Molecular Aspects Of G Protein Coupled Receptors

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Molecular Aspects of G Protein-coupled Receptors

Author : Francisco Ciruela
Publisher : Nova Publishers
ISBN 13 : 9781600219153
Total Pages : 328 pages
Book Rating : 4.2/5 (191 download)

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Book Synopsis Molecular Aspects of G Protein-coupled Receptors by : Francisco Ciruela

Download or read book Molecular Aspects of G Protein-coupled Receptors written by Francisco Ciruela and published by Nova Publishers. This book was released on 2008 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the recent years, studies based on two-hybrid screens, proteomic, biochemical and cell biology approaches, have shown that intracellular domains of G protein-coupled receptors (GPCR) or heptaspanning membrane receptors (HSMRs) interact with intracellular proteins. These interactions are the basis of a protein network associated to these receptors which includes scaffolding proteins containing one or several PDZ (post-synaptic density-95, discs large, zona occludens-1) domains, signalling proteins and proteins of the cytoskeleton. The present book is focused on the emerging evidence for interactions of G protein-coupled receptors with scaffolding, cytoskeletal and signalling proteins that will play a role in the targeting, anchoring and functioning of these receptors in the plasma membrane, thus contributing to cell development and plasticity.

G Protein-coupled Receptors

Author : Georges Vauquelin
Publisher : John Wiley & Sons
ISBN 13 : 9780470516645
Total Pages : 264 pages
Book Rating : 4.5/5 (166 download)

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Book Synopsis G Protein-coupled Receptors by : Georges Vauquelin

Download or read book G Protein-coupled Receptors written by Georges Vauquelin and published by John Wiley & Sons. This book was released on 2008-03-11 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions ranging from cell-cell communication processes to physiological responses. They play an important role in a variety of diseases from cancer and diabetes, to neurodegenerative, inflammatory and respiratory disorders. GPCRs are therefore of utmost interest in drug development: over half of all prescription drugs currently on the market act by targeting these receptors directly or indirectly. G Protein-coupled Receptors: Molecular Pharmacology provides a clear summary of the current knowledge in this fast-evolving field. The book sets out with an introduction to signalling molecules and their receptors, and an overview of the technical approaches used to investigate these interactions. Structural, functional and especially pharmacological aspects of GPCRs are then discussed in more detail and much attention is devoted to the analysis and interpretation of experimental data. The now widespread use of recombinant cell lies, receptor mutants and related artifices in drug research is critically evaluated. Special attention is also devoted to topical but often poorly understood concepts, such as insurmountable antagonism, inverse agonism and allosteric interactions. By combining general information with the major state-of-the-art concepts in GPCR-research, this outstanding book equips the reader with the necessary background for understanding and critically evaluating the current literature. Written by two experts from academia and industry, G Protein-coupled Receptors: Molecular Pharmacology offers a unique view of academic and applied approaches aiming to reveal new ideas in pharmaceutical research. The book is of interest to anyone involved in drug development and preclinical research and those who need to function within multi-disciplinary teams in the pharmaceutical industry: from investigators to product managers or clinicians who seek to have a broad mechanistic understanding of drug-receptor interactions. It is also an invaluable resource for final year undergraduate and postgraduate students in pharmacology and cell and molecular biology.

G Protein-Coupled Receptors - Part B

Author :
Publisher : Elsevier
ISBN 13 : 0323994350
Total Pages : 194 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis G Protein-Coupled Receptors - Part B by :

Download or read book G Protein-Coupled Receptors - Part B written by and published by Elsevier. This book was released on 2023-01-25 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: G Protein-Coupled Receptors, Part B, Volume 195 represents the largest class of cell H103 surface proteins that have intricate involvement in nearly every physiological process in our body. Approximately one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. Sections in this volume include Adhesion G protein-coupled receptors: Structure and functions, Molecular and cellular mechanisms underlying brain region-specific cannabinoid receptor modulation by estradiol across the rodent estrus cycle, Probing the orphan receptors: Tools and directions, Asymmetric activation of Class C GPCRs, Common and selective signal transduction mechanisms of GPCRs, and much more. Covers a broad range of topics related to GPCR activation and signaling Provides several receptor systems, with an emphasis on emerging paradigms Includes different processes and model systems, with a focus on GPCRs

G Protein-Coupled Receptors

Author : Tiina P. Iismaa
Publisher : Springer Science & Business Media
ISBN 13 : 3662219301
Total Pages : 189 pages
Book Rating : 4.6/5 (622 download)

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Book Synopsis G Protein-Coupled Receptors by : Tiina P. Iismaa

Download or read book G Protein-Coupled Receptors written by Tiina P. Iismaa and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the recent advances in the structural and functional characterization of receptors that influence intracellular signalling events through interaction with intracellular GTP-binding proteins (G proteins). Molecular cloning of members of the G protein-coupled receptor superfamily has complemented pharmacological investigations in providing a realization of the structural and functional diversity of these receptors. An increased understanding of the involvement of particular receptor subtypes in normal and pathophysiological processes represents exciting possibilities for the development of highly specific and effective therapeutic agents.

Molecular Biology of G-Protein-Coupled Receptors

Author : M. Brann
Publisher : Springer Science & Business Media
ISBN 13 : 1468467727
Total Pages : 343 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Molecular Biology of G-Protein-Coupled Receptors by : M. Brann

Download or read book Molecular Biology of G-Protein-Coupled Receptors written by M. Brann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: LESLIE L. IVERSEN The present series of volumes is well timed, as the impact of molecular genetics on pharmacology has been profound, and a comprehensive review of the rapid advances of the past decade is much needed. Since the pioneering work of Dale, Ariens, and others in the early years of this century, much of pharmacology has been founded on the concept of receptors. To begin with, the receptor was conceived of as a "black box," which recognized and transduced the biological effects of neurotransmit ters, hormones, or other biological messengers-and which could also represent a target for man-made drugs. It is only in the last two decades that "molecular pharmacology" has blossomed, first with the advent of radioligand binding techniques and second messenger studies which greatly facilitated the biochemical study of drug-receptor interactions, and latterly with increasing knowledge of the molecular architecture of the receptor proteins themselves. This started with the traditional biochemical approach of isolating and purifying the receptor molecules. This proved to be a task of immense technical difficulty because of the low density of receptors in most biological source tissues, although there were some notable successes, e. g. , the purification of the nicotinic acetylcholine receptor from the electric organ of Torpedo. It was the ap plication of molecular genetics technology during the 1980s, however, which really accelerated progress in this field.

G Protein-Coupled Receptor Signaling

Author : Mario Tiberi
Publisher : Humana Press
ISBN 13 : 9781493991204
Total Pages : 406 pages
Book Rating : 4.9/5 (912 download)

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Book Synopsis G Protein-Coupled Receptor Signaling by : Mario Tiberi

Download or read book G Protein-Coupled Receptor Signaling written by Mario Tiberi and published by Humana Press. This book was released on 2019-03-01 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume assembles comprehensive protocols to assist with the study of structural, molecular, cell biological, and in vivo facets of GPCRs, and to enable the development of experimental tools for screening novel GPCR drugs. Sections explore the tweaking of ligands, bioluminescence and FRET approaches, specific GPCR signaling properties, as well as visualization of subcellular compartmentalization. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, G Protein-Coupled Receptor Signaling: Methods and Protocols serves as an ideal reference for life scientists working in a variety of research fields including molecular pharmacology, cell and developmental biology, brain behavior and physiology, drug development and screening. Chapter 4 is available open access under a CC BY 4.0 license via link.springer.com.

G Protein-Coupled Receptors

Author : David Poyner
Publisher : John Wiley & Sons
ISBN 13 : 0470749229
Total Pages : 310 pages
Book Rating : 4.4/5 (77 download)

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Book Synopsis G Protein-Coupled Receptors by : David Poyner

Download or read book G Protein-Coupled Receptors written by David Poyner and published by John Wiley & Sons. This book was released on 2009-12-11 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: G-Protein Coupled Receptors (GPCRs) are not only the largest protein family in the human genome but are also the single biggest target for therapeutic agents. Research into GPCRs is therefore growing at a fast pace and the range of techniques that can be applied to GPCRs is vast and continues to grow. This book provides an invaluable bench-side guide into the best and most up-to-date techniques for current and future research on GPCRs. With contributions from leading international authorities, this book equips readers with clear and detailed protocols for both well-known and up-and-coming techniques along with hints and tips for success. All the methods have been tried and tested by leading international research labs and are presented in easy-to-follow stages along with a useful overview of each technique. This book is an essential resource for all researchers in molecular biology, biochemistry, pharmacology and for graduate students.

G Protein Coupled Receptors

Author :
Publisher : Academic Press
ISBN 13 : 0123918723
Total Pages : 440 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis G Protein Coupled Receptors by :

Download or read book G Protein Coupled Receptors written by and published by Academic Press. This book was released on 2013-01-17 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers G protein coupled receptors Contains chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain

G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation

Author :
Publisher : Academic Press
ISBN 13 : 0128137754
Total Pages : 200 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation by :

Download or read book G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation written by and published by Academic Press. This book was released on 2018-05-15 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists, and drawn from international sources Offers a wide range of perspectives on specific subjects

G Protein-Coupled Receptors - Part A

Author :
Publisher : Elsevier
ISBN 13 : 0323994326
Total Pages : 232 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis G Protein-Coupled Receptors - Part A by :

Download or read book G Protein-Coupled Receptors - Part A written by and published by Elsevier. This book was released on 2022-11-08 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: G Protein-Coupled Receptors, Part A, Volume 193 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field. G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins with an intricate involvement of nearly every physiological process in our body. Approximately, one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. These two volumes are focused on activation, signaling and regulation of GPCRs with specific examples of receptor systems and cellular processes. Covers a broad range of topics related to GPCR activation and signaling Covers several receptor systems with an emphasis on emerging paradigms Covers different processes and model systems with a focus on GPCRs

G Protein-Coupled Receptors in Drug Discovery

Author : Wayne R. Leifert
Publisher : Humana Press
ISBN 13 : 9781603273169
Total Pages : 0 pages
Book Rating : 4.2/5 (731 download)

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Book Synopsis G Protein-Coupled Receptors in Drug Discovery by : Wayne R. Leifert

Download or read book G Protein-Coupled Receptors in Drug Discovery written by Wayne R. Leifert and published by Humana Press. This book was released on 2009-06-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The G protein-coupled receptors (GPCRs) and associated peripheral G proteins underpin a multitude of physiological processes. The GPCRs represent one of the largest superfamilies in the human genome and are a significant target for bioactive and drug discovery programs. It is estimated that greater than 50% of all drugs, including those in development, currently target GPCRs. Many of the characterized GPCRs have known ligands; however, approximately 20% of GPCRs are described as orphan GPCRs, apparent GPCRs that share the generic high-level structure charact- istic of GPCRs but whose endogenous ligand is not known. Therefore, it is expected that the field of GPCR drug discovery and development will greatly expand in the coming years with emphasis on new generations of drugs against GPCRs with unique therapeuticuseswhichmayincludedrugssuchasallostericregulators,inverseagonists, and identification of orphan GPCR ligands. AswelearnmoreaboutthemolecularsignalingcascadesfollowingGPCRactivation, we acquire a better appreciation of the complexity of cell signaling and as a result, also acquire a vast array ofnew molecularmethods toinvestigate these andother processes. Thegeneralaimofthisbookistoprovideresearcherswitharangeofprotocolsthatmay be useful in their GPCR drug discovery programs. It is also the basis for the devel- ment of future assays in this field. Therefore, the range of topics covered and the appropriate methodological approaches in GPCR drug discovery are reflected in this book. Itisinterestingtonotethatfuturedirectionsindrugdiscoverywillrequireinput and collaboration from a plethora of fields of research. As such, this book will likely be of interest to scientists involved in such fields as molecular biology, pharmacology, biochemistry, cellular signaling, and bio-nanotechnology.

G Protein-Coupled Receptors

Author : Jesus Giraldo
Publisher : Royal Society of Chemistry
ISBN 13 : 1849733449
Total Pages : 548 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis G Protein-Coupled Receptors by : Jesus Giraldo

Download or read book G Protein-Coupled Receptors written by Jesus Giraldo and published by Royal Society of Chemistry. This book was released on 2011-08-16 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs. The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic. The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design.

G Protein-Coupled Receptors - Part A

Author :
Publisher : Elsevier
ISBN 13 : 0323994318
Total Pages : 230 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis G Protein-Coupled Receptors - Part A by :

Download or read book G Protein-Coupled Receptors - Part A written by and published by Elsevier. This book was released on 2022-12 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: G Protein-Coupled Receptors, Part A, Volume 193 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field. G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins with an intricate involvement of nearly every physiological process in our body. Approximately, one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. These two volumes are focused on activation, signaling and regulation of GPCRs with specific examples of receptor systems and cellular processes. Covers a broad range of topics related to GPCR activation and signaling Covers several receptor systems with an emphasis on emerging paradigms Covers different processes and model systems with a focus on GPCRs

G Protein-Coupled Receptors in Drug Discovery

Author : Wayne R. Leifert
Publisher : Humana Press
ISBN 13 : 9781493957064
Total Pages : 376 pages
Book Rating : 4.9/5 (57 download)

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Book Synopsis G Protein-Coupled Receptors in Drug Discovery by : Wayne R. Leifert

Download or read book G Protein-Coupled Receptors in Drug Discovery written by Wayne R. Leifert and published by Humana Press. This book was released on 2016-08-23 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The G protein-coupled receptors (GPCRs) and associated peripheral G proteins underpin a multitude of physiological processes. The GPCRs represent one of the largest superfamilies in the human genome and are a significant target for bioactive and drug discovery programs. It is estimated that greater than 50% of all drugs, including those in development, currently target GPCRs. Many of the characterized GPCRs have known ligands; however, approximately 20% of GPCRs are described as orphan GPCRs, apparent GPCRs that share the generic high-level structure charact- istic of GPCRs but whose endogenous ligand is not known. Therefore, it is expected that the field of GPCR drug discovery and development will greatly expand in the coming years with emphasis on new generations of drugs against GPCRs with unique therapeuticuseswhichmayincludedrugssuchasallostericregulators,inverseagonists, and identification of orphan GPCR ligands. AswelearnmoreaboutthemolecularsignalingcascadesfollowingGPCRactivation, we acquire a better appreciation of the complexity of cell signaling and as a result, also acquire a vast array ofnew molecularmethods toinvestigate these andother processes. Thegeneralaimofthisbookistoprovideresearcherswitharangeofprotocolsthatmay be useful in their GPCR drug discovery programs. It is also the basis for the devel- ment of future assays in this field. Therefore, the range of topics covered and the appropriate methodological approaches in GPCR drug discovery are reflected in this book. Itisinterestingtonotethatfuturedirectionsindrugdiscoverywillrequireinput and collaboration from a plethora of fields of research. As such, this book will likely be of interest to scientists involved in such fields as molecular biology, pharmacology, biochemistry, cellular signaling, and bio-nanotechnology.

Cell Biology, Physiology and Molecular Pharmacology of G protein Coupled Receptors

Author : Sameer Mohammad
Publisher : Frontiers Media SA
ISBN 13 : 288974213X
Total Pages : 146 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Cell Biology, Physiology and Molecular Pharmacology of G protein Coupled Receptors by : Sameer Mohammad

Download or read book Cell Biology, Physiology and Molecular Pharmacology of G protein Coupled Receptors written by Sameer Mohammad and published by Frontiers Media SA. This book was released on 2022-01-28 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:

G Protein Coupled Receptors

Author :
Publisher : Academic Press
ISBN 13 : 012407944X
Total Pages : 528 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis G Protein Coupled Receptors by :

Download or read book G Protein Coupled Receptors written by and published by Academic Press. This book was released on 2013-01-28 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers G protein coupled receptors, and includes chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers G protein coupled receptors Contains chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation

Pharmacology of G Protein Coupled Receptors

Author : Richard R. Neubig
Publisher : Academic Press
ISBN 13 : 0123859522
Total Pages : 408 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Pharmacology of G Protein Coupled Receptors by : Richard R. Neubig

Download or read book Pharmacology of G Protein Coupled Receptors written by Richard R. Neubig and published by Academic Press. This book was released on 2011-09-19 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: G protein coupled receptors remain the most important class of therapeutic targets in medicine. In the last 5 years, tremendous advances have been made in our understanding of the structure and mechanism of this critical family of drug targets. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors. It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones. In addition, emerging drug targets such as receptor families for fatty acids, carboxylic acids, lipid mediators, etc. are included. Final chapters cover novel mechanisms of signal regulation through PDZ domains and RGS proteins. This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists