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Author : Byung Pal Yu
Publisher : CRC PressI Llc
ISBN 13 : 9780849349942
Total Pages : 281 pages
Book Rating : 4.3/5 (499 download)
Download or read book Modulation of Aging Processes by Dietary Restriction written by Byung Pal Yu and published by CRC PressI Llc. This book was released on 1994 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : E.J. Masoro
Publisher : Elsevier
ISBN 13 : 0080528422
Total Pages : 193 pages
Book Rating : 4.0/5 (85 download)
Download or read book Caloric Restriction: A Key to Understanding and Modulating Aging written by E.J. Masoro and published by Elsevier. This book was released on 2002-12-20 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, it has been known that when rats and mice are given a reduced amount of food, their life span is increased and they remain healthy and vigorous at advanced ages. What is the reason for this change in the usual pattern of aging? The evidence is overwhelming that the life extension results from a slowing of aging processes. And the factor responsible is the decrease in caloric intake. The obvious question: How does this factor work? A good question - and the reason that research on the anti-aging action of caloric restriction is today one of the most studied research areas in biological gerontology. For it is felt that if the biological mechanisms of the anti-aging action of caloric restriction can be uncovered, we would gain an understanding of the basic nature of aging processes, which would, in turn, yield possible interventions in human aging. This book aims to provide the growing number of researchers in this field (faculty, postdoctoral trainees, and graduate students) with a detailed knowledge of what is known about caloric restriction within the frame of gerontology, as well as insights on future of this field.
Author : Donald K. Ingram
Publisher :
ISBN 13 :
Total Pages : 440 pages
Book Rating : 4.E/5 ( download)
Download or read book The Potential for Nutritional Modulation of Aging Processes written by Donald K. Ingram and published by . This book was released on 1991 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Reports the proceedings of a conference on the fundamental effects of nutritional variables on aging processes. Variables range from population demography and epidemiology to biochemistry and molecular genetics to the involvement of nutritional variables in the etiology of specific diseases. Research on animal models of the effects of calorie restriction on a number of age-related phenomena ranging from genetic expression to learning and memory and the involvement of specific nutrients on age-related processes are presented.
Author : S.I. Rattan
Publisher : Springer Science & Business Media
ISBN 13 : 9781402013690
Total Pages : 354 pages
Book Rating : 4.0/5 (136 download)
Download or read book Modulating Aging and Longevity written by S.I. Rattan and published by Springer Science & Business Media. This book was released on 2003-09-30 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: After decades of systematic collection of data describing age-related changes in organisms, organs, tissues, cells and macromolecules, biogerontologists are now in a position to construct general principles of ageing and explore various possibilities of intervention using rational approaches. While not giving serious consideration to the claims made by charlatans, it cannot be ignored that several researchers are making genuine attempts to test and develop various means of intervention for the prevention and treatment of age-related diseases, for regaining the functional abilities and for prolonging the lifespan of experimental organisms. This book provides the most up-to-date information and a critical evaluation of a variety of approaches being tried for modulating aging and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress. The goal of research on ageing is not to increase human longevity regardless of the consequences, but to increase active longevity free from disability and functional dependence.
Author : Vladimir I. Titorenko
Publisher : Frontiers E-books
ISBN 13 : 2889190900
Total Pages : 102 pages
Book Rating : 4.8/5 (891 download)
Download or read book The spatiotemporal dynamics of longevity-defining cellular processes and its modulation by genetic, dietary and pharmacological anti-aging interventions written by Vladimir I. Titorenko and published by Frontiers E-books. This book was released on with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging of multicellular and unicellular eukaryotic organisms is a highly complex biological phenomenon that affects a plethora of processes within cells. This wide array of longevity-defining cellular processes - which are governed by an evolutionarily conserved signaling network - includes oxidative metabolism and protein synthesis in mitochondria, lipid and carbohydrate metabolism, NAD+ homeostasis, amino acid biosynthesis and degradation, ammonium and amino acid uptake, ribosome biogenesis and translation, proteasomal protein degradation, nuclear DNA replication, chromatin assembly and maintenance, actin organization, apoptosis, necrosis, autophagy, protein folding, stress response, signal transduction, cell cycle, and cell growth. The focus of this Frontiers Special Topic Issue is on an important conceptual advance in our understanding of how cells integrate and control these numerous processes and how genetic, dietary and pharmacological anti-aging interventions extend longevity by altering their functional states and spatiotemporal dynamics. The Issue will highlight the various strategies used by evolutionarily diverse organisms for coordinating these longevity-defining cellular processes in space and time, critically evaluate the molecular and cellular mechanisms underlying such coordination, and outline the most important unanswered questions and directions for future research in this vibrant and rapidly evolving field.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309158834
Total Pages : 192 pages
Book Rating : 4.3/5 (91 download)
Download or read book Providing Healthy and Safe Foods As We Age written by Institute of Medicine and published by National Academies Press. This book was released on 2010-11-29 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Does a longer life mean a healthier life? The number of adults over 65 in the United States is growing, but many may not be aware that they are at greater risk from foodborne diseases and their nutritional needs change as they age. The IOM's Food Forum held a workshop October 29-30, 2009, to discuss food safety and nutrition concerns for older adults.
Author : Richard Weindruch
Publisher : Charles C Thomas Pub Limited
ISBN 13 : 9780398054960
Total Pages : 436 pages
Book Rating : 4.0/5 (549 download)
Download or read book The Retardation of Aging and Disease by Dietary Restriction written by Richard Weindruch and published by Charles C Thomas Pub Limited. This book was released on 1988-01-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mitalie B. Shah
Publisher :
ISBN 13 :
Total Pages : 234 pages
Book Rating : 4.:/5 (785 download)
Download or read book MicroRNAs Modulators of Dietary Restriction and Aging in Caenorhabditis Elegans written by Mitalie B. Shah and published by . This book was released on 2012 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging is a universal phenomenon that is experienced by diverse organism. Aging can be defined broadly as progressive decline in cellular functions in an organism with increasing age, decreasing the ability to survive challenges. Understanding and deciphering the mechanisms involved in this process has been a key focus of current science. An important goal of aging research is not only to identify different approaches to maximize human lifespan, but to also improve the quality of life with increasing age. MicroRNAs (miRNAs) are known to regulate a range of biological processes including cell differentiation, cell death, development, oncogenesis, and metabolism, but little is known about how they impact the biology of aging. Our research mainly focuses on identifying how miRNAs, small molecules that target partially homologous transcripts to block their translational expression, influence healthspan and lifespan in C. elegans. We have identified many mir deletion mutants that impact different aspects of aging like longevity, metabolic and muscle aging. There are four measures that reflect how well or how poorly the animals are aging: age pigment levels, swimming body bend frequency assays, pharyngeal pumping rates, and lifespan studies. Applying these tests, we have studied miRNAs mir-1, mir-256 and mir-238 in a focused manner. Importantly, we have also found that the mir-80 mutant modulates dietary restriction- a metabolic condition in which reduced caloric intake significantly increases lifespan in a wide range of species. mir-80 mutant exhibits multiple parameters of healthy aging, reduced reproductive phase and expression of molecular reporters associated with dietary restriction. Using RNAi knockdown, we have identified multiple transcription factors (SKN-1, DAF-16 and HSF-1) and a transcriptional co-factor CBP-1 that seems to play an important role in making mir-80 long-lived through dietary restriction. In short, we have discovered the first ever microRNA (miR-80) that modulates dietary restriction and longevity in C. elegans. In sum, we have shown that microRNAs can modulate various aspects of C. elegans healthspan, and determined the role of some microRNAs in aging, muscle physiology and dietary restriction. Becaue miRNA signaling can be conserved, our studies will provide clues to similar processes in vertebrates, including humans.
Author : H.D. Osiewacz
Publisher : Springer Science & Business Media
ISBN 13 : 9401706719
Total Pages : 278 pages
Book Rating : 4.4/5 (17 download)
Download or read book Aging of Organisms written by H.D. Osiewacz and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological aging as the time-depending general decline of biological systems associated with a progressively increasing mortality risk is a general phenomenom of great significance. The underlying processes are very complex and depending on genetic and environment factors. These factors encode or affect a network of interconnected cellular pathways. In no system this network has been deciphered in greater detail. However, the strategy of studying various biological systems has let to the identification of pathways and specific modules and makes it obvious that aging is the result of different overlapping mechanisms and pathways. Some of these appear to be conserved ("public") among species, others are specific or "private" and only of significance in one or a few organisms. This volume in the series on "Biology of aging and its modulation" specifically focuses on organismic aging. The book covers research on organisms from lower to higher complexity representing examples from very diverse taxa like photosynthetic plants, fungi, sponges, nematodes, flies, birds and mammals. Such a broad treatise of this complex topic provides a comprehensive "flavor" about the current issues dealt with in this rapidly growing scientific discipline.
Author : American Aging Association
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (777 download)
Download or read book Functional Modulation of Food Restriction During Aging written by American Aging Association and published by . This book was released on 1996 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hae-Young Chung
Publisher : MDPI
ISBN 13 : 3039438379
Total Pages : 186 pages
Book Rating : 4.0/5 (394 download)
Download or read book The Effect of Calorie Restriction and Intermittent Fasting on Health and Disease written by Hae-Young Chung and published by MDPI. This book was released on 2021-01-29 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent biochemical studies indicate that calorie restriction (CR) is a widely accepted method for anti-aging intervention. CR and intermittent fasting (IF), which involves reduced calories but proper nutritional intake during specific periods, are interventions that can consistently promote health benefits, delay biological aging, and extend both average and maximal lifespan. Furthermore, CR can modulate age-related diseases such as Alzheimer’s disease, atherosclerosis, diabetes, obesity, cancer, and others. Advances in omics technologies have provided a technical breakthrough that enabled the investigation of DNA, RNA, proteins, and other cellular molecules and their comprehensive interactions in a biological context. Nowadays, it is possible to analyze and integrate biological processes that occur in aging systems at the molecular level using state-of-the-art techniques such as next-generation sequencing (NGS), proteomics, lipidomics, metabolomics, and epigenomics. Omics technology and systems gerontology provide predictive information on CR effects, molecular mechanisms, and pathways underlying the anti-aging actions of CR and IF. This Special Issue, “The effects of calorie restriction and intermittent fasting on health and disease”, focuses on the effects of calorie restriction and intermittent fasting on age-related inflammation, autophagy, metabolism, longevity, mitochondrial function, and age-related diseases.
Author : Christian Sell
Publisher : Springer Science & Business Media
ISBN 13 : 160327507X
Total Pages : 203 pages
Book Rating : 4.6/5 (32 download)
Download or read book Life-Span Extension written by Christian Sell and published by Springer Science & Business Media. This book was released on 2009-07-27 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process. Single mutations that extend life span have been identified in yeast, worms, flies, and mice, whereas studies in humans have identified potentially important markers for successful aging. At the same time, it has been discovered that the genes and pathways identified in these studies involve a surprisingly small set of conserved functions, most of which have been the focus of aging research for some time. For example, the mTOR pathway, a regulator of translation and protein synthesis, has been identified as a common longevity pathway in yeast and Caenorhabditis elegans. In mammals, this pathway intersects with neuroendocrine pathways and with the insulin/insulin-like growth factor pathways, which have been identified as major modulators of life span and aging in both invertebrates and mice. Novel, emerging technologies and the increasingly wide variety of systems that are now used to study aging and the mechanisms of aging provide enormous opportunities for the identification of common pathways that modulate longevity. It is these common pathways that are the focus of this important volume.
Author : C. S. Pitchumoni
Publisher : Springer Science & Business Media
ISBN 13 : 1441916237
Total Pages : 660 pages
Book Rating : 4.4/5 (419 download)
Download or read book Geriatric Gastroenterology written by C. S. Pitchumoni and published by Springer Science & Business Media. This book was released on 2012-07-26 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: As aging trends in the United States and Europe in particular are strongly suggestive of increasingly older society, it would be prudent for health care providers to better prepare for such changes. By including physiology, disease, nutrition, pharmacology, pathology, radiology and other relevant associated topics, Geriatric Gastroenterology fills the void in the literature for a volume devoted specifically to gastrointestinal illness in the elderly. This unique volume includes provision of training for current and future generations of physicians to deal with the health problems of older adults. It will also serve as a comprehensive guide to practicing physicians for ease of reference. Relevant to the geriatric age group, the volume covers epidemiology, physiology of aging, gastrointestinal physiology, pharmacology, radiology, pathology, motility disorders, luminal disorders, hepato-biliary disease, systemic manifestations, neoplastic disorders, gastrointestinal bleeding, cancer and medication related interactions and adverse events, all extremely common in older adults; these are often hard to evaluate and judge, especially considering the complex aging physiology. All have become important components of modern medicine. Special emphasis is be given to nutrition and related disorders. Capsule endoscopy and its utility in the geriatric population is also covered. Presented in simple, easy to read style, the volume includes numerous tables, figures and key points enabling ease of understanding. Chapters on imaging and pathology are profusely illustrated. All chapters are written by specialists and include up to date scientific information. Geriatric Gastroenterology is of great utility to residents in internal medicine, fellows in gastroenterology and geriatric medicine as well as gastroenterologists, geriatricians and practicing physicians including primary care physicians caring for older adults.
Author : Trygve O. Tollefsbol
Publisher : Springer Science & Business Media
ISBN 13 : 1441906398
Total Pages : 462 pages
Book Rating : 4.4/5 (419 download)
Download or read book Epigenetics of Aging written by Trygve O. Tollefsbol and published by Springer Science & Business Media. This book was released on 2009-11-11 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
Author : Alexander M Vaiserman
Publisher : Royal Society of Chemistry
ISBN 13 : 178262435X
Total Pages : 592 pages
Book Rating : 4.7/5 (826 download)
Download or read book Anti-aging Drugs written by Alexander M Vaiserman and published by Royal Society of Chemistry. This book was released on 2017-02-01 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field. A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.
Author : Raymond Pearl
Publisher :
ISBN 13 :
Total Pages : 220 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Rate of Living written by Raymond Pearl and published by . This book was released on 1928 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Irwin H. Rosenberg
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805573219
Total Pages : 266 pages
Book Rating : 4.8/5 (55 download)
Download or read book Nutrition and Aging written by Irwin H. Rosenberg and published by Karger Medical and Scientific Publishers. This book was released on 2002 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humanity is aging. In the last century, life expectancy has increased by as much as 25 years, the greatest increase in 5'000 years of history. As a consequence the elderly constitute today the fastest growing segment of the world's population. This new situation creates many social problems and challenges to health care which both the developed as well as the developing countries will have to cope with. The present publication shows that scientific progress has reached a level where nutritional interventions may play a decisive part in the prevention of degenerative conditions of age, improvement of quality of life and impact on health care burden and resources. Topics deal with such different aspects as the influence of prenatal and early infant nutrition on the future aged individual and effects of energetic restriction on longevity. Further contributions include studies on mitochondrial alterations, digestive problems, specific metabolic deviations mediated by insulin, bone degradation, structural changes, neuromuscular dysfunctions, mental state of the elderly as well as the response of the immune system to nutrient intake. Finally the book offers a review of requirements appropriate to meet the age-related public health challenges of the 21st century.
