical imaging instrumentation and techniques as well as multidimensional image analysis and classification methods for research, education, and applications in computer-aided diagnostic radiology. Internationally renowned researchers and experts in their respective areas provide detailed descriptions of the basic foundation as well as the most recent developments in medical imaging, thus helping readers to understand theoretical and advanced concepts for important research and clinical applications.

Molecular Imaging: Computer Reconstruction and Practice

Author : Yves Lemoigne
Publisher : Springer Science & Business Media
ISBN 13 : 1402087527
Total Pages : 296 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Molecular Imaging: Computer Reconstruction and Practice by : Yves Lemoigne

Download or read book Molecular Imaging: Computer Reconstruction and Practice written by Yves Lemoigne and published by Springer Science & Business Media. This book was released on 2008-09-02 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reports the majority of lectures given during the NATO Advanced Study Institute ASI-982440, which was held at the European Scienti?c Institute of Archamps (ESI, Archamps – France) from November 9 to November 21, 2006. The ASI course was structured in two parts, the ?rst was dedicated to individual imaging techniques while the second is the object of this volume and focused on data modelling and processing and on image archiving and distribution. Courses devoted to nuclear medicine and digital imaging techniques are collected in a c- plementary volume of NATO Science Series entitled “Physics for Medical Imaging Applications” (ISBN 978-1-4020-5650-5). Every year in autumn ESI organises the European School of Medical Physics, which covers a large spectrum of topics ranging from Medical Imaging to Rad- therapy, over a period of ?ve weeks. Thanks to the Cooperative Science and Te- nology sub-programme of the NATO Science Division, weeks two and three were replaced this year by the ASI course dedicated to “Molecular Imaging from Physical Principles to Computer Reconstruction and Practice”. This allowed the participation ofexpertsandstudentsfrom20differentcountries,withdiverseculturalbackground and professional experience (Africa, America, Asia, and Europe). A further positive outcome of NATO ASI participation is the publication of this book, which contains the lectures series contributed by speakers during the second week of the ASI.

Targeted Molecular Imaging

Author : Michael J. Welch
Publisher : CRC Press
ISBN 13 : 1439841950
Total Pages : 390 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Targeted Molecular Imaging by : Michael J. Welch

Download or read book Targeted Molecular Imaging written by Michael J. Welch and published by CRC Press. This book was released on 2012-02-24 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies that form the core of this book deal with the development and translation of non-nuclear probes and radiotracers; other sections address critical topics such as In vitro studies, small animal research, and the application of targeted probes for nuclear, optical and MRI imaging. The chapters use a common format to demonstrate how various investigators approach the comprehensive task of validating a new targeted probe. Targeted Molecular Imaging is a timely resource for a rapidly advancing field, and addresses: Various methods of validating a new targeted probe through examples from human studies with imaging of breast cancer, cardiovascular disease, and neurodegenerative diseases Basic principles, disease models, imaging studies in animals, imaging in initial human studies, and the application of molecular imaging in pharmacy and drug discovery In vitro studies, small animal studies, and targeted radiopharmaceuticals Using these case studies, investigators can generalize and apply the information to their own specific targeted probe. The insights provided by the contributors, experts who have developed these approaches in their own groups, help guide scientists planning to translate imaging agents from the concept stage to clinical application.

Basic Science of PET Imaging

Author : Magdy M. Khalil
Publisher : Springer
ISBN 13 : 3319400703
Total Pages : 621 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Basic Science of PET Imaging by : Magdy M. Khalil

Download or read book Basic Science of PET Imaging written by Magdy M. Khalil and published by Springer. This book was released on 2016-11-07 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a wide-ranging and up-to-date overview of the basic science underlying PET and its preclinical and clinical applications in modern medicine. In addition, it provides the reader with a sound understanding of the scientific principles and use of PET in routine practice and biomedical imaging research. The opening sections address the fundamental physics, radiation safety, CT scanning dosimetry, and dosimetry of PET radiotracers, chemistry and regulation of PET radiopharmaceuticals, with information on labeling strategies, tracer quality control, and regulation of radiopharmaceutical production in Europe and the United States. PET physics and instrumentation are then discussed, covering the basic principles of PET and PET scanning systems, hybrid PET/CT and PET/MR imaging, system calibration, acceptance testing, and quality control. Subsequent sections focus on image reconstruction, processing, and quantitation in PET and hybrid PET and on imaging artifacts and correction techniques, with particular attention to partial volume correction and motion artifacts. The book closes by examining clinical applications of PET and hybrid PET and their physiological and/or molecular basis in conjunction with technical foundations in the disciplines of oncology, cardiology and neurology, PET in pediatric malignancy and its role in radiotherapy treatment planning. Basic Science of PET Imaging will meet the needs of nuclear medicine practitioners, other radiology specialists, and trainees in these fields.

Principles of Medical Imaging for Engineers

Author : Michael Chappell
Publisher : Springer Nature
ISBN 13 : 3030305112
Total Pages : 169 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Principles of Medical Imaging for Engineers by : Michael Chappell

Download or read book Principles of Medical Imaging for Engineers written by Michael Chappell and published by Springer Nature. This book was released on 2019-10-03 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This introduction to medical imaging introduces all of the major medical imaging techniques in wide use in both medical practice and medical research, including Computed Tomography, Ultrasound, Positron Emission Tomography, Single Photon Emission Tomography and Magnetic Resonance Imaging. Principles of Medical Imaging for Engineers introduces fundamental concepts related to why we image and what we are seeking to achieve to get good images, such as the meaning of ‘contrast’ in the context of medical imaging. This introductory text separates the principles by which ‘signals’ are generated and the subsequent ‘reconstruction’ processes, to help illustrate that these are separate concepts and also highlight areas in which apparently different medical imaging methods share common theoretical principles. Exercises are provided in every chapter, so the student reader can test their knowledge and check against worked solutions and examples. The text considers firstly the underlying physical principles by which information about tissues within the body can be extracted in the form of signals, considering the major principles used: transmission, reflection, emission and resonance. Then, it goes on to explain how these signals can be converted into images, i.e., full 3D volumes, where appropriate showing how common methods of ‘reconstruction’ are shared by some imaging methods despite relying on different physics to generate the ‘signals’. Finally, it examines how medical imaging can be used to generate more than just pictures, but genuine quantitative measurements, and increasingly measurements of physiological processes, at every point within the 3D volume by methods such as the use of tracers and advanced dynamic acquisitions. Principles of Medical Imaging for Engineers will be of use to engineering and physical science students and graduate students with an interest in biomedical engineering, and to their lecturers.