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Molecular Biology Of Hematopoiesis And Treatment Of Myeloproliferative Diseases
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Book Synopsis Molecular Biology of Hematopoiesis 5 by : Nader G. Abraham
Download or read book Molecular Biology of Hematopoiesis 5 written by Nader G. Abraham and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Molecular Biology of Hematopoiesis is dedicated to John W. Adam son, M. D. , Tadamitsu Kishimoto, M. D. , Robert C. Gallo, M. D. , Arthur W. Nienhuis, M. D. , and Franco Mandelli, M. D. , for their contributions in developing an overall view of the state-of-the-art knowledge in the field of hematopoiesis. Richard Champlin, among other renowned clinicians, presented updated information on stem cells and T-cell depletion for bone marrow transplant. A clinical update on thrombopoietin was presented by Pamela Hunt of Amgen and by Kenneth Kaushansky. Arthur Nienhuis' and Katherine Turner's contribu tions to our current knowledge and advances in the fields of growth factors and gene transfer were also recognized during the 9th Symposium on Molecular Biology of Hematopoiesis in Genoa. The chapters cover such diverse areas as preclinical and clinical updates on growth factors and positive and negative regulatory molecules. "Advances in Leukemia: Mechanism and Treatment by Interferon" was presented by Professor Sante Tura. Readers will find presentation of exciting advances that have occurred in the area of hematopoiesis. The elucidation of gene structures of key growth factor proteins such as IL-12 and IL-II will lead to new insights and new approaches in understanding the regulation of hematopoiesis, as well as application of new growth factors.
Book Synopsis Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases by : Nader G. Abraham
Download or read book Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases written by Nader G. Abraham and published by . This book was released on 1999 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Biology of Hematopoiesis 6 by : Nader G. Abraham
Download or read book Molecular Biology of Hematopoiesis 6 written by Nader G. Abraham and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Molecular Biology of Hematopoiesis is dedicated to many inter national scientists and clinicians for their contribution to the field of Hematology/ Oncology presented at the 11th International Symposium on Molecular Biology of Hematopoiesis, which was held in Bormio, Italy, June 25-29, 1998. The continuous support of the Presidents of the meeting, Professor F. Takaku, President of Jichi University, and E. D. Thomas, Nobel Laureate, was greatly acknowledged, especially Professor Takaku, for his vision and support for development of gene therapy in Japan. New information on BMT for autoimmune disease and organ transplantation was presented at the symposium and is published in this volume. Several new findings on gene therapy/transfer into HSC were presented by E. F. Vanin and A. Nienhuis, K. Humphries, 1. A. Nolta, H. E. Heslop, and M. K. Brenner. Professors S. Asano and K. Tani presented new studies on gene transfer into primates. Among the highlights were the new papers on gene transfer presented by G. Wage maker, N. G. Abraham, and M. Onoderea from R. M. BJaese's group. The use of BMT for organ transplant and autoim mune disease was updated and a representative paper is presented in this volume.
Book Synopsis Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases by :
Download or read book Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases written by and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Basis of Hematopoiesis by : Amittha Wickrema
Download or read book Molecular Basis of Hematopoiesis written by Amittha Wickrema and published by Springer Science & Business Media. This book was released on 2008-12-26 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although much is known with respect to blood cell formation and function, many new concepts in the areas of the regulation of hematopoietic stem cell commitment and the subsequent survival, proliferation, and differentiation of progenitors have been elucidated in the last five years. Our understanding of the microenvironment where stem cells reside and commit to distinct blood types (the niche) has grown significantly in recent years. Furthermore, blood cells have been used as the key model system to study microRNA function and the role of microRNAs in the transformation of normal cells into cancer cells. The current volume Molecular Basis of Hematopoiesis, edited by Amittha Wickrema & Barbara Kee, provides the most recent developments in the area in addition to a chapter on the utilization of basic science knowledge for the treatment of blood diseases. Each chapter in this book has been written and edited by faculty in major academic and research institutions around the world, who are pushing the frontiers of research in this important area.
Book Synopsis Biology and Treatment of Leukemia and Bone Marrow Neoplasms by : Vinod Pullarkat
Download or read book Biology and Treatment of Leukemia and Bone Marrow Neoplasms written by Vinod Pullarkat and published by Springer Nature. This book was released on 2021-10-09 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.
Book Synopsis Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases by : Nader G. Abraham
Download or read book Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases written by Nader G. Abraham and published by S Karger Ag. This book was released on 1999-01-01 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special issue of Acta Haematologica contains selected papers presented at the 11th International Symposium on Molecular Biology of Hematopoiesis, held in Bormio, Italy in June 1998. The following topics are considered: - the use of BMT for organ transplantation and autoimmune disease - new methods for stable gene transfer with increased transduction rate into pluripotent human stem cells - the state of the art in retrovirus gene transfer - the use of adenoviral- and retroviral-mediated interferon gene transfer for a possible treatment of patients with chronic myelogenous leukemia and colon cancer Bringing together the experience of leading specialists, this publication will be appreciated by hematologists, oncologists, and scientists working on gene therapy.
Book Synopsis 11th Symposium on Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases by :
Download or read book 11th Symposium on Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases written by and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases by : Nader G. Abraham
Download or read book Molecular Biology of Hematopoiesis and Treatment of Myeloproliferative Diseases written by Nader G. Abraham and published by S. Karger AG (Switzerland). This book was released on 1998 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hematopoietic Stem Cell Biology by : Motonari Kondo
Download or read book Hematopoietic Stem Cell Biology written by Motonari Kondo and published by Springer Science & Business Media. This book was released on 2009-12-04 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the summer of 1988, my developmental biology professor announced to the class that hematopoietic stem cells (HSCs) had finally been purified. Somehow, I never forgot the professor’s words. When I started working in Dr. Irv Weissman’s labo- tory at Stanford as a postdoctoral fellow, I realized that the findings mentioned by the professor were from Weissman’s laboratory and had been published in a 1988 edition of the journal Science. It has been over 20 years since the publication of that seminal paper, and since then tremendous advances in understanding the biology and maturation of HSCs, namely the process of hematopoiesis, which includes lymphocyte development, have been made. These discoveries were made possible in part by advancements in technology. For example, recent availability of user friendly fluorescence activated cell sorting (FACS) machines and monoclonal an- bodies with a variety of fluorescent labels has allowed more scientists to sort and analyze rare populations in the bone marrow, such as HSCs. All classes of hematopoietic cells are derived from HSCs. Stem cell biology draws enormous attention not only from scientists, but also from ordinary people because of the tremendous potential for development of new therapeutic application to diseases that currently lack any type of effective therapy. Thus, this type of “regenerative medicine” is a relatively new and attractive field in both basic science and clinical medicine.
Book Synopsis Molecular Hematology by : Drew Provan
Download or read book Molecular Hematology written by Drew Provan and published by John Wiley & Sons. This book was released on 2010-01-28 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its third edition, Molecular Hematology has beenthoroughly updated to incorporate recent advances in molecularresearch. The aim of the book remains the same – to provide acore knowledge base for those with little exposure to molecularbiological techniques. Molecular biology has had a significant impact on theunderstanding of blood diseases and this book shows how moleculartechniques can be used in diagnosis and treatment. In each chapterthe authors summarize the impact made by molecular research on theunderstanding of the pathogenesis of the disorder featured, andhighlight the molecular strategies that exist, or are beingcurrently investigated, for therapeutic purposes. There are sixbrand new chapters in this edition: History and development of molecular biology Pharmacogenomics Anemia of chronic disease Molecular pathogenesis of malaria Molecular basis of transplantation Cancer stem cells Presented in an extremely readable style with clear two-colorline diagrams, this book is designed for the non-specialist andwill be an invaluable resource for all trainee hematologists.
Book Synopsis Myeloproliferative Disorders by : Richard T. Silver
Download or read book Myeloproliferative Disorders written by Richard T. Silver and published by CRC Press. This book was released on 2007-10-11 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the recent discovery of JAK2 mutations in myeloproliferative disorders, medical science has taken a revolutionary stride forward toward understanding the pathogenesis of these diseases. This new advancement translates not only to a more rapid and reliable diagnosis, but also allows groundbreaking research into the development of new therapeuti
Book Synopsis Hematopoietic Stem Cells by : Louis M. Pelus
Download or read book Hematopoietic Stem Cells written by Louis M. Pelus and published by Springer Nature. This book was released on 2022-10-18 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume collects updates on the technical advances in hematopoietic stem cell research and incorporates new techniques focused on the molecular/genetic, cellular, and whole organism levels. Exploring methods that apply stress to hematopoiesis, the book also contains chapters focused on better understanding the role of hematopoietic niches and their cellular components, as well as in vivo models that test and quantitate stem cell function and are key to further development of therapeutic applications. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Hematopoietic Stem Cells: Methods and Protocols serves as a valued addition to laboratories focused on understanding hematopoietic stem cell biology and the therapeutic advances that can be derived from it.
Book Synopsis Molecular Biology of Hematopoiesis and Treatment of Leukemias and Lymphomas by : Nader G. Abraham
Download or read book Molecular Biology of Hematopoiesis and Treatment of Leukemias and Lymphomas written by Nader G. Abraham and published by S. Karger AG (Switzerland). This book was released on 1998 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematopoietic stem cells give rise to all the differentiated elements of the blood, and much progress has been made in recent years in understanding the intricate network of cytokines that regulate the survival, self-renewal and differentiation of these cells. This special issue of Acta Haematologica contains selected contributions from the 10th Symposium on 'Molecular Biology of Hematopoiesis', held in Hamburg in 1997. Leading specialists in the field discuss the roles of cytokines and report preclinical and clinical experience with growth factors and chemotherapy in the treatment of leukemia and lymphoma. Revealing the mechanisms responsible for normal and abnormal cell proliferation and differentiation, and presenting innovative approaches for blood and marrow transplantation, this publication is recommended reading for all oncologists and hematologists.
Book Synopsis Myeloproliferative Neoplasms: Biology and Treatment by :
Download or read book Myeloproliferative Neoplasms: Biology and Treatment written by and published by Frontiers Media SA. This book was released on 2024-04-10 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) - including polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PM) - are clonal stem cell disorders characterized by acquired activating mutations which result in an excessive production of red blood cells, platelets, and neutrophils. Recent advances in the understanding of the molecular biology and genomics of MPNs have led to the development of novel targeted treatment approaches; however, the high rate of life-threatening vascular events and the high risk of disease progression with myelofibrotic and leukemic transformation continue to present challenges in the management of MPNs. Thereby, there remains a need for novel treatment strategies. Recently, research has revealed a role for clonal hematopoiesis, driver mutations and inflammation in thrombosis risk, which may provide a basis for novel thrombosis-prevention strategies.
Download or read book Hematopoiesis written by Leonard I. Zon and published by Oxford University Press. This book was released on 2001-04-12 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematopoiesis, or the process of blood formation, has been extensively studied at both basic and clinical levels. Human diseases such as thalassemia, immunodeficiency, and leukemia represent defects in this process. Approaches to treat these disorders have required a basic understanding of the biology of blood cells. For instance, hemapoietic stem cell replacement or bone marrow transplantation has been used to ameliorate disease. This volume focuses on hematopoiesis at a cellular and molecular level, and establishes the basis for clinical manipulation of hematopoietic cells for therapeutic benefit. In Part I, the cellular characteristics of progenitors and stem cells are explored. Emphasis is placed on purification of stem cells and both in vitro and in vivo assays. The regulation of normal and leukemis stem cells is illustrated. An excellent discussion of potential use of these cells for gene therapy concludes this section. Hemapoiesis is easily studied during embryogenesis. Part II develops the concept of the waves of hemapoiesis during development. Comparative hematology is making a major comeback as a field in the 1990's. One hope is that general principles of hematopoiesis will be established by studying many models and systems. Part III delves into critical factors that regulate hematopoiesis, including both intracellular and extracellular signals. Part IV and V describe lineage programs for myeloid and lymphoid lineages. These chapters are meant to be illustrative of the different cell fates, but are not exhaustive. Part VI examines the genetics of hematopoisis, particularly in animal models. The hematopoietic system is in constant contact with stromal cells and endothelial cells during development and in the adult. Evidence suggests that endothelial cells and blood cells may arise from a common progenitor, the hemangioblast. Part VII and VIII discuss the stromal and endothelial cells with the emphasis on their interaction with hematopoietic cells.
Book Synopsis Myeloproliferative Neoplasms by : Srdan Verstovsek
Download or read book Myeloproliferative Neoplasms written by Srdan Verstovsek and published by Humana Press. This book was released on 2010-10-21 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This succinct resource provides an ideal balance of the biology and practical therapeutic strategies for classic and non-classic BCR-ABL-negative myeloproliferative neoplasms. Utilizing current World Health Organization nomenclature, classification, and diagnostic criteria, international experts have assembled to convey the most up-to-date knowledge in this rapidly evolving field. The opening chapters cover the diagnosis and classification, genetics, cytogenetic findings, and prognostic factors of MPNs. Further chapters explore therapies specific to the different disease entities, including polycythemia vera, essential thrombocytopenia, myelofibrosis, and eosinophilic disorders, and mastocytosis. Unique areas of discussion include JAK2 inhibitor therapy, hematopoietic stem cell transplantation, and blastic transformation. A valuable reference for practicing hematologists, this forefront book enriches our understanding of recent discoveries and their impact on conventional and investigational treatments.
