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Molecular Genetics Of Immunoglobulin
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Book Synopsis Molecular Genetics of Immunoglobulin by : F. Calabi
Download or read book Molecular Genetics of Immunoglobulin written by F. Calabi and published by Elsevier. This book was released on 1987-12-01 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the molecular genetics of immunoglobulins has been enormously advanced by the application of recombinant DNA technology. This new volume in the popular series New Comprehensive Biochemistry contains eight chapters that draw together reviews summarising the research into immunoglobulins and the arrangement, rearrangement and expression of their gene structure. Molecular Genetics of Immunoglobulin will be of particular importance to those working in the areas of genetics and molecular biology, immunology, and cell biology.
Book Synopsis Immunoglobulin Genes by : Tasuku Honjo
Download or read book Immunoglobulin Genes written by Tasuku Honjo and published by Academic Press. This book was released on 2012-12-02 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunoglobin Genes is the first comprehensive book on the structure, function, and expression of the genes encoding antibodies in normal and neoplastic cells.
Book Synopsis The Genetic Markers of Human Immunoglobulins by : Rune E. Grubb
Download or read book The Genetic Markers of Human Immunoglobulins written by Rune E. Grubb and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has long been known that every individual has a large number of antibodies of different specificities. Antibodies are gammaglobulins, and protein structure in cells is genetically determined. The extreme multiplicity of structure of the combining sites of antibodies relative to the degree of multiplicity generated by ordinary genetic mechanisms is a fascinating problem of bio-medical importance. The functional heterogeneity of reactions mediated by immunoglobulins-is remarkable, ranging from protection against life-threatening toxins and microbes to the production of laryngeal edema leading to suffocation and death from anaphylaxis. An approach to the understanding of immunoglobulin polymorphism based upon "a knowledge of genetic markers of immunoglobulin structure is not biased by the question of whether or not this polymorphism is related to combining site diversity. Though several recent reviews of the multifacetted problems related to immuno globulins are available, it was decided to publish this survey in the belief that know ledge of the genetic markers of immunoglobulins prqvides such information about immunoglobulin differentiation and its control as cannot be obtained from other sources. Several of the human genetic im~unoglobulin markers are well understood at the molecular level. The Gm system may serv~ as a model for other immuno genetic systems. The published data on the human immunoglobulin factors are widely scattered in journals of different perspectives. There is a need for a systematic presentation of these data and for their critical evaluation.
Book Synopsis Molecular Biology of B Cells by : Tasuku Honjo
Download or read book Molecular Biology of B Cells written by Tasuku Honjo and published by Academic Press. This book was released on 2014-12-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.
Book Synopsis The Genetic Markers of Human Immunoglobulins by : Rune E. Grubb
Download or read book The Genetic Markers of Human Immunoglobulins written by Rune E. Grubb and published by Springer. This book was released on 2012-03-19 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has long been known that every individual has a large number of antibodies of different specificities. Antibodies are gammaglobulins, and protein structure in cells is genetically determined. The extreme multiplicity of structure of the combining sites of antibodies relative to the degree of multiplicity generated by ordinary genetic mechanisms is a fascinating problem of bio-medical importance. The functional heterogeneity of reactions mediated by immunoglobulins-is remarkable, ranging from protection against life-threatening toxins and microbes to the production of laryngeal edema leading to suffocation and death from anaphylaxis. An approach to the understanding of immunoglobulin polymorphism based upon "a knowledge of genetic markers of immunoglobulin structure is not biased by the question of whether or not this polymorphism is related to combining site diversity. Though several recent reviews of the multifacetted problems related to immuno globulins are available, it was decided to publish this survey in the belief that know ledge of the genetic markers of immunoglobulins prqvides such information about immunoglobulin differentiation and its control as cannot be obtained from other sources. Several of the human genetic im~unoglobulin markers are well understood at the molecular level. The Gm system may serv~ as a model for other immuno genetic systems. The published data on the human immunoglobulin factors are widely scattered in journals of different perspectives. There is a need for a systematic presentation of these data and for their critical evaluation.
Book Synopsis Janeway's Immunobiology by : Kenneth Murphy
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Book Synopsis The Variation and Adaptive Expression of Antibodies by : George P. Smith
Download or read book The Variation and Adaptive Expression of Antibodies written by George P. Smith and published by Harvard University Press. This book was released on 1973 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past ten years, several theories have been proposed on the origin of the diversity of antibodies. George P. Smith presents a critical study of these theories in this detailed treatment of immunological problems from the point of view of molecular genetics. Mr. Smith uses a new and simplifying approach to this long-standing controversy. By a comprehensive computerized analysis of antibody amino acid sequences (particularly the myeloma proteins), the author traces their evolution and matches his results against the expectations of the various theories of diversity. He discusses at length the other types of evidence as well. Mr. Smith also deals with the clonal specialization of cells to produce a single antibody, and the relationship of this specialization to the somatic joining of antibody half-genes, which is one of the immune system's most important peculiarities. Introductory material is provided to make this work understandable to molecular geneticists not versed in immunology and to immunologists not versed in molecular genetics. This is a timely book offering a succinct and coherent summary of the various lines of evidence in a confused and controversial field.
Book Synopsis Molecular Biology of B Cells by : Tasuku Honjo
Download or read book Molecular Biology of B Cells written by Tasuku Honjo and published by Elsevier. This book was released on 2024-01-15 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of B Cells, Third Edition is a comprehensive reference to how B cells are generated, selected, activated, and engaged in antibody production. These developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Third Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on B cell development and function, the use of therapeutic antibodies in cancer and infectious disease, therapeutic targeting of B cells for clinical application, new developments in lymphoma biology. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Third Edition is the definitive resource, vital for researchers across molecular biology, immunology, and genetics. Provides new research on normal versus abnormal B cell development and function Contains studies on therapeutic antibodies in cancer and infectious diseases Covers research on therapeutically targeting B cells in inflammation or autoimmune diseases
Book Synopsis Analysis of Immunoglobulin Gene Expression by : Karin Johansson
Download or read book Analysis of Immunoglobulin Gene Expression written by Karin Johansson and published by . This book was released on 1995 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Generation of Diversity by : Alfred I. Tauber
Download or read book The Generation of Diversity written by Alfred I. Tauber and published by Harvard University Press. This book was released on 2000 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an intellectual history of the major theoretical problem in immunology and its resolution in the post-World War II period. In recent years immunology has been one of the most exciting--and successful--fields of biomedical research; this book provides essential background for understanding the conceptual conflicts occurring in the field.
Book Synopsis Immunogenetics: A Molecular and Clinical Overview by : Muneeb U. Rehman
Download or read book Immunogenetics: A Molecular and Clinical Overview written by Muneeb U. Rehman and published by Academic Press. This book was released on 2021-11-30 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Molecular Approach to Immunogenetics, Immunogenetics: A Molecular and Clinical Overview, Volume One provides readers with an exclusive, updated overview on the scientific knowledge, achievements and findings in the field of immunogenetics. The book presents readily available, updated information on the molecular and clinical aspects of immunogenetics, from origin and development to clinical applications and future prospects. The breadth of information goes from basics to developments, clinical applications and future prospects. The book's most attractive attribute is its academic and clinical amalgamation that covers both the theoretical and practical aspects of immunogenetics. An additional feature of the book is a special chapter on viral genetics that covers COVID-19. Above all, the book contains chapters that discuss immunogenetics in relation to pharmaco-genomics and immune-toxicology. Contains exclusive information about research on immunogenetics from around the globe Includes minute and recent details that will be the prerequisite requirement for any researcher who wants to work on immunogenetics and its applications Comes fully-equipped with pictures, illustrations and tables that deliver information in a meticulous manner
Book Synopsis AID for Immunoglobulin Diversity by : Frederick W. Alt
Download or read book AID for Immunoglobulin Diversity written by Frederick W. Alt and published by Elsevier. This book was released on 2007-06-05 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Immunology, a long established and highly respected serial, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Book Synopsis Antibody Engineering by : Benny K. C. Lo
Download or read book Antibody Engineering written by Benny K. C. Lo and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: The exquisite binding specificity of antibodies has made them valuable tools from the laboratory to the clinic. Since the description of the murine hybridoma technology by Köhler and Milstein in 1975, a phenomenal number of mo- clonal antibodies have been generated against a diverse array of targets. Some of these have become indispensable reagents in biomedical research, while others were developed for novel therapeutic applications. The attractiveness of an- bodies in this regard is obvious—high target specificity, adaptability to a wide range of disease states, and the potential ability to direct the host’s immune s- tem for a therapeutic response. The initial excitement in finding Paul Ehrlich’s “magic bullet,” however, was met with widespread disappointment when it was demonstrated that murine antibodies frequently elicit the human anti-murine an- body (HAMA) response, thus rendering them ineffective and potentially unsafe in humans. Despite this setback, advances in recombinant DNA techniques over the last 15–20 years have empowered the engineering of recombinant antibodies with desired characteristics, including properties to avoid HAMA. The ability to p- duce bulk quantities of recombinant proteins from bacterial fermentation also fueled the design of numerous creative antibody constructs. To date, the United States Food and Drug Administration has approved more than 10 recombinant antibodies for human use, and hundreds more are in the development pipeline. The recent explosion in genomic and proteomic information appears ready to deliver many more disease targets amenable to antibody-based therapy.
Book Synopsis Molecular Genetic Pathology by : Liang Cheng
Download or read book Molecular Genetic Pathology written by Liang Cheng and published by Springer. This book was released on 2013-03-05 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.
Book Synopsis Advanced Immunochemistry by : Eugene D. Day
Download or read book Advanced Immunochemistry written by Eugene D. Day and published by . This book was released on 1990-03-19 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive treatment of immunochemistry theory offers the kind of information essential to furthering the biotechnological development of advances in molecular and cellular immunology. More than just a review of the principles, the Second Edition of Advanced Immunochemistry presents a full exposition of modern immunochemical theory and knowledge. Incorporating the major developments in immunochemistry over the past two decades, this exciting text presents the latest information on the progress in such areas as: immunoglobulin structures; applications of molecular genetics to the understanding of immunoglobulin genes and supergene families; molecular and cellular bases of antibody diversity; antibody binding to specific epitopes of antigen molecules; and idiotypy. This Second Edition will serve as a comprehensive reference to the structure and function of immunoglobulins and as a basis for understanding the complexities of immune responses.
Book Synopsis The Immunoglobulin FactsBook by : Marie-Paule Lefranc
Download or read book The Immunoglobulin FactsBook written by Marie-Paule Lefranc and published by Academic Press. This book was released on 2001-05-23 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The FactsBook series has established itself as the best source of easily accessible and accurate facts about protein groups. Books in the series use an easy-to-follow format and are meticulously researched and compiled by experts in the field.The Immunoglobulin FactsBook is the first published reference for all 203 human functional and ORF immunoglobulin genes. It is complete and standardized and employs nomenclature approved by the HUGO Nomenclature Committee.
Book Synopsis Mucosal Immune Defense: Immunoglobulin A by : Charlotte S. Kaetzel
Download or read book Mucosal Immune Defense: Immunoglobulin A written by Charlotte S. Kaetzel and published by Springer Science & Business Media. This book was released on 2007-10-04 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: This key work in the field draws on a broad spectrum of molecular biologic, biochemical, and immunogenetic approaches in combination with human and murine in vitro cell culture and in vivo model systems to address questions in mucosal immunity. Humans produce more immunoglobulin A (IgA) than all other antibody isotypes combined. This book is designed to serve as a concise reference of the present knowledge of the biology of IgA.
