Modern Avenues in Metal-Nucleic Acid Chemistry

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Author :
Publisher : CRC Press
ISBN 13 : 100084787X
Total Pages : 465 pages
Book Rating : 4.0/5 (8 download)

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Book Synopsis Modern Avenues in Metal-Nucleic Acid Chemistry by : Jens Müller

Download or read book Modern Avenues in Metal-Nucleic Acid Chemistry written by Jens Müller and published by CRC Press. This book was released on 2023-04-24 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 25, entitled Modern Avenues in Metal-Nucleic Acid Chemistry, of the series Metal Ions in Life Sciences (MILS), provides a timely overview of selected relevant developments in a field which previously had a pronounced focus on fundamental chemistry aspects such as coordination principles, structural chemistry, and consequences for biological processes and disease-related medicinal issues. More recently, also as a consequence of the advent of supramolecular chemistry, advancements in nanochemistry, and new bio-analytical methods, novel aspects of this field have emerged. MILS-25 gives a state-of-the-art account on the present state of research in this field, addressing, among others, porous materials, non-covalent interactions, stimuli-responsive bioconjugates, DNA-templated metal arrays and nanoclusters, genotyping, guanine quadruplexes, and riboswitches. It consists of 15 comprehensive chapters with over 1600 citations, 160 figures (90 of them in color), with key contributions from 40 international experts from Europe, Asia, and America. It is an essential resource for scientists from numerous disciplines, ranging from materials science to biochemistry, by way of classical chemistry and physics. • It offers an update on nucleic acid – metal complex bioconjugates and their applications • It provides an insight into coordination polymers involving nucleic acid components • It covers a wide range of nucleic acids, from DNA duplexes, triplexes and quadruplexes to RNA

Interplay Between Metal Ions and Nucleic Acids

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 9400721714
Total Pages : 386 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Interplay Between Metal Ions and Nucleic Acids by : Astrid Sigel

Download or read book Interplay Between Metal Ions and Nucleic Acids written by Astrid Sigel and published by Springer Science & Business Media. This book was released on 2012-01-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interplay between Metal Ions and Nucleic Acids provides in an authoritative and timely manner in 12 stimulating chapters, written by 24 internationally recognized experts from 8 nations, and supported by nearly 1500 references, about 20 tables, and 125 illustrations, many in color, a most up-to-date view on metal ion-nucleic acid interactions; the characterization of which is covered in solution and in the solid state. The volume concentrates on modern developments encompassing topics in the wide range from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs) being thus of relevance, e.g., for chemistry and nanotechnology but also for molecular biology and (genetic) diagnostics.

Metal Ions in Biological Systems

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Author :
Publisher : CRC Press
ISBN 13 : 9780824795498
Total Pages : 860 pages
Book Rating : 4.7/5 (954 download)

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Book Synopsis Metal Ions in Biological Systems by : Astrid Sigel

Download or read book Metal Ions in Biological Systems written by Astrid Sigel and published by CRC Press. This book was released on 1996-02-05 with total page 860 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 32 covers metal ion bonding to phosphate, sugar and nucleobase residues; the ambidentate as well as the stacking properties of nucleotides; kinetic aspects as well as properties of nucleobase and nucleotide analogs; and the oligonucleotides and nucleic acids. It examines electron transfer reactions over a large number of base repairs in DNA, the role of metal ions in ribozymes, ternary metal-nucleic acid base-protein complexes, metal responsive gene regulation, and the structure-activity relationships of anticancer drugs and their action on DNA, including cisplatin and the role of proteins.

Metal Ions in Biological Systems

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Author :
Publisher : CRC Press
ISBN 13 : 9780824796884
Total Pages : 736 pages
Book Rating : 4.7/5 (968 download)

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Book Synopsis Metal Ions in Biological Systems by : Astrid Sigel

Download or read book Metal Ions in Biological Systems written by Astrid Sigel and published by CRC Press. This book was released on 1996-02-29 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Volume 33 focuses on the vibrant research area of probing nucleic acids--the carriers of the genetic code--by metal ion complexes of small molecules providing an authoritative, timely account of this fascinating topic by over 50 distinguished experts."

Nucleic Acid-metal Ion Interactions

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Author :
Publisher : Royal Society of Chemistry
ISBN 13 : 0854041958
Total Pages : 449 pages
Book Rating : 4.8/5 (54 download)

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Book Synopsis Nucleic Acid-metal Ion Interactions by : Nicholas V. Hud

Download or read book Nucleic Acid-metal Ion Interactions written by Nicholas V. Hud and published by Royal Society of Chemistry. This book was released on 2009 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a perspective on nucleic acid-metal ion interactions with an emphasis on experimental biophysical studies which will prove indispensable to biophysicists and molecular biologists.

Interplay Between Metal Ions and Nucleic Acids

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Author :
Publisher :
ISBN 13 : 9789400721739
Total Pages : 388 pages
Book Rating : 4.7/5 (217 download)

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Book Synopsis Interplay Between Metal Ions and Nucleic Acids by :

Download or read book Interplay Between Metal Ions and Nucleic Acids written by and published by . This book was released on 2012-01-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Organic Chemistry of Nucleic Acids

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1468429736
Total Pages : 382 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Organic Chemistry of Nucleic Acids by : N. Kochetkov

Download or read book Organic Chemistry of Nucleic Acids written by N. Kochetkov and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of nucleic acids is one of the most rapidly developing fields in modern science. The exceptionally important role of the nucleic acids as a key to the understanding of the nature of life is reflected in the enormous number of published works on the subject, including many outstanding monographs and surveys. The pathways of syn thesis and metabolism of nucleic acid,s and the many and varied biological functions of these biopolymers are examined with the utmost detail in the literature. Nearly as much attention has been paid to the macromolecular chemistry of the nucleic acids: elucidation of the size and shape of their molecules, the study of the physicochemical properties of their solutions, and the appropriate methods to be used in such research. The surveys of the chemistry of nucleic acids which have been published so far deal almost entirely with their synthesis and, in particular, with the synthetic chemistry of monomers (nucleosides and nucleotides) ; less attention has been paid to the synthesis of poly nucleotides. There is yet another highly important aspect of the chemistry of nucleic acids which is still in the formative stage, the study of the reactivity of nucleic acid macromolecules and their components. This can make an important contribution to the deter mination of the structure of these remarkable biopolymers and to the correct understanding of their biological functions.

Nucleic Acid Chemistry

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Author :
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 442 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Nucleic Acid Chemistry by : Leroy B. Townsend

Download or read book Nucleic Acid Chemistry written by Leroy B. Townsend and published by Wiley-Interscience. This book was released on 1978 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth part of a continuing series gives detailed information on up-to-date approaches that enable researchers to select suitable procedures. The descriptions provided are detailed so the novice, as well as those with experience, will be able to apply information in the laboratory.

Radical and Radical Ion Reactivity in Nucleic Acid Chemistry

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 0470526262
Total Pages : 400 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Radical and Radical Ion Reactivity in Nucleic Acid Chemistry by : Michael D. Greenberg

Download or read book Radical and Radical Ion Reactivity in Nucleic Acid Chemistry written by Michael D. Greenberg and published by John Wiley & Sons. This book was released on 2009-09-22 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive coverage of radical reactive intermediates in nucleic acid chemistry and biochemistry The Wiley Series on Reactive Intermediates in Chemistry and Biology investigates reactive intermediates from the broadest possible range of disciplines. The contributions in each volume offer readers fresh insights into the latest findings, emerging applications, and ongoing research in the field from a diverse perspective. The chemistry and biochemistry of reactive intermediates is central to organic chemistry and biochemistry, and underlies a significant portion of modern synthetic chemistry. Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides the only comprehensive review of the chemistry and biochemistry of nucleic acid radical intermediates. With contributions by world leaders in the field, the text covers a broad range of topics, including: A discussion of the relevant theory Ionization of DNA Nucleic acid sugar radicals Halopyrimidines Oxidative, reductive, and low energy electron transfer Electron affinity sensitizers Photochemical generative of reactive oxygen species Reactive nitrogen species Enediyne rearrangements Phenoxyl radicals A unique compilation on the cutting edge of our understanding, Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides an unparalleled resource to student and professional researchers in such fields as organic chemistry, biochemistry, molecular biology, and physical chemistry, as well as the industries associated with these disciplines.

Basic Principles in Nucleic Acid Chemistry V1

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Author :
Publisher : Elsevier
ISBN 13 : 0323144004
Total Pages : 651 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Basic Principles in Nucleic Acid Chemistry V1 by : Paul O.P. Ts'o

Download or read book Basic Principles in Nucleic Acid Chemistry V1 written by Paul O.P. Ts'o and published by Elsevier. This book was released on 2012-12-02 with total page 651 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Principles in Nucleic Acid Chemistry, Volume I provides information pertinent to the fundamental aspects of nucleic acids. This book discusses the development of the basic principles in nucleic acid research that will serve as a foundation for further advancement in nucleic acid research. Organized into six chapters, this volume begins with an overview of the history of the scientific study of nucleic acid as a genetic material. This text then examines the utility of the analogs of the naturally occurring nucleic acid components as biochemical tools and as therapeutic agents. Other chapters consider mass spectrometry that deals with the production and chemistry of ions in the vapor phase. This book discusses as well the various aspects of the excited states of the nucleic acids. The final chapter deals with the systematic study of the physiochemical properties of the monomeric units of nucleic acid. This book is a valuable resource for molecular biologists, scientists, and research workers.

Nucleic Acids in Chemistry and Biology

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Author :
Publisher : Royal Society of Chemistry
ISBN 13 : 1782625771
Total Pages : 824 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Nucleic Acids in Chemistry and Biology by : G Michael Blackburn

Download or read book Nucleic Acids in Chemistry and Biology written by G Michael Blackburn and published by Royal Society of Chemistry. This book was released on 2015-11-09 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

Basic Principles in Nucleic Acid Chemistry V2

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Author :
Publisher : Elsevier
ISBN 13 : 0323146899
Total Pages : 532 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Basic Principles in Nucleic Acid Chemistry V2 by : Paul O.P. Ts'o

Download or read book Basic Principles in Nucleic Acid Chemistry V2 written by Paul O.P. Ts'o and published by Elsevier. This book was released on 2012-12-02 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Principles in Nuclear Acid Chemistry, Volume II presents the significant progress in nucleic acid research and its contribution and influence on various aspects of human life. This book contains five chapters and begins with the susceptibility of nucleic acids towards attack by chemical reagents whose reactions with polynucleotides have been studied. This topic is followed by a presentation of experimental techniques used to study the properties of nucleic acids. The following chapter discusses some basic features embodied in the polyribo- and poly-deoxyribonucleotide backbone chains; the possibility of rotation around backbone bonds in the ""random"" single-stranded form; and the short- and long-range interactions in idealized and real chains. This chapter also looks into the thermodynamic and polyelectrolyte aspects of nucleic acid behavior. A chapter describes the special features of the third class of DNA, namely, closed duplex DNA, in which covalent chain scissions are absent. The last chapter examines the intrinsic properties and the interaction of the dimers and oligomers, with special emphasis on the influence of the phosphodiester linkages on the conformation and interaction of these short segments of nucleic acids. This book is of great value to workers in biomedical research and to higher level biochemistry instructors.

Chemistry of Nucleic Acids

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Author :
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110609290
Total Pages : 364 pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis Chemistry of Nucleic Acids by : Harri Lönnberg

Download or read book Chemistry of Nucleic Acids written by Harri Lönnberg and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-08-10 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides.

Supramolecular Nucleic Acid Chemistry

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889661105
Total Pages : 125 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Supramolecular Nucleic Acid Chemistry by : James Tucker

Download or read book Supramolecular Nucleic Acid Chemistry written by James Tucker and published by Frontiers Media SA. This book was released on 2020-10-28 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Principles of Nucleic Acid Structure

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Author :
Publisher : Springer
ISBN 13 :
Total Pages : 584 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Principles of Nucleic Acid Structure by : Wolfram Saenger

Download or read book Principles of Nucleic Acid Structure written by Wolfram Saenger and published by Springer. This book was released on 1984 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical ther modynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the grad uate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses. CHARLES R. CANTOR New York Preface This monograph is based on a review on polynucleotide structures written for a book series in 1976.

Metal Complex - DNA Interactions

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Author :
Publisher : Wiley-Blackwell
ISBN 13 : 9781405176293
Total Pages : 544 pages
Book Rating : 4.1/5 (762 download)

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Book Synopsis Metal Complex - DNA Interactions by : Nick Hadjiliadis

Download or read book Metal Complex - DNA Interactions written by Nick Hadjiliadis and published by Wiley-Blackwell. This book was released on 2009-05-11 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents. Understanding how metal complexes interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine. Metal Complex - DNA Interactions provides a comprehensive overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity. The text is divided into four parts: Basic Structural and Kinetic Aspects: includes chapters on sequence-selective metal binding to DNA and thermodynamic models. Medical Applications: focuses on anticancer platinum drugs, including discussions on DNA repair in antitumor effects of platinum drugs and photo-dynamic therapy. DNA-Recognition - Nucleases and Sensor: describes probes for DNA recognition, artificial restriction agents, metallo-DNAzymes for metal sensing applications and metal ion dependent catalysis in nucleic acid enzymes. Toxicological Aspects: deals with structural studies of mercury–DNA interactions, chromium-induced DNA damage and repair, and the effect of arsenic and nickel on DNA integrity. This book will be a valuable resource for academic researchers and professionals from a range of pharmaceutical and chemical industries, particularly those involved in the development of new and less toxic anticancer metallo-drugs, and in the field of environmental and toxicological chemistry.

The Nucleic Acids

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Author :
Publisher :
ISBN 13 :
Total Pages : 612 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Nucleic Acids by : Erwin Chargaff

Download or read book The Nucleic Acids written by Erwin Chargaff and published by . This book was released on 1960 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: