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Molecular Exploitation Of Apoptosis Pathways In Prostate Cancer
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Book Synopsis Molecular Exploitation Of Apoptosis Pathways In Prostate Cancer by : Natasha Kyprianou
Download or read book Molecular Exploitation Of Apoptosis Pathways In Prostate Cancer written by Natasha Kyprianou and published by World Scientific. This book was released on 2012-03-07 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the functional significance of targeting apoptosis for the treatment of prostate cancer. New concepts on the challenges relating to the development of resistance by androgen-independent tumors are introduced, in terms of the contribution of anoikis and cross-talk of androgens with key growth factor signaling pathways. This volume also provides insightful discussion on the exploitation of the apoptotic and angiogenic synergism towards complete eradication of prostate tumors. Last but not least, it includes reflections on the drug development challenge based on the analysis of data from existing clinical trials.
Book Synopsis Managing Metastatic Prostate Cancer In Your Urological Oncology Practice by : K.C Balaji
Download or read book Managing Metastatic Prostate Cancer In Your Urological Oncology Practice written by K.C Balaji and published by Springer. This book was released on 2016-04-25 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a comprehensive review of pathophysiology, molecular and cell biology aspects of CRPC, discusses all major clinical trials that have led to approval of 6 new drugs since 2004, explores the role of bone preservation strategies, in depth analysis of combination and sequencing strategies, outlines upcoming novel drugs and trends in research, and stresses the role of palliative care in this incurable disease. Managing Metastatic Prostate Cancer in Your Urological Oncology Practice will serve as a very useful resource for physicians and researchers dealing with, and interested in prostate cancer. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and will include the most up to date scientific and clinical information.
Book Synopsis Revival: Integrins – The Biological Problems (1994) by : Yoshikazu Takada
Download or read book Revival: Integrins – The Biological Problems (1994) written by Yoshikazu Takada and published by CRC Press. This book was released on 2017-11-22 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: * the structure and functions of integrin cytoplasmic domains * the role of b2 integrins in leukocyte adhesion * the role of platelet membrane fibrinogen receptor glycoprotein IIb-IIIa (aIIbb3) in thrombosis and hemostasis * the functions of aV integrin family * the role of integrins in signal transduction
Book Synopsis MicroRNAs in Development and Cancer by : Frank J. Slack
Download or read book MicroRNAs in Development and Cancer written by Frank J. Slack and published by World Scientific. This book was released on 2011 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer.
Book Synopsis Alzheimer's Disease: Insights Into Low Molecular Weight And Cytotoxic Aggregates From In Vitro And Computer Experiments - Molecular Basis Of Amyloid-beta Protein Aggregation And Fibril Formation by : Philippe Derreumaux
Download or read book Alzheimer's Disease: Insights Into Low Molecular Weight And Cytotoxic Aggregates From In Vitro And Computer Experiments - Molecular Basis Of Amyloid-beta Protein Aggregation And Fibril Formation written by Philippe Derreumaux and published by World Scientific. This book was released on 2012-12-31 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease is the most common form of senile dementia, affecting more than 24 million people worldwide. It is characterised pathologically by abnormally high levels of neurofibrillary tangles resulting from the accumulation of tau protein in dead and dying neurons, and by elevated numbers of senile plaques in the cortex and hippocampus of the brain. The major component of senile plaques is a small protein of 39-43 amino acids called amyloid-β (Aβ). Thus far, no treatment has been shown to slow the progression of sporadic and familial Alzheimer's disease.A large body of evidence points, however, to the early Aβ-formed oligomers as the primary toxic species in Alzheimer's disease. A powerful strategy for developing pharmaceutical treatments against Alzheimer's is to elucidate the pathways of oligomer formation and determine the structures of the toxic aggregates.This book provides a panoramic view across recent in vitro and in vivo studies along with state-of-the-art computer simulations, designed to increase the readers' understanding of Aβ oligomerisation and fibril formation. At the same time, the book delves into the pathogenesis of familial and sporadic Alzheimer's disease at the atomic level of detail.Written by leading authors in their respective fields, this book will be valuable to all scientists working on Alzheimer's disease./a
Book Synopsis Molecular Biology of Prostate Cancer by : Manfred Wirth
Download or read book Molecular Biology of Prostate Cancer written by Manfred Wirth and published by Walter de Gruyter. This book was released on 2013-05-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Antibody Drug Discovery by : Clive R. Wood
Download or read book Antibody Drug Discovery written by Clive R. Wood and published by World Scientific. This book was released on 2012 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field. Each chapter is written with a historical perspective that sets into context the significance of the key developments, and with the provision of “points to consider” for the reader as a value-added feature of the volume. All contributors are experts in their fields and have played pivotal roles in the creation of the technology.
Book Synopsis Merkel Cell Carcinoma by : Vernon K. Sondak
Download or read book Merkel Cell Carcinoma written by Vernon K. Sondak and published by World Scientific. This book was released on 2010-09-01 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Merkel cell carcinoma is an uncommon but not rare aggressive cutaneous malignancy. It has many similarities to melanoma, particularly in the need for aggressive multidisciplinary treatment, but far less is known about this disease by most practicing physicians. This book summarizes all of the existing knowledge about Merkel cell carcinoma and provides a much-needed perspective on future opportunities for diagnostic and therapeutic advances. It offers practical ?how to? advice on diagnosis, treatment and follow-up, and also insight into how to establish a multidisciplinary Merkel cell carcinoma clinic. In addition, it will serve as a unique resource for trainees (medical students, residents and fellows) as well as for Merkel cell carcinoma patients and their advocates and caregivers. There is currently no such textbook, even an outdated one, covering this topic.
Book Synopsis Dna Deamination And The Immune System: Aid In Health And Disease by : Nina Papavasiliou
Download or read book Dna Deamination And The Immune System: Aid In Health And Disease written by Nina Papavasiliou and published by World Scientific. This book was released on 2010-10-27 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions remain hotly contested, such as: how does this enzyme get to the antibody locus leaving the rest of the genome intact, and why are DNA repair pathways which normally repair deamination events co-opted into actually fixing mutations into the genome? These questions, among others, will be addressed in this monograph from various perspectives. Being leading experts in their respective fields, the contributors of this highly valued title summarize current research in the field of AID and put forth hypotheses in order to provide a platform for future experiments./a
Book Synopsis Alzheimer's Disease by : Philippe Derreumaux
Download or read book Alzheimer's Disease written by Philippe Derreumaux and published by World Scientific. This book was released on 2013 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease is the most common form of senile dementia, affecting more than 24 million people worldwide. It is characterised pathologically by abnormally high levels of brain lesions in dead and dying neurons, and by elevated numbers of amyloid deposits in the walls of cerebral blood vessels. This book provides a panoramic view across recent in vitro and in vivo studies along with state-of-the-art computer simulations, designed to increase the readers' understanding of oligomerisation and fibril formation.
Book Synopsis Mechanisms of Cell Death by : Zahra Zakeri
Download or read book Mechanisms of Cell Death written by Zahra Zakeri and published by . This book was released on 1999 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains papers from a July 1998 conference held at the Queens College Campus of the City University of New York. Papers are arranged in sections on mechanisms and general considerations, programmed (developmental) cell death, and cell death and pathological and clinical situations. Specific topics
Book Synopsis Fluorine In Pharmaceutical And Medicinal Chemistry: From Biophysical Aspects To Clinical Applications by : Veronique Gouverneur
Download or read book Fluorine In Pharmaceutical And Medicinal Chemistry: From Biophysical Aspects To Clinical Applications written by Veronique Gouverneur and published by World Scientific. This book was released on 2012-04-26 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging.This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For examples, the reader will discover how fluorine has found its place as a key element improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging./a
Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Book Synopsis Apoptosis Induction/Suppression: A Feasible Approach for Natural Products to Treatment of Diseases, Volume II by : Hong Zhang
Download or read book Apoptosis Induction/Suppression: A Feasible Approach for Natural Products to Treatment of Diseases, Volume II written by Hong Zhang and published by Frontiers Media SA. This book was released on 2022-05-30 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Signal Transduction in Cancer by : David A. Frank
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :United States. Public Health Service. Office of the Surgeon General Publisher : ISBN 13 : Total Pages :728 pages Book Rating :4.:/5 (318 download)
Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
