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Molecular Genetic Epidemiology
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Book Synopsis Molecular Epidemiology by : Paul A. Schulte
Download or read book Molecular Epidemiology written by Paul A. Schulte and published by Academic Press. This book was released on 2012-12-02 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.
Book Synopsis An Introduction to Genetic Epidemiology by : Palmer, Lyle J.
Download or read book An Introduction to Genetic Epidemiology written by Palmer, Lyle J. and published by Policy Press. This book was released on 2011-05-31 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together leading experts to provide an introduction to genetic epidemiology that begins with a primer in human molecular genetics through all the standard methods in population genetics and genetic epidemiology required for an adequate grounding in the field.
Book Synopsis Principles of Genetics and Molecular Epidemiology by : Juan Carlos Gomez-Verjan
Download or read book Principles of Genetics and Molecular Epidemiology written by Juan Carlos Gomez-Verjan and published by Springer Nature. This book was released on 2022-01-28 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers some of the most novel genetic and genomic concepts in epidemiology, such as geospatial statistics and systems biology from a clinical point of view by explaining molecular applications with accessible human studies. Featuring a comprehensive table of contents, it includes chapters from genomics and epidemiology surveillance to transcriptomics and alternative splicing principles. Across 17 well-organized chapters, this book meets attempt to explain easily to clinicians and students with basic principles of the genetics, genomics, molecular biology and its applications to epidemiology and public health. The text is distinct from other literature on the market because it covers useful genomic tools applied in epidemiology for clinicians who may not be experts in this branch of health science. Principles of Genetics and Molecular Epidemiology demystifies the idea that biomedicine is far from being applied in both epidemiology and clinical practice.
Book Synopsis Molecular Genetic Epidemiology by : Ian N.M. Day
Download or read book Molecular Genetic Epidemiology written by Ian N.M. Day and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes high-throughput approaches to a series of robust, established methodologies in molecular genetic studies of population samples. Such developments have been essential not only to linkage and association studies of single-gene and complex traits in humans, animals and plants, but also to the characterisation of clone banks, for example in mapping of genomes. Chapters have been written by developers or highly experienced end-users concerned with a diverse array of biological applications. The book should appeal to any researcher for whom costs and throughput in their genetics laboratory have become an issue.
Book Synopsis Molecular Tools and Infectious Disease Epidemiology by : Betsy Foxman
Download or read book Molecular Tools and Infectious Disease Epidemiology written by Betsy Foxman and published by Academic Press. This book was released on 2017-11-13 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of modern molecular genetic and biologic techniques to infectious disease epidemiology dramatically improves measurement of disease and putative risk factors, increasing our ability to detect and track outbreaks, identify risk factors and detect new infectious agents. However, integration of these techniques into epidemiologic studies also poses new challenges in the design, conduct, and analysis. We examine these opportunities and methodologic challenges giving specific examples. The book will be written for the reader with limited understanding of genetics, biology and epidemiology. Presents the key points of consideration when integrating molecular biology and epidemiologyDiscusses how using molecular tools in epidemiologic research affects program design and conductConsiders the ethical concerns that arise in molecular epidemiologic studiesProvides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field
Book Synopsis Clinical Genetics and Genomics of Aging by : Juan Carlos Gomez-Verjan
Download or read book Clinical Genetics and Genomics of Aging written by Juan Carlos Gomez-Verjan and published by Springer. This book was released on 2021-04-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world population is rapidly aging—it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another. For a long time, medical care for older adults has focused on treating chronic, age-related diseases and their associated consequences. Recently, biomedical research brings a novel point of view to develop more effective interventions by targeting the aging process itself rather than separate conditions. There is a growing number of reports indicating that aging is driven by several interconnected mechanisms and biological components referred to as the molecular pillars of aging. Interfering with these mechanisms could help to treat, prevent, and understand the development of age-related diseases and associated syndromes. This book provides a clinical perspective and general update on biomedical and genetic research in aging, moving from an update in the molecular pillars of aging to a perspective of the most recent pharmacological, clinical, and diagnostic applications using genomic approaches and techniques. While this book focuses on the specifics of genetics and genomics, it also adopts a clinical perspective of geroscience, which seeks to understand the genetic, molecular and cellular mechanisms that make aging an important risk factor and, sometimes, a determining factor in the diseases and common chronic conditions of older people. Additionally, Clinical Genetics and Genomics of Aging is a significant contribution to support aging research, as it shows that collaboration across disciplines is relevant to progress in the field. As more and more people benefit from increased longevity, clinician and researchers will be empowered by this knowledge to contribute to the progress of aging research.
Book Synopsis A Statistical Approach to Genetic Epidemiology by : Andreas Ziegler
Download or read book A Statistical Approach to Genetic Epidemiology written by Andreas Ziegler and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Statistical Approach to Genetic Epidemiology After studying statistics and mathematics at the University of Munich and obtaining his doctoral degree from the University of Dortmund, Andreas Ziegler received the Johann-Peter-Süssmilch-Medal of the German Association for Medical Informatics, Biometry and Epidemiology for his post-doctoral work on “Model Free Linkage Analysis of Quantitative Traits” in 1999. In 2004, he was one of the recipients of the Fritz-Linder-Forum-Award from the German Association for Surgery.
Book Synopsis Human Genome Epidemiology, 2nd Edition by : Muin Khoury
Download or read book Human Genome Epidemiology, 2nd Edition written by Muin Khoury and published by Oxford University Press. This book was released on 2010-01-20 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text describes the role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It provides a foundation that should help researchers, policy makers and practitioners integrate genomics into medical and public health practice.
Book Synopsis Statistical Methods in Genetic Epidemiology by : Duncan C. Thomas
Download or read book Statistical Methods in Genetic Epidemiology written by Duncan C. Thomas and published by Oxford University Press. This book was released on 2004-01-29 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.
Book Synopsis Genetic Epidemiology by : Evangelos Evangelou
Download or read book Genetic Epidemiology written by Evangelos Evangelou and published by Humana Press. This book was released on 2018-06-07 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented. The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls.
Book Synopsis Fundamentals of Genetic Epidemiology by : Muin J. Khoury
Download or read book Fundamentals of Genetic Epidemiology written by Muin J. Khoury and published by Monographs in Epidemiology and. This book was released on 1993 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease aetiology. The authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations.
Book Synopsis Genetic Epidemiology by : M. Dawn Teare
Download or read book Genetic Epidemiology written by M. Dawn Teare and published by Humana Press. This book was released on 2010-12-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arising from firm foundations laid by mathematical population genetics, clinical genetics, and statistical epidemiology, genetic epidemiology attempts to identify the many components of risk attributable to genes, environments, and interactions, and the course of its research can follow many diverse paths. In Genetic Epidemiology, the success of genome-wide association studies in their identification of hundreds of disease susceptibility loci has inspired renowned experts to contribute thorough methodologies, which aim to bring together bioinformaticians, geneticists, clinicians, statisticians, and epidemiologists in the study of this vital field. The volume opens with chapters covering the basics; however, it quickly moves on to coverage of more specialist topics such as twin studies, Mendelian randomization, genetic association studies, more advanced areas, as well as case studies. As a part of the highly successful Methods in Molecular BiologyTM series, this work provides the detailed description of the application and analysis of the most commonly employed methods that are necessary for a firm grounding in the field. Authoritative and cutting-edge, Genetic Epidemiology aims to provide a basic framework for crucial interdisciplinary communication and understanding suited to newcomers to the field as well as experienced researchers and graduate level students.
Book Synopsis Genetic Epidemiology of Cancer by : Henry T. Lynch
Download or read book Genetic Epidemiology of Cancer written by Henry T. Lynch and published by CRC Press. This book was released on 1989-06-30 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multi-authored book provides a unique accounting of the cancer problem from the standpoint of those primary genetic factors which may be interacting with myriad environmental exposures in cancer etiology. It provides a comprehensive coverage of cancer of all anatomical sites in conjunction with a genetic/environmental thrust. It includes a survey chapter dealing with the role of primary genetic factors in cancer of differing anatomic sites and a similar comprehensive survey chapter tracing the history of epidemiology, with focus upon multiple anatomic sites, including classical epidemiologic cancer models such as cigarette smoking, asbestos, vinyl chloride, and uranium exposure. Chapters are devoted to tumor biomarkers and their applicability to cancer of multiple anatomic sites. Clinical correlation will involve surveillance/management programsand focus on high-risk groups-such as those involving primary genetic or environmental factors and/or their interaction. The development of registries involving families with differing hereditary cancer syndromes are considered. Also, many chapters are devoted to environmental protective measures, as well as the need for more responsibility for coverage of patients at inordinately high risk for cancer by third party carriers. Other chapters address segregation and linkage analysis, oncogenes, cytogenetics, and other biomarkers. This book will be of interest to general clinicians, oncologists, surgeons, geneticists, and carcinogenesis investigators.
Book Synopsis Biostatistical Genetics and Genetic Epidemiology by : Robert C. Elston
Download or read book Biostatistical Genetics and Genetic Epidemiology written by Robert C. Elston and published by John Wiley & Sons. This book was released on 2002-04-22 with total page 860 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Human Genetics and Genetic Epidemiology" ist der 3. Band aus der sehr erfolgreichen Reihe 'Wiley Biostatistics Reference Series', die auf Artikeln der "Encyclopedia of Biostatistics" basiert. Dieser Band gibt einen topaktuellen und umfassenden Überblick über ein Forschungsgebiet, das insbesondere im Zuge des Human-Genomprojekts eine regelrechte Explosion an Forschungsaktivitäten erlebt hat. Enthalten sind komplett aktualisierte Artikel aus der "Encyclopedia of Biostatistics" sowie über 25% neue Artikel. Mit einem komplexen System an Querverweisen, die das Auffinden der gewünschten Information erheblich erleichtern. Eine interessante Lektüre für Genetiker, Epidemiologen, Biostatistiker und Forscher in diesen Bereichen.
Book Synopsis Molecular Epidemiology of Chronic Diseases by : Chris Wild
Download or read book Molecular Epidemiology of Chronic Diseases written by Chris Wild and published by John Wiley & Sons. This book was released on 2011-09-09 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: "I think this is an excellent book–I recommend it to anyone involved in molecular epidemiology... The 26 chapters are written by topic specialists, in an explanatory, east to read style." –BTS Newsletter, Summer 2009 "This text provides an accessible and useful handbook for the epidemiologist who wants to survey the field, to become better informed, to look at recent developments and get some background on these or simply to appreciate further the relatively rapid changes in informatic and analytical technologies which increasingly will serve and underpin future epidemiological studies. One of the strengths in this book is the extensive array of practical illustrative examples, and it would also in my opinion have useful potential as a teaching text." –American Journal of Human Biology, March 2009 With the sequencing of the human genome and the mapping of millions of single nucleotide polymorphisms, epidemiology has moved into the molecular domain. Scientists can now use molecular markers to track disease-associated genes in populations, enabling them to study complex chronic diseases that might result from the weak interactions of many genes with the environment. Use of these laboratory generated biomarker data and an understanding of disease mechanisms are increasingly important in elucidating disease aetiology. Molecular Epidemiology of Disease crosses the disciplinary boundaries between laboratory scientists, epidemiologists, clinical researchers and biostatisticians and is accessible to all these relevant research communities in focusing on practical issues of application, rather than reviews of current areas of research. Covers categories of biomarkers of exposure, susceptibility and disease Includes chapters on novel technologies: genomics, transcriptomics, proteomics and metabonomics, which are increasingly finding application in population studies Emphasizes new statistical and bioinformatics approaches necessitated by the large data sets generated using these new methodologies Demonstrates the potential applications of laboratory techniques in tackling epidemiological problems while considering their limitations, including the sources of uncertainty and inaccuracy Discusses issues such as reliability (compared to traditional epidemiological methods) and the timing of exposure Explores practical elements of conducting population studies, including biological repositories and ethics Molecular Epidemiology of Disease provides an easy-to-use, clearly presented handbook that allows epidemiologists to understand the specifics of research involving biomarkers, and laboratory scientists to understand the main issues of epidemiological study design and analysis. It also provides a useful tool for courses on molecular epidemiology, using many examples from population studies to illustrate key concepts and principles.
Book Synopsis Genetic Epidemiology by : Evangelos Evangelou
Download or read book Genetic Epidemiology written by Evangelos Evangelou and published by Humana. This book was released on 2019-06-21 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented. The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls.
Book Synopsis Genetic Epidemiology by : Benja Rambeloson
Download or read book Genetic Epidemiology written by Benja Rambeloson and published by Scitus Academics LLC. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic epidemiology is the study of the role of genes and environments on markers of health and disease risk in populations. It emerged as a mainstream discipline in the early 1980s, arising from firm foundations laid by mathematical population genetics, clinical genetics, and statistical epidemiology. Though genetic epidemiology attempts to identify the many components of risk attributable to genes, environments, and interactions between these two factors, the course of the research towards this goal can follow many diverse paths. In the last few years, the success of genome-wide association studies in their identification of hundreds of disease susceptibility loci has brought this specialist field to the forefront of biomedical research. Advances in molecular genetics will soon offer affordable means to measure or observe study participant's genetic material at the sequence level as well as more detailed functional data, such as gene expression.
