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Molecular Biology Of Hematopoiesis Proceedings
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Download or read book Hematopoiesis written by David W. Golde and published by . This book was released on 1990 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronicles the latest advances in the cellular, molecular and biochemical analysis of hematopoiesis, including findings from both basic research and clinical medicine. In reporting new methodology for the isolation and characterization of stem cells, it details the successful in vitro establishment of hematopoietic and stromal cell lines, that have facilitated analysis of the complex interactions between growth factor-producing accessory cells and target hematopoietic cells. In probing the molecular biology, the book assesses progress in the dissection of the mechanisms controlling the expression of the hematopoietic growth factor genes. It highlights new data relating to oxygen regulation of erythropoietin gene expression and transcription factors controlling IL-1 or GM-CSF gene expression. In exploring receptor physiology, Hematopoiesis features considerable advances in the characterization of receptors for GM-CSF and IL-3 and knowledge gained from the cloned gene for the erythropoietin receptor. Recent results from clinical studies with different hematopoietic growth factors reveal that patients receiving
Book Synopsis Molecular Biology of Hematopoiesis Proceedings by : Nader G. Abraham
Download or read book Molecular Biology of Hematopoiesis Proceedings written by Nader G. Abraham and published by S Karger Ag. This book was released on 1996 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revealing the mechanisms responsible for normal and abnormal cell proliferation and differentiation, and presenting innovative approaches for blood and bone marrow transplantation, this publication is recommended reading for all oncologists and hematologists.
Book Synopsis Molecular Biology of Hemopoiesis by : Mehdi Tavassoli
Download or read book Molecular Biology of Hemopoiesis written by Mehdi Tavassoli and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perhaps no scientific field in recent years has gained in techniques and applications as much as molecular biology, and it is certainly no ex aggeration to·say that among all the applications of molecular biology, hematology in general, and hemopoiesis in particular, have benefited most. Owing to the applications of molecular biology, we now live in a golden era of hemopoiesis. Our understanding of the intricate regulatory system in hemopoiesis has vastly expanded. The potential for future exploration is ever expanding, and finally, the possibility of gene manipulation, has provided the promise of fundamental treatment and "cure" of many genetic disorders involving hemopoietic cells. In the ambiance of this rapidly moving scientific era, the necessity for review of what is being accomplished and where the technical potential is taking us needs no argument. This volume presents the proceedings of the third annual symposium on the Molecular Biology of Hemopoiesis, held in the Rye Town Hilton, New York, November 6 and 7, 1987, under the auspices of New York Medical College, Valhalla, New York. The fact that this was the third regular symposium covering this area in itself testifies to a need for exchange of the rapidly developing knowledge in this area. But this third symposium also coincided with the centennial of the National Institutes of Health and consequently the symposium was dedicated to this festive occasion.
Book Synopsis Molecular Biology of Hematopoiesis 5 by : Nader G. Abraham
Download or read book Molecular Biology of Hematopoiesis 5 written by Nader G. Abraham and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Molecular Biology of Hematopoiesis is dedicated to John W. Adam son, M. D. , Tadamitsu Kishimoto, M. D. , Robert C. Gallo, M. D. , Arthur W. Nienhuis, M. D. , and Franco Mandelli, M. D. , for their contributions in developing an overall view of the state-of-the-art knowledge in the field of hematopoiesis. Richard Champlin, among other renowned clinicians, presented updated information on stem cells and T-cell depletion for bone marrow transplant. A clinical update on thrombopoietin was presented by Pamela Hunt of Amgen and by Kenneth Kaushansky. Arthur Nienhuis' and Katherine Turner's contribu tions to our current knowledge and advances in the fields of growth factors and gene transfer were also recognized during the 9th Symposium on Molecular Biology of Hematopoiesis in Genoa. The chapters cover such diverse areas as preclinical and clinical updates on growth factors and positive and negative regulatory molecules. "Advances in Leukemia: Mechanism and Treatment by Interferon" was presented by Professor Sante Tura. Readers will find presentation of exciting advances that have occurred in the area of hematopoiesis. The elucidation of gene structures of key growth factor proteins such as IL-12 and IL-II will lead to new insights and new approaches in understanding the regulation of hematopoiesis, as well as application of new growth factors.
Book Synopsis Molecular Basis of Hematopoiesis by : Amittha Wickrema
Download or read book Molecular Basis of Hematopoiesis written by Amittha Wickrema and published by Springer Science & Business Media. This book was released on 2008-12-26 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although much is known with respect to blood cell formation and function, many new concepts in the areas of the regulation of hematopoietic stem cell commitment and the subsequent survival, proliferation, and differentiation of progenitors have been elucidated in the last five years. Our understanding of the microenvironment where stem cells reside and commit to distinct blood types (the niche) has grown significantly in recent years. Furthermore, blood cells have been used as the key model system to study microRNA function and the role of microRNAs in the transformation of normal cells into cancer cells. The current volume Molecular Basis of Hematopoiesis, edited by Amittha Wickrema & Barbara Kee, provides the most recent developments in the area in addition to a chapter on the utilization of basic science knowledge for the treatment of blood diseases. Each chapter in this book has been written and edited by faculty in major academic and research institutions around the world, who are pushing the frontiers of research in this important area.
Book Synopsis Molecular Biology of Hematopoiesis and Treatment of Leukemias and Lymphomas by : Nader G. Abraham
Download or read book Molecular Biology of Hematopoiesis and Treatment of Leukemias and Lymphomas written by Nader G. Abraham and published by S. Karger AG (Switzerland). This book was released on 1998 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematopoietic stem cells give rise to all the differentiated elements of the blood, and much progress has been made in recent years in understanding the intricate network of cytokines that regulate the survival, self-renewal and differentiation of these cells. This special issue of Acta Haematologica contains selected contributions from the 10th Symposium on 'Molecular Biology of Hematopoiesis', held in Hamburg in 1997. Leading specialists in the field discuss the roles of cytokines and report preclinical and clinical experience with growth factors and chemotherapy in the treatment of leukemia and lymphoma. Revealing the mechanisms responsible for normal and abnormal cell proliferation and differentiation, and presenting innovative approaches for blood and marrow transplantation, this publication is recommended reading for all oncologists and hematologists.
Book Synopsis Molecular Biology of Hematopoiesis 6 by : Nader G. Abraham
Download or read book Molecular Biology of Hematopoiesis 6 written by Nader G. Abraham and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Molecular Biology of Hematopoiesis is dedicated to many inter national scientists and clinicians for their contribution to the field of Hematology/ Oncology presented at the 11th International Symposium on Molecular Biology of Hematopoiesis, which was held in Bormio, Italy, June 25-29, 1998. The continuous support of the Presidents of the meeting, Professor F. Takaku, President of Jichi University, and E. D. Thomas, Nobel Laureate, was greatly acknowledged, especially Professor Takaku, for his vision and support for development of gene therapy in Japan. New information on BMT for autoimmune disease and organ transplantation was presented at the symposium and is published in this volume. Several new findings on gene therapy/transfer into HSC were presented by E. F. Vanin and A. Nienhuis, K. Humphries, 1. A. Nolta, H. E. Heslop, and M. K. Brenner. Professors S. Asano and K. Tani presented new studies on gene transfer into primates. Among the highlights were the new papers on gene transfer presented by G. Wage maker, N. G. Abraham, and M. Onoderea from R. M. BJaese's group. The use of BMT for organ transplant and autoim mune disease was updated and a representative paper is presented in this volume.
Download or read book Hematopoiesis written by Leonard I. Zon and published by Oxford University Press. This book was released on 2001-04-12 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematopoiesis, or the process of blood formation, has been extensively studied at both basic and clinical levels. Human diseases such as thalassemia, immunodeficiency, and leukemia represent defects in this process. Approaches to treat these disorders have required a basic understanding of the biology of blood cells. For instance, hemapoietic stem cell replacement or bone marrow transplantation has been used to ameliorate disease. This volume focuses on hematopoiesis at a cellular and molecular level, and establishes the basis for clinical manipulation of hematopoietic cells for therapeutic benefit. In Part I, the cellular characteristics of progenitors and stem cells are explored. Emphasis is placed on purification of stem cells and both in vitro and in vivo assays. The regulation of normal and leukemis stem cells is illustrated. An excellent discussion of potential use of these cells for gene therapy concludes this section. Hemapoiesis is easily studied during embryogenesis. Part II develops the concept of the waves of hemapoiesis during development. Comparative hematology is making a major comeback as a field in the 1990's. One hope is that general principles of hematopoiesis will be established by studying many models and systems. Part III delves into critical factors that regulate hematopoiesis, including both intracellular and extracellular signals. Part IV and V describe lineage programs for myeloid and lymphoid lineages. These chapters are meant to be illustrative of the different cell fates, but are not exhaustive. Part VI examines the genetics of hematopoisis, particularly in animal models. The hematopoietic system is in constant contact with stromal cells and endothelial cells during development and in the adult. Evidence suggests that endothelial cells and blood cells may arise from a common progenitor, the hemangioblast. Part VII and VIII discuss the stromal and endothelial cells with the emphasis on their interaction with hematopoietic cells.
Book Synopsis Hematopoietic Stem Cell Biology by : Motonari Kondo
Download or read book Hematopoietic Stem Cell Biology written by Motonari Kondo and published by Springer Science & Business Media. This book was released on 2009-12-04 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the summer of 1988, my developmental biology professor announced to the class that hematopoietic stem cells (HSCs) had finally been purified. Somehow, I never forgot the professor’s words. When I started working in Dr. Irv Weissman’s labo- tory at Stanford as a postdoctoral fellow, I realized that the findings mentioned by the professor were from Weissman’s laboratory and had been published in a 1988 edition of the journal Science. It has been over 20 years since the publication of that seminal paper, and since then tremendous advances in understanding the biology and maturation of HSCs, namely the process of hematopoiesis, which includes lymphocyte development, have been made. These discoveries were made possible in part by advancements in technology. For example, recent availability of user friendly fluorescence activated cell sorting (FACS) machines and monoclonal an- bodies with a variety of fluorescent labels has allowed more scientists to sort and analyze rare populations in the bone marrow, such as HSCs. All classes of hematopoietic cells are derived from HSCs. Stem cell biology draws enormous attention not only from scientists, but also from ordinary people because of the tremendous potential for development of new therapeutic application to diseases that currently lack any type of effective therapy. Thus, this type of “regenerative medicine” is a relatively new and attractive field in both basic science and clinical medicine.
Book Synopsis The Biology of Hematopoiesis by : Nicholas Dainiak
Download or read book The Biology of Hematopoiesis written by Nicholas Dainiak and published by John Wiley & Sons. This book was released on 1990 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents technical material on the most recent developments in the field of blood cell production, including the isolation and purification of haematopoietic stem cells, their characteristics in gene transfer and expression, and the applications of purified stem cells and recombinant growth factors in bone marrow therapy. Comprehensive in scope, the book includes reviews of the general history and status of the entire field.
Book Synopsis Proceedings of the 13th Symposium on Molecular Biology of Hematopoiesis and Treatment of Leukemia and Cancer by : Nader G Abraham
Download or read book Proceedings of the 13th Symposium on Molecular Biology of Hematopoiesis and Treatment of Leukemia and Cancer written by Nader G Abraham and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Biology Hematopoiesis and Treatment of Leukemia and Cancer by : Nader G. Abraham
Download or read book Molecular Biology Hematopoiesis and Treatment of Leukemia and Cancer written by Nader G. Abraham and published by S Karger Ag. This book was released on 2001-01-01 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Biology of Hematopoiesis 5 by : Nader G. Abraham
Download or read book Molecular Biology of Hematopoiesis 5 written by Nader G. Abraham and published by Springer. This book was released on 1996-11-30 with total page 737 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Molecular Biology of Hematopoiesis is dedicated to John W. Adam son, M. D. , Tadamitsu Kishimoto, M. D. , Robert C. Gallo, M. D. , Arthur W. Nienhuis, M. D. , and Franco Mandelli, M. D. , for their contributions in developing an overall view of the state-of-the-art knowledge in the field of hematopoiesis. Richard Champlin, among other renowned clinicians, presented updated information on stem cells and T-cell depletion for bone marrow transplant. A clinical update on thrombopoietin was presented by Pamela Hunt of Amgen and by Kenneth Kaushansky. Arthur Nienhuis' and Katherine Turner's contribu tions to our current knowledge and advances in the fields of growth factors and gene transfer were also recognized during the 9th Symposium on Molecular Biology of Hematopoiesis in Genoa. The chapters cover such diverse areas as preclinical and clinical updates on growth factors and positive and negative regulatory molecules. "Advances in Leukemia: Mechanism and Treatment by Interferon" was presented by Professor Sante Tura. Readers will find presentation of exciting advances that have occurred in the area of hematopoiesis. The elucidation of gene structures of key growth factor proteins such as IL-12 and IL-II will lead to new insights and new approaches in understanding the regulation of hematopoiesis, as well as application of new growth factors.
Book Synopsis Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases by : Nader G. Abraham
Download or read book Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases written by Nader G. Abraham and published by . This book was released on 1999 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cellular and Molecular Biology of Hemopoietic Stem Cell Differentiation by : Tak W. Mak
Download or read book Cellular and Molecular Biology of Hemopoietic Stem Cell Differentiation written by Tak W. Mak and published by New York : A.R. Liss. This book was released on 1982 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Biology of Hematopoiesis 5 by : Nader G. Abraham
Download or read book Molecular Biology of Hematopoiesis 5 written by Nader G. Abraham and published by Plenum Publishing Corporation. This book was released on 1996-01-01 with total page 715 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Molecular Biology of Hematopoiesis is dedicated to John W. Adam son, M. D. , Tadamitsu Kishimoto, M. D. , Robert C. Gallo, M. D. , Arthur W. Nienhuis, M. D. , and Franco Mandelli, M. D. , for their contributions in developing an overall view of the state-of-the-art knowledge in the field of hematopoiesis. Richard Champlin, among other renowned clinicians, presented updated information on stem cells and T-cell depletion for bone marrow transplant. A clinical update on thrombopoietin was presented by Pamela Hunt of Amgen and by Kenneth Kaushansky. Arthur Nienhuis' and Katherine Turner's contribu tions to our current knowledge and advances in the fields of growth factors and gene transfer were also recognized during the 9th Symposium on Molecular Biology of Hematopoiesis in Genoa. The chapters cover such diverse areas as preclinical and clinical updates on growth factors and positive and negative regulatory molecules. "Advances in Leukemia: Mechanism and Treatment by Interferon" was presented by Professor Sante Tura. Readers will find presentation of exciting advances that have occurred in the area of hematopoiesis. The elucidation of gene structures of key growth factor proteins such as IL-12 and IL-II will lead to new insights and new approaches in understanding the regulation of hematopoiesis, as well as application of new growth factors.
Book Synopsis Molecular Biology of B-Cell and T-Cell Development by : John G. Monroe
Download or read book Molecular Biology of B-Cell and T-Cell Development written by John G. Monroe and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.
