Author : Xin Wei Wang
Publisher : Springer Science & Business Media
ISBN 13 : 1441960821
Total Pages : 390 pages
Book Rating : 4.4/5 (419 download)
Book Synopsis Molecular Genetics of Liver Neoplasia by : Xin Wei Wang
Download or read book Molecular Genetics of Liver Neoplasia written by Xin Wei Wang and published by Springer Science & Business Media. This book was released on 2010-11-08 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Primary liver cancer is the third most deadly and fifth most common cancer worldwide (~500,000 deaths annually), with a sharp increase of incidence in the United States in recent years. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of primary liver cancer. Risk factors include gender, hepatitis B virus (HBV), hepatitis C virus (HCV), cirrhosis, metabolism diseases, diabetes, obesity, toxins, excess alcohol consumption and smoking. Liver cancer arises most frequently in inflammatory livers with extensive oxidative stress due to viral hepatitis which causes over 80% of HCC cases worldwide. Currently, survival remains dismal for most HCC and CC patients, largely due to the tumor’s aggressiveness at the time of diagnosis and the lack of effective therapy.